All Stories

  1. ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain

    Article • PLoS Neglected Tropical Diseases, September 2020, PLOS

    Friedemann Weber

  2. NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3

    Article • Journal of Virology, September 2018, ASM Journals

    Friedemann Weber

  3. Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

    Article • Journal of Virology, March 2017, ASM Journals

    Friedemann Weber

  4. Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins

    Article • Virus Research, January 2017, Elsevier

    Friedemann Weber

  5. Standing on three legs: antiviral activities of RIG-I against influenza viruses

    Article • Current Opinion in Immunology, October 2016, Elsevier

    Friedemann Weber

  6. Homage to Richard M. Elliott

    Article • Viruses, August 2016, MDPI AG

    Friedemann Weber

  7. To Conquer the Host, Influenza Virus Is Packing It In: Interferon-Antagonistic Strategies beyond NS1

    Article • Journal of Virology, July 2016, ASM Journals

    Friedemann Weber

  8. Phleboviruses and the Type I Interferon Response

    Article • Viruses, June 2016, MDPI AG

    Friedemann Weber

  9. Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses

    Article • Scientific Reports, May 2016, Nature

    Friedemann Weber

  10. NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR

    Article • Journal of Virology, April 2016, ASM Journals

    Friedemann Weber

  11. High-Throughput Screening Using a Whole-Cell Virus Replication Reporter Gene Assay to Identify Inhibitory Compounds against Rift Valley Fever Virus Infection

    Article • SLAS DISCOVERY, April 2016, SAGE Publications

    Friedemann Weber

  12. The catcher in the RIG-I

    Article • Cytokine, November 2015, Elsevier

    Friedemann Weber

  13. Meeting report: First International Conference on Crimean-Congo hemorrhagic fever

    Article • Antiviral Research, August 2015, Elsevier

    Friedemann Weber

  14. Orthobunyaviruses and innate immunity induction: alieNSs vs. PredatoRRs

    Article • European Journal of Cell Biology, July 2015, Elsevier

    Friedemann Weber

  15. A Virus-Like Particle System Identifies the Endonuclease Domain of Crimean-Congo Hemorrhagic Fever Virus

    Article • Journal of Virology, March 2015, ASM Journals

    Dr Éric Bergeron, Friedemann Weber

  16. Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

    Article • Cell Host & Microbe, March 2015, Elsevier

    Friedemann Weber

  17. SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, January 2015, Elsevier

    Friedemann Weber

  18. RIG-I-like receptors and negative-strand RNA viruses: RLRly bird catches some worms

    Article • Cytokine & Growth Factor Reviews, October 2014, Elsevier

    Friedemann Weber

  19. Segmented negative-strand RNA viruses and RIG-I: divide (your genome) and rule

    Article • Current Opinion in Microbiology, August 2014, Elsevier

    Friedemann Weber

  20. Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

    Article • Journal of Visualized Experiments, July 2014, MyJove Corporation

    Friedemann Weber

  21. Bunyaviruses and Innate Immunity

    Article • April 2014, ASM Journals

    Professor Richard M Elliott, Friedemann Weber

  22. Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein

    Article • Nucleic Acids Research, March 2014, Oxford University Press (OUP)

    Erica Ollmann Saphire, Friedemann Weber

  23. Virulence Factor NSs of Rift Valley Fever Virus Recruits the F-Box Protein FBXO3 To Degrade Subunit p62 of General Transcription Factor TFIIH

    Article • Journal of Virology, January 2014, ASM Journals

    Friedemann Weber

  24. Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity

    Article • Cellular Microbiology, December 2013, Wiley

    Friedemann Weber

  25. Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist

    Article • Journal of Virology, September 2013, ASM Journals

    Friedemann Weber

  26. IFIT2 Is an Effector Protein of Type I IFN-Mediated Amplification of Lipopolysaccharide (LPS)-Induced TNF-  Secretion and LPS-Induced Endotoxin Shock

    Article • The Journal of Immunology, September 2013, The American Association of Immunologists

    Friedemann Weber

  27. Systems To Establish Bunyavirus Genome Replication in the Absence of Transcription

    Article • Journal of Virology, May 2013, ASM Journals

    Friedemann Weber

  28. Crystal structure of tetramer of La Crosse virus nucleoprotein in complex with ssRNA

    Article • April 2013, Protein Data Bank, Rutgers University

    Friedemann Weber

  29. Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein

    Article • Proceedings of the National Academy of Sciences, April 2013, Proceedings of the National Academy of Sciences

    Friedemann Weber

  30. Incoming RNA Virus Nucleocapsids Containing a 5′-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling

    Article • Cell Host & Microbe, March 2013, Elsevier

    Friedemann Weber

  31. Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus

    Article • Journal of Virology, February 2013, ASM Journals

    Friedemann Weber

  32. Structure of Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein: Superhelical Homo-Oligomers and the Role of Caspase-3 Cleavage

    Article • Journal of Virology, September 2012, ASM Journals

    Friedemann Weber

  33. Viral immune modulators perturb the human molecular network by common and unique strategies

    Article • Nature, July 2012, Nature

    Friedemann Weber, Ralf Bartenschlager

  34. Regulatory, biosafety and safety challenges for novel cells as substrates for human vaccines

    Article • Vaccine, April 2012, Elsevier

    Friedemann Weber

  35. Reverse Genetics of SARS-Related Coronavirus Using Vaccinia Virus-Based Recombination

    Article • PLoS ONE, March 2012, PLOS

    Professor Eric J. Snijder, Friedemann Weber

  36. Induction of DNA Damage Signaling upon Rift Valley Fever Virus Infection Results in Cell Cycle Arrest and Increased Viral Replication

    Article • Journal of Biological Chemistry, January 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Friedemann Weber

  37. The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

    Article • PLoS Pathogens, October 2011, PLOS

    Professor Stefan Pöhlmann, Friedemann Weber

  38. IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

    Article • Nature Immunology, June 2011, Nature

    Friedemann Weber

  39. Hiding from intracellular pattern recognition receptors, a passive strategy of flavivirus immune evasion

    Article • Virulence, May 2011, Taylor & Francis

    Friedemann Weber

  40. The Crimean Congo Hemorrhagic Fever European Consortium: Modern Approaches to Diagnostics, Epidemiology, Prevention, Therapy and Preparedness

    Article • Antiviral Research, May 2011, Elsevier

    Friedemann Weber

  41. Completion of Hepatitis C Virus Replication Cycle in Heterokaryons Excludes Dominant Restrictions in Human Non-liver and Mouse Liver Cell Lines

    Article • PLoS Pathogens, April 2011, PLOS

    Friedemann Weber

  42. The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

    Article • Journal of General Virology, April 2011, Society for General Microbiology

    Friedemann Weber

  43. Old World hantaviruses do not produce detectable amounts of dsRNA in infected cells and the 5' termini of their genomic RNAs are monophosphorylated

    Article • Journal of General Virology, February 2011, Society for General Microbiology

    Friedemann Weber

  44. Interferon Antagonist NSs of La Crosse Virus Triggers a DNA Damage Response-like Degradation of Transcribing RNA Polymerase II

    Article • Journal of Biological Chemistry, November 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Friedemann Weber

  45. N-terminal endonuclease domain of La Crosse virus L-protein

    Article • October 2010, Protein Data Bank, Rutgers University

    Friedemann Weber

  46. N-terminal endonuclease domain of La Crosse virus L-protein

    Article • October 2010, Protein Data Bank, Rutgers University

    Friedemann Weber

  47. Toscana virus induces interferon although its NSs protein reveals antagonistic activity

    Article • Journal of General Virology, September 2010, Society for General Microbiology

    Friedemann Weber

  48. Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription

    Article • PLoS Pathogens, September 2010, PLOS

    Friedemann Weber

  49. Extracellular 2′-5′ Oligoadenylate Synthetase Stimulates RNase L-Independent Antiviral Activity: a Novel Mechanism of Virus-Induced Innate Immunity

    Article • Journal of Virology, September 2010, ASM Journals

    Friedemann Weber

  50. La Crosse virus (LACV) Gc fusion peptide mutants have impaired growth and fusion phenotypes, but remain neurotoxic

    Article • Virology, September 2010, Elsevier

    Friedemann Weber

  51. Virus-Like Particles Expressing the Nucleocapsid Gene as an Efficient Vaccine Against Rift Valley Fever Virus

    Article • Vector-Borne and Zoonotic Diseases, September 2010, Mary Ann Liebert Inc

    Friedemann Weber

  52. Interferon interplay helps tissue cells to cope with SARS-Coronavirus infection

    Article • Virulence, July 2010, Taylor & Francis

    Friedemann Weber

  53. Tick-Borne Encephalitis Virus Delays Interferon Induction and Hides Its Double-Stranded RNA in Intracellular Membrane Vesicles

    Article • Journal of Virology, June 2010, ASM Journals

    Friedemann Weber

  54. Molecular Biology of Rift Valley Fever Virus~!2009-11-04~!2009-11-25~!2010-04-22~!

    Article • The Open Virology Journal, May 2010, Bentham Science Publishers

    Friedemann Weber

  55. Species-independent bioassay for sensitive quantification of antiviral type I interferons

    Article • Virology Journal, January 2010, Springer Science + Business Media

    Friedemann Weber

  56. Bunyaviruses and the Type I Interferon System

    Article • Viruses, November 2009, MDPI AG

    Professor Richard M Elliott, Friedemann Weber

  57. Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

    Article • Journal of Virology, October 2009, ASM Journals

    Friedemann Weber, Professor Stefan Pöhlmann

  58. Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor

    Article • Journal of General Virology, October 2009, Society for General Microbiology

    Professor Luis Martinez-Sobrido, Friedemann Weber

  59. Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation

    Article • Journal of General Virology, July 2009, Society for General Microbiology

    Professor Luis Martinez-Sobrido, Friedemann Weber

  60. Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses

    Article • Virology, March 2009, Elsevier

    Dr Juha T Huiskonen, Friedemann Weber

  61. Vaccination with virus-like particles protects mice from lethal infection of Rift Valley Fever Virus

    Article • Virology, March 2009, Elsevier

    Friedemann Weber

  62. NSs Protein of Rift Valley Fever Virus Induces the Specific Degradation of the Double-Stranded RNA-Dependent Protein Kinase

    Article • Journal of Virology, February 2009, ASM Journals

    Friedemann Weber

  63. Electron Cryo-Microscopy and Single-Particle Averaging of Rift Valley Fever Virus: Evidence for GN-GC Glycoprotein Heterodimers

    Article • Journal of Virology, February 2009, ASM Journals

    Dr Juha T Huiskonen, Friedemann Weber

  64. Severe Acute Respiratory Syndrome Coronavirus Triggers Apoptosis via Protein Kinase R but Is Resistant to Its Antiviral Activity

    Article • Journal of Virology, December 2008, ASM Journals

    Friedemann Weber

  65. Interferon and cytokine responses to Crimean Congo hemorrhagic fever virus; an emerging and neglected viral zonoosis

    Article • Cytokine & Growth Factor Reviews, October 2008, Elsevier

    Friedemann Weber

  66. The Interferon Antagonist ML Protein of Thogoto Virus Targets General Transcription Factor IIB

    Article • Journal of Virology, September 2008, ASM Journals

    Friedemann Weber

  67. T7 RNA polymerase-dependent and -independent systems for cDNA-based rescue of Rift Valley fever virus

    Article • Journal of General Virology, September 2008, Society for General Microbiology

    Friedemann Weber

  68. Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

    Article • PLoS ONE, April 2008, PLOS

    Friedemann Weber

  69. Interferon and cytokine responses to SARS-coronavirus infection

    Article • Cytokine & Growth Factor Reviews, April 2008, Elsevier

    Friedemann Weber

  70. Crimean-Congo hemorrhagic fever virus delays activation of the innate immune response

    Article • Journal of Medical Virology, January 2008, Wiley

    Professor Luis Martinez-Sobrido, Friedemann Weber

  71. Innate Immunity: Introduction

    Article • January 2008, Elsevier

    Friedemann Weber

  72. Interferon, Mx, and viral countermeasures

    Article • Cytokine & Growth Factor Reviews, October 2007, Elsevier

    Friedemann Weber

  73. Viral suppression of the interferon system

    Article • Biochimie, June 2007, Elsevier

    Friedemann Weber

  74. Interferon-induced Mx proteins in antiviral host defense

    Article • Biochimie, June 2007, Elsevier

    Friedemann Weber

  75. The intracellular sites of early replication and budding of SARS-coronavirus

    Article • Virology, May 2007, Elsevier

    Professor Luis Martinez-Sobrido, Friedemann Weber

  76. La Crosse Bunyavirus Nonstructural Protein NSs Serves To Suppress the Type I Interferon System of Mammalian Hosts

    Article • Journal of Virology, March 2007, ASM Journals

    Friedemann Weber, Thomas Michiels

  77. Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter

    Article • Journal of Medical Virology, January 2007, Wiley

    Professor Alexander Plyusnin, Friedemann Weber

  78. Interaction of hepatitis C virus with the type I interferon system

    Article • World Journal of Gastroenterology, January 2007, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Friedemann Weber

  79. Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines

    Article • PLoS Pathogens, January 2007, PLOS

    Friedemann Weber

  80. RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

    Article • Science, November 2006, American Association for the Advancement of Science

    Professor Peter Liljeström, Friedemann Weber

  81. Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

    Article • Blood, October 2006, American Society of Hematology

    Friedemann Weber

  82. Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells

    Article • Journal of General Virology, July 2006, Society for General Microbiology

    Friedemann Weber

  83. Neurons produce type I interferon during viral encephalitis

    Article • Proceedings of the National Academy of Sciences, May 2006, Proceedings of the National Academy of Sciences

    Friedemann Weber, Thomas Michiels

  84. Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses

    Article • Journal of Virology, May 2006, ASM Journals

    Friedemann Weber

  85. Global Suppression of the Host Antiviral Response by Ebola- and Marburgviruses: Increased Antagonism of the Type I Interferon Response Is Associated with Enhanced Virulence

    Article • Journal of Virology, March 2006, ASM Journals

    Friedemann Weber

  86. A target on the move: Innate and adaptive immune escape strategies of hepatitis C virus

    Article • Antiviral Research, March 2006, Elsevier

    Friedemann Weber

  87. The interferon response circuit: Induction and suppression by pathogenic viruses

    Article • Virology, January 2006, Elsevier

    Friedemann Weber

  88. Induction of Interferon Synthesis by the PKR-Inhibitory VA RNAs of Adenoviruses

    Article • Journal of Interferon & Cytokine Research, January 2006, Mary Ann Liebert Inc

    Friedemann Weber

  89. Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner

    Article • Journal of Virology, October 2005, ASM Journals

    Friedemann Weber

  90. Efficient cDNA-Based Rescue of La Crosse Bunyaviruses Expressing or Lacking the Nonstructural Protein NSs

    Article • Journal of Virology, August 2005, ASM Journals

    Friedemann Weber

  91. Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3

    Article • Journal of Virology, February 2005, ASM Journals

    Professor Luis Martinez-Sobrido, Friedemann Weber, Dr Jerome Cros

  92. Thogoto virus ML protein suppresses IRF3 function

    Article • Virology, January 2005, Elsevier

    Professor Luis Martinez-Sobrido, Friedemann Weber

  93. Inverse Interference: How Viruses Fight the Interferon System

    Article • Viral Immunology, December 2004, Mary Ann Liebert Inc

    Friedemann Weber

  94. NSs Protein of Rift Valley Fever Virus Blocks Interferon Production by Inhibiting Host Gene Transcription

    Article • Journal of Virology, September 2004, ASM Journals

    Friedemann Weber

  95. The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein

    Article • Journal of Clinical Virology, July 2004, Elsevier

    Friedemann Weber

  96. Inhibition of RNA Polymerase II Phosphorylation by a Viral Interferon Antagonist

    Article • Journal of Biological Chemistry, May 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Friedemann Weber

  97. Inhibition of Dugbe nairovirus replication by human MxA protein

    Article • Virus Research, January 2004, Elsevier

    Professor Richard M Elliott, Friedemann Weber

  98. Bunyamwera Virus Nonstructural Protein NSs Counteracts Interferon Regulatory Factor 3-Mediated Induction of Early Cell Death

    Article • Journal of Virology, July 2003, ASM Journals

    Friedemann Weber

  99. Activation of PKR by Bunyamwera Virus Is Independent of the Viral Interferon Antagonist NSs

    Article • Journal of Virology, May 2003, ASM Journals

    Friedemann Weber

  100. Functional L polymerase of La Crosse virus allows in vivo reconstitution of recombinant nucleocapsids

    Article • Journal of General Virology, May 2003, Society for General Microbiology

    Friedemann Weber

  101. Viral Evasion of the Interferon System: Old Viruses, New Tricks

    Article • Journal of Interferon & Cytokine Research, April 2003, Mary Ann Liebert Inc

    Friedemann Weber

  102. Novel Gene Product of Thogoto Virus Segment 6 Codes for an Interferon Antagonist

    Article • Journal of Virology, February 2003, ASM Journals

    Friedemann Weber

  103. Antigenic drift, antigenic shift and interferon antagonists: how bunyaviruses counteract the immune system

    Article • Virus Research, September 2002, Elsevier

    Professor Richard M Elliott, Friedemann Weber

  104. Bunyamwera Bunyavirus Nonstructural Protein NSs Counteracts the Induction of Alpha/Beta Interferon

    Article • Journal of Virology, August 2002, ASM Journals

    Friedemann Weber

  105. The Bunyamwera Virus Nonstructural Protein NSs Inhibits Viral RNA Synthesis in a Minireplicon System

    Article • Virology, March 2001, Elsevier

    Professor Richard M Elliott, Friedemann Weber

  106. Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis

    Article • Proceedings of the National Academy of Sciences, January 2001, Proceedings of the National Academy of Sciences

    Friedemann Weber

  107. Formation of virus-like particles from cloned cDNAs of Thogoto virus

    Article • Journal of General Virology, December 2000, Society for General Microbiology

    Friedemann Weber

  108. Thogoto Virus Matrix Protein Is Encoded by a Spliced mRNA

    Article • Journal of Virology, November 2000, ASM Journals

    Friedemann Weber

  109. MxA GTPase Blocks Reporter Gene Expression of Reconstituted Thogoto Virus Ribonucleoprotein Complexes

    Article • Journal of Virology, January 2000, ASM Journals

    Friedemann Weber

  110. PB2 polymerase subunit of Thogoto virus (Orthomyxoviridae family)

    Article • Archives of Virology, August 1999, Springer Science + Business Media

    Friedemann Weber

  111. The Polypeptides pucD and pucE Stabilize the LHII (B800–850) Light-Harvesting Complex of Rhodobacter Capsulatus 37B4 and Support an Effective Assembly

    Article • January 1999, Springer Science + Business Media

    Friedemann Weber

  112. In vivo reconstitution of active Thogoto virus polymerase: assays for the compatibility with other orthomyxovirus core proteins and template RNAs

    Article • Virus Research, November 1998, Elsevier

    Friedemann Weber

  113. A Classical Bipartite Nuclear Localization Signal on Thogoto and Influenza A Virus Nucleoproteins

    Article • Virology, October 1998, Elsevier

    Friedemann Weber

  114. Mx1 sensitivity: Batken virus is an orthomyxovirus closely related to Dhori virus.

    Article • Journal of General Virology, October 1997, Society for General Microbiology

    Friedemann Weber

  115. The fourth genus in the Orthomyxoviridae: sequence analyses of two Thogoto virus polymerase proteins and comparison with influenza viruses

    Article • Virus Research, August 1997, Elsevier

    Friedemann Weber

  116. Conserved vRNA end sequences of Thogoto-orthomyxovirus suggest a new panhandle structure

    Article • Archives of Virology, May 1997, Springer Science + Business Media

    Friedemann Weber

  117. Pathogenic Viruses: Smart Manipulators of the Interferon System

    Article • Springer Science + Business Media

    Friedemann Weber