All Stories

  1. The phospholipid profile of T cells shapes ACSL4 dependency and ferroptosis sensitivity of naive, effector, and memory T cells

    Article • Proceedings of the National Academy of Sciences, March 2026, Proceedings of the National Academy of Sciences

    Manfred Kopf

  2. Versatile and Scalable Nanoparticle Vaccine as a Scaffold Against Newly Emerging Influenza Viruses

    Article • Viruses, August 2025, MDPI AG

    Manfred Kopf

  3. GM-CSF derived from alveolar type 2 cells promotes CD301b + cDC2 generation and allergic airway inflammation

    Article • Science Immunology, August 2025, American Association for the Advancement of Science

    Manfred Kopf

  4. IL-6 mediates defense against influenza virus by promoting protective antibody responses but not innate inflammation

    Article • Mucosal Immunology, June 2025, Elsevier

    Manfred Kopf

  5. Treatment of a metabolic liver disease in mice with a transient prime editing approach

    Article • Nature Biomedical Engineering, May 2025, Springer Science + Business Media

    Manfred Kopf

  6. Peroxisomes are critical for a unique metabolic demand and survival of alveolar macrophages

    Article • Cell Reports, May 2025, Elsevier

    PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Manfred Kopf

  7. Investigating Polyreactivity of CD4 + T Cells to the Intestinal Microbiota

    Article • European Journal of Immunology, April 2025, Wiley

    Manfred Kopf

  8. IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia

    Article • Nature Communications, March 2025, Springer Science + Business Media

    Manfred Kopf

  9. Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma

    Article • Nature Communications, January 2025, Springer Science + Business Media

    Manfred Kopf

  10. An Nrf2-NF-κB Crosstalk Controls Hepatocyte Proliferation in the Normal and Injured Liver

    Article • Cellular and Molecular Gastroenterology and Hepatology, January 2025, Elsevier

    Manfred Kopf

  11. IL-21/IL-21R signaling renders acute myeloid leukemia stem cells more susceptible to cytarabine treatment and CAR T cell therapy

    Article • Cell Reports Medicine, November 2024, Elsevier

    Manfred Kopf

  12. Endothelial metabolic control of insulin sensitivity through resident macrophages

    Article • Cell Metabolism, November 2024, Elsevier

    Manfred Kopf

  13. Inflammatory Mediators Suppress FGFR2 Expression in Human Keratinocytes to Promote Inflammation

    Article • Molecular and Cellular Biology, September 2024, Taylor & Francis

    Manfred Kopf

  14. Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs

    Article • Nature Chemical Biology, September 2024, Springer Science + Business Media

    Manfred Kopf

  15. A guideline on the molecular ecosystem regulating ferroptosis

    Article • Nature Cell Biology, February 2024, Springer Science + Business Media

    Manfred Kopf

  16. Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes

    Article • Nature, December 2023, Springer Science + Business Media

    Manfred Kopf

  17. The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function

    Article • Nature Immunology, August 2023, Springer Science + Business Media

    Manfred Kopf

  18. Data from A Protumorigenic mDia2–MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts

    Article • March 2023, American Association for Cancer Research (AACR)

    Manfred Kopf

  19. Supplementary Data from A Protumorigenic mDia2–MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts

    Article • March 2023, American Association for Cancer Research (AACR)

    Manfred Kopf

  20. Supplementary Figure from A Protumorigenic mDia2–MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts

    Article • March 2023, American Association for Cancer Research (AACR)

    Manfred Kopf

  21. Supplementary Figure from A Protumorigenic mDia2–MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts

    Article • March 2023, American Association for Cancer Research (AACR)

    Manfred Kopf

  22. The thioredoxin system: Balancing redox responses in immune cells and tumors

    Article • European Journal of Immunology, November 2022, Wiley

    Manfred Kopf

  23. A Protumorigenic mDia2–MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts

    Article • Cancer Research, August 2022, American Association for Cancer Research (AACR)

    Manfred Kopf

  24. Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection

    Article • Science Immunology, July 2022, American Association for the Advancement of Science

    Manfred Kopf

  25. High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escape

    Article • Science Advances, April 2022, American Association for the Advancement of Science

    Manfred Kopf

  26. LCMV induced downregulation of HVEM on antiviral T cells is critical for an efficient effector response

    Article • European Journal of Immunology, April 2022, Wiley

    Manfred Kopf

  27. Gene therapy of Csf2ra deficiency in mouse fetal monocyte precursors restores alveolar macrophage development and function

    Article • JCI Insight, April 2022, American Society for Clinical Investigation

    Manfred Kopf

  28. Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

    Article • Nature Communications, April 2022, Springer Science + Business Media

    Manfred Kopf

  29. KappaBle fluorescent reporter mice enable low-background single-cell detection of NF-κB transcriptional activity in vivo

    Article • Mucosal Immunology, April 2022, Elsevier

    Manfred Kopf

  30. In vivo prime editing of a metabolic liver disease in mice

    Article • Science Translational Medicine, March 2022, American Association for the Advancement of Science

    Manfred Kopf

  31. Peroxisomes Are Critical for the Development and Maintenance of B1 and Marginal Zone B Cells but Dispensable for Follicular B Cells and T Cells

    Article • The Journal of Immunology, February 2022, Oxford University Press (OUP)

    Manfred Kopf

  32. Fibroblast growth factor receptor 3 in hepatocytes protects from toxin-induced liver injury and fibrosis

    Article • iScience, October 2021, Elsevier

    Manfred Kopf

  33. Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF

    Article • Journal of Experimental Medicine, September 2021, Rockefeller University Press

    Manfred Kopf

  34. Differential sensitivity of inflammatory macrophages and alternatively activated macrophages to ferroptosis

    Article • European Journal of Immunology, July 2021, Wiley

    Prof Jesmond Dalli, Manfred Kopf

  35. Cytomegalovirus subverts macrophage identity

    Article • Cell, July 2021, Elsevier

    Manfred Kopf

  36. GM-CSF instigates a dendritic cell–T-cell inflammatory circuit that drives chronic asthma development

    Article • Journal of Allergy and Clinical Immunology, June 2021, Elsevier

    Manfred Kopf

  37. Tissue-resident macrophages: guardians of organ homeostasis

    Article • Trends in Immunology, June 2021, Elsevier

    Manfred Kopf

  38. PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions

    Article • Nature Communications, May 2021, Springer Science + Business Media

    Manfred Kopf

  39. PPARγ is essential for the development of bone marrow erythroblastic island macrophages and splenic red pulp macrophages

    Article • Journal of Experimental Medicine, March 2021, Rockefeller University Press

    Manfred Kopf

  40. Comparative analysis of the role of mast cells in murine asthma models using Kit‐sufficient mast cell‐deficient animals

    Article • Allergy, March 2021, Wiley

    Manfred Kopf

  41. Redox regulation of immunometabolism

    Article • Nature Reviews Immunology, December 2020, Springer Science + Business Media

    Manfred Kopf

  42. The thioredoxin‐1 inhibitor Txnip restrains effector T‐cell and germinal center B‐cell expansion

    Article • European Journal of Immunology, September 2020, Wiley

    Manfred Kopf

  43. The GM-CSF–IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses

    Article • Journal of Experimental Medicine, September 2020, Rockefeller University Press

    Manfred Kopf

  44. Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose

    Article • Redox Biology, September 2020, Elsevier

    Manfred Kopf

  45. High-Dimensional T Helper Cell Profiling Reveals a Broad Diversity of Stably Committed Effector States and Uncovers Interlineage Relationships

    Article • Immunity, September 2020, Elsevier

    Manfred Kopf

  46. Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

    Article • Cell Metabolism, June 2020, Elsevier

    Manfred Kopf

  47. Comprehensive characterization of myeloid cells during wound healing in healthy and healing‐impaired diabetic mice

    Article • European Journal of Immunology, May 2020, Wiley

    Manfred Kopf

  48. Mice carrying an analogous heterozygous dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy

    Article • Human Molecular Genetics, March 2020, Oxford University Press (OUP)

    Manfred Kopf

  49. Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways

    Article • Cell Reports, March 2020, Elsevier

    Manfred Kopf

  50. Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

    Article • eLife, February 2020, eLife

    Manfred Kopf

  51. Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development

    Article • The EMBO Journal, January 2020, Springer Science + Business Media

    Manfred Kopf

  52. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

    Article • Nature Immunology, December 2019, Springer Science + Business Media

    Manfred Kopf

  53. B1 and Marginal Zone B Cells but Not Follicular B2 Cells Require Gpx4 to Prevent Lipid Peroxidation and Ferroptosis

    Article • Cell Reports, November 2019, Elsevier

    Manfred Kopf

  54. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Article • European Journal of Immunology, October 2019, Wiley

    Mr Maximilien Evrard, Mr Gert Van Isterdael, Prof Anna Vittoria Mattioli, Manfred Kopf

  55. Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

    Article • Nature Communications, September 2019, Springer Science + Business Media

    Manfred Kopf

  56. A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice

    Article • Molecular Metabolism, July 2019, Elsevier

    Manfred Kopf

  57. Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis

    Article • Haematologica, June 2019, Ferrata Storti Foundation (Haematologica)

    Manfred Kopf

  58. IL-21 promotes allergic airway inflammation by driving apoptosis of FoxP3+ regulatory T cells

    Article • Journal of Allergy and Clinical Immunology, June 2019, Elsevier

    Manfred Kopf

  59. Author Correction: Deciphering CD4+ T cell specificity using novel MHC–TCR chimeric receptors

    Article • Nature Immunology, April 2019, Springer Science + Business Media

    Manfred Kopf

  60. GM-CSF intrinsically controls eosinophil accumulation in the setting of allergic airway inflammation

    Article • Journal of Allergy and Clinical Immunology, April 2019, Elsevier

    Manfred Kopf

  61. Deciphering CD4+ T cell specificity using novel MHC–TCR chimeric receptors

    Article • Nature Immunology, March 2019, Springer Science + Business Media

    Manfred Kopf

  62. The thioredoxin‐1 and glutathione/glutaredoxin‐1 systems redundantly fuel murine B‐cell development and responses

    Article • European Journal of Immunology, March 2019, Wiley

    Manfred Kopf

  63. Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis

    Article • Immunity, June 2018, Elsevier

    Manfred Kopf

  64. PPAR-γ in innate and adaptive lung immunity

    Article • Journal of Leukocyte Biology, May 2018, Oxford University Press (OUP)

    Manfred Kopf

  65. The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation

    Article • Nature Communications, May 2018, Springer Science + Business Media

    Manfred Kopf

  66. Synthesis and Structure–Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues

    Article • Organic Letters, May 2018, American Chemical Society (ACS)

    Manfred Kopf

  67. Training myeloid precursors with fungi, bacteria and chips

    Article • Nature Immunology, March 2018, Springer Science + Business Media

    Manfred Kopf

  68. Regulatory T cells are required for normal and activin‐promoted wound repair in mice

    Article • European Journal of Immunology, March 2018, Wiley

    Manfred Kopf

  69. Inhibition of Poxvirus Gene Expression and Genome Replication by Bisbenzimide Derivatives

    Article • Journal of Virology, September 2017, ASM Journals

    Manfred Kopf

  70. PPARγ in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation

    Article • Journal of Experimental Medicine, August 2017, Rockefeller University Press

    Manfred Kopf

  71. Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

    Article • Nature Immunology, January 2017, Springer Science + Business Media

    Manfred Kopf

  72. Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ−/− mice causes alveolar macrophage deficiency and fatal respiratory viral infection

    Article • Journal of Leukocyte Biology, July 2016, Oxford University Press (OUP)

    Manfred Kopf

  73. PI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus Infection

    Article • PLoS Pathogens, March 2016, PLOS

    Manfred Kopf

  74. PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development

    Article • Immunity, October 2015, Elsevier

    Manfred Kopf

  75. Total Synthesis of Prostaglandin 15d-PGJ2 and Investigation of its Effect on the Secretion of IL-6 and IL-12

    Article • Organic Letters, August 2015, American Chemical Society (ACS)

    Manfred Kopf

  76. tEMPting Fate MaYBe the Solution

    Article • Immunity, April 2015, Elsevier

    Manfred Kopf

  77. T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

    Article • Journal of Experimental Medicine, March 2015, Rockefeller University Press

    Manfred Kopf

  78. Phospholipid oxidation generates potent anti‐inflammatory lipid mediators that mimic structurally related pro‐resolving eicosanoids by activating Nrf2

    Article • EMBO Molecular Medicine, March 2015, Springer Science + Business Media

    Manfred Kopf

  79. Protective effect of a germline, IL-17-neutralizing antibody in murine models of autoimmune inflammatory disease

    Article • European Journal of Immunology, January 2015, Wiley

    Manfred Kopf

  80. The development and function of lung-resident macrophages and dendritic cells

    Article • Nature Immunology, December 2014, Springer Science + Business Media

    Manfred Kopf

  81. Discovery of a Highly Potent Anti-inflammatory Epoxyisoprostane-Derived Lactone

    Article • Journal of the American Chemical Society, December 2014, American Chemical Society (ACS)

    Manfred Kopf

  82. Influenza A virus uses the aggresome processing machinery for host cell entry

    Article • Science, October 2014, American Association for the Advancement of Science

    Manfred Kopf

  83. Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

    Article • Cancer Cell, October 2014, Elsevier

    Dr Kristian Unger, Manfred Kopf

  84. Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

    Article • Nature Immunology, September 2014, Springer Science + Business Media

    Manfred Kopf

  85. Endothelial cells translate pathogen signals into G-CSF–driven emergency granulopoiesis

    Article • Blood, August 2014, American Society of Hematology

    Manfred Kopf

  86. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection

    Article • PLoS Pathogens, April 2014, PLOS

    Manfred Kopf

  87. TREM-1 Deficiency Can Attenuate Disease Severity without Affecting Pathogen Clearance

    Article • PLoS Pathogens, January 2014, PLOS

    Christian M Schuerch, Manfred Kopf

  88. Cell-wall deficient L. monocytogenes L-forms feature abrogated pathogenicity

    Article • Frontiers in Cellular and Infection Microbiology, January 2014, Frontiers

    Manfred Kopf

  89. Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

    Article • Nature Immunology, September 2013, Springer Science + Business Media

    Manfred Kopf

  90. Innate Signaling Promotes Formation of Regulatory Nitric Oxide–Producing Dendritic Cells Limiting T-Cell Expansion in Experimental Autoimmune Myocarditis

    Article • Circulation, June 2013, Wolters Kluwer Health

    Professor Urs Eriksson, Manfred Kopf

  91. IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection

    Article • PLoS Pathogens, May 2013, PLOS

    Professor Tim D Sparwasser, Manfred Kopf

  92. Synthesis of Epoxyisoprostanes: Effects in Reducing Secretion of Pro‐inflammatory Cytokines IL‐6 and IL‐12

    Article • Angewandte Chemie, April 2013, Wiley

    Manfred Kopf

  93. Lymphocyte development

    Article • Current Opinion in Immunology, April 2013, Elsevier

    Manfred Kopf

  94. The origin and fate of γδT cell subsets

    Article • Current Opinion in Immunology, April 2013, Elsevier

    Manfred Kopf

  95. Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalk

    Article • Journal of Clinical Investigation, October 2012, American Society for Clinical Investigation

    Manfred Kopf

  96. Cooperation of T h1 and T h17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy

    Article • European Journal of Immunology, July 2012, Wiley

    Manfred Kopf

  97. Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells

    Article • The Journal of Immunology, June 2012, Oxford University Press (OUP)

    Manfred Kopf

  98. IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis

    Article • Blood, May 2012, American Society of Hematology

    Manfred Kopf

  99. Evidence for the divergence of innate and adaptive T-cell precursors before commitment to the αβ and γδ lineages

    Article • Blood, December 2011, American Society of Hematology

    Manfred Kopf

  100. Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity

    Article • Immunity, November 2011, Elsevier

    Manfred Kopf

  101. Nrf2 is essential for cholesterol crystal‐induced inflammasome activation and exacerbation of atherosclerosis

    Article • European Journal of Immunology, June 2011, Wiley

    Manfred Kopf

  102. HVEM Signalling Promotes Colitis

    Article • PLOS One, April 2011, PLOS

    Manfred Kopf

  103. Bacterial-induced protection against allergic inflammation through a multicomponent immunoregulatory mechanism

    Article • Thorax, March 2011, BMJ

    Manfred Kopf

  104. IL-21 induces death of marginal zone B cells during chronic inflammation

    Article • Blood, December 2010, American Society of Hematology

    Manfred Kopf

  105. IL-17A/F-Signaling Does Not Contribute to the Initial Phase of Mucosal Inflammation Triggered by S. Typhimurium

    Article • PLOS One, November 2010, PLOS

    Dr Jean-Claude SIRARD, Manfred Kopf

  106. Averting inflammation by targeting the cytokine environment

    Article • Nature Reviews Cancer, September 2010, Springer Science + Business Media

    Manfred Kopf

  107. Cutting Edge: IL-21 and TLR Signaling Regulate Germinal Center Responses in a B Cell-Intrinsic Manner

    Article • The Journal of Immunology, May 2010, Oxford University Press (OUP)

    Manfred Kopf

  108. Combined vaccination against IL-5 and eotaxin blocks eosinophilia in mice

    Article • Vaccine, April 2010, Elsevier

    Manfred Kopf

  109. Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis

    Article • Journal of Cell Biology, March 2010, Rockefeller University Press

    Manfred Kopf

  110. A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

    Article • Cancer Cell, November 2009, Elsevier

    Manfred Kopf

  111. A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

    Article • Cancer Cell, October 2009, Elsevier

    Manfred Kopf

  112. Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

    Article • PLOS One, August 2009, PLOS

    Manfred Kopf

  113. The Kinase Activity of Rip2 Determines Its Stability and Consequently Nod1- and Nod2-mediated Immune Responses

    Article • Journal of Biological Chemistry, July 2009, Elsevier

    Manfred Kopf

  114. Role of GM-CSF signaling in cell-based tumor immunization

    Article • Blood, June 2009, American Society of Hematology

    Manfred Kopf

  115. IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

    Article • Science, June 2009, American Association for the Advancement of Science

    Manfred Kopf

  116. IL-17–producing T cells in lung immunity and inflammation

    Article • Journal of Allergy and Clinical Immunology, May 2009, Elsevier

    Manfred Kopf

  117. CD40–CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4 + T cells

    Article • Proceedings of the National Academy of Sciences, January 2009, Proceedings of the National Academy of Sciences

    Manfred Kopf

  118. GM-CSF mediates autoimmunity by enhancing IL-6–dependent Th17 cell development and survival

    Article • Journal of Experimental Medicine, September 2008, Rockefeller University Press

    Manfred Kopf

  119. IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunity in vivo

    Article • European Journal of Immunology, June 2008, Wiley

    Manfred Kopf

  120. Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

    Article • Cell, April 2008, Elsevier

    Dr Ruud Veldhuizen, Manfred Kopf

  121. Effective T-cell immune responses in the absence of the serine/threonine kinase RIP2

    Article • Microbes and Infection, April 2008, Elsevier

    Manfred Kopf

  122. T-cell fate and function: PKC-θ and beyond

    Article • Trends in Immunology, April 2008, Elsevier

    Manfred Kopf

  123. Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages

    Article • European Journal of Immunology, January 2008, Wiley

    Manfred Kopf

  124. Toll-like receptors: paving the path to T cell-driven autoimmunity?

    Article • Current Opinion in Immunology, December 2007, Elsevier

    Manfred Kopf

  125. IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance

    Article • European Journal of Immunology, September 2007, Wiley

    Manfred Kopf

  126. Dyslipidemia inhibits Toll-like receptor–induced activation of CD8α-negative dendritic cells and protective Th1 type immunity

    Article • Journal of Experimental Medicine, February 2007, Rockefeller University Press

    Manfred Kopf

  127. IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo

    Article • Blood, October 2006, American Society of Hematology

    Manfred Kopf

  128. Neutralization of IL‐17 by active vaccination inhibits IL‐23‐dependent autoimmune myocarditis

    Article • European Journal of Immunology, October 2006, Wiley

    Manfred Kopf

  129. Vaccination against IL‐17 suppresses autoimmune arthritis and encephalomyelitis

    Article • European Journal of Immunology, October 2006, Wiley

    Manfred Kopf

  130. VSIG4, a B7 family-related protein, is a negative regulator of T cell activation

    Article • Journal of Clinical Investigation, October 2006, American Society for Clinical Investigation

    Manfred Kopf

  131. Distinct roles for IL‐6 and IL‐12p40 in mediating protection against Leishmania donovani and the expansion of IL‐10+ CD4+ T cells

    Article • European Journal of Immunology, June 2006, Wiley

    Manfred Kopf

  132. ABERRANT ACUTE-PHASE RESPONSE IN AGED INTERLEUKIN-6 KNOCKOUT MICE

    Article • Shock, June 2006, Wolters Kluwer Health

    Manfred Kopf

  133. Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6

    Article • Proceedings of the National Academy of Sciences, May 2006, Proceedings of the National Academy of Sciences

    Manfred Kopf

  134. The osteopontin – CD44 pathway is superfluous for the development of autoimmune myocarditis

    Article • European Journal of Immunology, February 2006, Wiley

    Professor Urs Eriksson, Manfred Kopf

  135. Chemokines: more than just road signs

    Article • Nature Reviews Immunology, February 2006, Springer Science + Business Media

    Manfred Kopf

  136. Innate signals compensate for the absence of PKC-θ duringin vivoCD8+ T cell effector and memory responses

    Article • Proceedings of the National Academy of Sciences, September 2005, Proceedings of the National Academy of Sciences

    Manfred Kopf

  137. Interleukin-1 Is Responsible for Acute Lung Immunopathology but Increases Survival of Respiratory Influenza Virus Infection

    Article • Journal of Virology, May 2005, ASM Journals

    Manfred Kopf

  138. IL‐4Rα signaling is important for CD8+ T cell cytotoxicity in the absence of CD4+ T cell help

    Article • European Journal of Immunology, April 2005, Wiley

    Manfred Kopf

  139. CCL19 and CCL21 Induce a Potent Proinflammatory Differentiation Program in Licensed Dendritic Cells

    Article • Immunity, April 2005, Elsevier

    Manfred Kopf

  140. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1

    Article • Journal of Experimental Medicine, March 2005, Rockefeller University Press

    Manfred Kopf

  141. Mechanisms of autoimmune heart disease

    Article • Drug Discovery Today Disease Mechanisms, December 2004, Elsevier

    Professor Urs Eriksson, Manfred Kopf

  142. Models of autoimmune heart disease

    Article • Drug Discovery Today Disease Models, December 2004, Elsevier

    Professor Urs Eriksson, Manfred Kopf

  143. Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen‐specific T‐helper type 2 cells

    Article • Clinical & Experimental Allergy, August 2004, Wiley

    Manfred Kopf

  144. Protein Kinase C θ Is Critical for the Development of In Vivo T Helper (Th)2 Cell But Not Th1 Cell Responses

    Article • Journal of Experimental Medicine, July 2004, Rockefeller University Press

    Manfred Kopf

  145. Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells

    Article • Proceedings of the National Academy of Sciences, April 2004, Proceedings of the National Academy of Sciences

    Manfred Kopf

  146. IL-6 is required for glioma development in a mouse model

    Article • Oncogene, April 2004, Springer Science + Business Media

    Manfred Kopf

  147. Maintenance of memory CTL responses by T helper cells and CD40‐CD40 ligand: antibodies provide the key

    Article • European Journal of Immunology, March 2004, Wiley

    Manfred Kopf

  148. Maintenance of memory CTL responses by T helper cells and CD40‐CD40 ligand: antibodies provide the key

    Article • European Journal of Immunology, February 2004, Wiley

    Manfred Kopf

  149. Dendritic cell–induced autoimmune heart failure requires cooperation between adaptive and innate immunity

    Article • Nature Reports Stem Cells, November 2003, Springer Science + Business Media

    Professor Urs Eriksson, Manfred Kopf

  150. Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis

    Article • Brain, June 2003, Oxford University Press (OUP)

    Manfred Kopf

  151. A role for antibodies in the generation of memory antifungal immunity

    Article • European Journal of Immunology, April 2003, Wiley

    Manfred Kopf

  152. The IL‐1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model

    Article • European Journal of Immunology, March 2003, Wiley

    Manfred Kopf

  153. Activation of Dendritic Cells through the Interleukin 1 Receptor 1 Is Critical for the Induction of Autoimmune Myocarditis

    Article • Journal of Experimental Medicine, January 2003, Rockefeller University Press

    Professor Urs Eriksson, Manfred Kopf

  154. Interleukin-6–Deficient Mice Resist Development of Autoimmune Myocarditis Associated With Impaired Upregulation of Complement C3

    Article • Circulation, January 2003, Wolters Kluwer Health

    Professor Urs Eriksson, Manfred Kopf

  155. Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia

    Article • Brain Research, October 2002, Elsevier

    Manfred Kopf

  156. Balancing protective immunity and immunopathology

    Article • Current Opinion in Immunology, August 2002, Elsevier

    Manfred Kopf

  157. Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens

    Article • Proceedings of the National Academy of Sciences, June 2002, Proceedings of the National Academy of Sciences

    Manfred Kopf

  158. Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection

    Article • Nature Reports Stem Cells, April 2002, Springer Science + Business Media

    Manfred Kopf

  159. A high-throughput alphavirus-based expression cloning system for mammalian cells

    Article • Nature Biotechnology, September 2001, Springer Science + Business Media

    Manfred Kopf

  160. Retarded Liver Growth in Interleukin-6-Deficient and Tumor Necrosis Factor Receptor-1-Deficient Mice

    Article • Endocrinology, July 2001, Endocrine Society

    Ville Wallenius, Manfred Kopf

  161. IL‐5 deficiency abolishes aspects of airway remodelling in a murine model of lung inflammation

    Article • Clinical & Experimental Allergy, June 2001, Wiley

    Manfred Kopf

  162. Severe Schistosomiasis in the Absence of Interleukin-4 (IL-4) Is IL-12 Independent

    Article • Infection and Immunity, January 2001, ASM Journals

    Manfred Kopf

  163. Inducible Costimulator Protein (Icos) Controls T Helper Cell Subset Polarization after Virus and Parasite Infection

    Article • Journal of Experimental Medicine, July 2000, Rockefeller University Press

    Manfred Kopf

  164. Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-α and interleukin-1, but not by interferon-γ nor interleukin-6

    Article • AIDS, July 2000, Wolters Kluwer Health

    Manfred Kopf

  165. Antifungal type 1 responses are upregulated in IL-10-deficient mice

    Article • Microbes and Infection, December 1999, Elsevier

    Manfred Kopf

  166. Interleukin‐4 Causes Susceptibility to Invasive Pulmonary Aspergillosis through Suppression of Protective Type I Responses

    Article • The Journal of Infectious Diseases, December 1999, Oxford University Press (OUP)

    Manfred Kopf

  167. Cd2 Sets Quantitative Thresholds in T Cell Activation

    Article • Journal of Experimental Medicine, November 1999, Rockefeller University Press

    Manfred Kopf

  168. Schistosoma mansoni: IL-4 Is Necessary for Concomitant Immunity in Mice

    Article • Journal of Parasitology, August 1999, JSTOR

    Manfred Kopf

  169. CD8+ T Cells Mediate CD40-independent Maturation of Dendritic Cells In Vivo

    Article • Journal of Experimental Medicine, June 1999, Rockefeller University Press

    Manfred Kopf

  170. Developmental Regulation of Lck Targeting to the CD8 Coreceptor Controls Signaling in Naive and Memory T Cells

    Article • Journal of Experimental Medicine, May 1999, Rockefeller University Press

    Manfred Kopf

  171. Influenza virus: a novel method to assess viral and neutralizing antibody titers in vitro

    Article • Journal of Immunological Methods, May 1999, Elsevier

    Manfred Kopf

  172. Interleukin 6 Influences Germinal Center Development and Antibody Production via a Contribution of C3 Complement Component

    Article • Journal of Experimental Medicine, November 1998, Rockefeller University Press

    Manfred Kopf

  173. Interleukin 6 plays a key role in the development of antigen-induced arthritis

    Article • Proceedings of the National Academy of Sciences, July 1998, Proceedings of the National Academy of Sciences

    Manfred Kopf

  174. Induction of Gut Mucosal Immune Responses: Importance of Genetic Background and Th1/Th2 Cross‐Regulation

    Article • Scandinavian Journal of Immunology, May 1998, Wiley

    Manfred Kopf

  175. Endogenous Interleukin 4 Is Required for Development of Protective CD4+ T Helper Type 1 Cell Responses to Candida albicans

    Article • Journal of Experimental Medicine, February 1998, Rockefeller University Press

    Manfred Kopf

  176. Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness

    Article • Journal of Experimental Medicine, May 1997, Rockefeller University Press

    Manfred Kopf

  177. Cytokines and infectious diseases

    Article • Immunology Today, February 1997, Elsevier

    Manfred Kopf

  178. Lymphocyte subsets in experimental bronchopulmonary inflammation and hyperresponsiveness

    Article • Research in Immunology, January 1997, Elsevier

    Manfred Kopf

  179. Lipopolysaccharide-sensitivity of interferon-γ receptor deficient mice

    Article • Journal of Endotoxin Research, August 1996, SAGE Publications

    Manfred Kopf

  180. Distinct Tumorigenic Potential of abl and raf in B Cell Neoplasia: abl Activates the IL-6 Signaling Pathway

    Article • Immunity, July 1996, Elsevier

    Manfred Kopf

  181. IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

    Article • Immunity, January 1996, Elsevier

    Manfred Kopf

  182. Innate versus acquired immunity in listeriosis

    Article • Research in Immunology, January 1996, Elsevier

    Manfred Kopf

  183. Mouse Eotaxin Expression Parallels Eosinophil Accumulation during Lung Allergic Inflammation but It Is Not Restricted to a Th2-Type Response

    Article • Immunity, January 1996, Elsevier

    Manfred Kopf

  184. Schistosoma mansoni in IL-4-deficient mice

    Article • International Immunology, January 1996, Oxford University Press (OUP)

    Manfred Kopf

  185. Immune Responses of IL‐4, IL‐5, IL‐6 Deficient Mice

    Article • Immunological Reviews, December 1995, Wiley

    Manfred Kopf

  186. Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness).

    Article • Journal of Experimental Medicine, October 1995, Rockefeller University Press

    Manfred Kopf

  187. Interleukin 6 is essential for in vivo development of B lineage neoplasms.

    Article • Journal of Experimental Medicine, July 1995, Rockefeller University Press

    Manfred Kopf

  188. Pleiotropic Defects of IL‐6—deficient Mice Including Early Hematopoiesis, T and B Cell Function, and Acute Phase Responses

    Article • Annals of the New York Academy of Sciences, July 1995, Wiley

    Manfred Kopf

  189. B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24)

    Article • Transgenic Research, May 1995, Springer Science + Business Media

    Manfred Kopf

  190. Impaired mucosal immune responses in interleukin 4-targeted mice.

    Article • Journal of Experimental Medicine, January 1995, Rockefeller University Press

    Manfred Kopf

  191. Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system

    Article • Immunity, December 1994, Elsevier

    Manfred Kopf

  192. The immune response to Plasmodium chabaudi malaria in interleukin‐4‐deficient mice

    Article • European Journal of Immunology, October 1994, Wiley

    Manfred Kopf