All Stories

  1. Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer
  2. Mixed acinar cell carcinoma/non-ampullary adenocarcinoma of the duodenum
  3. Studying therapy effects and disease outcomes in silico using artificial counterfactual tissue samples
  4. A Validation Workflow for Novel Oligonucleotide Sequences to Expand the Multiplexing Capacity of the CO-Detection by indEXing (CODEX) Platform
  5. Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett’s Esophagus to adenocarcinoma
  6. Real-world data of azacitidine for relapsed/refractory nodal T-follicular helper cell lymphoma in 11 patients
  7. ROSIE: AI generation of multiplex immunofluorescence staining from histopathology images
  8. B7-H3: a consistent marker in metastatic colorectal cancer with potential for targeted treatment
  9. Streamlining a Patchwork - Exploring the Challenges of Digital Transformation in Pathology: Ethnographic Study
  10. PET-based immunomapping of intratumoral CD4 + cells to monitor acquired resistance to checkpoint inhibitors
  11. MCSP+ metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization
  12. The extra-islet pancreas supports autoimmunity in human type 1 diabetes
  13. High-dimensional imaging using combinatorial channel multiplexing and deep learning
  14. Liver cancer recurrence predicted by immune-cell location and gene expression
  15. Implementing digital pathology: qualitative and financial insights from eight leading European laboratories
  16. Preclinical in vitro and in vivo evidence for targeting CD74 as an effective treatment strategy for cutaneous T-cell lymphomas
  17. Adenosine Receptor 3 in Liver Cancer: Expression Variability, Epigenetic Modulation, and Enhanced Histone Deacetylase Inhibitor Effects
  18. ROSIE: AI generation of multiplex immunofluorescence staining from histopathology images
  19. Collagen fleece grafting for surgical treatment of patients with mild to severe peyronie’s curvatures
  20. Targeting CD276 for T cell-based immunotherapy of breast cancer
  21. Streamlining a Patchwork - Exploring the Challenges of Digital Transformation in Pathology: Ethnographic Study (Preprint)
  22. :Crossing the Boundaries of Life: Günter Blobel and the Origins of Molecular Cell Biology
  23. Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate
  24. Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities
  25. A replicating LCMV-based vaccine for the treatment of solid tumors
  26. Histological and functional characterization of 3D human skin models mimicking the inflammatory skin diseases psoriasis and atopic dermatitis
  27. Spatial subsetting enables integrative modeling of oral squamous cell carcinoma multiplex imaging data
  28. CD70/CD27 Signaling Promotes Expansion of Clonal Plasma Cells in Multiple Myeloma and Is a Promising Therapeutic Target in Advanced Disease
  29. Spatial Dissection of the Bone Marrow Microenvironment in Multiple Myeloma By High Dimensional Multiplex Tissue Imaging
  30. EGFR expression is associated with relapse in a melanoma cohort receiving adjuvant PD-1-based immunotherapy
  31. Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer
  32. Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes
  33. Corrigendum: A review on deep learning applications in highly multiplexed tissue imaging data analysis
  34. Escalating High-dimensional Imaging using Combinatorial Channel Multiplexing and Deep Learning
  35. S3-CIMA: Supervised spatial single-cell image analysis for identifying disease-associated cell-type compositions in tissue
  36. Translational data from a multicenter phase II study on dimethyl fumarate treatment in relapsed and refractory cutaneous T cell lymphoma
  37. Dimethyl fumarate treatment in relapsed and refractory cutaneous T-cell lymphoma: a multicenter phase 2 study
  38. Case Report: Paraneoplastic psoriasis in thymic carcinoma
  39. Impact of P-selectin–PSGL-1 Axis on Platelet-Endothelium-Leukocyte Interactions in Fatal COVID-19
  40. A review on deep learning applications in highly multiplexed tissue imaging data analysis
  41. Organization of the human intestine at single-cell resolution
  42. Expanded vacuum-stable gels for multiplexed high-resolution spatial histopathology
  43. Concerted epithelial and stromal changes during progression of Barrett’s Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis
  44. EGFR expression and relapse in patients with melanoma receiving adjuvant PD-1-based immunotherapy.
  45. S3-CIMA: Supervised spatial single-cell image analysis for the identification of disease-associated cell type compositions in tissue
  46. The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes
  47. Comprehensive analysis of SARS‐CoV‐2 receptor proteins in human respiratory tissues identifies alveolar macrophages as potential virus entry site
  48. Towards multiomic analysis of oral mucosal pathologies
  49. High-multiplex tissue imaging in routine pathology—are we there yet?
  50. Implementing deep learning models for the classification of Echinococcus multilocularis infection in human liver tissue
  51. A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy
  52. Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma
  53. SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
  54. Multimodal and spatially resolved profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities
  55. Charakterisierung des Tumormikromilieus mittels Hochmultiplexmikroskopieverfahren
  56. Multiomics surface receptor profiling of the NCI-60 tumor cell panel uncovers novel theranostics for cancer immunotherapy
  57. Splenic red pulp macrophages provide a niche for CML stem cells and induce therapy resistance
  58. Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV
  59. Immunotherapy of glioblastoma explants induces interferon-γ responses and spatial immune cell rearrangements in tumor center, but not periphery
  60. A single cell spatial temporal atlas of skeletal muscle reveals cellular neighborhoods that orchestrate regeneration and become disrupted in aging
  61. Tissue schematics map the specialization of immune tissue motifs and their appropriation by tumors
  62. Immunotherapy of glioblastoma explants induces interferon-γ responses and spatial immune cell rearrangements in tumor center, but not periphery
  63. CellSeg: a robust, pre-trained nucleus segmentation and pixel quantification software for highly multiplexed fluorescence images
  64. Systematic Investigation of SARS-CoV-2 Receptor Protein Distribution along Viral Entry Routes in Humans
  65. Rhesus Macaque CODEX Multiplexed Immunohistochemistry Panel for Studying Immune Responses During Ebola Infection
  66. Human influenza virus challenge identifies cellular correlates of protection for oral vaccination
  67. High Resolution Single Cell Maps Reveals Distinct Cell Organization and Function Across Different Regions of the Human Intestine
  68. Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
  69. Diagnostic and Prognostic Implications of Caspase-1 and PD-L1 Co-Expression Patterns in Myelodysplastic Syndromes
  70. Molecular Progression of Myeloproliferative and Myelodysplastic/Myeloproliferative Neoplasms: A Study on Sequential Bone Marrow Biopsies
  71. SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19
  72. Multiples Myelom aus Sicht der Pathologie
  73. Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers
  74. Supporting the Next Generation of Scientists to Lead Cancer Immunology Research
  75. Tracing tumor evolution and subtype specification in pancreatic cancer
  76. CODEX multiplexed tissue imaging with DNA-conjugated antibodies
  77. Virtual and augmented reality for biomedical applications
  78. Diversity, localization, and (patho)physiology of mature lymphocyte populations in the bone marrow
  79. Highly Multiplexed Phenotyping of Immunoregulatory Proteins in the Tumor Microenvironment by CODEX Tissue Imaging
  80. Electrospray Mediated Localized and Targeted Chemotherapy in a Mouse Model of Lung Cancer
  81. Highly multiplexed tissue imaging using repeated oligonucleotide exchange reaction
  82. A tissue atlas of ulcerative colitis to guide TNF inhibitor therapy
  83. Nanoscopic subcellular imaging enabled by ion beam tomography
  84. SARS-CoV-2 entry factors are expressed in nasal, ocular, and oral tissues: implications for COVID-19 prophylaxes/therapeutics
  85. Author Correction: Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity
  86. Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
  87. Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
  88. Metoclopramide treatment blocks CD93-signaling-mediated self-renewal of chronic myeloid leukemia stem cells
  89. Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
  90. Abstract PO-036: Defining the role of chromatin remodelers in pancreatic cancer
  91. ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs
  92. Landscape of coordinated immune responses to H1N1 challenge in humans
  93. Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front
  94. O3 High-dimensional analysis of tumor architecture predicts cancer immunotherapy response
  95. Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics
  96. Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front
  97. Memory CD8+ T Cells Balance Pro- and Anti-inflammatory Activity by Reprogramming Cellular Acetate Handling at Sites of Infection
  98. Abstract 6669: Cellular neighborhoods predict pembrolizumab response in cutaneous T cell lymphoma
  99. PET Imaging of the Natural Killer Cell Activation Receptor NKp30
  100. Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers
  101. Bispecific Antibodies for Multiple Myeloma: A Review of Targets, Drugs, Clinical Trials, and Future Directions
  102. Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity
  103. TNIK signaling imprints CD8+ T cell memory formation early after priming
  104. Functional comparison of PBMCs isolated by Cell Preparation Tubes (CPT) vs. Lymphoprep Tubes
  105. A review on tumor heterogeneity and evolution in multiple myeloma: pathological, radiological, molecular genetics, and clinical integration
  106. CD93-Signaling Regulates Self-Renewal and Proliferation of Chronic Myeloid Leukemia Stem Cells in Mice and Humans and Might be a Promising Target for Treatment
  107. Dynamics of the Cutaneous T Cell Lymphoma Microenvironment in Patients Treated with Pembrolizumab Revealed By Highly Multiplexed Tissue Imaging
  108. Splenic CD24low Red Pulp Macrophages Provide an Alternate Niche for Chronic Myeloid Leukemia Stem Cells
  109. Lobular neoplasia and invasive lobular breast cancer: Inter-observer agreement for histological grading and subclassification
  110. The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
  111. Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front
  112. P12.09 Multidimensional Personalized Response Assessment to Microglia Modulators in Gioblastoma Bioreactors
  113. Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy
  114. CARving up colorectal cancer organoids in vitro
  115. A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma
  116. Ion beam subcellular tomography
  117. Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front
  118. Dynamics of the Bone Marrow Microenvironment during Leukemic Progression Revealed By Codex Hyper-Parameter Tissue Imaging
  119. Therapeutic Antibodies for Myeloid Neoplasms—Current Developments and Future Directions
  120. The “don't eat me” signal CD47 is a novel diagnostic biomarker and potential therapeutic target for diffuse malignant mesothelioma
  121. Tumor Heterogeneity in Lymphomas: A Different Breed
  122. How mechanisms explain interfield cooperation: biological–chemical study of plant growth hormones in Utrecht and Pasadena, 1930–1938
  123. Innate immunity restricts Citrobacter rodentium A/E pathogenesis initiation to an early window of opportunity
  124. The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34 + Stem/Progenitor Cells
  125. CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia
  126. Functional Intestinal Bile Acid 7α-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model
  127. Tyrosine kinase inhibitor-induced CD70 expression mediates drug resistance in leukemia stem cells by activating Wnt signaling
  128. CD47 protein expression in acute myeloid leukemia: A tissue microarray-based analysis
  129. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms
  130. Blocking programmed cell death 1 in combination with adoptive cytotoxic T-cell transfer eradicates chronic myelogenous leukemia stem cells
  131. CD70/CD27 Signaling Mediates Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors By Compensatory Activation of the Wnt Pathway
  132. Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling
  133. Regulation of hematopoietic and leukemic stem cells by the immune system
  134. Cytotoxic CD8+ T Cells Stimulate Hematopoietic Progenitors by Promoting Cytokine Release from Bone Marrow Mesenchymal Stromal Cells
  135. TREM-1 Deficiency Can Attenuate Disease Severity without Affecting Pathogen Clearance
  136. Interferons in hematopoiesis and leukemia
  137. “Leiomyomatoid angiomatous neuroendocrine tumor” (LANT) of the pituitary reflects idiosyncratic angiogenesis in adenomas of the gonadotroph cell lineage
  138. Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ
  139. From "magic bullets" to specific cancer immunotherapy
  140. Dendritic Cell-Based Immunotherapy for Myeloid Leukemias
  141. Modulating CD27 signaling to treat cancer
  142. CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth
  143. CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression
  144. Destruction of Lymphoid Organ Architecture and Hepatitis Caused by CD4+ T Cells
  145. Chronic myelogenous leukemia maintains specific CD8+ T cells through IL-7 signaling
  146. Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression
  147. Defective homing and impaired induction of cytotoxic T cells by BCR/ABL-expressing dendritic cells
  148. Prevention of Brain Injury by the Nonbacteriolytic Antibiotic Daptomycin in Experimental Pneumococcal Meningitis