Professor Stefan Pöhlmann

Virosomes interfere with Ebola virus control by the immune system

• Cell Reports
• February 2019

• We show that the Ebola virus glycoprotein can be incorporated into non-infectious particles, termed virosomes. Virosomes can serve as antibody decoys and modulate macrophage function. The Interfero...

Inhibition of lectin-dependent enhancement of Ebola virus entry into cells

• Journal of the American Chemical Society
• August 2017

• The cellular lectins DC-SIGN and DC-SIGNR bind to glycans present on Ebola virus and can augment viral entry into cells. This study shows that quantum dots (QD) displaying a dense array of glycans ...

The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor...

• Journal of Virology
• March 2013

Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin

• Journal of Virology
• January 2009

Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus recept...

• Proceedings of the National Academy of Sciences
• May 2005

DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein ...

• Journal of Virology
• November 2004

Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR

• Journal of Virology
• April 2003

Diversity of receptors binding HIV on dendritic cell subsets

• Nature Immunology
• September 2002

DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian...

• Proceedings of the National Academy of Sciences
• February 2001

SARS-CoV-2 uses ACE2 and TMPRSS2 for infection of lung cells

• Cell
• April 2020

• Viruses interact with host cell factors for attachment and entry into target cells. The spike (S) protein of coronaviruses facilitates host cell entry and which host cell factors are exploited by t...

Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Mult...

• Angewandte Chemie International Edition
• March 2016

Protease inhibitors targeting coronavirus and filovirus entry

• Antiviral Research
• April 2015

Furin cleavage of SARS-CoV-2 spike is required for infection of lung cells

• Molecular Cell
• May 2020

• The S1/S2 cleavage site of the SARS-CoV-2 spike protein contains several arginine residues and is not found in closely related coronaviruses. Here, we show that this site is cleaved by the cellular...

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Cameli...

• Cell
• May 2020

Chloroquine does not inhibit SARS-CoV-2

• Nature
• July 2020

• Chloroquine is a drug used to treat Malaria. Chloroquine was also found to block SARS-CoV-2 infection of the kidney cell line Vero, which is frequently used to study virus infections, and has thus...