All Stories

  1. Role of Arctiin in Fibrosis and Apoptosis in Experimentally Induced Hepatocellular Carcinoma in Rats

    Article • Cureus, January 2024, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  2. The Involvement of Calcium Channels in the Endoplasmic Reticulum Membrane in Nonalcoholic Fatty Liver Disease Pathogenesis

    Article • Cureus, November 2023, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  3. Arctiin Inhibits Inflammation, Fibrosis, and Tumor Cell Migration in Rats With Ehrlich Solid Carcinoma

    Article • Cureus, September 2023, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  4. Garcinol-Attenuated Gastric Ulcer (GU) Experimentally Induced in Rats Via Affecting Inflammation, Cell Proliferation, and DNA Polymerization

    Article • Cureus, August 2023, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  5. Antitumor Activity of Ligustilide Against Ehrlich Solid Carcinoma in Rats via Inhibition of Proliferation and Activation of Autophagy

    Article • Cureus, June 2023, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  6. Genistein ameliorated experimentally induced gastric ulcer in rats via inhibiting gastric tissues fibrosis by modulating Wnt/β-catenin/TGF-β/PKB pathway

    Article • Redox Report, June 2023, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar

  7. Antitumor Activity of Luteolin Against Ehrlich Solid Carcinoma in Rats via Blocking Wnt/β-Catenin/SMAD4 Pathway

    Article • Cureus, May 2023, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  8. Curative effects of crocin in ulcerative colitis via modulating apoptosis and inflammation

    Article • International Immunopharmacology, May 2023, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  9. Therapeutic effects of genistein in experimentally induced ulcerative colitis in rats via affecting mitochondrial biogenesis

    Article • Molecular and Cellular Biochemistry, April 2023, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  10. WRH-2412 alleviates the progression of hepatocellular carcinoma through regulation of TGF-β/β-catenin/α-SMA pathway

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, March 2023, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar, Wagdy Eldehna

  11. Effect of COVID-19 on Glycemic Control, Insulin Resistance, and pH in Elderly Patients With Type 2 Diabetes

    Article • Cureus, February 2023, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  12. Evaluating the Anticancer Activity of Blocking TNF Type 1 Receptors in Thioacetamide-Induced Hepatocellular Carcinoma in a Rat Model

    Article • Cureus, December 2022, Cureus, Inc.

    Prof Dr Mohammed M H Al-Gayyar

  13. The therapeutic effects of cycloastragenol in ulcerative colitis by modulating SphK/MIP‐1α/miR‐143 signalling

    Article • Basic & Clinical Pharmacology & Toxicology, August 2022, Wiley

    Prof Dr Mohammed M H Al-Gayyar

  14. Curative effects of fucoidan on acetic acid induced ulcerative colitis in rats via modulating aryl hydrocarbon receptor and phosphodiesterase-4

    Article • BMC Complementary Medicine and Therapies, July 2022, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  15. Therapeutic effects of sulforaphane in ulcerative colitis: effect on antioxidant activity, mitochondrial biogenesis and DNA polymerization

    Article • Redox Report, June 2022, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar

  16. Chemopreventive and hepatoprotective effects of genistein via inhibition of oxidative stress and the versican/PDGF/PKC signaling pathway in experimentally induced hepatocellular carcinoma in rats by thioacetamide

    Article • Redox Report, January 2022, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar, Dr Ziad Emarah

  17. QNZ alleviated hepatocellular carcinoma by targeting inflammatory pathways in a rat model

    Article • Cytokine, December 2021, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  18. Therapeutic effects of blocking β-catenin against hepatocellular carcinoma-induced activation of inflammation, fibrosis and tumor invasion

    Article • Biomedicine & Pharmacotherapy, March 2021, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  19. Impact of Knowledge and Attitude on Saudis’ Physical Activity Practice and Inactivity Barriers: A Questionnaire-based Study

    Article • Open Access Macedonian Journal of Medical Sciences, January 2021, Macedonian Journal of Medical Science

    Prof Dr Mohammed M H Al-Gayyar

  20. Heparan sulfate proteoglycans and their modification as promising anticancer targets in hepatocellular carcinoma (Review)

    Article • Oncology Letters, January 2021, Spandidos Publications

    Prof Dr Mohammed M H Al-Gayyar

  21. Comprehensive Study of Scientific Evidence and Potential Risk of Herbal Medicine Use for Body Weight Reduction in North West Saudi Arabia

    Article • Cureus, October 2020, Cureus, Inc.

    Prof Dr Mohammed M H Al-Gayyar

  22. Glycyrrhizic acid ameliorates sodium nitrite-induced lung and salivary gland toxicity: Impact on oxidative stress, inflammation and fibrosis

    Article • Human & Experimental Toxicology, October 2020, SAGE Publications

    Prof Dr Mohammed M H Al-Gayyar

  23. Evaluation of the Diagnostic and Prognostic Value of Syndecan-1 in Acute Leukemia Patients

    Article • Cureus, September 2020, Cureus, Inc.

    Prof Dr Mohammed M H Al-Gayyar

  24. Engaging Pharmacy Students in Interactive Life-Based Situations as the Basis for Teaching a Biochemistry Course

    Article • Cureus, August 2020, Cureus, Inc.

    Prof Dr Mohammed M H Al-Gayyar

  25. Fucoidan Ameliorates Hepatocellular Carcinoma Induced in Rats: Effect on miR143 and Inflammation

    Article • Nutrition and Cancer, July 2020, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar, Dr Ziad Emarah

  26. Measuring the appropriateness of carbamazepine and valproic acid prescribing and utilization using a newly implemented online system in the Tabuk Region of Saudi Arabia

    Article • Saudi Pharmaceutical Journal, July 2020, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  27. Selective cytotoxic activity and protective effects of sodium ascorbate against hepatocellular carcinoma through its effect on oxidative stress and apoptosis in vivo and in vitro

    Article • Redox Report, January 2020, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar

  28. Targeting p53/TRAIL/caspase-8 signaling by adiponectin reverses thioacetamide-induced hepatocellular carcinoma in rats

    Article • Environmental Toxicology and Pharmacology, November 2019, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  29. Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives

    Article • Scientific Reports, May 2019, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  30. The therapeutic effects of nicotinamide in hepatocellular carcinoma through blocking IGF-1

    Article • Biomedicine & Pharmacotherapy, April 2019, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  31. Clinical significance of the TNF-α receptors, TNFRSF2 and TNFRSF9, on cell migration molecules Fascin-1 and Versican in acute leukemia

    Article • Cytokine, November 2018, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  32. Cytotoxic and partial hepatoprotective activity of sodium ascorbate against hepatocellular carcinoma through inhibition of sulfatase-2 in vivo and in vitro

    Article • Biomedicine & Pharmacotherapy, July 2018, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  33. Oleuropein potentiates anti-tumor activity of cisplatin against HepG2 through affecting proNGF/NGF balance

    Article • Life Sciences, April 2018, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  34. Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: Impact on inflammation and apoptosis

    Article • Life Sciences, July 2017, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  35. Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis

    Article • PLoS ONE, December 2016, PLOS

    Prof Dr Mohammed M H Al-Gayyar

  36. Anti-tumor activity of arjunolic acid against Ehrlich Ascites Carcinoma cells in vivo and in vitro through blocking TGF-β type 1 receptor

    Article • Biomedicine & Pharmacotherapy, August 2016, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  37. Thymoquinone ameliorated elevated inflammatory cytokines in testicular tissue and sex hormones imbalance induced by oral chronic toxicity with sodium nitrite

    Article • Cytokine, July 2016, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  38. The role of IL-18 in type 1 diabetic nephropathy: The problem and future treatment

    Article • Cytokine, May 2016, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  39. Corrigendum to “Crocin protects against doxorubicin-induced myocardial toxicity in rats through down-regulation of inflammatory and apoptic pathways” [Chemico-Biol. Interact. 247 (2016) 39–48]

    Article • Chemico-Biological Interactions, April 2016, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  40. Nigella sativaoil attenuates chronic nephrotoxicity induced by oral sodium nitrite: Effects on tissue fibrosis and apoptosis

    Article • Redox Report, March 2016, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar

  41. Crocin protects against doxorubicin-induced myocardial toxicity in rats through down-regulation of inflammatory and apoptic pathways

    Article • Chemico-Biological Interactions, March 2016, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  42. Chemopreventive and hepatoprotective roles of adiponectin (SULF2 inhibitor) in hepatocelluar carcinoma

    Article • Biological Chemistry, January 2016, De Gruyter

    Prof Dr Mohammed M H Al-Gayyar

  43. Renal protective effects of arjunolic acid in a cisplatin-induced nephrotoxicity model

    Article • Cytokine, January 2016, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  44. Nephroprotective role of dipyridamole in diabetic nephropathy: Effect on inflammation and apoptosis

    Article • Life Sciences, December 2015, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  45. Thymoquinone ameliorates testicular tissue inflammation induced by chronic administration of oral sodium nitrite

    Article • Andrologia, August 2015, Wiley

    Prof Dr Mohammed M H Al-Gayyar

  46. Hepatoprotective and anti-tumor effects of targeting MMP-9 in hepatocellular carcinoma and its relation to vascular invasion markers

    Article • Clinical & Experimental Metastasis, May 2015, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  47. Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma

    Article • European Journal of Pharmacology, January 2015, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  48. Cod liver oil ameliorates sodium nitrite-induced insulin resistance and degradation of rat hepatic glycogen through inhibition of cAMP/PKA pathway

    Article • Life Sciences, January 2015, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  49. Tumor Necrosis Factor Receptor 2: Its Clinical Significance and Clinicopathologic Correlation in acute leukemias

    Article • Journal of Applied Pharmaceutical Science, January 2015, Journal of Applied Pharmaceutical Science

    Prof Dr Mohammed M H Al-Gayyar

  50. Erratum to: Modulation of p75NTR prevents diabetes- and proNGF-induced retinal inflammation and blood–retina barrier breakdown in mice and rats

    Article • Diabetologia, December 2014, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  51. Protective effects of arjunolic acid against cardiac toxicity induced by oral sodium nitrite: Effects on cytokine balance and apoptosis

    Article • Life Sciences, August 2014, Elsevier

    Dr Iman O. Sherif, Prof Dr Mohammed M H Al-Gayyar

  52. Cod liver oil in sodium nitrite induced hepatic injury: Does it have a potential protective effect?

    Article • Redox Report, June 2014, Taylor & Francis

    Dr Iman O. Sherif, Prof Dr Mohammed M H Al-Gayyar

  53. Correction: Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway

    Article • PLoS ONE, April 2014, PLOS

    Prof Dr Mohammed M H Al-Gayyar

  54. Erratum to: Modulation of p75NTR prevents diabetes- and proNGF-induced retinal inflammation and blood–retina barrier breakdown in mice and rats

    Article • Diabetologia, April 2014, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  55. Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme

    Article • European Journal of Pharmacology, April 2014, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  56. Chemopreventive and hepatoprotective effects of Epigallocatechin-gallate against hepatocellular carcinoma: role of heparan sulfate proteoglycans pathway

    Article • Journal of Pharmacy and Pharmacology, February 2014, Wiley

    Prof Dr Mohammed M H Al-Gayyar

  57. Effect of Simvastatin on Inflammatory Cytokines Balance in Air Pouch Granuloma Model

    Article • Inflammation & Allergy - Drug Targets, January 2014, Bentham Science Publishers

    Prof Dr Mohammed M H Al-Gayyar

  58. Evaluation of renal protective effects of inhibiting TGF-β type I receptor in a cisplatin-induced nephrotoxicity model

    Article • European Cytokine Network, October 2013, John Libbey Eurotext

    Prof Dr Mohammed M H Al-Gayyar

  59. Modulation of p75NTR prevents diabetes- and proNGF-induced retinal inflammation and blood–retina barrier breakdown in mice and rats

    Article • Diabetologia, August 2013, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  60. Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats

    Article • Pharmaceutical Biology, July 2013, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar

  61. ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy

    Article • Life Sciences, July 2013, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  62. Measuring serum levels of glycosaminoglycans for prediction and using viscum fraxini-2 for treatment of patients with hepatocellular carcinoma

    Article • Journal of Pharmacy Research, July 2013, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  63. Potential roles of adenosine deaminase-2 in diabetic retinopathy

    Article • Biochemical and Biophysical Research Communications, July 2013, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  64. Antioxidant, anti-inflammatory and hepatoprotective effects of silymarin on hepatic dysfunction induced by sodium nitrite

    Article • European Cytokine Network, July 2013, John Libbey Eurotext

    Prof Dr Mohammed M H Al-Gayyar

  65. Adenosine Receptors: New Therapeutic Targets for Inflammation in Diabetic Nephropathy

    Article • Inflammation & Allergy - Drug Targets, June 2013, Bentham Science Publishers

    Prof Dr Mohammed M H Al-Gayyar

  66. Contribution of TNF-α to the development of retinal neurodegenerative disorders

    Article • European Cytokine Network, March 2013, John Libbey Eurotext

    Prof Dr Mohammed M H Al-Gayyar

  67. Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway

    Article • PLoS ONE, January 2013, PLOS

    Prof Dr Mohammed M H Al-Gayyar

  68. Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1

    Article • European Cytokine Network, July 2012, John Libbey Eurotext

    Prof Dr Mohammed M H Al-Gayyar

  69. Relevance of Serum Levels of Interleukin-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma

    Article • Scientia Pharmaceutica, January 2012, MDPI AG

    Prof Dr Mohammed M H Al-Gayyar

  70. Fish oil improves lipid metabolism and ameliorates inflammation in patients with metabolic syndrome: Impact of nonalcoholic fatty liver disease

    Article • Pharmaceutical Biology, November 2011, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar

  71. Circulating adiponectin: a potential prognostic marker for hepatocellular carcinoma

    Article • The Chinese-German Journal of Clinical Oncology, October 2011, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  72. Thioredoxin interacting protein is a novel mediator of retinal inflammation and neurotoxicity

    Article • British Journal of Pharmacology, August 2011, Wiley

    Prof Dr Mohammed M H Al-Gayyar

  73. Evaluation of renal protective effects of the green-tea (EGCG) and red grape resveratrol: role of oxidative stress and inflammatory cytokines

    Article • Natural Product Research, April 2011, Taylor & Francis

    Prof Dr Mohammed M H Al-Gayyar

  74. Cannabinoid 1 receptor activation contributes to vascular inflammation and cell death in a mouse model of diabetic retinopathy and a human retinal cell line

    Article • Diabetologia, March 2011, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  75. Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes

    Article • Diabetes, February 2011, American Diabetes Association

    Prof Dr Mohammed M H Al-Gayyar

  76. Erratum: Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes

    Article • Diabetologia, January 2011, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  77. Type 2 Diabetes Mellitus-Induced Hyperglycemia in Patients with NAFLD and Normal LFTs: Relationship to Lipid Profile, Oxidative Stress and Pro-Inflammatory Cytokines

    Article • Scientia Pharmaceutica, January 2011, MDPI AG

    Prof Dr Mohammed M H Al-Gayyar

  78. Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor proNGF expression in a rat model of diabetes

    Article • Diabetologia, December 2010, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  79. Novel chemotherapeutic and renal protective effects for the green tea (EGCG): Role of oxidative stress and inflammatory-cytokine signaling

    Article • Phytomedicine, December 2010, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  80. Diabetes-induced peroxynitrite impairs the balance of pro-nerve growth factor and nerve growth factor, and causes neurovascular injury

    Article • Diabetologia, October 2010, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  81. Neurovascular Protective Effect of FeTPPs in N-Methyl-D-Aspartate Model

    Article • American Journal Of Pathology, September 2010, Elsevier

    Prof Dr Mohammed M H Al-Gayyar

  82. Prominent Chemopreventive and Chemoenhancing Effects for Resveratrol: Unraveling Molecular Targets and the Role of C-Reactive Protein

    Article • Chemotherapy, January 2010, Karger Publishers

    Prof Dr Mohammed M H Al-Gayyar

  83. Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implications of CRP and lipid peroxides

    Article • Cell Division, January 2009, Springer Science + Business Media

    Prof Dr Mohammed M H Al-Gayyar

  84. Measurements of oxidative stress status and antioxidant activity in chronic leukaemia patients

    Article • Journal of Pharmacy and Pharmacology, March 2007, Wiley

    Prof Dr Mohammed M H Al-Gayyar