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  1. Damage by being put on a mechanical ventilator gets worse with aging.

    Article • JCI Insight, February 2025, American Society for Clinical Investigation

    Dr Ruud Veldhuizen

  2. Collagen Tubular Airway‐on‐Chip for Extended Epithelial Culture and Investigation of Ventilation Dynamics

    Article • Small, March 2024, Wiley

    Dr Ruud Veldhuizen

  3. Pulmonary Surfactant: A Mighty Thin Film

    Article • Chemical Reviews, October 2023, American Chemical Society (ACS)

    Dr Ruud Veldhuizen

  4. Bronchopneumonia with interstitial pneumonia in beef feedlot cattle: Characterization and laboratory investigation

    Article • Veterinary Pathology, January 2023, SAGE Publications

    Dr Ruud Veldhuizen

  5. The negative effect of vaping on the material that stabilizes your lung, surfactant.

    Article • PLOS One, November 2022, PLOS

    Dr Ruud Veldhuizen

  6. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome

    Article • JCI Insight, December 2021, American Society for Clinical Investigation

    Dr Ruud Veldhuizen

  7. The effect of maternal protein restriction during perinatal life on the inflammatory response in pediatric rats

    Article • Canadian Journal of Physiology and Pharmacology, May 2021, Canadian Science Publishing

    Dr Ruud Veldhuizen

  8. National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research

    Article • Intensive Care Medicine Experimental, March 2021, Springer Science + Business Media

    Dr Ruud Veldhuizen

  9. Can a drug used to help premature babies breathe also be of benefit in patients with COVID-19?

    Article • Expert Review of Respiratory Medicine, December 2020, Taylor & Francis

    Dr Ruud Veldhuizen

  10. The impact of maternal protein restriction during perinatal life on the response to a septic insult in adult rats

    Article • Journal of Developmental Origins of Health and Disease, December 2020, Cambridge University Press

    Dr Ruud Veldhuizen

  11. Exogenous Surfactant as a Pulmonary Delivery Vehicle for Budesonide In Vivo

    Article • Lung, October 2020, Springer Science + Business Media

    Dr Ruud Veldhuizen

  12. Novel Functions and Signaling Specificity for the GraS Sensor Kinase of Staphylococcus aureus in Response to Acidic pH

    Article • Journal of Bacteriology, August 2020, ASM Journals

    Dr Martin J McGavin, Dr Ruud Veldhuizen

  13. Optimizing a novel therapy for bacterial lung infections.

    Article • Scientific Reports, June 2020, Springer Science + Business Media

    Dr Ruud Veldhuizen

  14. Therapy to reduce the damaging effects of mechanical ventilation

    Article • International Journal of Pharmaceutics, June 2020, Elsevier

    Dr Ruud Veldhuizen

  15. The effects of aging and exercise on lung mechanics, surfactant and alveolar macrophages

    Article • Experimental Lung Research, June 2019, Taylor & Francis

    Dr Ruud Veldhuizen

  16. Delivery of lung therapeutics using surfactant: a review

    Article • Biochemical Pharmacology, June 2019, Elsevier

    Dr Ruud Veldhuizen, Dr Andre S Pimentel

  17. Low protein diet during pregnancy will have effect on the lungs of the offspring.

    Article • PLOS One, April 2019, PLOS

    Dr Ruud Veldhuizen

  18. Autocrine GABA signaling distinctively regulates phenotypic activation of mouse pulmonary macrophages

    Article • July 2018, Elsevier

    Dr Ruud Veldhuizen

  19. Designing an artificial therapeutic for lung diseases

    Article • Scientific Reports, May 2018, Springer Science + Business Media

    Dr Ruud Veldhuizen

  20. Dysfunction of pulmonary surfactant mediated by phospholipid oxidation is cholesterol-dependent

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, April 2018, Elsevier

    Dr Ruud Veldhuizen

  21. Alveolar injury and regeneration following deletion of ABCA3

    Article • JCI Insight, December 2017, American Society for Clinical Investigation

    Dr Ruud Veldhuizen

  22. A new potential therapy for bacterial lung infections

    Article • Scientific Reports, November 2017, Springer Science + Business Media

    Dr Ruud Veldhuizen

  23. Killing of Pseudomonas aeruginosa by Chicken Cathelicidin-2 Is Immunogenically Silent, Preventing Lung Inflammation In Vivo

    Article • Infection and Immunity, September 2017, ASM Journals

    Dr Ruud Veldhuizen

  24. Impact of ventilation-induced lung injury on the structure and function of lamellar bodies

    Article • AJP Lung Cellular and Molecular Physiology, September 2017, American Physiological Society

    Dr Ruud Veldhuizen

  25. Studying the effect of exercise on acute inflammation in old mice

    Article • Critical Care, August 2017, Springer Science + Business Media

    Dr Ruud Veldhuizen

  26. A respiratory-gated micro-CT comparison of respiratory patterns in free-breathing and mechanically ventilated rats

    Article • Physiological Reports, January 2017, Wiley

    Dr Ruud Veldhuizen

  27. Lung remodeling associated with recovery from acute lung injury

    Article • Cell and Tissue Research, October 2016, Springer Science + Business Media

    Dr Ruud Veldhuizen

  28. The effect of diet-induced serum hypercholesterolemia on the surfactant system and the development of lung injury

    Article • Biochemistry and Biophysics Reports, September 2016, Elsevier

    Dr Ruud Veldhuizen

  29. Lack of matrix metalloproteinase 3 in mouse models of lung injury ameliorates the pulmonary inflammatory response in female but not in male mice

    Article • Experimental Lung Research, August 2016, Taylor & Francis

    Dr Ruud Veldhuizen

  30. The effect of matrix metalloproteinase-3 deficiency on pulmonary surfactant in a mouse model of acute lung injury

    Article • Canadian Journal of Physiology and Pharmacology, June 2016, Canadian Science Publishing

    Dr Ruud Veldhuizen

  31. Decreased neuroinflammation correlates to higher vagus nerve activity fluctuations in near-term ovine fetuses: a case for the afferent cholinergic anti-inflammatory pathway?

    Article • Journal of Neuroinflammation, May 2016, Springer Science + Business Media

    Dr Ruud Veldhuizen

  32. Antimicrobial and Biophysical Properties of Surfactant Supplemented with an Antimicrobial Peptide for Treatment of Bacterial Pneumonia

    Article • Antimicrobial Agents and Chemotherapy, March 2015, ASM Journals

    Dr Ruud Veldhuizen

  33. Cholesterol-mediated surfactant dysfunction is mitigated by surfactant protein A

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2015, Elsevier

    Dr Ruud Veldhuizen

  34. Apolipoprotein E-Deficient Mice Are Susceptible to the Development of Acute Lung Injury

    Article • Respiration, January 2014, Karger Publishers

    Dr Ruud Veldhuizen

  35. The effects of exogenous surfactant administration on ventilation-induced inflammation in mouse models of lung injury

    Article • BMC Pulmonary Medicine, November 2013, Springer Science + Business Media

    Dr Ruud Veldhuizen

  36. Adaptations to hibernation in lung surfactant composition of 13-lined ground squirrels influence surfactant lipid phase segregation properties

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 2013, Elsevier

    Dr Ruud Veldhuizen

  37. Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties

    Article • The International Journal of Biochemistry & Cell Biology, August 2013, Elsevier

    Dr Ruud Veldhuizen

  38. Human Alveolar Epithelial Cells Attenuate Pulmonary Microvascular Endothelial Cell Permeability under Septic Conditions

    Article • PLOS One, February 2013, PLOS

    Dr Ruud Veldhuizen

  39. Lung-Derived Mediators Induce Cytokine Production in Downstream Organs via anNF-κB-Dependent Mechanism

    Article • Mediators of Inflammation, January 2013, Hindawi Publishing Corporation

    Dr Ruud Veldhuizen

  40. Adaptation to low body temperature influences pulmonary surfactant composition thereby increasing fluidity while maintaining appropriately ordered membrane structure and surface activity

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 2012, Elsevier

    Dr Ruud Veldhuizen

  41. The Impact of Intermittent Umbilical Cord Occlusions on the Inflammatory Response in Pre-Term Fetal Sheep

    Article • PLOS One, June 2012, PLOS

    Dr Ruud Veldhuizen

  42. A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, May 2012, Elsevier

    Dr Ruud Veldhuizen

  43. Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids

    Article • AJP Lung Cellular and Molecular Physiology, January 2012, American Physiological Society

    Dr Ruud Veldhuizen

  44. Atomic force microscopy analysis of rat pulmonary surfactant films

    Article • Biophysical Chemistry, October 2011, Elsevier

    Dr Ruud Veldhuizen

  45. The biological effects of lung-derived mediators on the liver

    Article • Experimental Lung Research, July 2011, Taylor & Francis

    Dr Ruud Veldhuizen

  46. A ToF-SIMS study of the lateral organization of lipids and proteins in pulmonary surfactant systems

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2011, Elsevier

    Dr Ruud Veldhuizen

  47. The Effect of Tidal Volume on Systemic Inflammation in Acid-Induced Lung Injury

    Article • Respiration, January 2011, Karger Publishers

    Dr Ruud Veldhuizen

  48. Recent advances in alveolar biology: Some new looks at the alveolar interface

    Article • Respiratory Physiology & Neurobiology, August 2010, Elsevier

    Dr Ruud Veldhuizen

  49. Surfactant protein-A reduces translocation of mediators from the lung into the circulation

    Article • Experimental Lung Research, August 2010, Taylor & Francis

    Dr Ruud Veldhuizen

  50. IL-6 and TNFα across the umbilical circulation in term pregnancies: Relationship with labour events

    Article • Early Human Development, February 2010, Elsevier

    Dr Ruud Veldhuizen

  51. High-frequency oscillation and surfactant treatment in an acid aspiration model

    Article • Canadian Journal of Physiology and Pharmacology, January 2010, Canadian Science Publishing

    Dr Ruud Veldhuizen

  52. Role of cholesterol in the biophysical dysfunction of surfactant in ventilator-induced lung injury

    Article • AJP Lung Cellular and Molecular Physiology, January 2010, American Physiological Society

    Dr Ruud Veldhuizen

  53. Systemic and cerebral inflammatory response to umbilical cord occlusions with worsening acidosis in the ovine fetus

    Article • American Journal of Obstetrics and Gynecology, January 2010, Elsevier

    Dr Ruud Veldhuizen

  54. Mediators released from LPS-challenged lungs induce inflammatory responses in liver vascular endothelial cells and neutrophilic leukocytes

    Article • AJP Gastrointestinal and Liver Physiology, December 2009, American Physiological Society

    Dr Ruud Veldhuizen

  55. Quantifying lung morphology with respiratory-gated micro-CT in a murine model of emphysema

    Article • Physics in Medicine and Biology, March 2009, Institute of Physics Publishing

    Dr Ruud Veldhuizen

  56. ELEVATED ENDOGENOUS SURFACTANT REDUCES INFLAMMATION IN AN ACUTE LUNG INJURY MODEL

    Article • Experimental Lung Research, January 2009, Taylor & Francis

    Dr Ruud Veldhuizen

  57. THE EFFECTS OF HYPEROXIA EXPOSURE ON LUNG FUNCTION AND PULMONARY SURFACTANT IN A RAT MODEL OF ACUTE LUNG INJURY

    Article • Experimental Lung Research, January 2009, Taylor & Francis

    Dr Ruud Veldhuizen

  58. Current perspectives in pulmonary surfactant — Inhibition, enhancement and evaluation

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, October 2008, Elsevier

    Dr Ruud Veldhuizen

  59. Atomic Force Microscopy Studies of Functional and Dysfunctional Pulmonary Surfactant Films, II: Albumin-Inhibited Pulmonary Surfactant Films and the Effect of SP-A

    Article • Biophysical Journal, September 2008, Elsevier

    Dr Ruud Veldhuizen

  60. The effects of long-term conventional mechanical ventilation on the lungs of adult rats*

    Article • Critical Care Medicine, August 2008, Wolters Kluwer Health

    Dr Ruud Veldhuizen

  61. Alterations to surfactant precede physiological deterioration during high tidal volume ventilation

    Article • AJP Lung Cellular and Molecular Physiology, May 2008, American Physiological Society

    Dr Ruud Veldhuizen

  62. Atomic Force Microscopy Studies of Functional and Dysfunctional Pulmonary Surfactant Films. I. Micro- and Nanostructures of Functional Pulmonary Surfactant Films and the Effect of SP-A

    Article • Biophysical Journal, May 2008, Elsevier

    Dr Ruud Veldhuizen

  63. Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

    Article • Cell, April 2008, Elsevier

    Dr Ruud Veldhuizen

  64. Protective effects of elevated endogenous surfactant pools to injurious mechanical ventilation

    Article • AJP Lung Cellular and Molecular Physiology, April 2008, American Physiological Society

    Dr Ruud Veldhuizen

  65. The anatomy, physics, and physiology of gas exchange surfaces: is there a universal function for pulmonary surfactant in animal respiratory structures?

    Article • Integrative and Comparative Biology, October 2007, Oxford University Press (OUP)

    Dr Ruud Veldhuizen

  66. Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult

    Article • AJP Lung Cellular and Molecular Physiology, September 2007, American Physiological Society

    Dr Ruud Veldhuizen

  67. Alveolar macrophage depletion is associated with increased surfactant pool sizes in adult rats

    Article • Journal of Applied Physiology, August 2007, American Physiological Society

    Dr Ruud Veldhuizen

  68. Effect of Cholesterol on the Biophysical and Physiological Properties of a Clinical Pulmonary Surfactant

    Article • Biophysical Journal, August 2007, Elsevier

    Dr Ruud Veldhuizen

  69. In vivo characterization of lung morphology and function in anesthetized free-breathing mice using micro-computed tomography

    Article • Journal of Applied Physiology, May 2007, American Physiological Society

    Dr Ruud Veldhuizen

  70. LUNG MECHANICS IN THE TIMP3 NULL MOUSE AND ITS RESPONSE TO MECHANICAL VENTILATION

    Article • Experimental Lung Research, January 2007, Taylor & Francis

    Dr Ruud Veldhuizen

  71. Physiological effects of oxidized exogenous surfactant in vivo: effects of high tidal volume and surfactant protein A

    Article • AJP Lung Cellular and Molecular Physiology, October 2006, American Physiological Society

    Dr Ruud Veldhuizen

  72. The Future of Surfactant Therapy during ALI/ARDS

    Article • Seminars in Respiratory and Critical Care Medicine, August 2006, Thieme Publishing Group

    Dr Ruud Veldhuizen

  73. Pre-emptive and continuous inhaled NO counteracts the cardiopulmonary consequences of extracorporeal circulation in a pig model

    Article • Nitric Oxide, May 2006, Elsevier

    Pr Eric Troncy, Dr Ruud Veldhuizen

  74. INTERLEUKIN-6 HAS NO EFFECT ON SURFACTANT OR LUNG FUNCTION IN DIFFERENT LUNG INSULTS

    Article • Experimental Lung Research, January 2006, Taylor & Francis

    Dr Ruud Veldhuizen

  75. Mechanisms responsible for surfactant changes in sepsis-induced lung injury

    Article • European Respiratory Journal, December 2005, European Respiratory Society (ERS)

    Dr Ruud Veldhuizen

  76. Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia

    Article • AJP Lung Cellular and Molecular Physiology, August 2005, American Physiological Society

    Dr Ruud Veldhuizen

  77. Pseudomonas aeruginosa protease IV degrades surfactant proteins and inhibits surfactant host defense and biophysical functions

    Article • AJP Lung Cellular and Molecular Physiology, February 2005, American Physiological Society

    Dr Ruud Veldhuizen

  78. PROTEIN INHIBITION OF SURFACTANT DURING MECHANICAL VENTILATION OF ISOLATED RAT LUNGS

    Article • Experimental Lung Research, January 2005, Taylor & Francis

    Dr Ruud Veldhuizen

  79. Host response to intratracheally instilled bacteria in ventilated and nonventilated rats

    Article • Critical Care Medicine, December 2004, Wolters Kluwer Health

    Dr Ruud Veldhuizen

  80. Ventilation and oxygen: Just what the doctor ordered. . .Unfortunately*

    Article • Critical Care Medicine, December 2004, Wolters Kluwer Health

    Dr Ruud Veldhuizen

  81. Hyperoxia exposure impairs surfactant function and metabolism

    Article • Critical Care Medicine, May 2004, Wolters Kluwer Health

    Dr Ruud Veldhuizen

  82. Physiological and inflammatory response to instillation of an oxidized surfactant in a rat model of surfactant deficiency

    Article • Journal of Applied Physiology, May 2004, American Physiological Society

    Dr Ruud Veldhuizen

  83. Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis

    Article • AJP Lung Cellular and Molecular Physiology, December 2003, American Physiological Society

    Dr Ruud Veldhuizen

  84. High-frequency oscillation and exogenous surfactant administration in lung-injured adult sheep

    Article • Critical Care Medicine, October 2003, Wolters Kluwer Health

    Dr Ruud Veldhuizen

  85. Early surfactant administration protects against lung dysfunction in a mouse model of ARDS

    Article • AJP Lung Cellular and Molecular Physiology, May 2003, American Physiological Society

    Dr Ruud Veldhuizen

  86. High oxygen concentrations predispose mouse lungsto the deleterious effects of high stretch ventilation

    Article • Journal of Applied Physiology, March 2003, American Physiological Society

    Dr Ruud Veldhuizen

  87. The Role of Exogenous Surfactant in the Treatment of Acute Lung Injury

    Article • Annual Review of Physiology, March 2003, Annual Reviews

    Dr Ruud Veldhuizen

  88. Sepsis and hyperoxia effects on the pulmonary surfactant system in wild-type and iNOS knockout mice

    Article • European Respiratory Journal, July 2002, European Respiratory Society (ERS)

    Dr Ruud Veldhuizen

  89. Mechanical ventilation of isolated rat lungs changes the structure and biophysical properties of surfactant

    Article • Journal of Applied Physiology, March 2002, American Physiological Society

    Dr Ruud Veldhuizen

  90. Evaluation of alveolar surfactant aggregatesin vitroandin vivo

    Article • European Respiratory Journal, January 2002, European Respiratory Society (ERS)

    Dr Ruud Veldhuizen

  91. Effects of alveolar surfactant aggregates on T-lymphocyte proliferation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, March 2001, Elsevier

    Dr Ruud Veldhuizen

  92. Effects of mechanical ventilation of isolated mouse lungs on surfactant and inflammatory cytokines

    Article • European Respiratory Journal, March 2001, European Respiratory Society (ERS)

    Dr Ruud Veldhuizen

  93. SURFACTANT TREATMENT FOR VENTILATION-INDUCED LUNG INJURY IN RATS: EFFECTS ON LUNG COMPLIANCE AND CYTOKINES

    Article • Experimental Lung Research, January 2001, Taylor & Francis

    Dr Ruud Veldhuizen

  94. Dissociation of surfactant protein B from canine surfactant large aggregates during formation of small surfactant aggregates by in vitro surface area cycling

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, August 1999, Elsevier

    Dr Ruud Veldhuizen

  95. AN EXAMINATION OF THE DIFFERENT VARIABLES AFFECTING SURFACTANT AGGREGATE CONVERSION IN VITRO

    Article • Experimental Lung Research, January 1999, Taylor & Francis

    Dr Ruud Veldhuizen

  96. The role of lipids in pulmonary surfactant

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, November 1998, Elsevier

    Dr Ruud Veldhuizen

  97. Mitigation of injury in canine lung grafts by exogenous surfactant therapy

    Article • Journal of Thoracic and Cardiovascular Surgery, February 1997, Elsevier

    Dr Ruud Veldhuizen

  98. THE EFFECT OF LUNG PRESERVATION ON ALVEOLAR SURFACTANT

    Article • Transplantation, July 1996, Wolters Kluwer Health

    Dr Ruud Veldhuizen

  99. Surfactant: Current and Potential Therapeutic Application in Infants and Adults

    Article • Journal of Aerosol Medicine, January 1996, Mary Ann Liebert Inc

    Dr Ruud Veldhuizen

  100. Pulmonary surfactant subfractions in patients with the acute respiratory distress syndrome.

    Article • American Review of Respiratory Disease, December 1995, American Thoracic Society

    Dr Ruud Veldhuizen

  101. Factors Influencing Efficacy of Exogenous Surfactant in Acute Lung Injury

    Article • Neonatology, January 1995, Karger Publishers

    Dr Ruud Veldhuizen

  102. Surfactant-associated proteins (SP-A, SP-B) are increased proportionally to alveolar phospholipids in sheep silicosis

    Article • Lung, January 1993, Springer Science + Business Media

    Dr Ruud Veldhuizen

  103. Surfactant analysis and replacement therapy: A future tool of the lung transplant surgeon?

    Article • The Annals of Thoracic Surgery, November 1991, Elsevier

    Dr Ruud Veldhuizen

  104. Rat liver and lung mitochondria do not incorporate radioactivity from glycerol-3-phosphate or CDP-choline into glycero-3-phosphocholine

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, May 1991, Elsevier

    Dr Ruud Veldhuizen

  105. Examination of the potential role of the glycerophosphorylcholine (GPC) pathway in the biosynthesis of phosphatidylcholine by liver and lung

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, September 1989, Elsevier

    Dr Ruud Veldhuizen