What is it about?
The Ebola virus glycoprotein antagonizes the interferon-induced antiviral host cell factor tetherin. However, it has been incompletely understood which determinants of GP control tetherin antagonism. González-Hernández and colleagues show that a GXXXA motif within the transmembrane domain of the Ebola virus glycoprotein is required for inhibition of tetherin. Thus, a chimeric VSV encoding EBOV-GP spreads less efficient in tetherin-positive cells as compared to tetherin-negative control cells.
Why is it important?
This finding should help to define the contribution of tetherin antagonism to Ebola virus spread and pathogenesis in the host.
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This page is a summary of: A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism, Journal of Virology, April 2018, ASM Journals, DOI: 10.1128/jvi.00403-18.
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