Developmental delays in exploration and locomotor activity in male rats exposed to low level lead

  • K.M. Crofton, D.H. Taylor, R.J. Bull, D.J. Sivulka, S.D. Lutkenhoff
  • Life Sciences, March 1980, Elsevier
  • DOI: 10.1016/0024-3205(80)90289-1

What is it about?

Delays in the development of exploratory and locomotor behavior in neonatal male rats (up to 21 days of age) are shown to accrue as a consequence of low level lead exposure. Cross fostering experiments indicate that these delays are primarily due to prenatal exposure. These Pb induced behavioral modifications appear to be associated with the delays in synaptogenesis and biochemical development of the cerebral cortex reported previously (4, 18).

Why is it important?

A new behavioral bioassay for detecting delays in brain development is described.

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The following have contributed to this page: Dr Kevin M Crofton

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