What is it about?
The cellular lectins DC-SIGN and DC-SIGNR bind to glycans present on Ebola virus and can augment viral entry into cells. This study shows that quantum dots (QD) displaying a dense array of glycans allow to dissect the multivalent protein-glycan interactions underlying ligand binding to DC-SIGN/R. Moreover, the research demonstrates that QDs can be used to block augmentation of Ebola virus cell entry by DC-SIGN/R.
Why is it important?
The study establishes quantum dots (QD) as powerful tools to study multivalent lectin-ligand interactions. It also suggests that QD or related reagents can be used to block lectin-dependent augmentation of host cell entry of Ebola virus and likely other viral pathogens.
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This page is a summary of: Dissecting Multivalent Lectin–Carbohydrate Recognition Using Polyvalent Multifunctional Glycan-Quantum Dots, Journal of the American Chemical Society, August 2017, American Chemical Society (ACS), DOI: 10.1021/jacs.7b05104.
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