All Stories

  1. Development of covalent chemogenetic K2P channel activators

    Article • Cell Chemical Biology, July 2024, Elsevier

    Professor Adam Robert Renslo

  2. Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases

    Article • Antimicrobial Agents and Chemotherapy, May 2018, ASM Journals

    Professor Adam Robert Renslo

  3. Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes

    Article • Antimicrobial Agents and Chemotherapy, April 2017, ASM Journals

    Professor Adam Robert Renslo

  4. Protease inhibitors targeting coronavirus and filovirus entry

    Article • Antiviral Research, April 2015, Elsevier

    Professor Adam Robert Renslo, Professor Stefan Pöhlmann

  5. Simple Plate-Based, Parallel Synthesis of Disulfide Fragments using the CuAAC Click Reaction

    Article • ACS Combinatorial Science, December 2014, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  6. Efficient and Stereocontrolled Synthesis of 1,2,4-Trioxolanes Useful for Ferrous Iron-Dependent Drug Delivery

    Article • Organic Letters, November 2014, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  7. Drug Delivery to the Malaria Parasite Using an Arterolane-Like Scaffold

    Article • ChemMedChem, October 2014, Wiley

    Professor Adam Robert Renslo

  8. Successes and Challenges in Phenotype-Based Lead Discovery for Prion Diseases

    Article • Journal of Medicinal Chemistry, August 2014, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  9. Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases

    Article • Biochemistry, July 2014, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  10. UCSF Small Molecule Discovery Center: Innovation, Collaboration and Chemical Biology in the Bay Area

    Article • Combinatorial Chemistry & High Throughput Screening, April 2014, Bentham Science Publishers

    Professor Adam Robert Renslo, Dr Michelle R Arkin

  11. Fragment-based inhibitor discovery against β-lactamase

    Article • Future Medicinal Chemistry, March 2014, Future Science

    Professor Adam Robert Renslo

  12. Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells

    Article • Bioorganic & Medicinal Chemistry, March 2014, Elsevier

    Professor Adam Robert Renslo

  13. Inside Cover: Tailoring Small Molecules for an Allosteric Site on Procaspase-6 (ChemMedChem 1/2014)

    Article • ChemMedChem, December 2013, Wiley

    Professor Adam Robert Renslo

  14. Antimalarial Drug Discovery: From Quinine to the Dream of Eradication

    Article • ACS Medicinal Chemistry Letters, December 2013, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  15. Modulating caspase activity: beyond the active site

    Article • Current Opinion in Structural Biology, December 2013, Elsevier

    Professor Adam Robert Renslo

  16. Antiprion compounds that reduce PrPSc levels in dividing and stationary-phase cells

    Article • Bioorganic & Medicinal Chemistry, December 2013, Elsevier

    Professor Adam Robert Renslo

  17. Tailoring Small Molecules for an Allosteric Site on Procaspase-6

    Article • ChemMedChem, November 2013, Wiley

    Professor Adam Robert Renslo

  18. A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2PChannels

    Article • ACS Chemical Biology, August 2013, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  19. Correction: Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

    Article • eLife, July 2013, eLife

    Professor Adam Robert Renslo

  20. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

    Article • eLife, July 2013, eLife

    Professor Adam Robert Renslo

  21. Genetic and Neural Mechanisms that Inhibit Drosophila from Mating with Other Species

    Article • Cell, July 2013, Elsevier

    Professor Adam Robert Renslo

  22. Pharmacological brake-release of mRNA translation enhances cognitive memory

    Article • eLife, May 2013, eLife

    Dr Carmela Sidrauski, Dr Michelle R Arkin, Professor Adam Robert Renslo, Arkady Khoutorsky

  23. 2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease

    Article • ChemMedChem, March 2013, Wiley

    Professor Adam Robert Renslo

  24. Pharmacokinetics and Metabolism of 2-Aminothiazoles with Antiprion Activity in Mice

    Article • Pharmaceutical Research, February 2013, Springer Science + Business Media

    Professor Adam Robert Renslo

  25. Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

    Article • Beilstein Journal of Organic Chemistry, January 2013, Beilstein Institut

    Professor Adam Robert Renslo

  26. Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

    Article • PLOS One, December 2012, PLOS

    Professor Adam Robert Renslo

  27. Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite

    Article • Future Medicinal Chemistry, December 2012, Future Science

    Professor Adam Robert Renslo

  28. Predicting and Improving the Membrane Permeability of Peptidic Small Molecules

    Article • Journal of Medicinal Chemistry, April 2012, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  29. Structure-Based Design of Potent and Ligand-Efficient Inhibitors of CTX-M Class A β-Lactamase

    Article • Journal of Medicinal Chemistry, March 2012, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  30. Investigating the Antimalarial Action of 1,2,4-Trioxolanes with Fluorescent Chemical Probes

    Article • Journal of Medicinal Chemistry, December 2011, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  31. Drug discovery for neglected tropical diseases at the Sandler Center

    Article • Future Medicinal Chemistry, August 2011, Future Science

    Professor Adam Robert Renslo

  32. Predicting Binding to P-Glycoprotein by Flexible Receptor Docking

    Article • PLoS Computational Biology, June 2011, PLOS

    Professor Adam Robert Renslo

  33. Simple One-Pot Synthesis of Disulfide Fragments for Use in Disulfide-Exchange Screening

    Article • ACS Combinatorial Science, May 2011, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  34. Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

    Article • PLoS Neglected Tropical Diseases, May 2011, PLOS

    Professor Adam Robert Renslo

  35. Inside Cover: A Fragmenting Hybrid Approach for Targeted Delivery of Multiple Therapeutic Agents to the Malaria Parasite (ChemMedChem 3/2011)

    Article • ChemMedChem, March 2011, Wiley

    Professor Adam Robert Renslo

  36. 2-Aminothiazoles as Therapeutic Leads for Prion Diseases

    Article • Journal of Medicinal Chemistry, February 2011, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  37. Identification of Small Molecule Lead Compounds for Visceral Leishmaniasis Using a Novel Ex Vivo Splenic Explant Model System

    Article • PLoS Neglected Tropical Diseases, February 2011, PLOS

    Professor Adam Robert Renslo

  38. A Fragmenting Hybrid Approach for Targeted Delivery of Multiple Therapeutic Agents to the Malaria Parasite

    Article • ChemMedChem, January 2011, Wiley

    Professor Adam Robert Renslo

  39. ChemInform Abstract: Synthesis of Substituted Pyridines via Regiocontrolled [4 + 2] Cycloadditions of Oximinosulfonates.

    Article • ChemInform, June 2010, Wiley

    Professor Adam Robert Renslo

  40. Antibacterial oxazolidinones: emerging structure–toxicity relationships

    Article • Expert Review of Anti-infective Therapy, May 2010, Taylor & Francis

    Professor Adam Robert Renslo

  41. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases

    Article • Bioorganic & Medicinal Chemistry Letters, November 2009, Elsevier

    Professor Adam Robert Renslo

  42. Divergent Modes of Enzyme Inhibition in a Homologous Structure−Activity Series

    Article • Journal of Medicinal Chemistry, August 2009, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  43. Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

    Article • PLoS Neglected Tropical Diseases, July 2009, PLOS

    Professor Adam Robert Renslo

  44. Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes

    Article • Bioorganic & Medicinal Chemistry Letters, January 2008, Elsevier

    Professor Adam Robert Renslo

  45. The Echinocandins: Total and Semisynthetic Approaches in Antifungal Drug Discovery

    Article • ChemInform, October 2007, Wiley

    Professor Adam Robert Renslo

  46. A Practical Synthesis of Differentially Protected 2-(Hydroxymethyl)piperazines

    Article • The Journal of Organic Chemistry, October 2007, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  47. A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials

    Article • Bioorganic & Medicinal Chemistry Letters, September 2007, Elsevier

    Professor Adam Robert Renslo

  48. The Echinocandins: Total and Semi-Synthetic Approaches in Antifungal Drug Discovery

    Article • Anti-Infective Agents in Medicinal Chemistry, July 2007, Bentham Science Publishers

    Professor Adam Robert Renslo

  49. Drug discovery and development for neglected parasitic diseases

    Article • Nature Chemical Biology, December 2006, Springer Science + Business Media

    Professor Adam Robert Renslo

  50. Synthesis and Structure—Activity Studies of Antibacterial Oxazolidinones Containing Dihydrothiopyran or Dihydrothiazine C-Rings.

    Article • ChemInform, September 2006, Wiley

    Professor Adam Robert Renslo

  51. Synthesis and structure–activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings

    Article • Bioorganic & Medicinal Chemistry Letters, July 2006, Elsevier

    Professor Adam Robert Renslo

  52. Recent developments in the identification of novel oxazolidinone antibacterial agents

    Article • Bioorganic & Medicinal Chemistry, June 2006, Elsevier

    Professor Adam Robert Renslo

  53. Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure–activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones

    Article • Bioorganic & Medicinal Chemistry Letters, March 2006, Elsevier

    Professor Adam Robert Renslo

  54. Synthesis of Aza-, Oxa-, and Thiabicyclo[3.1.0]hexane Heterocycles from a Common Synthetic Intermediate.

    Article • ChemInform, November 2005, Wiley

    Professor Adam Robert Renslo

  55. Conformational Constraint in Oxazolidinone Antibacterials. Synthesis and Structure−Activity Studies of (Azabicyclo[3.1.0]hexylphenyl)oxazolidinones

    Article • Journal of Medicinal Chemistry, July 2005, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  56. Synthesis of Aza-, Oxa-, and Thiabicyclo[3.1.0]hexane Heterocycles from a Common Synthetic Intermediate

    Article • Organic Letters, June 2005, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  57. Intramolecular [4 + 2] Cycloadditions of Iminoacetonitriles: A New Class of Azadienophiles for Hetero Diels—Alder Reactions.

    Article • ChemInform, September 2003, Wiley

    Professor Adam Robert Renslo

  58. Preparation of Substituted Pyridines Via Regiocontrolled [4 + 2] Cycloadditions of Oximinosulfonates: Methyl 5-Methylpyridine-2-Carboxylate

    Article • August 2003, Wiley

    Professor Adam Robert Renslo

  59. Intramolecular [4 + 2] Cycloadditions of Iminoacetonitriles:  A New Class of Azadienophiles for Hetero Diels−Alder Reactions

    Article • Journal of the American Chemical Society, April 2003, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  60. Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion

    Article • Angewandte Chemie, April 2001, Wiley

    Professor Adam Robert Renslo

  61. Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion

    Article • Angewandte Chemie, April 2001, Wiley

    Professor Adam Robert Renslo

  62. Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion

    Article • Angewandte Chemie, April 2001, Wiley

    Professor Adam Robert Renslo

  63. Molecular Recognition with Introverted Functionality

    Article • Angewandte Chemie, September 2000, Wiley

    Professor Adam Robert Renslo

  64. Molecular Recognition with Introverted Functionality

    Article • Angewandte Chemie, September 2000, Wiley

    Professor Adam Robert Renslo

  65. Supercritical Fluids as Solvent Replacements in Chemical Synthesis

    Article • August 2000, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  66. Synthesis and Assembly of Self-Complementary Cavitands

    Article • Journal of the American Chemical Society, May 2000, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  67. Nanoscale Container Structures and Their Host - Guest Properties

    Article • Angewandte Chemie, March 2000, Wiley

    Professor Adam Robert Renslo

  68. Nanoscale Container Structures and Their Host – Guest Properties

    Article • Angewandte Chemie, March 2000, Wiley

    Professor Adam Robert Renslo

  69. Self-Complementary Cavitands

    Article • Journal of the American Chemical Society, August 1999, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  70. Encapsulation of Ion−Molecule Complexes:  Second-Sphere Supramolecular Chemistry

    Article • Journal of the American Chemical Society, August 1999, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  71. Synthesis of Substituted Pyridines via Regiocontrolled [4 + 2] Cycloadditions of Oximinosulfonates

    Article • The Journal of Organic Chemistry, October 1998, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  72. Concerning the Regiochemical Course of the Diels−Alder Reaction in Supercritical Carbon Dioxide

    Article • The Journal of Organic Chemistry, June 1997, American Chemical Society (ACS)

    Professor Adam Robert Renslo

  73. Kinetic Correlation of Diels−Alder Reactions in Supercritical Carbon Dioxide

    Article • The Journal of Physical Chemistry, January 1996, American Chemical Society (ACS)

    Professor Adam Robert Renslo