Postnatal evaluation of prenatal exposure to p-xylene in the rat

  • Mitchell B. Rosen, Kevin M. Crofton, Neil Chernoff
  • Toxicology Letters, December 1986, Elsevier
  • DOI: 10.1016/0378-4274(86)90214-6

What is it about?

Developmental exposures during pregnancy to p-xylene in rats. Dams were allowed to give birth, and litters were counted, weighed, and observed for external malformations on postnatal days (PD) 1 and 3. Litters were normalized to 8 pups (4 males and 4 females ± 1) on PD4. On PD21 animals were weaned and littermates housed by sex. Body weights were recorded weekly until weaning and once every 2 weeks thereafter. Central nervous system (CNS) development was evaluated by acoustic startle response on PD13, 17, 21, and 63 as well as figure-8 maze activity on PD22 and 65. Maternal weight gain during the treatment period was significantly less in the high-dose group. No effects were seen on litter size or weight at birth or on PD3.

Why is it important?

There were no effects of xylene exposure on growth rate. There were no treatment-related effects on acoustic startle response or figure-8 maze activity. Thus, p-xylene as administered in this study does not appear to be a selective developmental toxicant in the rat.

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