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This work shows for the first time the high-affinity interaction of S100A12, a prominent member of the S100 family of EF hand calcium binding proteins, with the class B scavenger receptor CD36. Both S100A12 and CD36 are involved in vascular inflammation and atherosclerosis. The observations suggest that the S100A12-CD36 axis may play a role in the pathogenesis of atherosclerosis and thus may be an interesting molecular target for the development of therapeutics.

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This page is a summary of: Insights into binding of S100 proteins to scavenger receptors: class B scavenger receptor CD36 binds S100A12 with high affinity, Amino Acids, October 2016, Springer Science + Business Media,
DOI: 10.1007/s00726-016-2349-2.
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