Prof. Dr. Jens Pietzsch

Adjuvant drug-assisted bone healing: Part I – Modulation of inflammation

• Clinical Hemorheology and Microcirculation
• January 2020

• This is the first of a total of three very comprehensive reviews of preclinical and clinical findings supporting the healing of critical bone defects using adjuvant therapy approaches. These have b...

Adjuvant drug-assisted bone healing: Part II – Modulation of angiogenesis

• Clinical Hemorheology and Microcirculation
• January 2020

• This is the second of a total of three very comprehensive reviews of preclinical and clinical findings supporting the healing of critical bone defects using adjuvant therapy approaches. These have ...

Adjuvant drug-assisted bone healing: Part III – Further strategies for local and system...

• Clinical Hemorheology and Microcirculation
• January 2020

• This is the third of a total of three very comprehensive reviews of preclinical and clinical findings supporting the healing of critical bone defects using adjuvant therapy approaches. These have b...

Regulation of bone regeneration

• Clinical Hemorheology and Microcirculation
• January 2020

• It is an editorial on a special issue on Bone Healing with three very comprehensive review articles on recent preclinical and clinical findings to support the healing of critical bone defects by ad...

Human Endothelial Cell Models in Biomaterial Research

• Trends in Biotechnology
• March 2017

• This review article on endothelial cell (EC) models as an important tool in biomaterials research critically examines, among other things, unrealistic experimental set-ups and far too far-reaching ...

S100 proteins and scavenger receptors: what's going on?

• Amino Acids
• October 2016

• This work shows for the first time the high-affinity interaction of S100A12, a prominent member of the S100 family of EF hand calcium binding proteins, with the class B scavenger receptor CD36. Bot...

Extracellular S100A4 affects endothelial cell integrity and stimulates transmigration o...

• Biochemical and Biophysical Research Communications
• September 2016

• A role for high concentrations of extracellular S100A4, a calcium-binding EF-hand protein, in reducing inter-endothelial tight junction integrity has been demonstrated. This may be a mechanism by w...

Copper-mediated cross-linking of S100A4, but not of S100A2, results in proinflammatory ...

• Biochemical and Biophysical Research Communications
• September 2011

• First observation that oxidative stress in the tumor microenvironment enhances the proinflammatory and prometastatic effects of extracellular S100A4 protein.

Small animal positron emission tomography in food sciences

• Amino Acids
• September 2005

• Editorial to a Special Issue, which for the first time familiarizes with the possibilities and the potential of positron emission tomography methodology in the field of food sciences.

Strain-specific metastatic phenotypes in pheochromocytoma allograft mice

• Endocrine Related Cancer
• December 2018

• Report on pheochromocytoma mouse allograft models that show a reproducible and clinically relevant spread of catecholamine-producing and somatostatin receptor-positive metastases. These preclinical...

Cysteine cathepsins: their role in tumor progression and recent trends in the developme...

• Frontiers in Chemistry
• June 2015

• Reports the radiochemist's and radiopharmacologist's view on this class of enzymes highly relevant for theranostic approaches in cancer treatment.

Tissue transglutaminase: An emerging target for therapy and imaging

• Bioorganic & Medicinal Chemistry Letters
• December 2013

• Reports the radiochemist's and radiopharmacologist's view on this enzyme highly relevant for theranostic approaches in cancer and fibrosis treatment.

Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging

• Small
• December 2019

• Nanosniffers to track down cancer: the authors design and synthesize functionalized bimodal probes for diagnostic cancer imaging. These renally excretible, actively targeted nanomaterials specifica...

Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/N...

• Advanced Science
• May 2019

Nitric Oxide-Releasing Selective Estrogen Receptor Modulators: A Bifunctional Approach ...

• Journal of Medicinal Chemistry
• May 2019

• Selective estrogen receptor modulators (SERMs), which release nitric oxide (•NO), improve desired antitumor effects and minimize unwanted side effects on the vascular system. The use of these bifun...

In Vivo Examination of an Injectable Hydrogel System Crosslinked by Peptide-Oligosaccha...

• Advanced Functional Materials
• March 2017

• Further development of a methodological platform for characterizing the in vivo behavior of hydrogels (biomaterials) with high sensitivity, versatility and reproducibility using dedicated multimoda...

Protein and non-protein biomarkers in melanoma: a critical update

• Amino Acids
• October 2012

• A critical view on the current debate on serologic protein markers and some selected non-protein markers in malignant melanoma is offered. Special emphasis is put on the S100 family of calcium bind...

Validation of different chemilumigenic substrates for detecting extracellular generatio...

• Luminescence
• January 2003

Copper(ii) chemistry of the functionalized macrocycle cyclam tetrapropionic acid

• Dalton Transactions
• January 2013

Measurement of 5-hydroxy-2-aminovaleric acid as a specific marker of metal catalysed ox...

• Journal of Clinical Pathology
• August 2003

Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 in human skin equivalents

• Experimental Dermatology
• April 2000

Zwitterionic Polymer-Coated Ultrasmall Superparamagnetic Iron Oxide Nanoparticles with ...

• ChemNanoMat
• September 2016

Development of a18F-labeled Diaryl-Substituted Dihydropyrrolo[3,2,1-hi]indole as Potent...

• ChemistrySelect
• November 2016

Technetium-99m based small molecule radiopharmaceuticals and radiotracers targeting inf...

• Dalton Transactions
• January 2017

Surface charge and particle size determine the metabolic fate of dendritic polyglycerols

• Nanoscale
• January 2017

Interaction of extracellular S100A4 with RAGE prompts prometastatic activation of A375 ...

• Journal of Cellular and Molecular Medicine
• March 2016

Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship...

• MedChemComm
• January 2015

Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopep...

• Organic & Biomolecular Chemistry
• January 2015

2,3-Diaryl-substituted indole based COX-2 inhibitors as leads for imaging tracer develo...

• RSC Advances
• January 2014

Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nit...

• MedChemComm
• January 2018

Cell Cycle Regulating Kinase Cdk4 as a Potential Target for Tumor Cell Treatment and Tu...

• Journal of Oncology
• January 2009

• This complements our initial work on development of radiolabeled derivatives of the cyclin-dependent kinase 4/6 inhibitor palbociclib (PD 0332991) for functional imaging of this key enzyme in vario...

Cyclin-Dependent Kinase 4/6 (Cdk4/6) Inhibitors: Perspectives in Cancer Therapy and Ima...

• Mini-Reviews in Medicinal Chemistry
• June 2010

• This complements our initial work on functional in vivo imaging of Cdk4/6 using radiolabeled derivatives of palbociclib (PD 0332991) and the PET radionuclides iodine-124 and fluorine-18.

Radiosynthesis and radiopharmacological evaluation of cyclin-dependent kinase 4 (Cdk4) ...

• European Journal of Medicinal Chemistry
• February 2010

• To the best of our knowledge this is the first report on an in vivo cyclin-dependent kinase 4/6 (CDK4/6) imaging agent based on palbociclib (PD 0332991), a potent selective inhibitor of cyclin depe...

Carboranyl Derivatives of Rofecoxib with Cytostatic Activity against Human Melanoma and...

• Scientific Reports
• March 2020

• The hypothesis that the incorporation of a carboranyl moiety instead of a phenyl ring into scaffolds of established NSAIDs may lead to compounds with improved activity is being tested.

Pheochromocytoma/Paraganglioma: A Guide for the Practicing Clinician

• Cancers
• October 2019

Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Back...

• Cancers
• May 2019

Bone healing made visible

• Clinical Hemorheology and Microcirculation
• November 2019

• With the in vivo and ex vivo small animal imaging approach presented here, it is possible to investigate essential hallmarks of the bone healing process in experimental models. This particularly co...

Carboranyl Analogues of Ketoprofen with Cytostatic Activity against Human Melanoma and ...

• ACS Omega
• May 2019

Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or P...

• Cancers
• April 2019

Cover Feature: Carboranyl Analogues of Celecoxib with Potent Cytostatic Activity agains...

• ChemMedChem
• February 2019

Carboranyl Analogues of Celecoxib with Potent Cytostatic Activity against Human Melanom...

• ChemMedChem
• January 2019

Fluorine-18 Labeling of S100 Proteins for Small Animal Positron Emission Tomography

• January 2019

Fluorescent mouse pheochromocytoma spheroids expressing hypoxia-inducible factor 2 alph...

• Journal of Cellular Biotechnology
• December 2019

Gelatin-based Hydrogel Degradation and Tissue Interactionin vivo: Insights from Multimo...

• Theranostics
• January 2016

• Introduction of a methodological platform for characterizing the in vivo behavior of hydrogels (biomaterials) with high sensitivity, versatility and reproducibility using dedicated multimodal small...

Multimodal Somatostatin Receptor Theranostics Using [64Cu]Cu-/[177Lu]Lu-DOTA-(Tyr3)octr...

• Theranostics
• January 2016

S100A2 in cancerogenesis: a friend or a foe?

• Amino Acids
• June 2010

S100 proteins in health and disease

• Amino Acids
• December 2010

• It is an editorial for a special issue on S100 proteins, which highlights the ongoing debate on the complex levels of cell and tissue regulatory specificity and functional diversity of this subfami...

Human S100A12: a novel key player in inflammation?

• Amino Acids
• April 2008

• This review highlights the importance and pathophysiological consequences of S100A12 as a multi-receptor ligand, as a proinflammatory cytokine, and as potential marker of inflammation.

Scavenger receptors are associated with cellular interactions of S100A12 in vitro and i...

• The International Journal of Biochemistry & Cell Biology
• May 2010

• To the best of our knowledge this is the first report on the interaction of scavenger receptors with the proinflammatory cytokine S100A12.

Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation The...

• Antioxidants
• April 2016

• This review aims to substantiate the hypothesis that antioxidant COX-2 inhibitors are promising radioprotectants because of intercepting radiation-induced oxidative stress and inflammation in norma...

Radiolabeled COX-2 Inhibitors for Non-Invasive Visualization of COX-2 Expression and Ac...

• Molecules
• May 2013

• This review initiates a critical discussion on imaging agents targeting COX-2 which have been developed for positron emission tomography (PET) and single photon emission computed tomography (SPECT).

Synthesis, radiolabelling and initial biological characterisation of 18F-labelled xanth...

• Organic & Biomolecular Chemistry
• January 2020

• This complements our initial work on functional in vivo imaging of Eph receptor tyrosine kinases.

Limited importance of EphrinA1–ligand, Src kinase, and focal adhesion kinase in EphA2-m...

• Journal of Cellular Biotechnology
• April 2019

Regulation of A375 melanoma cell adhesion and migration by EphB4 and EphrinB2 – insight...

• Journal of Cellular Biotechnology
• April 2019

Overexpression of Receptor Tyrosine Kinase EphB4 Triggers Tumor Growth and Hypoxia in A...

• Molecules
• February 2018

Preparation of a novel radiotracer targeting the EphB4 receptor via radiofluorination u...

• Journal of Labelled Compounds and Radiopharmaceuticals
• August 2017

Development of indazolylpyrimidine derivatives as high-affine EphB4 receptor ligands an...

• Bioorganic & Medicinal Chemistry
• September 2015

Fluorine-18 Radiolabeling and Radiopharmacological Characterization of a Benzodioxolylp...

• ChemMedChem
• October 2012

Irradiation affects cellular properties and Eph receptor expression in human melanoma c...

• Cell Adhesion & Migration
• March 2012

Experimental hypoxia does not influence gene expression and protein synthesis of Eph re...

• Melanoma Research
• April 2013

Radiofluorination and first radiopharmacological characterization of a SWLAY peptide-ba...

• Journal of Labelled Compounds and Radiopharmaceuticals
• September 2014

Eph receptors and ephrins: bloody players

• Journal of Oncology
• January 2010

• This review outlines the importance of the Eph/ephrin system for tumor vascularization and first targeted theranostic approaches as one starting point for our own efforts to develop radiotracers fo...

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

• Pharmaceutics
• May 2020

• Current developments, progress, but also pitfalls and setbacks of drug delivery approaches to support or control bone healing are discussed. The focus is on critical evaluation of recent preclinica...

Fighting Cancer: Targeting the Eph Receptor Tyrosine Kinase Subfamily

• ACS Omega
• June 2020

• This mini-review summarizes the different approaches to Eph-targeting radiotracers using antibodies, peptides and small molecules. The focus is on the development of specific and selective probes f...

Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogen...

• The Journal of Pathology
• July 2020

• Predictive models for interpreting metabolite data in phaeochromocytomas/paraganglioma (PPGL) patients