All Stories

  1. Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone

    Article • Journal of Biological Chemistry, October 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philipp Kaldis

  2. Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death

    Article • Cell Death Discovery, March 2018, Springer Science + Business Media

    Dr Philipp Kaldis

  3. Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis

    Article • Cell Death and Differentiation, January 2018, Nature

    Dr Philipp Kaldis

  4. CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays

    Article • The American Journal of Human Genetics, September 2017, Elsevier

    Dr Philipp Kaldis

  5. Cell size control - a mechanism for maintaining fitness and function

    Article • BioEssays, July 2017, Wiley

    Mikael Bjorklund, Dr Philipp Kaldis

  6. Emi2 Is Essential for Mouse Spermatogenesis

    Article • Cell Reports, July 2017, Elsevier

    Dr Philipp Kaldis

  7. Cyclin-Dependent Kinase-Dependent Phosphorylation of Sox2 at Serine 39 Regulates Neurogenesis

    Article • Molecular and Cellular Biology, June 2017, ASM Journals

    Dr Philipp Kaldis

  8. NF-κB as a Potential Molecular Target for Therapy of Gastrointestinal Cancers

    Article • April 2017, World Scientific Pub Co Pte Lt

    Dr Philipp Kaldis

  9. MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice

    Article • Cell Discovery, February 2017, Nature

    Dr Philipp Kaldis

  10. Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes

    Article • Journal of Biological Chemistry, January 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philipp Kaldis

  11. Speedy A–Cdk2 binding mediates initial telomere–nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation

    Article • Proceedings of the National Academy of Sciences, December 2016, Proceedings of the National Academy of Sciences

    Dr Philipp Kaldis

  12. Faculty of 1000 evaluation for A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis.

    Article • December 2016, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  13. Faculty of 1000 evaluation for Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.

    Article • December 2016, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  14. Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function

    Article • Structure, November 2016, Elsevier

    Dr Philipp Kaldis

  15. Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan

    Article • Cell Research, October 2016, Nature

    Dr Philipp Kaldis

  16. Faculty of 1000 evaluation for Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.

    Article • October 2016, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  17. Cyclin A2 regulates erythrocyte morphology and numbers

    Article • Cell Cycle, September 2016, Taylor & Francis

    Dr Philipp Kaldis

  18. Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint

    Article • PLoS Genetics, September 2016, PLOS

    Dr Philipp Kaldis

  19. Quo Vadis Cell Growth and Division?

    Article • Frontiers in Cell and Developmental Biology, August 2016, Frontiers

    Dr Philipp Kaldis

  20. Cdk2 catalytic activity is essential for meiotic cell division in vivo

    Article • Biochemical Journal, July 2016, Portland Press Ltd.

    Dr Philipp Kaldis

  21. The Indispensable Role of Cyclin-Dependent Kinase 1 in Skeletal Development

    Article • Scientific Reports, February 2016, Nature

    Dr Philipp Kaldis

  22. Vacuum template synthesis of multifunctional nanotubes with tailored nanostructured walls

    Article • Scientific Reports, February 2016, Nature

    Dr Philipp Kaldis

  23. The Speedy A, Cdk2, p27 triangle

    Article • Cell Cycle, January 2016, Taylor & Francis

    Dr Philipp Kaldis

  24. Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development

    Article • January 2016, Elsevier

    Dr Philipp Kaldis

  25. A haploid genetic screen identifies the G 1 /S regulatory machinery as a determinant of Wee1 inhibitor sensitivity

    Article • Proceedings of the National Academy of Sciences, November 2015, Proceedings of the National Academy of Sciences

    Dr Philipp Kaldis

  26. TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

    Article • Oncotarget, September 2015, Impact Journals, LLC

    Dr Philipp Kaldis

  27. Mastl/PP2A regulate Cdk1 in ooycte maturation

    Article • Oncotarget, August 2015, Impact Journals, LLC

    Dr Philipp Kaldis

  28. Faculty of 1000 evaluation for Quo vadis, enzymology?

    Article • June 2015, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  29. Faculty of 1000 evaluation for The expanding implications of polyploidy.

    Article • June 2015, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  30. Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress

    Article • Haematologica, January 2015, Ferrata Storti Foundation (Haematologica)

    Dr Philipp Kaldis

  31. Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

    Article • The Journal of Cell Biology, September 2014, Rockefeller University Press

    Dr Philipp Kaldis

  32. IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice

    Article • Journal of Autoimmunity, September 2014, Elsevier

    Dr Howard A Young, Dr Philipp Kaldis

  33. Spy1/SpeedyA accelerates neuroblastoma

    Article • Oncotarget, August 2014, Impact Journals, LLC

    Dr Philipp Kaldis

  34. Faculty of 1000 evaluation for Necessary and sufficient role for a mitosis skip in senescence induction.

    Article • July 2014, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  35. Faculty of 1000 evaluation for Transient Activation of p53 in G2 Phase Is Sufficient to Induce Senescence.

    Article • July 2014, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  36. p57Kip2 regulates T-cell development and lymphoma

    Article • Blood, May 2014, American Society of Hematology

    Dr Philipp Kaldis

  37. Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis

    Article • Cancer Research, May 2014, American Association for Cancer Research (AACR)

    Dr Philipp Kaldis

  38. Faculty of 1000 evaluation for A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells.

    Article • March 2014, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  39. Faculty of 1000 evaluation for Assessing Kinetics from Fixed Cells Reveals Activation of the Mitotic Entry Network at the S/G2 Transition.

    Article • March 2014, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  40. Identification of Transcriptional and Metabolic Programs Related to Mammalian Cell Size

    Article • Current Biology, March 2014, Elsevier

    Dr Philipp Kaldis

  41. MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2

    Article • Oncogene, February 2014, Nature

    Dr Philipp Kaldis

  42. Faculty of 1000 evaluation for AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression.

    Article • February 2014, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  43. p27 is regulated independently of Skp2 in the absence of Cdk2

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, February 2014, Elsevier

    Dr Philipp Kaldis

  44. The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations

    Article • Cancers, January 2014, MDPI AG

    Dr Philipp Kaldis

  45. Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1

    Article • Open Biology, January 2014, Royal Society Publishing

    Professor Julian Blow, Dr Philipp Kaldis

  46. Faculty of 1000 evaluation for Role for regulated phosphatase activity in generating mitotic oscillations in Xenopus cell-free extracts.

    Article • December 2013, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  47. Cyclin E1 regulates hematopoietic stem cell quiescence

    Article • Cell Cycle, December 2013, Taylor & Francis

    Dr Philipp Kaldis

  48. Faculty of 1000 evaluation for Concurrent deletion of cyclin e1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice.

    Article • July 2013, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  49. Cdks, cyclins and CKIs: roles beyond cell cycle regulation

    Article • Development, July 2013, The Company of Biologists

    Dr Philipp Kaldis

  50. Faculty of 1000 evaluation for Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia.

    Article • November 2012, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  51. Faculty of 1000 evaluation for The requirement for cyclin D function in tumor maintenance.

    Article • November 2012, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  52. Faculty of 1000 evaluation for Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration.

    Article • July 2012, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  53. Evolution of the Cdk-activator Speedy/RINGO in vertebrates

    Article • Cellular and Molecular Life Sciences, July 2012, Springer Science + Business Media

    Dr Philipp Kaldis

  54. Loss of Cdk2 and Cdk4 Induces a Switch from Proliferation to Differentiation in Neural Stem Cells

    Article • Stem Cells, June 2012, Wiley

    Dr Philipp Kaldis

  55. Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

    Article • Cell, March 2012, Elsevier

    Shivshankar Umashankar, Dr. Amit Rai, Dr Philipp Kaldis

  56. Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes

    Article • Human Molecular Genetics, February 2012, Oxford University Press (OUP)

    Dr Philipp Kaldis

  57. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

    Article • Proceedings of the National Academy of Sciences, February 2012, Proceedings of the National Academy of Sciences

    Dr Philipp Kaldis

  58. Faculty of 1000 evaluation for Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation.

    Article • February 2012, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  59. Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

    Article • Cell, January 2012, Elsevier

    Dr Paul Robson, Shivshankar Umashankar, Dr. Amit Rai, Dr Philipp Kaldis

  60. Faculty of 1000 evaluation for Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells.

    Article • December 2011, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  61. When cell cycle meets development

    Article • Development, November 2011, The Company of Biologists

    Dr Philipp Kaldis

  62. Faculty of 1000 evaluation for Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases.

    Article • August 2011, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  63. Faculty of 1000 evaluation for A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.

    Article • June 2011, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  64. Cell cycle transitions and Cdk inhibition in melanoma therapy: Cyclin' through the options

    Article • Cell Cycle, May 2011, Taylor & Francis

    Dr Philipp Kaldis

  65. Cdk2-Null Mice Are Resistant to ErbB-2-Induced Mammary Tumorigenesis

    Article • Neoplasia, May 2011, Elsevier

    Dr Philipp Kaldis

  66. Faculty of 1000 evaluation for The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A.

    Article • March 2011, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  67. Faculty of 1000 evaluation for Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis.

    Article • March 2011, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  68. Faculty of 1000 evaluation for CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6.

    Article • February 2011, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  69. Established and Novel Cdk/Cyclin Complexes Regulating the Cell Cycle and Development

    Article • January 2011, Springer Science + Business Media

    Dr Philipp Kaldis

  70. Enforcing the Greatwall in Mitosis

    Article • Science, December 2010, American Association for the Advancement of Science

    Dr Philipp Kaldis

  71. Faculty of 1000 evaluation for G1 arrest and differentiation can occur independently of Rb family function.

    Article • December 2010, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  72. Down-regulation of Myc Is Essential for Terminal Erythroid Maturation

    Article • Journal of Biological Chemistry, October 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philipp Kaldis

  73. Faculty of 1000 evaluation for Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive.

    Article • September 2010, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  74. Faculty of 1000 evaluation for Loss of pRB causes centromere dysfunction and chromosomal instability.

    Article • September 2010, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  75. Faculty of 1000 evaluation for Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling.

    Article • September 2010, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  76. Faculty of 1000 evaluation for Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3.

    Article • July 2010, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  77. Faculty of 1000 evaluation for Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair.

    Article • June 2010, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  78. Faculty of 1000 evaluation for Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence.

    Article • April 2010, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  79. Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53

    Article • Cell Death and Differentiation, March 2010, Springer Science + Business Media

    Dr Philipp Kaldis

  80. Faculty of 1000 evaluation for E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.

    Article • February 2010, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  81. Faculty of 1000 evaluation for Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.

    Article • January 2010, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  82. Wnt Signaling in Mitosis

    Article • Developmental Cell, December 2009, Elsevier

    Dr Philipp Kaldis

  83. Faculty of 1000 evaluation for Suppression of cancer cell growth by promoting cyclin D1 degradation.

    Article • November 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  84. Cdk2 and Cdk4 Regulate the Centrosome Cycle and Are Critical Mediators of Centrosome Amplification in p53-Null Cells

    Article • Molecular and Cellular Biology, November 2009, ASM Journals

    Dr Philipp Kaldis

  85. Faculty of 1000 evaluation for Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.

    Article • September 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  86. Faculty of 1000 evaluation for Phosphoproteomic analysis of human embryonic stem cells.

    Article • September 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  87. Faculty of 1000 evaluation for Phosphorylation dynamics during early differentiation of human embryonic stem cells.

    Article • September 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  88. Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo

    Article • Cell Cycle, September 2009, Taylor & Francis

    Dr Philipp Kaldis

  89. Faculty of 1000 evaluation for Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry.

    Article • August 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  90. 'Hot Spots' of Creatine Kinase Localization in Brain: Cerebellum, Hippocampus and Choroid Plexus

    Article • Developmental Neuroscience, August 2009, Karger Publishers

    Dr Philipp Kaldis

  91. Faculty of 1000 evaluation for Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.

    Article • July 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  92. Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms

    Article • Oncogene, June 2009, Nature

    Dr Philipp Kaldis

  93. Faculty of 1000 evaluation for Crystal structure of human CDK4 in complex with a D-type cyclin.

    Article • May 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  94. Faculty of 1000 evaluation for The structure of CDK4/cyclin D3 has implications for models of CDK activation.

    Article • May 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  95. Genetic mouse models to investigate cell cycle regulation

    Article • Transgenic Research, May 2009, Springer Science + Business Media

    Dr Philipp Kaldis

  96. Faculty of 1000 evaluation for Proapoptotic function of the retinoblastoma tumor suppressor protein.

    Article • April 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  97. Faculty of 1000 evaluation for Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model.

    Article • March 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  98. Cdk2 and Cdk4 Activities Are Dispensable for Tumorigenesis Caused by the Loss of p53

    Article • Molecular and Cellular Biology, March 2009, ASM Journals

    Dr Philipp Kaldis

  99. Faculty of 1000 evaluation for p53 represses c-Myc through induction of the tumor suppressor miR-145.

    Article • March 2009, Faculty of 1000, Ltd.

    Dr Philipp Kaldis

  100. Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G 1 /S transition

    Article • Proceedings of the National Academy of Sciences, January 2009, Proceedings of the National Academy of Sciences

    Dr Philipp Kaldis

  101. A dual role of Cdk2 in DNA damage response

    Article • Cell Division, January 2009, Springer Science + Business Media

    Dr Philipp Kaldis

  102. Degradation of BRCA2 in Alkyltransferase-Mediated DNA Repair and Its Clinical Implications

    Article • Cancer Research, December 2008, American Association for Cancer Research (AACR)

    Dr Philipp Kaldis

  103. Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury

    Article • Journal of Molecular and Cellular Cardiology, November 2008, Elsevier

    Dr Philipp Kaldis

  104. Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

    Article • Development, September 2008, The Company of Biologists

    Dr Philipp Kaldis

  105. The Metastasis-Associated Gene Prl-3 Is a p53 Target Involved in Cell-Cycle Regulation

    Article • Molecular Cell, May 2008, Elsevier

    Dr Philipp Kaldis

  106. Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone

    Article • The Journal of Cell Biology, December 2007, Rockefeller University Press

    Dr Philipp Kaldis

  107. CDK2 is Dispensable for Adult Hippocampal Neurogenesis

    Article • Cell Cycle, December 2007, Taylor & Francis

    Dr Philipp Kaldis

  108. p21 Inhibits Cdk1 in the Absence of Cdk2 to Maintain the G1/S Phase DNA Damage Checkpoint

    Article • Molecular Biology of the Cell, October 2007, American Society for Cell Biology (ASCB)

    Dr Philipp Kaldis

  109. p27kip1(Cyclin-Dependent Kinase Inhibitor 1B) Controls Ovarian Development by Suppressing Follicle Endowment and Activation and Promoting Follicle Atresia in Mice

    Article • Molecular Endocrinology, September 2007, Endocrine Society

    Dr Philipp Kaldis

  110. Hematopoiesis and Thymic Apoptosis Are Not Affected by the Loss of Cdk2

    Article • Molecular and Cellular Biology, May 2007, ASM Journals

    Dr Philipp Kaldis

  111. Cell-specific responses to loss of cyclin-dependent kinases

    Article • Oncogene, February 2007, Nature

    Dr Philipp Kaldis

  112. Another Piece of the p27Kip1 Puzzle

    Article • Cell, January 2007, Elsevier

    Dr Philipp Kaldis

  113. Kinase-Independent Function of Cyclin E

    Article • Molecular Cell, January 2007, Elsevier

    Dr Philipp Kaldis

  114. Loss of centrosome integrity induces p38—p53—p21-dependent G1—S arrest

    Article • Nature Cell Biology, December 2006, Springer Science + Business Media

    Dr Agata Jurczyk, Dr Philipp Kaldis

  115. PRKAR1A Inactivation Leads to Increased Proliferation and Decreased Apoptosis in Human B Lymphocytes

    Article • Cancer Research, November 2006, American Association for Cancer Research (AACR)

    Dr Philipp Kaldis

  116. Identification of Yin-Yang Regulators and a Phosphorylation Consensus for Male Germ Cell-Associated Kinase (MAK)-Related Kinase

    Article • Molecular and Cellular Biology, September 2006, ASM Journals

    Dr Philipp Kaldis

  117. Dependence of Cisplatin-Induced Cell Death In Vitro and In Vivo on Cyclin-Dependent Kinase 2

    Article • Journal of the American Society of Nephrology, August 2006, American Society of Nephrology

    Dr Philipp Kaldis

  118. CDK2 Is Required By MYC to Induce Apoptosis

    Article • Cell Cycle, June 2006, Taylor & Francis

    Dr Philipp Kaldis

  119. Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation

    Article • Developmental Cell, May 2006, Elsevier

    Dr Philipp Kaldis

  120. IL-7 promotes T cell proliferation through destabilization of p27 Kip1

    Article • The Journal of Cell Biology, March 2006, Rockefeller University Press

    Dr Philipp Kaldis

  121. IL-7 promotes T cell proliferation through destabilization of p27 Kip1

    Article • The Journal of Experimental Medicine, February 2006, Rockefeller University Press

    Dr Philipp Kaldis

  122. p205, A potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation

    Article • FEBS Letters, January 2006, Wiley

    Professor David J. Garfinkel, Dr Philipp Kaldis

  123. Article • Cell Division, January 2006, Springer Science + Business Media

    Dr Philipp Kaldis

  124. Article • Cell Division, January 2006, Springer Science + Business Media

    Dr Philipp Kaldis

  125. Cell Cycle Sibling Rivalry: Cdc2 Versus Cdk2

    Article • Cell Cycle, November 2005, Taylor & Francis

    Dr Philipp Kaldis

  126. Sil Phosphorylation in a Pin1 Binding Domain Affects the Duration of the Spindle Checkpoint

    Article • Molecular and Cellular Biology, August 2005, ASM Journals

    Dr Philipp Kaldis

  127. Cdc2–cyclin E complexes regulate the G1/S phase transition

    Article • Nature, July 2005, Nature

    Dr Philipp Kaldis

  128. Activation of a Nuclear Cdc2-Related Kinase within a Mitogen-Activated Protein Kinase-Like TDY Motif by Autophosphorylation and Cyclin-Dependent Protein Kinase-Activating Kinase

    Article • Molecular and Cellular Biology, July 2005, ASM Journals

    Dr Philipp Kaldis

  129. Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter

    Article • Blood, March 2005, American Society of Hematology

    Dr Philipp Kaldis

  130. The N-terminal Peptide of the Kaposi's Sarcoma-associated Herpesvirus (KSHV)-cyclin Determines Substrate Specificity

    Article • Journal of Biological Chemistry, January 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philipp Kaldis

  131. Article • BMC Biochemistry, January 2005, Springer Science + Business Media

    Dr Philipp Kaldis

  132. Cell Cycle-Dependent Phosphorylation of C/EBPβ Mediates Oncogenic Cooperativity between C/EBPβ and H-RasV12

    Article • Molecular and Cellular Biology, September 2004, ASM Journals

    Dr Philipp Kaldis

  133. Cdk2 as a Master of S phase Entry: Fact or Fake?

    Article • Cell Cycle, January 2004, Taylor & Francis

    Dr Philipp Kaldis

  134. Cdk2 Knockout Mice Are Viable

    Article • Current Biology, October 2003, Elsevier

    Dr Philipp Kaldis

  135. CAK1 Promotes Meiosis and Spore Formation in Saccharomyces cerevisiae in a CDC28-Independent Fashion

    Article • Molecular and Cellular Biology, January 2002, ASM Journals

    Dr Philipp Kaldis

  136. CAK-independent Activation of CDK6 by a Viral Cyclin

    Article • Molecular Biology of the Cell, December 2001, American Society for Cell Biology (ASCB)

    Dr Philipp Kaldis

  137. Dephosphorylation of Human Cyclin-dependent Kinases by Protein Phosphatase Type 2Cα and β2 Isoforms

    Article • Journal of Biological Chemistry, August 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philipp Kaldis

  138. Kinetic Analysis of the Cyclin-dependent Kinase-activating Kinase (Cak1p) from Budding Yeast

    Article • Journal of Biological Chemistry, August 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philipp Kaldis

  139. The Effects of Changing the Site of Activating Phosphorylation in CDK2 from Threonine to Serine

    Article • Journal of Biological Chemistry, August 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philipp Kaldis

  140. Analysis of CAK activities from human cells

    Article • European Journal of Biochemistry, July 2000, Wiley

    Dr Philipp Kaldis

  141. Activating Phosphorylation of the Saccharomyces cerevisiae Cyclin-dependent Kinase, Cdc28p, Precedes Cyclin Binding

    Article • Molecular Biology of the Cell, May 2000, American Society for Cell Biology (ASCB)

    Dr Philipp Kaldis

  142. Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity

    Article • Proceedings of the National Academy of Sciences, December 1999, Proceedings of the National Academy of Sciences

    Dr Philipp Kaldis

  143. Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases

    Article • Genes & Development, November 1999, Cold Spring Harbor Laboratory Press

    Dr Philipp Kaldis

  144. Activating Phosphorylation of the Kin28p Subunit of Yeast TFIIH by Cak1p

    Article • Molecular and Cellular Biology, July 1999, ASM Journals

    Dr Philipp Kaldis

  145. The cdk-activating kinase (CAK): from yeast to mammals

    Article • Cellular and Molecular Life Sciences, February 1999, Springer Science + Business Media

    Dr Philipp Kaldis

  146. The CDK-activating Kinase (Cak1p) from Budding Yeast Has an Unusual ATP-binding Pocket

    Article • Journal of Biological Chemistry, January 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philipp Kaldis

  147. Human and Yeast Cdk-activating Kinases (CAKs) Display Distinct Substrate Specificities

    Article • Molecular Biology of the Cell, September 1998, American Society for Cell Biology (ASCB)

    Dr Philipp Kaldis

  148. Regulation of CDKs by phosphorylation

    Article • January 1998, Springer Science + Business Media

    Dr Philipp Kaldis

  149. Functions of Creatine Kinase Isoenzymes in Spermatozoa

    Article • January 1997, Elsevier

    Dr Philipp Kaldis

  150. The Cdk-Activating Kinase (CAK) from Budding Yeast

    Article • Cell, August 1996, Elsevier

    Dr Philipp Kaldis

  151. Functional differences between dimeric and octameric mitochondrial creatine kinase

    Article • Biochemical Journal, June 1995, Portland Press Ltd.

    Dr Philipp Kaldis

  152. The N-terminal heptapeptide of mitochondrial creatine kinase is important for octamerization

    Article • Biochemistry, February 1994, American Chemical Society (ACS)

    Dr Philipp Kaldis

  153. A Short N-Terminal Domain of Mitochondrial Creatine Kinase is Involved in Octamer Formation but not in Membrane Binding

    Article • January 1993, Springer Science + Business Media

    Dr Philipp Kaldis

  154. Mouse Models of Cell Cycle Regulators: New Paradigms

    Article • Springer Science + Business Media

    Dr Philipp Kaldis

  155. A Novel Function for Cyclin E in Cell Cycle Progression

    Article • Springer Science + Business Media

    Dr Philipp Kaldis