All Stories

  1. Development of new pyrazoles as class I HDAC inhibitors: Synthesis, molecular modeling, and biological characterization in leukemia cells

    Article • Archiv der Pharmazie, September 2024, Wiley

    Hany Ibrahim

  2. Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells

    Article • Journal of Advanced Research, June 2024, Elsevier

    Hany Ibrahim

  3. Design, synthesis, and biological evaluation of dinaciclib and CAN508 hybrids as CDK inhibitors

    Article • Drug Development Research, April 2024, Wiley

    Hany Ibrahim

  4. Histone Acetyltransferase and Deacetylase Inhibitors—New Aspects and Developments

    Article • International Journal of Molecular Sciences, November 2023, MDPI AG

    Hany Ibrahim

  5. Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells

    Article • Archiv der Pharmazie, November 2023, Wiley

    Hany Ibrahim

  6. Histone deacetylase inhibitors modulate hormesis in leukemic cells with mutant FMS-like tyrosine kinase-3

    Article • Leukemia, September 2023, Springer Science + Business Media

    Hany Ibrahim

  7. Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, April 2023, Taylor & Francis

    Hany Ibrahim

  8. Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors

    Article • Molecules, April 2022, MDPI AG

    Hany Ibrahim

  9. Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity

    Article • International Journal of Molecular Sciences, December 2021, MDPI AG

    Hany Ibrahim

  10. Importance of glutamine 189 flexibility in SARS-CoV-2 main protease: Lesson learned from in silico virtual screening of ChEMBL database and molecular dynamics

    Article • European Journal of Pharmaceutical Sciences, May 2021, Elsevier

    Hany Ibrahim

  11. Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX

    Article • European Journal of Medicinal Chemistry, October 2019, Elsevier

    Hany Ibrahim, Wagdy Eldehna

  12. 3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

    Article • European Journal of Medicinal Chemistry, October 2019, Elsevier

    Hany Ibrahim, Wagdy Eldehna

  13. Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase

    Article • Bioorganic Chemistry, April 2019, Elsevier

    Hany Ibrahim

  14. One-pot synthesis of spiro(indoline-3,4′-pyrazolo[3,4-b]pyridine)-5′-carbonitriles as p53-MDM2 interaction inhibitors

    Article • Future Medicinal Chemistry, December 2018, Future Science

    Hany Ibrahim, Wagdy Eldehna

  15. Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies

    Article • European Journal of Medicinal Chemistry, September 2018, Elsevier

    Hany Ibrahim, Wagdy Eldehna

  16. Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation

    Article • Molecules, June 2018, MDPI AG

    Hany Ibrahim, Wagdy Eldehna

  17. Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform

    Article • European Journal of Medicinal Chemistry, April 2018, Elsevier

    Hany Ibrahim

  18. Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2018, Taylor & Francis

    Hany Ibrahim, Dr. Hazem A. Ghabbour, Wagdy Eldehna

  19. One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, December 2017, Taylor & Francis

    Dr. Hazem A. Ghabbour, Hany Ibrahim, Wagdy Eldehna

  20. 3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

    Article • European Journal of Medicinal Chemistry, October 2016, Elsevier

    Hany Ibrahim

  21. ChemInform Abstract: 3-Hydrazinoindolin-2-one Derivatives: Chemical Classification and Investigation of Their Targets as Anticancer Agents

    Article • ChemInform, October 2016, Wiley

    Hany Ibrahim

  22. Synthesis and Cytotoxic Activity of Biphenylurea Derivatives Containing Indolin-2-one Moieties

    Article • Molecules, June 2016, MDPI AG

    Hany Ibrahim, Wagdy Eldehna

  23. Bis-isatin hydrazones with novel linkers: Synthesis and biological evaluation as cytotoxic agents

    Article • European Journal of Medicinal Chemistry, January 2016, Elsevier

    Hany Ibrahim

  24. Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII

    Article • European Journal of Medicinal Chemistry, October 2015, Elsevier

    Hany Ibrahim

  25. Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking

    Article • European Journal of Medicinal Chemistry, July 2015, Elsevier

    Hany Ibrahim, Wagdy Eldehna

  26. Design, synthesis and in vitro antitumor activity of novel N-substituted-4-phenyl/benzylphthalazin-1-ones

    Article • European Journal of Medicinal Chemistry, January 2015, Elsevier

    Hany Ibrahim, Wagdy Eldehna

  27. Hydrolysis and Hydrazinolysis of Isatin-Based Ald- and Ketazines

    Article • Journal of Chemistry, January 2015, Hindawi Publishing Corporation

    Hany Ibrahim

  28. Improvement of antibacterial activity of some sulfa drugs through linkage to certain phthalazin-1(2H)-one scaffolds

    Article • European Journal of Medicinal Chemistry, October 2014, Elsevier

    Hany Ibrahim, Wagdy Eldehna

  29. Analogue-based design, synthesis and biological evaluation of 3-substituted-(methylenehydrazono)indolin-2-ones as anticancer agents

    Article • European Journal of Medicinal Chemistry, May 2014, Elsevier

    Hany Ibrahim

  30. Synthesis and Biological Evaluation of SomeN-Arylpyrazoles and Pyrazolo[3,4-d]pyridazines as Anti-Inflammatory Agents

    Article • Archiv der Pharmazie, August 2013, Wiley

    Hany Ibrahim

  31. Microwave-assisted Synthesis of Novel 3,4-Bis-chalcone-N-arylpyrazoles and Their Anti-inflammatory Activity

    Article • Journal of the Chinese Chemical Society, December 2011, Wiley

    Hany Ibrahim

  32. Synthesis of Diarylpyrazoles Containing a Phenylsulphone or Carbonitrile Moiety and their Chalcones as Possible Anti-Inflammatory Agents

    Article • Scientia Pharmaceutica, January 2011, MDPI AG

    Hany Ibrahim