Wagdy Eldehna

All Stories

1. 
   Design, synthesis, and biological evaluation of isatin-based benzenesulfonamides as carbonic anhydrase II/VII inhibitors with anticonvulsant activity

   Article • European Journal of Medicinal Chemistry, January 2027, Elsevier

   Wagdy Eldehna

2. 
   Pyrazoline- and hydrazone-linked thiazole-triazole hybrids as potent dual-stage antileishmanial agents with antifolate activity

   Article • European Journal of Medicinal Chemistry Reports, December 2026, Elsevier

   Wagdy Eldehna

3. 
   Design of 4-(Piperazin-1-yl)thieno[2,3-d]pyrimidine derivatives Targeting the DFG-out Conformation of VEGFR-2: Synthesis, Biological Evaluations, and Molecular modeling approaches

   Article • European Journal of Medicinal Chemistry, October 2026, Elsevier

   Wagdy Eldehna

4. 
   Targeting CDK‐2 With Novel Indole‐Pyrazole Hybrids: Discovery of Potent Anticancer Agents Supported by Mechanistic and In Silico Studies

   Article • Drug Development Research, August 2026, Wiley

   Wagdy Eldehna

5. 
   N-(Benzofuran-3-ylmethyl)isatin derivatives as potential SARS-CoV-2 main protease inhibitors: Synthesis, biological evaluation, kinetic analysis, and molecular modeling insights

   Article • Journal of Molecular Structure, June 2026, Elsevier

   Wagdy Eldehna

6. 
   Molecular Boomerangs Against Cancer: Design, Synthesis, Biological Evaluation, and In Silico Study of Novel Dual PARP‐1/EGFR Inhibitors

   Article • Drug Development Research, May 2026, Wiley

   Wagdy Eldehna, Dr. Moataz Ahmed Shaldam

7. 
   Design and Synthesis of Indole-Based Imidazo[1,2- a ]pyridine Derivatives as Antiseizure Candidates: Evaluation in Chemically Induced Seizure Models and In Vitro ...

   Article • ACS Chemical Neuroscience, May 2026, American Chemical Society (ACS)

   Wagdy Eldehna

8. 
   Discovery of a Mixed and Prodrug-Like Inhibition Mechanism for Phosphocoumarins and Phosphoquinolinones against Human Carbonic Anhydrases

   Article • Journal of Medicinal Chemistry, April 2026, American Chemical Society (ACS)

   Wagdy Eldehna

9. 
   Thiazole‐Semicarbazone Hybrids as Dual‐Stage Inhibitors of Leishmania major Growth: Design, Synthesis, and Mechanistic Insights

   Article • Drug Development Research, March 2026, Wiley

   Wagdy Eldehna, Dr. Moataz Ahmed Shaldam

10. 
    Multi-target pyrazolopyrimidine-coumarin derivatives as potent CA IX/XII and tubulin polymerization inhibitors: Design, synthesis, and biological evaluation

    Article • European Journal of Medicinal Chemistry, March 2026, Elsevier

    Wagdy Eldehna

11. 
    Synthesis and Biological Evaluation of Imidazopyridine-Isatin Hybrids as Inhibitors of Leishmania major Growth

    Article • Drug Design Development and Therapy, March 2026, Taylor & Francis

    Wagdy Eldehna

12. 
    Discovery of enaminone-linked benzofuran derivatives as dual VEGFR-2/hCA IX inhibitors exhibiting hypoxia-mediated chemosensitization

    Article • RSC Medicinal Chemistry, January 2026, Royal Society of Chemistry

    Wagdy Eldehna

13. 
    Synthesis of new trans -ferulic acid derivatives as potential anticancer agents and VEGFR-2 inhibitors

    Article • RSC Medicinal Chemistry, January 2026, Royal Society of Chemistry

    Wagdy Eldehna

14. 
    Pyrazole–triazole hybrids as kinase-triad inhibitors: a triple-target strategy for synergistic anticancer therapy

    Article • RSC Medicinal Chemistry, January 2026, Royal Society of Chemistry

    Wagdy Eldehna

15. 
    Imidazopyridine derivatives as promising anti- Toxoplasma gondii agents: in vitro studies, in vivo testing, and...

    Article • RSC Advances, January 2026, Royal Society of Chemistry

    Wagdy Eldehna

16. 
    Ring-opening simplification of thiazolyl–pyrazoline–triazole hybrids: synthesis, SAR and antifolate mechanism against Leishmania major

    Article • RSC Medicinal Chemistry, January 2026, Royal Society of Chemistry

    Wagdy Eldehna

17. 
    Quinazolinone–triazole hybrids as multi-target-directed ligands for Alzheimer's disease: discovery of potent and selective MAO-B inhibitors with cholinesterase modulating activity

    Article • RSC Advances, January 2026, Royal Society of Chemistry

    Wagdy Eldehna

18. 
    Development of isonicotinoyl–azole hybrids as potential InhA inhibitors for anti-tubercular activity

    Article • RSC Medicinal Chemistry, January 2026, Royal Society of Chemistry

    Wagdy Eldehna

19. 
    Discovery of tricyclic benzo[4,5]imidazo[2,1- b ]thiazole-3-hydroxyindolin-2-one hybrids as selective MAO-B and cholinesterase inhibitors

    Article • RSC Advances, January 2026, Royal Society of Chemistry

    Wagdy Eldehna

20. 
    Evaluation of 6-substituted coumarins as SARS-CoV-2 main protease inhibitors: enzymatic, cellular, and computational insights

    Article • RSC Advances, January 2026, Royal Society of Chemistry

    Wagdy Eldehna

21. 
    Discovery of Novel Piperidinyl-Based Benzoxazole Derivatives as Anticancer Agents Targeting VEGFR-2 and c-Met Kinases

    Article • Pharmaceuticals, December 2025, MDPI AG

    Wagdy Eldehna

22. 
    Blue chemistry as a novel framework supported by BLOOM software to evaluate reaction practicality

    Article • Sustainable Chemistry and Pharmacy, December 2025, Elsevier

    Wagdy Eldehna

23. 
    Development of New Pyrazolo [3,4-b]Pyridine Derivatives as Potent Anti-Leukemic Agents and Topoisomerase IIα Inhibitors with Broad-Spectrum Cytotoxicity

    Article • Pharmaceuticals, November 2025, MDPI AG

    Wagdy Eldehna, Dr. Moataz Ahmed Shaldam

24. 
    Development of isatin-functionalized benzenesulfonamides as novel carbonic anhydrase II and VII inhibitors with antiepileptic potential

    Article • European Journal of Medicinal Chemistry, August 2025, Elsevier

    Wagdy Eldehna

25. 
    Identification of Novel Triazole–Pyrazole Conjugates as Potential Anticonvulsant Agents: Synthesis and Biological Evaluations

    Article • ACS Chemical Neuroscience, July 2025, American Chemical Society (ACS)

    Wagdy Eldehna

26. 
    LC–MS/MS Assay for Simultaneous Quantification of Dual‐Targeting 1,5‐Diaryl‐1,2,4‐Triazole Sulfonamides (WA11–13) in Human Plasma

    Article • Biomedical Chromatography, July 2025, Wiley

    Wagdy Eldehna

27. 
    Novel benzenesulfonamide derivatives linked to diaryl pyrazole tail as potential carbonic anhydrase II/VII inhibitors with anti-epileptic activity

    Article • European Journal of Medicinal Chemistry, July 2025, Elsevier

    Wagdy Eldehna

28. 
    Click Chemistry‐Aided Synthesis of Triazole‐Tethered Benzothiazoles as Novel Multifunctional Agents Against Alzheimer's Disease

    Article • Archiv der Pharmazie, July 2025, Wiley

    Wagdy Eldehna

29. 
    DprE1 inhibitors: An insight into the recent developments and synthetic approaches

    Article • European Journal of Pharmaceutical Sciences, June 2025, Elsevier

    Wagdy Eldehna

30. 
    Targeting sensitive and multidrug resistant leukemia cells with a novel benzofuran-isatin conjugate

    Article • European Journal of Pharmacology, June 2025, Elsevier

    Wagdy Eldehna

31. 
    Investigation of Moxifloxacin-loaded terpenes enriched cationic cerosomes (TECs) as an adjunct pulmonary therapy for COVID-19: In-silico study; D-optimal optimization; aerodynamic simulation assessment and cytotoxic evaluation

    Article • Journal of Drug Delivery Science and Technology, April 2025, Elsevier

    Wagdy Eldehna

32. 
    Chemical composition and biological activity of lemongrass volatile oil and n-Hexane extract: GC/MS analysis, in vitro and molecular modelling studies

    Article • PLOS One, February 2025, PLOS

    Prof Omayma A. Eldahshan, Wagdy Eldehna

33. 
    Exploring antitumor activity of novel imidazo[2,1-b]thiazole and imidazo[1,2-a]pyridine derivatives on MDA-MB-231 cell line: Targeting VEGFR-2 enzyme with computational insight

    Article • Journal of Molecular Structure, February 2025, Elsevier

    Wagdy Eldehna

34. 
    Novel N-(3-(1-(4-sulfamoylphenyl)triazol-4-yl)phenyl)benzamide Derivatives as Potent Carbonic Anhydrase Inhibitors with Broad-Spectrum Anticancer Activity: Leveraging Tail and Dual-Tail Approaches

    Article • Journal of Medicinal Chemistry, January 2025, American Chemical Society (ACS)

    Wagdy Eldehna

35. 
    Exploring the anticancer potential of new pyrazolopyrimidine analogues as multi-target directed EGFR/STAT3 downregulatory candidates with apoptotic potential

    Article • New Journal of Chemistry, January 2025, Royal Society of Chemistry

    Wagdy Eldehna

36. 
    New nicotinamide–thiadiazol hybrids as VEGFR-2 inhibitors for breast cancer therapy: design, synthesis and in silico and in vitro evaluation

    Article • RSC Advances, January 2025, Royal Society of Chemistry

    Wagdy Eldehna, Dr walid Ebaied elgammal

37. 
    Discovery and characterization of phenoxyacetic acid derivatives as potential antiepileptic agents

    Article • RSC Advances, January 2025, Royal Society of Chemistry

    Wagdy Eldehna

38. 
    An exploration of potent antileishmanial agents derived from quinoline–thiazole and thiadiazole hybrids, targeting DHFR-TS and PTR1: design, synthesis, and computational analyses

    Article • RSC Medicinal Chemistry, January 2025, Royal Society of Chemistry

    Wagdy Eldehna

39. 
    A Modified Green Star Area (MoGSA) and software to assess greenness of reactions in the chemistry laboratories

    Article • PLOS One, December 2024, PLOS

    Wagdy Eldehna

40. 
    Identification of Coumarin-Chalcone and Coumarin-Pyrazoline Derivatives as Novel Anti-Toxoplasma gondii Agents

    Article • Drug Design Development and Therapy, December 2024, Taylor & Francis

    Wagdy Eldehna

41. 
    4-(Pyrazolyl)benzenesulfonamide Ureas as Carbonic Anhydrases Inhibitors and Hypoxia-Mediated Chemo-Sensitizing Agents in Colorectal Cancer Cells

    Article • Journal of Medicinal Chemistry, November 2024, American Chemical Society (ACS)

    Wagdy Eldehna

42. 
    Exploring the phytochemicals, antioxidant properties, and hepatoprotective potential of Moricandia sinaica leaves against paracetamol-induced toxicity: Biological evaluations and in Silico insights

    Article • PLOS One, October 2024, PLOS

    Wagdy Eldehna, Dr Rabab Rasheed

43. 
    Hydrogen Sulfide-Releasing Carbonic Anhydrase Inhibitors Effectively Suppress Cancer Cell Growth

    Article • International Journal of Molecular Sciences, September 2024, MDPI AG

    Wagdy Eldehna

44. 
    Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic simulations

    Article • Journal of Molecular Structure, August 2024, Elsevier

    Wagdy Eldehna, Dr. Moataz Ahmed Shaldam

45. 
    Discovery of new quinoline derivatives bearing 1-Aryl-1,2,3-Triazole motif as influenza H1N1 virus neuraminidase inhibitors

    Article • Bioorganic Chemistry, August 2024, Elsevier

    Wagdy Eldehna

46. 
    Inhibitory Effect of Two Carbonic Anhydrases Inhibitors on the Activity of Major Cytochrome P450 Enzymes

    Article • European Journal of Drug Metabolism and Pharmacokinetics, June 2024, Springer Science + Business Media

    Wagdy Eldehna

47. 
    In vitro biological evaluation and in silico insights into the antiviral activity of standardized olive leaves extract against SARS-CoV-2

    Article • PLOS One, April 2024, PLOS

    Wagdy Eldehna

48. 
    DFT and molecular simulation validation of the binding activity of PDEδ inhibitors for repression of oncogenic k-Ras

    Article • PLOS One, March 2024, PLOS

    Wagdy Eldehna, Ahmed Sabt, Dr. Moataz Ahmed Shaldam

49. 
    Novel indolinone-tethered benzothiophenes as anti-tubercular agents against MDR/XDR M. tuberculosis: Design, synthesis, biological evaluation and in vivo pharmacokinetic study

    Article • Bioorganic Chemistry, February 2024, Elsevier

    Wagdy Eldehna

50. 
    An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review

    Article • Molecular Diversity, January 2024, Springer Science + Business Media

    Wagdy Eldehna

51. 
    1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking

    Article • Pharmaceuticals, January 2024, MDPI AG

    Wagdy Eldehna

52. 
    New pyrazolylindolin-2-one based coumarin derivatives as anti-melanoma agents: design, synthesis, dual BRAFV600E/VEGFR-2 inhibition, and computational studies

    Article • RSC Advances, January 2024, Royal Society of Chemistry

    Wagdy Eldehna

53. 
    Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with antibiofilm activity

    Article • RSC Advances, January 2024, Royal Society of Chemistry

    Wagdy Eldehna, Dr. Moataz Ahmed Shaldam

54. 
    Phthalimide‐tethered isatins as novel poly(ADP‐ribose) polymerase inhibitors: Design, synthesis, biological evaluations, and molecular modeling investigations

    Article • Archiv der Pharmazie, December 2023, Wiley

    Wagdy Eldehna

55. 
    New nicotinamide derivatives as potential anticancer agents targeting VEGFR-2: design, synthesis, in vitro , and in silico studies

    Article • Journal of Biomolecular Structure and Dynamics, December 2023, Taylor & Francis

    Wagdy Eldehna

56. 
    Comparative metabolic study of the chloroform fraction of three Cystoseira species based on UPLC/ESI/MS analysis and biological activities

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, December 2023, Taylor & Francis

    Wagdy Eldehna

57. 
    Phytochemical profiling and mechanistic evaluation of black garlic extract on multiple sclerosis rat model

    Article • Journal of Functional Foods, December 2023, Elsevier

    Wagdy Eldehna

58. 
    Novel N -Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, November 2023, Taylor & Francis

    Wagdy Eldehna

59. 
    Design and synthesis of benzo[b]thiophene‐based hybrids as novel antitubercular agents against MDR/XDR Mycobacterium tuberculosis

    Article • Archiv der Pharmazie, November 2023, Wiley

    Wagdy Eldehna

60. 
    Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights

    Article • Bioorganic Chemistry, November 2023, Elsevier

    Dr. Moataz Ahmed Shaldam, Wagdy Eldehna

61. 
    Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties

    Article • European Journal of Medicinal Chemistry, November 2023, Elsevier

    Wagdy Eldehna

62. 
    Identification of 3‐(5‐cyano‐6‐oxo‐pyridin‐2‐yl)benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity

    Article • Archiv der Pharmazie, October 2023, Wiley

    Dr. Moataz Ahmed Shaldam, Wagdy Eldehna

63. 
    3-Acetyl-11-keto-β-boswellic Acid-Based Hybrids Alleviate Acetaminophen-Induced Hepatotoxicity in HepG2 by the Regulation of Inflammatory and Oxidative Stress Pathways: An Integrated Approach

    Article • ACS Omega, October 2023, American Chemical Society (ACS)

    Wagdy Eldehna

64. 
    2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling

    Article • European Journal of Medicinal Chemistry, October 2023, Elsevier

    Wagdy Eldehna

65. 
    Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer

    Article • European Journal of Medicinal Chemistry, October 2023, Elsevier

    Wagdy Eldehna

66. 
    Discovery of pyrimidine-tethered benzothiazole derivatives as novel anti-tubercular agents towards multi- and extensively drug resistant Mycobacterium tuberculosis

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, August 2023, Taylor & Francis

    Wagdy Eldehna

67. 
    Investigating the promising SARS-CoV-2 main protease inhibitory activity of secoiridoids isolated from Jasminum humile ; in silico and in Vitro assessments wit...

    Article • Journal of Biomolecular Structure and Dynamics, July 2023, Taylor & Francis

    Wagdy Eldehna

68. 
    Morphologic design of nanogold carriers for a carbonic anhydrase inhibitor: Effect on ocular retention and intraocular pressure

    Article • International Journal of Pharmaceutics, July 2023, Elsevier

    Wagdy Eldehna

69. 
    Chemical composition, seasonal variation and antiaging activities of essential oil from Callistemon subulatus leaves growing in Egypt

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, June 2023, Taylor & Francis

    Wagdy Eldehna

70. 
    Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N -(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico...

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, April 2023, Taylor & Francis

    Wagdy Eldehna

71. 
    Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, April 2023, Taylor & Francis

    Wagdy Eldehna, Professor Bahaa Elgendy

72. 
    1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights

    Article • Molecules, April 2023, MDPI AG

    Wagdy Eldehna

73. 
    Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies

    Article • Molecules, March 2023, MDPI AG

    Wagdy Eldehna

74. 
    Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, March 2023, Taylor & Francis

    Wagdy Eldehna

75. 
    WRH-2412 alleviates the progression of hepatocellular carcinoma through regulation of TGF-β/β-catenin/α-SMA pathway

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, March 2023, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar, Wagdy Eldehna

76. 
    4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments

    Article • European Journal of Medicinal Chemistry, March 2023, Elsevier

    Wagdy Eldehna, Professor Bahaa Elgendy

77. 
    GC/MS Profiling of the Essential Oil and Lipophilic Extract of Moricandia sinaica Boiss. and Evaluation of Their Cytotoxic and Antioxidant Activities

    Article • Molecules, February 2023, MDPI AG

    Wagdy Eldehna

78. 
    Papaverinol-N-Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening

    Article • Molecules, February 2023, MDPI AG

    Wagdy Eldehna

79. 
    Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, February 2023, Taylor & Francis

    Wagdy Eldehna

80. 
    New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies

    Article • PLOS One, January 2023, PLOS

    Samiha El-Sebaey, Wagdy Eldehna

81. 
    Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro , molecular docking, molecular dynamics, and SAR studies

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2023, Taylor & Francis

    Wagdy Eldehna

82. 
    New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2023, Taylor & Francis

    Wagdy Eldehna

83. 
    Design and synthesis of novel rigid dibenzo[ b,f ]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2023, Taylor & Francis

    Wagdy Eldehna

84. 
    Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative, docking and MD simulation studies

    Article • Journal of Biomolecular Structure and Dynamics, January 2023, Taylor & Francis

    Wagdy Eldehna

85. 
    An updated review of fatty acid residue-tethered heterocyclic compounds: synthetic strategies and biological significance

    Article • RSC Advances, January 2023, Royal Society of Chemistry

    Wagdy Eldehna

86. 
    Development of potent nanosized carbonic anhydrase inhibitor for targeted therapy of hypoxic solid tumors

    Article • International Journal of Pharmaceutics, January 2023, Elsevier

    Wagdy Eldehna

87. 
    New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies

    Article • European Journal of Medicinal Chemistry, January 2023, Elsevier

    Wagdy Eldehna

88. 
    Theophylline-based hybrids as acetylcholinesterase inhibitors endowed with anti-inflammatory activity: synthesis, bioevaluation,in silicoand preliminary kinetic studies

    Article • RSC Advances, January 2023, Royal Society of Chemistry

    Wagdy Eldehna

89. 
    Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies

    Article • Metabolites, December 2022, MDPI AG

    Wagdy Eldehna

90. 
    Chemical Constituents, Antioxidant, and Enzyme Inhibitory Activities Supported by In-Silico Study of n-Hexane Extract and Essential Oil of Guava Leaves

    Article • Molecules, December 2022, MDPI AG

    Wagdy Eldehna

91. 
    Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis

    Article • Molecules, December 2022, MDPI AG

    Wagdy Eldehna

92. 
    Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer

    Article • European Journal of Medicinal Chemistry, December 2022, Elsevier

    Wagdy Eldehna

93. 
    Investigating the Potential Anti-SARS-CoV-2 and Anti-MERS-CoV Activities of Yellow Necklacepod among Three Selected Medicinal Plants: Extraction, Isolation, Identification, In Vitro, Modes of Action, and Molecular Docking Studies

    Article • Metabolites, November 2022, MDPI AG

    Wagdy Eldehna

94. 
    Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR WT and EGFR T790M i...

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, November 2022, Taylor & Francis

    Wagdy Eldehna

95. 
    Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Wagdy Eldehna

96. 
    Identification of Novel Cyanopyridones and Pyrido[2,3-d]Pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies

    Article • Pharmaceuticals, October 2022, MDPI AG

    Wagdy Eldehna

97. 
    In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Wagdy Eldehna

98. 
    Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies

    Article • Bioorganic Chemistry, October 2022, Elsevier

    Wagdy Eldehna

99. 
    The Antioxidant and Enzyme Inhibitory Potential of n-Hexane-Extracted Oils Obtained from Three Egyptian Cultivars of the Golden Dewdrop Duranta erecta Linn. Supported by Their GC-MS Metabolome Analysis and Docking Studies

    Article • Antioxidants, September 2022, MDPI AG

    Wagdy Eldehna

100. 
     Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway

     Article • PLOS One, September 2022, PLOS

     Wagdy Eldehna

101. 
     Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, September 2022, Taylor & Francis

     Wagdy Eldehna

102. 
     Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies

     Article • Molecules, September 2022, MDPI AG

     Wagdy Eldehna

103. 
     Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and selectivity

     Article • Bioorganic Chemistry, September 2022, Elsevier

     Wagdy Eldehna

104. 
     Phytochemical Investigation of Egyptian Riverhemp: A Potential Source of Antileukemic Metabolites

     Article • Journal of Chemistry, August 2022, Hindawi Publishing Corporation

     Wagdy Eldehna

105. 
     Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, August 2022, Taylor & Francis

     Wagdy Eldehna

106. 
     Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, August 2022, Taylor & Francis

     Wagdy Eldehna

107. 
     Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, August 2022, Taylor & Francis

     Wagdy Eldehna

108. 
     New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, August 2022, Taylor & Francis

     Wagdy Eldehna

109. 
     The Anticancer Effects of the Pro-Apoptotic Benzofuran-Isatin Conjugate (5a) Are Associated With p53 Upregulation and Enhancement of Conventional Chemotherapeutic Drug Efficiency in Colorectal Cancer Cell Lines

     Article • Frontiers in Pharmacology, August 2022, Frontiers

     Wagdy Eldehna

110. 
     Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors

     Article • European Journal of Medicinal Chemistry, August 2022, Elsevier

     Wagdy Eldehna

111. 
     In-Silico targeting of SARS-CoV-2 NSP6 for drug and natural products repurposing

     Article • Virology, August 2022, Elsevier

     Wagdy Eldehna

112. 
     Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity

     Article • Scientific Reports, July 2022, Springer Science + Business Media

     Wagdy Eldehna

113. 
     The old worldsalsolaas a source of valuable secondary metabolites endowed with diverse pharmacological activities: a review

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, July 2022, Taylor & Francis

     Wagdy Eldehna

114. 
     GC-MS metabolites profiling of anethole-rich oils by different extraction techniques: antioxidant, cytotoxicity and in-silico enzymes inhibitory insights

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, July 2022, Taylor & Francis

     Wagdy Eldehna

115. 
     New [1,2,4]triazolo[4,3‐c]quinazoline derivatives as vascular endothelial growth factor receptor‐2 inhibitors and apoptosis inducers: Design, synthesis, docking, and antiproliferative evaluation

     Article • Archiv der Pharmazie, July 2022, Wiley

     Wagdy Eldehna

116. 
     Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, July 2022, Taylor & Francis

     Wagdy Eldehna

117. 
     In Silico Docking, Resistance Modulation and Biofilm Gene Expression in Multidrug-Resistant Acinetobacter baumannii via Cinnamic and Gallic Acids

     Article • Antibiotics, June 2022, MDPI AG

     Wagdy Eldehna

118. 
     Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2

     Article • Molecules, June 2022, MDPI AG

     Wagdy Eldehna

119. 
     GC/MS analysis and potential synergistic effect of mandarin and marjoram oils on Helicobacter pylori

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, May 2022, Taylor & Francis

     Wagdy Eldehna

120. 
     A patent review of anticancer CDK2 inhibitors (2017–present)

     Article • Expert Opinion on Therapeutic Patents, May 2022, Taylor & Francis

     Wagdy Eldehna

121. 
     Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, May 2022, Taylor & Francis

     Wagdy Eldehna

122. 
     Phytonutrients, Colorant Pigments, Phytochemicals, and Antioxidant Potential of Orphan Leafy Amaranthus Species

     Article • Molecules, May 2022, MDPI AG

     Wagdy Eldehna

123. 
     Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights

     Article • Drug Design Development and Therapy, May 2022, Taylor & Francis

     Wagdy Eldehna

124. 
     Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, April 2022, Taylor & Francis

     Wagdy Eldehna

125. 
     Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, April 2022, Taylor & Francis

     Dr. Moataz Ahmed Shaldam, Wagdy Eldehna

126. 
     Olive Leaves as a Potential Phytotherapy in the Treatment of COVID-19 Disease; A Mini-Review

     Article • Frontiers in Pharmacology, April 2022, Frontiers

     Wagdy Eldehna

127. 
     Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal

     Article • Drug Delivery, April 2022, Taylor & Francis

     Wagdy Eldehna

128. 
     GC/MS Profiling, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase and Anti-Hyaluronidase Activities of a Stenocarpus sinuatus Leaves Extract

     Article • Plants, March 2022, MDPI AG

     Wagdy Eldehna

129. 
     Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors 

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2022, Taylor & Francis

     Wagdy Eldehna

130. 
     Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2022, Taylor & Francis

     Wagdy Eldehna

131. 
     Computational Prediction of the Potential Target of SARS‐CoV‐2 Inhibitor Plitidepsin via Molecular Docking, Dynamic Simulations and MM‐PBSA Calculations

     Article • Chemistry & Biodiversity, January 2022, Wiley

     Wagdy Eldehna

132. 
     Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors

     Article • European Journal of Medicinal Chemistry, January 2022, Elsevier

     Wagdy Eldehna

133. 
     One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents

     Article • European Journal of Medicinal Chemistry, January 2022, Elsevier

     Wagdy Eldehna

134. 
     Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens

     Article • RSC Advances, January 2022, Royal Society of Chemistry

     Wagdy Eldehna

135. 
     Development of potent nanosized isatin-isonicotinohydrazide hybrid for management of Mycobacterium tuberculosis

     Article • International Journal of Pharmaceutics, January 2022, Elsevier

     Wagdy Eldehna

136. 
     2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, December 2021, Taylor & Francis

     Wagdy Eldehna

137. 
     Recent Advancements in the Development of Anti-Breast Cancer Synthetic Small Molecules

     Article • Molecules, December 2021, MDPI AG

     Wagdy Eldehna

138. 
     Natural inspired piperine-based ureas and amides as novel antitumor agents towards breast cancer

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, December 2021, Taylor & Francis

     Wagdy Eldehna

139. 
     Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation

     Article • European Journal of Medicinal Chemistry, December 2021, Elsevier

     Wagdy Eldehna

140. 
     Recombinant human growth hormone improves the immune status of rats with septic encephalopathy: The role of VEGFR2 in the prevalence of endoplasmic reticulum stress repair module

     Article • International Immunopharmacology, December 2021, Elsevier

     Wagdy Eldehna

141. 
     GC/MS Analysis of Essential Oil and Enzyme Inhibitory Activities of Syzygium cumini (Pamposia) Grown in Egypt: Chemical Characterization and Molecular Docking Studies

     Article • Molecules, November 2021, MDPI AG

     Wagdy Eldehna

142. 
     Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors

     Article • International Journal of Molecular Sciences, October 2021, MDPI AG

     Dr. Moataz Ahmed Shaldam, Wagdy Eldehna

143. 
     Toward the Identification of Potential α-Ketoamide Covalent Inhibitors for SARS-CoV-2 Main Protease: Fragment-Based Drug Design and MM-PBSA Calculations

     Article • Processes, June 2021, MDPI AG

     Wagdy Eldehna

144. 
     Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities

     Article • European Journal of Medicinal Chemistry, June 2021, Elsevier

     Wagdy Eldehna

145. 
     Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations

     Article • Bioorganic Chemistry, May 2021, Elsevier

     Wagdy Eldehna

146. 
     Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors

     Article • European Journal of Medicinal Chemistry, April 2021, Elsevier

     Dr. Moataz Ahmed Shaldam, Wagdy Eldehna

147. 
     Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

     Article • European Journal of Medicinal Chemistry, April 2021, Elsevier

     Wagdy Eldehna

148. 
     Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis

     Article • European Journal of Medicinal Chemistry, January 2021, Elsevier

     Wagdy Eldehna

149. 
     Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2021, Taylor & Francis

     Wagdy Eldehna, Dr Syed Nasir Abbas Bukhari

150. 
     Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2021, Taylor & Francis

     Wagdy Eldehna

151. 
     Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistantMycobacterium tuberculosisand bronchitis causing–bacteria

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2021, Taylor & Francis

     Wagdy Eldehna

152. 
     In silico identification of novel SARS-COV-2 2′-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM-PBSA approaches

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2021, Taylor & Francis

     Wagdy Eldehna

153. 
     In silico identification of potential SARS COV-2 2′-O-methyltransferase inhibitor: fragment-based screening approach and MM-PBSA calculations

     Article • RSC Advances, January 2021, Royal Society of Chemistry

     Wagdy Eldehna

154. 
     Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors

     Article • Biophysical Journal, January 2021, Elsevier

     Wagdy Eldehna

155. 
     Development of 2-oxindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, December 2020, Taylor & Francis

     Wagdy Eldehna

156. 
     Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, December 2020, Taylor & Francis

     Wagdy Eldehna

157. 
     Development and Validation of High-Throughput Bioanalytical Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for the Quantification of Newly Synthesized Antitumor Carbonic Anhydrase Inhibitors in Human Plasma

     Article • Molecules, December 2020, MDPI AG

     Wagdy Eldehna

158. 
     3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies

     Article • European Journal of Medicinal Chemistry, December 2020, Elsevier

     Wagdy Eldehna

159. 
     Identification of a New Potential SARS-COV-2 RNA-Dependent RNA Polymerase Inhibitor via Combining Fragment-Based Drug Design, Docking, Molecular Dynamics, and MM-PBSA Calculations

     Article • Frontiers in Chemistry, October 2020, Frontiers

     Wagdy Eldehna

160. 
     Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

     Article • Metabolites, October 2020, MDPI AG

     Wagdy Eldehna

161. 
     Recent advancements of coumarin-based anticancer agents: An up-to-date review

     Article • Bioorganic Chemistry, October 2020, Elsevier

     Wagdy Eldehna

162. 
     Dual Targeting of VEGFR2 and C-Met Kinases via the Design and Synthesis of Substituted 3-(Triazolo-thiadiazin-3-yl)indolin-2-one Derivatives as Angiogenesis Inhibitors

     Article • ACS Omega, July 2020, American Chemical Society (ACS)

     Wagdy Eldehna

163. 
     Modulation of endoplasmic reticulum stress response in gut-origin encephalopathy: Impact of vascular endothelial growth factor receptor-2 manipulation

     Article • Life Sciences, July 2020, Elsevier

     Wagdy Eldehna

164. 
     Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights

     Article • Bioorganic & Medicinal Chemistry, July 2020, Elsevier

     Wagdy Eldehna

165. 
     Unexpected Synthesis, Single-Crystal X-ray Structure, Anticancer Activity, and Molecular Docking Studies of Certain 2–((Imidazole/Benzimidazol–2–yl)thio)–1–arylethanones

     Article • Crystals, May 2020, MDPI AG

     Wagdy Eldehna

166. 
     Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors

     Article • Molecules, April 2020, MDPI AG

     Wagdy Eldehna

167. 
     Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation

     Article • Marine Drugs, April 2020, MDPI AG

     Wagdy Eldehna

168. 
     Inhibition of Major Cytochrome P450 Enzyme Activities in Human Liver Microsomes by 9‐a and WES‐1, two Novel Carbonic Anhydrase Inhibitors.

     Article • The FASEB Journal, April 2020, Wiley

     Wagdy Eldehna

169. 
     Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer

     Article • ACS Medicinal Chemistry Letters, March 2020, American Chemical Society (ACS)

     Wagdy Eldehna

170. 
     Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells

     Article • European Journal of Medicinal Chemistry, March 2020, Elsevier

     Wagdy Eldehna, Prof. Zeid A. ALOthman

171. 
     Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation

     Article • European Journal of Medicinal Chemistry, March 2020, Elsevier

     Wagdy Eldehna

172. 
     Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

     Article • Journal of Medicinal Chemistry, February 2020, American Chemical Society (ACS)

     Wagdy Eldehna

173. 
     <p>Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety</p>

     Article • Drug Design Development and Therapy, February 2020, Taylor & Francis

     Wagdy Eldehna

174. 
     Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2020, Taylor & Francis

     Wagdy Eldehna

175. 
     Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2020, Taylor & Francis

     Wagdy Eldehna

176. 
     Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2020, Taylor & Francis

     Wagdy Eldehna

177. 
     Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors

     Article • European Journal of Medicinal Chemistry, January 2020, Elsevier

     Wagdy Eldehna

178. 
     Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, December 2019, Taylor & Francis

     Wagdy Eldehna

179. 
     “A Sweet Combination”: Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII

     Article • Journal of Medicinal Chemistry, December 2019, American Chemical Society (ACS)

     Wagdy Eldehna, Prof. Zeid A. ALOthman

180. 
     Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX

     Article • European Journal of Medicinal Chemistry, October 2019, Elsevier

     Hany Ibrahim, Wagdy Eldehna

181. 
     3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

     Article • European Journal of Medicinal Chemistry, October 2019, Elsevier

     Hany Ibrahim, Wagdy Eldehna

182. 
     Synthesis, in vitro biological evaluation and in silico studies of certain arylnicotinic acids conjugated with aryl (thio)semicarbazides as a novel class of anti-leishmanial agents

     Article • European Journal of Medicinal Chemistry, October 2019, Elsevier

     Wagdy Eldehna

183. 
     Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity

     Article • Bioorganic Chemistry, September 2019, Elsevier

     Wagdy Eldehna

184. 
     Synthesis and in vitro anticancer evaluation of some fused indazoles, quinazolines and quinolines as potential EGFR inhibitors

     Article • Bioorganic Chemistry, August 2019, Elsevier

     Wagdy Eldehna

185. 
     Induction of ROS‑mediated cell death and activation of the JNK pathway by a sulfonamide derivative

     Article • International Journal of Molecular Medicine, July 2019, Spandidos Publications

     Wagdy Eldehna

186. 
     Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies

     Article • Bioorganic Chemistry, June 2019, Elsevier

     Wagdy Eldehna

187. 
     Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights

     Article • International Journal of Molecular Sciences, May 2019, MDPI AG

     Wagdy Eldehna

188. 
     SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX

     Article • Bioorganic Chemistry, March 2019, Elsevier

     Wagdy Eldehna

189. 
     Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel ...

     Article • European Journal of Medicinal Chemistry, February 2019, Elsevier

     Wagdy Eldehna

190. 
     Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2019, Taylor & Francis

     Ahmed Altyar, Wagdy Eldehna

191. 
     Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2019, Taylor & Francis

     Mohamed Abdelgawad, Wagdy Eldehna

192. 
     Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

     Article • European Journal of Medicinal Chemistry, January 2019, Elsevier

     Wagdy Eldehna

193. 
     One-pot synthesis of spiro(indoline-3,4′-pyrazolo[3,4-b]pyridine)-5′-carbonitriles as p53-MDM2 interaction inhibitors

     Article • Future Medicinal Chemistry, December 2018, Future Science

     Hany Ibrahim, Wagdy Eldehna

194. 
     Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents

     Article • European Journal of Medicinal Chemistry, December 2018, Elsevier

     Wagdy Eldehna

195. 
     Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer

     Article • Bioorganic Chemistry, December 2018, Elsevier

     Wagdy Eldehna

196. 
     Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies

     Article • European Journal of Medicinal Chemistry, September 2018, Elsevier

     Hany Ibrahim, Wagdy Eldehna

197. 
     Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells

     Article • European Journal of Medicinal Chemistry, July 2018, Elsevier

     Wagdy Eldehna

198. 
     Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation

     Article • Molecules, June 2018, MDPI AG

     Hany Ibrahim, Wagdy Eldehna

199. 
     Novel Thiazolidinone/Thiazolo[3,2-a]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In Vitro Biological Evaluation

     Article • Molecules, June 2018, MDPI AG

     Wagdy Eldehna

200. 
     Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2–STAT3 pathway

     Article • OncoTargets and Therapy, June 2018, Dove Medical Press

     Wagdy Eldehna

201. 
     Synthesis and biological evaluation of 2-aminothiazole-thiazolidinone conjugates as potential antitubercular agents

     Article • Future Medicinal Chemistry, May 2018, Future Science

     Wagdy Eldehna

202. 
     Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer

     Article • Bioorganic Chemistry, April 2018, Elsevier

     Wagdy Eldehna

203. 
     Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2018, Taylor & Francis

     Hany Ibrahim, Dr. Hazem A. Ghabbour, Wagdy Eldehna

204. 
     Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2018, Taylor & Francis

     Professor omaima mohamed abdehafez, Radwan El-Haggar, Wagdy Eldehna

205. 
     Solvent-Free Ring Cleavage Hydrazinolysis of Certain Biginelli Pyrimidines

     Article • Journal of Chemistry, January 2018, Hindawi Publishing Corporation

     Wagdy Eldehna

206. 
     Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2018, Taylor & Francis

     Wagdy Eldehna

207. 
     An improved synthesis of pyrido[2,3-d]pyrimidin-4(1H)-ones and their antimicrobial activity

     Article • Organic & Biomolecular Chemistry, January 2018, Royal Society of Chemistry

     Wagdy Eldehna

208. 
     One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, December 2017, Taylor & Francis

     Dr. Hazem A. Ghabbour, Hany Ibrahim, Wagdy Eldehna

209. 
     Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies

     Article • European Journal of Medicinal Chemistry, October 2017, Elsevier

     Wagdy Eldehna

210. 
     Synthesis, biological evaluation and in silico study of bis-thiourea derivatives as anticancer, antimalarial and antimicrobial agents

     Article • Medicinal Chemistry Research, September 2017, Springer Science + Business Media

     Wagdy Eldehna

211. 
     Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

     Article • Drug Design Development and Therapy, August 2017, Dove Medical Press

     Dr Ali S Abdelhameed, Mohamed Attwa, Wagdy Eldehna

212. 
     New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

     Article • PLOS One, July 2017, PLOS

     Wagdy Eldehna

213. 
     Synthesis and Biophysical Insights into the Binding of a Potent Anti-Proliferative Non-symmetric Bis-isatin Derivative with Bovine Serum Albumin: Spectroscopic and Molecular Docking Approaches

     Article • Applied Sciences, June 2017, MDPI AG

     Dr Ali S Abdelhameed, Wagdy Eldehna

214. 
     Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3- d ][1,2,4]triazolo[4,3- a ]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects

     Article • Bioorganic & Medicinal Chemistry, April 2017, Elsevier

     Wagdy Eldehna

215. 
     Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies

     Article • European Journal of Medicinal Chemistry, February 2017, Elsevier

     Wagdy Eldehna

216. 
     Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2017, Taylor & Francis

     Wagdy Eldehna

217. 
     Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation

     Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2017, Taylor & Francis

     Wagdy Eldehna

218. 
     Novel 6-Phenylnicotinohydrazide Derivatives: Design, Synthesis and Biological Evaluation as a Novel Class of Antitubercular and Antimicrobial Agents

     Article • Biological and Pharmaceutical Bulletin, January 2017, Pharmaceutical Society of Japan

     Wagdy Eldehna

219. 
     Synthesis, Crystal Study, and Anti-Proliferative Activity of Some 2-Benzimidazolylthioacetophenones towards Triple-Negative Breast Cancer MDA-MB-468 Cells as Apoptosis-Inducing Agents

     Article • International Journal of Molecular Sciences, July 2016, MDPI AG

     Wagdy Eldehna

220. 
     Synthesis and Cytotoxic Activity of Biphenylurea Derivatives Containing Indolin-2-one Moieties

     Article • Molecules, June 2016, MDPI AG

     Hany Ibrahim, Wagdy Eldehna

221. 
     Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives

     Article • European Journal of Medicinal Chemistry, May 2016, Elsevier

     Wagdy Eldehna

222. 
     Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII

     Article • European Journal of Medicinal Chemistry, March 2016, Elsevier

     Wagdy Eldehna

223. 
     Development of certain new 2-substituted-quinazolin-4-yl-aminobenzenesulfonamide as potential antitumor agents

     Article • European Journal of Medicinal Chemistry, February 2016, Elsevier

     Wagdy Eldehna

224. 
     Synthesis, Biological Evaluation and Molecular Docking of Certain Sulfones as Potential Nonazole Antifungal Agents

     Article • Molecules, January 2016, MDPI AG

     Wagdy Eldehna

225. 
     1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation

     Article • European Journal of Medicinal Chemistry, January 2016, Elsevier

     Wagdy Eldehna

226. 
     2-((Benzimidazol-2-yl)thio)-1-arylethan-1-ones: Synthesis, crystal study and cancer stem cells CD133 targeting potential

     Article • European Journal of Medicinal Chemistry, November 2015, Elsevier

     Wagdy Eldehna

227. 
     Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking

     Article • European Journal of Medicinal Chemistry, July 2015, Elsevier

     Hany Ibrahim, Wagdy Eldehna

228. 
     Design, Synthesis and Antitubercular Activity of Certain Nicotinic Acid Hydrazides

     Article • Molecules, May 2015, MDPI AG

     Wagdy Eldehna

229. 
     Synthesis, Biological Evaluation and 2D-QSAR Study of Halophenyl Bis-Hydrazones as Antimicrobial and Antitubercular Agents

     Article • International Journal of Molecular Sciences, April 2015, MDPI AG

     Wagdy Eldehna

230. 
     Design, Synthesis andIn VitroAntiproliferative Activity of Novel Isatin-Quinazoline Hybrids

     Article • Archiv der Pharmazie, February 2015, Wiley

     Mai Tolba, Wagdy Eldehna

231. 
     Design, synthesis and in vitro antitumor activity of novel N-substituted-4-phenyl/benzylphthalazin-1-ones

     Article • European Journal of Medicinal Chemistry, January 2015, Elsevier

     Hany Ibrahim, Wagdy Eldehna

232. 
     Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents

     Article • European Journal of Medicinal Chemistry, January 2015, Elsevier

     Wagdy Eldehna

233. 
     Synthesis, <i>in Vitro</i> and <i>in Silico</i> Studies of Some Novel 5-Nitrofuran-2-yl Hydrazones as Antimicrobial and Antitubercular Agents

     Article • Biological and Pharmaceutical Bulletin, January 2015, Pharmaceutical Society of Japan

     Wagdy Eldehna

234. 
     Improvement of antibacterial activity of some sulfa drugs through linkage to certain phthalazin-1(2H)-one scaffolds

     Article • European Journal of Medicinal Chemistry, October 2014, Elsevier

     Hany Ibrahim, Wagdy Eldehna

235. 
     Design, Synthesis, and Molecular Docking of 1-(1-(4-Chlorophenyl)-2-(phenylsulfonyl)ethylidene)-2-phenylhydrazine as Potent Nonazole Anticandidal Agent

     Article • Journal of Chemistry, January 2014, Hindawi Publishing Corporation

     Wagdy Eldehna

236. 
     Synthesis, Crystal Structure, and Biological Activity ofcis/transAmide Rotomers of (Z)-N′-(2-Oxoindolin-3-ylidene)formohydrazide

     Article • Journal of Chemistry, January 2014, Hindawi Publishing Corporation

     Wagdy Eldehna