All Stories

  1. Editing B cells at the IGHA2 gene position provides alternative route to therapeutic IgA production
  2. Synthetic Lethal Combinations of DNA Repair Inhibitors and Genotoxic Agents to Target High‐Risk Diffuse Large B Cell Lymphoma
  3. CD200 immune checkpoint expression is associated with inferior outcome in multiple myeloma patients treated with anti-CD38 monoclonal antibodies
  4. Targeting transcription-replication conflicts using G-quadruplexes stabilizers in multiple myeloma
  5. Inflammatory microenvironment impairs the therapeutic effect of daratumumab-lenalidomide in multiple myeloma
  6. Development of a robust BH3 drug toolkit for precision medicine in hematologic malignancies
  7. Dual targeting of EZH2 and DOT1L in DLBCL
  8. The de novo DNA methyltransferase 3B is a novel epigenetic regulator of MYC in multiple myeloma, representing a promising therapeutic target to counter relapse
  9. Ironomycin induces mantle cell lymphoma cell death by targeting iron metabolism addiction
  10. Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
  11. Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
  12. PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression
  13. Knockdown of Gene Expression Following Activation of the NMD Pathway Using Splice-Switching Oligonucleotides
  14. Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
  15. “Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR) reveals bortezomib resistance mechanisms in Multiple Myeloma”
  16. KDM6A controls immunogenicity in MM
  17. Single-hit genome editing optimized for maturation in B cells redirects their specificity toward tumor antigens
  18. CD38, CD39, and BCL2 differentiate disseminated forms of high‐grade B‐cell lymphomas in biological fluids from Burkitt lymphoma and diffuse large B‐cell lymphoma
  19. BHLHE41, a transcriptional repressor involved in physiological processes and tumor development
  20. A non-catalytic function for Rad18 in sustaining glioblastoma proliferation
  21. A case of refractory IgG4-related disease successfully treated with daratumumab and lenalidomide
  22. FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population
  23. Integrative single-cell chromatin and transcriptome analysis of human plasma cell differentiation
  24. Quantitative Integrative Survival Prediction in Multiple Myeloma Patients Treated With Bortezomib-Based Induction, High-Dose Therapy and Autologous Stem Cell Transplantation
  25. MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling
  26. Single-hit genome editing in B cells to redirect their specificity toward tumor antigens
  27. Transient loss of Polycomb components induces an epigenetic cancer fate
  28. An atlas of cells in the human tonsil
  29. Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma
  30. Immunophenotypic portrait of leukemia‐associated‐phenotype markers in B acute lymphoblastic leukemia
  31. RNA-sequencing based first choice of treatment and determination of risk in multiple myeloma
  32. Extreme thrombocytosis with an aggressive evolution harboring a novel variant of calreticulin (CALR) in exon 3
  33. EZH2 targeting induces CD38 upregulation and response to anti-CD38 immunotherapies in multiple myeloma
  34. S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma
  35. MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling
  36. Var∣Decrypt: a novel and user-friendly tool to explore and prioritize variants in whole-exome sequencing data
  37. 3-O sulfation of syndecan-1 mediated by the sulfotransferase HS3ST3a1 enhances myeloma aggressiveness
  38. Regulation of oncogene-induced senescence by the MRE11 and TREX1 nucleases
  39. Editorial: Transcriptional control in normal and malignant B-lymphocytes
  40. Transient loss of Polycomb components induces an epigenetic cancer fate
  41. LAIR1, an ITIM-Containing Receptor Involved in Immune Disorders and in Hematological Neoplasms
  42. The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance
  43. Targeting the β 2 ‐adrenergic receptor increases chemosensitivity in multiple myeloma by induction of apoptosis and modulating cancer cell metabolism
  44. miRNA profile at diagnosis predicts treatment outcome in patients with B-chronic lymphocytic leukemia: A FILO study
  45. Var|Decrypt: a novel and user-friendly tool to explore and prioritize variants in whole-exome sequencing data
  46. Inhibition of the Protein Arginine Methyltransferase PRMT5 in High-Risk Multiple Myeloma as a Novel Treatment Approach
  47. Single-hit genome edition for expression of single-chain immunoglobulins by edited B cells
  48. PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma
  49. Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma
  50. The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of acute myeloid leukemias
  51. Comprehensive characterization of the epigenetic landscape in Multiple Myeloma
  52. Angiogenic factors could help us to define patients obtaining complete response with undetectable minimal residual disease in untreated CLL patients treated by FCR: results from the CLL2010FMP, a FILO study
  53. The microenvironment of DLBCL is characterized by noncanonical macrophages recruited by tumor-derived CCL5
  54. RNA-Sequencing-Based Transcriptomic Score with Prognostic and Theranostic Values in Multiple Myeloma
  55. Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma
  56. Transcription/Replication Conflicts in Tumorigenesis and Their Potential Role as Novel Therapeutic Targets in Multiple Myeloma
  57. Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types
  58. Discovery of Candidate DNA Methylation Cancer Driver Genes
  59. G9a/GLP targeting in MM promotes autophagy-associated apoptosis and boosts proteasome inhibitor–mediated cell death
  60. RNA-sequencing data-driven dissection of human plasma cell differentiation reveals new potential transcription regulators
  61. Immunotherapy perspectives in the new era of B-cell editing
  62. The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of Acute Myeloid Leukemias
  63. The origin of preplasmablastic cells
  64. Multi-omics tumor profiling technologies to develop precision medicine in multiple myeloma
  65. Multi-omics tumor profiling technologies to develop precision medicine in multiple myeloma
  66. Targeting DNA Repair to Overcome Drug Resistance in Hodgkin Lymphoma
  67. Role of Polycomb Complexes in Normal and Malignant Plasma Cells
  68. DNA Repair Expression Profiling to Identify High-Risk Cytogenetically Normal Acute Myeloid Leukemia and Define New Therapeutic Targets
  69. A Retrospective Comparison of DLI and gDLI for Post-Transplant Treatment
  70. Correction to: Characterization of immortalized human islet stromal cells reveals a MSC-like profile with pancreatic features
  71. Characterization of immortalized human islet stromal cells reveals a MSC-like profile with pancreatic features
  72. Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites
  73. Anticorps anti-CD38 dans le myélome multiple
  74. Maternal embryonic leucine zipper kinase is a novel target for diffuse large B cell lymphoma and mantle cell lymphoma
  75. Prediction of Malingant Plasma Cell Biology Related Survival in AL-Amyloidosis
  76. Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma
  77. Treatment May Be Harmful: Mechanisms/Prediction/Prevention of Drug-Induced DNA Damage and Repair in Multiple Myeloma
  78. Phenotypic Characterization of Diffuse Large B-Cell Lymphoma Cells and Prognostic Impact
  79. Kinome expression profiling to target new therapeutic avenues in multiple myeloma
  80. Prospective target assessment and multimodal prediction of survival for personalized and risk-adapted treatment strategies in multiple myeloma in the GMMG-MM5 multicenter trial
  81. The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation
  82. Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related (ATR) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer
  83. The anaphase-promoting complex/cyclosome: a new promising target in diffuse large B-cell lymphoma and mantle cell lymphoma
  84. Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells
  85. Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner
  86. EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation
  87. Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway
  88. In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
  89. Characterization of the mutational landscape in multiple myeloma cell lines
  90. BrdU incorporation in multiparameter flow cytometry: A new cell cycle assessment approach in multiple myeloma
  91. PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs
  92. Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.
  93. Physiological and druggable skipping of immunoglobulin variable exons in plasma cells
  94. Rôle de EZH2 comme biomarqueur dans le traitement personnalisé du myélome multiple
  95. Tumor-associated neutrophils correlate with poor prognosis in diffuse large B-cell lymphoma patients
  96. GEP-based EpiScore predicts survival in patients with diffuse large B cell lymphoma
  97. DNMTi/HDACi induces reprogramming of myeloma cells in the direction of normal plasma cells
  98. Analysis of Global Gene Expression Profiles
  99. Loss of RASSF4 Promotes RAS-Driven Malignant Progression in MM
  100. CD24, CD27, CD36 and CD302 gene expression predict outcome in patients with multiple myeloma
  101. Automated and simplified identification of normal and abnormal plasma cells in Multiple Myeloma by flow cytometry
  102. Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion
  103. Characterization of human FCRL4-positive B cells
  104. Hypoxia favors the generation of human plasma cells
  105. Global miRNA expression analysis identifies novel key regulators of plasma cell differentiation and malignant plasma cell
  106. RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma
  107. Forced KLF4 expression increases the generation of mature plasma cells and uncovers a network linked with plasma cell stage
  108. Differential effects of lenalidomide during plasma cell differentiation
  109. RECQ helicases are deregulated in hematological malignancies in association with a prognostic value
  110. Identifying high-risk adult AML patients: epigenetic and genetic risk factors and their implications for therapy
  111. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma
  112. Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells
  113. miRNAs in multiple myeloma – a survival relevant complex regulator of gene expression
  114. EZH2 in normal hematopoiesis and hematological malignancies
  115. Factors influencing extramedullary relapse after allogeneic transplantation for multiple myeloma
  116. Drug metabolism and clearance system in tumor cells of patients with multiple myeloma
  117. In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma
  118. Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia
  119. SNaPshot as a Valuable Option for the Identification of Mutations in Myeloma
  120. The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells
  121. DNA repair in diffuse large B-cell lymphoma: a molecular portrait
  122. Identification and characterization of new Leishmania promastigote surface antigens, LaPSA-38S and LiPSA-50S, as major immunodominant excreted/secreted components of L. amazonensis and L. infantum
  123. A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy
  124. Identification of a 20-Gene Expression-Based Risk Score as a Predictor of Clinical Outcome in Chronic Lymphocytic Leukemia Patients
  125. The Glycome of Normal and Malignant Plasma Cells
  126. DNA methylation score is predictive of myeloma cell sensitivity to 5-azacitidine
  127. DNA repair pathways in human multiple myeloma
  128. Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors
  129. Nucleotide excision DNA repair pathway as a therapeutic target in patients with high-risk diffuse large B cell lymphoma
  130. Inhibition of DEPDC1A, a Bad Prognostic Marker in Multiple Myeloma, Delays Growth and Induces Mature Plasma Cell Markers in Malignant Plasma Cells
  131. Kruppel-like factor 4 blocks tumor cell proliferation and promotes drug resistance in multiple myeloma
  132. STEAP1 is overexpressed in cancers: A promising therapeutic target
  133. Gene expression-based risk score in diffuse large B-cell lymphoma
  134. Residual malignant and normal plasma cells shortly after high dose melphalan and stem cell transplantation. Highlight of a putative therapeutic window in Multiple Myeloma?
  135. Growth Factors in Multiple Myeloma
  136. Development of Gene Expression-Based Score to Predict Sensitivity of Multiple Myeloma Cells to DNA Methylation Inhibitors
  137. Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients
  138. Identification of Pluripotent and Adult Stem Cell Genes Unrelated to Cell Cycle and Associated with Poor Prognosis in Multiple Myeloma
  139. Clinical and prognostic role of annexin A2 in multiple myeloma
  140. Critical role of the NOTCH ligand JAG2 in self-renewal of myeloma cells
  141. New prognostic markers, determined using gene expression analyses, reveal two distinct subtypes of chronic myelomonocytic leukaemia patients
  142. Efficient transduction of healthy and malignant plasma cells by lentiviral vectors pseudotyped with measles virus glycoproteins
  143. Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma
  144. SULFs in human neoplasia: implication as progression and prognosis factors
  145. The role of fluorescence in situ hybridization and gene expression profiling in myeloma risk stratification
  146. A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines
  147. MYEOV is a prognostic factor in multiple myeloma
  148. Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration
  149. Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma
  150. Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays
  151. Abstract 124: Involvement of the notch pathway in the clonogenicity of human multiple myeloma cell lines
  152. NPM1 is overexpressed in hyperdiploid multiple myeloma due to a gain of chromosome 5 but is not delocalized to the cytoplasm
  153. Atacicept in relapsed/refractory multiple myeloma or active Waldenström's macroglobulinemia: a phase I study
  154. Bone morphogenic protein 6: a member of a novel class of prognostic factors expressed by normal and malignant plasma cells inhibiting proliferation and angiogenesis
  155. APRIL and TACI interact with syndecan-1 on the surface of multiple myeloma cells to form an essential survival loop
  156. Embryonic stem cell markers expression in cancers
  157. Induction of angiogenesis by normal and malignant plasma cells
  158. APRIL is overexpressed in cancer: link with tumor progression
  159. The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor
  160. MMSET is overexpressed in cancers: Link with tumor aggressiveness
  161. Cytokine Pathways in Myeloma Growth and Survival
  162. Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma
  163. CD200: A putative therapeutic target in cancer
  164. Input of DNA Microarrays to Identify Novel Mechanisms in Multiple Myeloma Biology and Therapeutic Applications
  165. Targeting NF-κB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth
  166. TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines
  167. CD200 is a new prognostic factor in multiple myeloma
  168. P20. TACI-signalling in multiple myeloma – From the identification as potential therapeutic target by gene expression analysis and functional testing to clinical trials
  169. P43. ErbB-signalling in multiple myeloma – From the identification as potential therapeutic target by gene expression analysis and functional testing to clinical trials
  170. P21. A molecular classification of multiple myeloma (MM) based on gene expression profiling and fluorescence in situ hybridisation as independent prognostic factor for event free survival (EFS)
  171. Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma
  172. Microarray-based understanding of normal and malignant plasma cells
  173. Lymphocytes of dogs immunised with purified excreted-secreted antigens of Leishmania infantum co-incubated with Leishmania infected macrophages produce IFN gamma resulting in nitric oxide-mediated amastigote apoptosis
  174. The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature
  175. Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells
  176. BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
  177. Survival and Proliferation Factors of Normal and Malignant Plasma Cells