What is it about?
The highly pathogenic Ebola virus (EBOV), a member of the family Filoviridae, can enter a diverse range of cell types and only lymphocytes are known to be non-susceptible. This study shows that the cell line SH-SY5Y is resistant to entry of EBOV and other filoviruses and that entry can be restored upon expression of diverse attachment factors.
Why is it important?
This study identifies the first adherent , non-lymphocyte human cell line resistant to filovirus infection. Moreover, it provides the first evidence that the attachment step can limit filovirus entry into target cells.
Read the Original
This page is a summary of: Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors, Viruses, March 2019, MDPI AG, DOI: 10.3390/v11030275.
You can read the full text:
The following have contributed to this page