Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

Wen Cai Zhang, Ng Shyh-Chang, He Yang, Amit Rai, Shivshankar Umashankar, Siming Ma, Boon Seng Soh, Li Li Sun, Bee Choo Tai, Min En Nga, Kishore Kumar Bhakoo, Senthil Raja Jayapal, Massimo Nichane, Qiang Yu, Dokeu A. Ahmed, Christie Tan, Wong Poo Sing, John Tam, Agasthian Thirugananam, Monireh Soroush Noghabi, Yin Huei Pang, Haw Siang Ang, Wayne Mitchell, Paul Robson, Philipp Kaldis, Ross Andrew Soo, Sanjay Swarup, Elaine Hsuen Lim, Bing Lim
  • Cell, January 2012, Elsevier
  • DOI: 10.1016/j.cell.2011.11.050

Why is it important?

Lung cancer is the leading cause of cancer-related mortality in both men and women worldwide with over 1 million deaths each year, and a 5-year survival below 15%. Non-small cell lung cancer accounts for approximately 85% of all lung cancers. In human patients, GLDC overexpression is significantly associated with higher mortality from lung cancer, and aberrant GLDC expression is observed in multiple cancer types. Our findings helped establish a novel link between glycine metabolism and tumorigenesis, and may provide novel targets for advancing anti-cancer therapy.

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The following have contributed to this page: Dr Paul Robson, Shivshankar Umashankar, Dr. Amit Rai, and Dr Philipp Kaldis