Professor Willem H. Koppenol
Swiss Federal Insitute of Technology (ETH)
Emeritus, Chemistry
Switzerland
My co-authors include
Paolo Di Mascio
Prof. Frank Jensen
Professor Cornelia Gabriala Palivan
Find me at
My Publications
Superoxide does not react with hydrogen peroxide in water.
Nature Communications
January 2022
The reaction of hydrogen peroxide with iron(II)
Dalton Transactions
January 2022
Fe(I) is not involved in the Fenton reaction
Physical Chemistry Chemical Physics
January 2021
The yield of radicals from the reaction of ONOO- with CO2 decreases at higher CO2 conce...
Chemical Research in Toxicology
May 2020
Superoxide does not react with hydrogen peroxide.
Free Radical Biology and Medicine
December 2019
A guide to reactions of iron
Free Radical Biology and Medicine
March 2019
The iron bolt is an award given during the Gordon Oxyradical Conference.
Free Radical Biology and Medicine
August 2018
Peroxynitrite forms very rapidly an adduct with CO2, which decays by reacting with a 2n...
Chemical Research in Toxicology
July 2018
Discovery and importance of hydrogen peroxide
Nature
July 2018
Rapid reduction of the oxyform of cytochrome P450 by a hydrated electron
Journal of Biological Chemistry
November 2017
Autoxidation of NO
Inorganic Chemistry
April 2017
Introduction for the special issue on the chemistry of redox signaling
Archives of Biochemistry and Biophysics
March 2017
Limits on the reactions of sulfur-containing biomolecules
Archives of Biochemistry and Biophysics
March 2017
Element names
January 2017
Electrode Potentials ofl-Tryptophan,l-Tyrosine, 3-Nitro-l-tyrosine, 2,3-Difluoro-l-tyro...
Biochemistry
May 2016
The title says it all.
Pure and Applied Chemistry
April 2016
History of hydrogen peroxide
Archives of Biochemistry and Biophysics
April 2016
Primary photochemistry of peroxynitrite in aqueous solution
Chemical Physics Letters
November 2015
Superoxide-mediated post-translational modification of tyrosine residues
Free Radical Biology and Medicine
September 2015
Corrigendum to “Rapid reaction of superoxide with insulin-tyrosyl radicals to generate ...
Free Radical Biology and Medicine
May 2015
Redox Properties and Activity of Iron–Citrate Complexes: Evidence for Redox Cycling
Chemical Research in Toxicology
April 2015
Protein thiyl radical reactions and product formation: a kinetic simulation
Free Radical Biology and Medicine
March 2015
Concurrent Cooperativity and Substrate Inhibition in the Epoxidation of Carbamazepine b...
Biochemistry
January 2015
Standard electrode potentials involving radicals in aqueous solution: inorganic radical...
Pure and Applied Chemistry
January 2015
CHAPTER 1. Peroxynitrite: The Basics
January 2015
Iron(II) binding by cereal beta-glucan
Carbohydrate Polymers
January 2015
ONOOH does not react with H2: Potential beneficial effects of H2 as an antioxidant by s...
Free Radical Biology and Medicine
October 2014
Why Selenocysteine Replaces Cysteine in Thioredoxin Reductase: A Radical Hypothesis
Biochemistry
August 2014
Rapid reaction of superoxide with insulin-tyrosyl radicals to generate a hydroperoxide ...
Free Radical Biology and Medicine
May 2014
The kinetics of the reaction of nitrogen dioxide with iron(II)- and iron(III) cytochrome c
Free Radical Biology and Medicine
April 2014
Intramolecular 1,2- and 1,3-Hydrogen Transfer Reactions of Thiyl Radicals
Israel Journal of Chemistry
March 2014
Repair of Protein Radicals by Antioxidants
Israel Journal of Chemistry
March 2014
The complex interplay of iron metabolism, reactive oxygen species, and reactive nitroge...
Free Radical Biology and Medicine
December 2013
Cytochrome c and superoxide
JBIC Journal of Biological Inorganic Chemistry
July 2013
Reactions of the tetraoxidosulfate(˙−) and hydroxyl radicals with poly(sodium α-methyls...
Physical Chemistry Chemical Physics
January 2013
Decomposition kinetics of peroxynitrite: influence of pH and buffer
Dalton Transactions
January 2013
Standard electrode potentials involving radicals in aqueous solution: inorganic radicals
BioInorganic Reaction Mechanisms
January 2013
Efficient depletion of ascorbate by amino acid and protein radicals under oxidative stress
Free Radical Biology and Medicine
October 2012
Chemical Characterization of the Smallest <i>S</i>-Nitrosothiol, HSNO; Cellular Cross-t...
Journal of the American Chemical Society
July 2012
Hydrogen Exchange Equilibria in Thiols
Chemical Research in Toxicology
July 2012
Nitrosation, Thiols, and Hemoglobin: Energetics and Kinetics
Inorganic Chemistry
May 2012
Fast repair of protein radicals by urate
Free Radical Biology and Medicine
May 2012
Reversible Hydrogen Transfer Reactions in Thiyl Radicals From Cysteine and Related Mole...
The Journal of Physical Chemistry B
May 2012
Peroxynitrous acid: controversy and consensus surrounding an enigmatic oxidant
Dalton Transactions
January 2012
Kinetic Simulation of the Chemical Stabilization Mechanism in Fuel Cell Membranes Using...
Journal of The Electrochemical Society
January 2012
Erratum: Otto Warburg's contributions to current concepts of cancer metabolism
Nature Reviews Cancer
July 2011
Otto Warburg's contributions to current concepts of cancer metabolism
Nature Reviews Cancer
April 2011
Why do fuel cell membranes break down?
Physical Chemistry Chemical Physics
January 2011
Water increases rates of epoxidation by Mn(iii)porphyrins/imidazole/IO4− in CH2Cl2. Ana...
Dalton Transactions
January 2011
Radicals in Fuel Cell Membranes: Mechanisms of Formation and Ionomer Attack
January 2011
Radical (HO●, H● and HOO●) Formation and Ionomer Degradation in Polymer Electrolyte Fue...
Journal of The Electrochemical Society
January 2011
Distance-Dependent Diffusion-Controlled Reaction of <sup>•</sup>NO and O<sub>2</sub><su...
The Journal of Physical Chemistry B
November 2010
Hydrogen Exchange Equilibria in Glutathione Radicals: Rate Constants
Chemical Research in Toxicology
September 2010
Selenium and Sulfur in Exchange Reactions: A Comparative Study
The Journal of Organic Chemistry
August 2010
Electrode potentials of partially reduced oxygen species, from dioxygen to water
Free Radical Biology and Medicine
August 2010
Reduction of protein radicals by GSH and ascorbate: potential biological significance
Amino Acids
June 2010
Why do proteins use selenocysteine instead of cysteine?
Amino Acids
May 2010
Damage to fuel cell membranes. Reaction of HO˙ with an oligomer of poly(sodium styrene ...
Physical Chemistry Chemical Physics
January 2010
Photon-Initiated Homolysis of Peroxynitrous Acid
Inorganic Chemistry
June 2009
Intermediates in the Autoxidation of Nitrogen Monoxide
Chemistry - A European Journal
June 2009
Efficient repair of protein radicals by ascorbate
Free Radical Biology and Medicine
April 2009
Peroxynitrate is formed rapidly during decomposition of peroxynitrite at neutral pH
Dalton Transactions
January 2009
Preparation and Properties of Lithium and Sodium Peroxynitrite
Chemical Research in Toxicology
November 2008
Reversible Intramolecular Hydrogen Transfer between Cysteine Thiyl Radicals and Glycine...
The Journal of Physical Chemistry B
October 2008
Kinetics of Tyrosyl Radical Reduction by Selenocysteine
Biochemistry
August 2008
Antioxidant Nanoreactor Based on Superoxide Dismutase Encapsulated in Superoxide-Permea...
The Journal of Physical Chemistry B
June 2008
Homolysis of the Peroxynitrite Anion Detected with Permanganate
Inorganic Chemistry
November 2007
Two Pathways of Carbon Dioxide Catalyzed Oxidative Coupling of Phenol by Peroxynitrite
Chemical Research in Toxicology
October 2007
The glutathione thiyl radical does not react with nitrogen monoxide
Biochemical and Biophysical Research Communications
August 2007
Oxygen Activation by Cytochrome P450: A Thermodynamic Analysis
Journal of the American Chemical Society
July 2007
Oxidation-state-dependent reactions of cytochrome c with the trioxidocarbonate(•1−) rad...
JBIC Journal of Biological Inorganic Chemistry
September 2006
Fenton Chemistry and Iron Chelation under Physiologically Relevant Conditions: Electro...
Chemical Research in Toxicology
September 2006
Catalysis of Electron Transfer by Selenocysteine
Biochemistry
April 2006
Two Pathways of Carbon Dioxide Catalyzed Oxidative Coupling of Phenol by Peroxynitrite
Chemical Research in Toxicology
February 2006
Dissociation of CP20 from Iron( <scp>II</scp> )(cp20) ...
European Journal of Inorganic Chemistry
January 2006
The kinetics of oxidation of GSH by protein radicals
Biochemical Journal
December 2005
Redox cycling of iron complexes of N-(dithiocarboxy)sarcosine and N-methyl-d-glucamine ...
Free Radical Biology and Medicine
December 2005
Corrigendum to “Kinetics properties of Cu,Zn-superoxide dismutase as a function of meta...
Archives of Biochemistry and Biophysics
December 2005
Peroxynitrite efficiently mediates the interconversion of redox intermediates of myelop...
Biochemical and Biophysical Research Communications
November 2005
Inhibition of the Fenton reaction by nitrogen monoxide
JBIC Journal of Biological Inorganic Chemistry
October 2005
Kinetics properties of Cu,Zn-superoxide dismutase as a function of metal content
Archives of Biochemistry and Biophysics
July 2005
Chemiluminescence of Pholasin caused by peroxynitrite
Free Radical Biology and Medicine
April 2005
Peroxynitritometal complexes
Coordination Chemistry Reviews
February 2005
On the Chemical and Electrochemical One-Electron Reduction of Peroxynitrous Acid
The Journal of Physical Chemistry A
January 2005
The history of naming elements.
Helvetica Chimica Acta
January 2005
Qualitative and Quantitative Determination of Nitrite and Nitrate with Ion Chromatography
January 2005
Intramolecular addition of cysteine thiyl radicals to phenylalanine in peptides: format...
Chemical Communications
January 2005
Calmodulin methionine residues are targets for one-electron oxidation by hydroxyl radic...
Chemical Communications
January 2005
Redox Properties of the Iron Complexes of Orally Active Iron ChelatorsCP20, CP502, CP50...
Helvetica Chimica Acta
December 2004
Preventing Nitrite Contamination in Tetramethylammonium Peroxynitrite Solutions
Inorganic Chemistry
September 2004
UV Photolysis of 3-Nitrotyrosine Generates Highly Oxidizing Species: A Potential Sourc...
Chemical Research in Toxicology
August 2004
Human peroxiredoxin 5 is a peroxynitrite reductase
FEBS Letters
July 2004
Kinetics Evidence for a Complex between Peroxynitrous Acid and Titanium(IV)
Inorganic Chemistry
July 2004
The mechanisms of S-nitrosothiol decomposition catalyzed by iron
Nitric Oxide
March 2004
Mechanistic insight into the peroxidase catalyzed nitration of tyrosine derivatives by ...
European Journal of Biochemistry
February 2004
Peroxynitrous Acid - Where is the Hydroxyl Radical?
IUBMB Life
January 2004
Rapid scavenging of peroxynitrous acid by monohydroascorbate
Free Radical Biology and Medicine
December 2003
Evaluation of Activation Volumes for the Conversion of Peroxynitrous to Nitric Acid
The Journal of Physical Chemistry A
November 2003
Peroxynitrite-mediated oxidation of dichlorodihydrofluorescein and dihydrorhodamine
Free Radical Biology and Medicine
September 2003
Oxidation of Nitrite by Peroxynitrous Acid
The Journal of Physical Chemistry A
February 2003
Erratum to “NO Nomenclature?” [Nitric Oxide 6 (2002), 96–98]
Nitric Oxide
November 2002
The Rate Constant of the Reaction of Superoxide with Nitrogen Monoxide: Approaching th...
The Journal of Physical Chemistry A
March 2002
The Haber-Weiss cycle—71 years later
Redox Report
February 2002
NO Nomenclature?
Nitric Oxide
February 2002
Studies of metal-binding properties of Cu,Zn superoxide dismutase by isothermal titrati...
January 2002
Naming of new elements(IUPAC Recommendations 2002)
Pure and Applied Chemistry
January 2002
Product Distribution of Peroxynitrite Decay as a Function of pH, Temperature, and Conce...
Journal of the American Chemical Society
December 2001
100 Years of peroxynitrite chemistry and 11 years of peroxynitrite biochemistry
Redox Report
December 2001
Hydrolysis and Photolysis of Tris(tetraethylammonium) Pentacyanoperoxynitritocobaltate(...
Helvetica Chimica Acta
October 2001
Oxidation of NADH by Chloramines and Chloramides and Its Activation by Iodide and by Te...
Archives of Biochemistry and Biophysics
September 2001
The Haber-Weiss cycle – 70 years later
Redox Report
August 2001
Reaction of peroxynitrite with carbon dioxide: intermediates and determination of the y...
JBIC Journal of Biological Inorganic Chemistry
July 2001
On the Oxidation of Cytochrome c by Hypohalous Acids
Archives of Biochemistry and Biophysics
May 2001
Gibbs Energy of Formation of Peroxynitrite
Chemical Research in Toxicology
March 2001
Names for muonium and hydrogen atoms and their ions(IUPAC Recommendations 2001)
Pure and Applied Chemistry
January 2001
Reactions of Peroxynitrite with Phenolic and Carbonyl Compounds: Flavonoids are not Sca...
Helvetica Chimica Acta
September 2000
Peroxynitrite does not decompose to singlet oxygen ( <sup>1</sup> ...
Proceedings of the National Academy of Sciences
September 2000
On the Irreversible Destruction of Reduced Nicotinamide Nucleotides by Hypohalous Acids
Archives of Biochemistry and Biophysics
August 2000
The Preparation of Apo-Cu,Zn Superoxide Dismutase by Ion-Exchange Chromatography on Imi...
Protein Expression and Purification
June 2000
The Quantitative Oxidation of Methionine to Methionine Sulfoxide by Peroxynitrite
Archives of Biochemistry and Biophysics
May 2000
Mechanism of Reaction of Myeloperoxidase with Nitrite
Journal of Biological Chemistry
April 2000
Synthesis and Characterization of Tris(tetraethylammonium) Pentacyanoperoxynitritocobal...
Helvetica Chimica Acta
April 2000
Names for inorganic radicals (IUPAC Recommendations 2000)
Pure and Applied Chemistry
January 2000
Helvetica Chimica Acta
May 1999
Conformation of Peroxynitrite: Determination by Crystallographic Analysis
Chemical Research in Toxicology
March 1999
Correspondence
Free Radical Biology and Medicine
March 1999
[36] Peroxynitrite studied by stopped-flow spectroscopy
January 1999
Kinetic Study of the Reaction of Glutathione Peroxidase with Peroxynitrite
Chemical Research in Toxicology
December 1998
Peroxynitrite Uncloaked? Volume 11, Number 7, July 1998, pp 716−717
Chemical Research in Toxicology
November 1998
The basic chemistry of nitrogen monoxide and peroxynitrite
Free Radical Biology and Medicine
September 1998
Peroxynitrite Uncloaked?
Chemical Research in Toxicology
July 1998
The chemistry of peroxynitrite, a biological toxin<a name=TOP1></a>
Química Nova
June 1998
Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pr...
Chemical Research in Toxicology
April 1998
The Reaction of Peroxynitrite with Zeaxanthin
Nitric Oxide
February 1998
Can ONOOH Undergo Homolysis?
Chemical Research in Toxicology
February 1998
Hydrogen Isotope Effect on the Isomerization of Peroxynitrous Acid
Helvetica Chimica Acta
January 1998
Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pr...
Chemical Research in Toxicology
November 1997
Kinetic study of the reaction of ebselen with peroxynitrite
FEBS Letters
December 1996
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
AJP Cell Physiology
November 1996
Reaction of peroxynitrite with L-tryptophan
Redox Report
June 1996
The enthalpy of isomerization of peroxynitrite to nitrate
Thermochimica Acta
February 1996
[27] Syntheses of peroxynitrite: To go with the flow or on solid grounds?
January 1996
Nitration and Hydroxylation of Phenolic Compounds by Peroxynitrite
Chemical Research in Toxicology
January 1996
<i>Ab Initio</i> and NMR Study of Peroxynitrite and Peroxynitrous Acid: Important Biol...
The Journal of Physical Chemistry
January 1996
Thermodynamics of reactions involving nitrogen-oxygen compounds
January 1996
Say NO to nitric oxide: Nomenclature for nitrogen- and oxygen-containing compounds
January 1996
[18] Nitration and hydroxylation of phenolic compounds by peroxynitrite
January 1996
A Novel Hexanuclear FeIII-cis-Inositolato Complex as a Model for FeIII–Polyol Interacti...
Angewandte Chemie International Edition in English
November 1995
Ein neuartiger sechskerniger FeIII-cis-Inositolato-Komplex als Modell für FeIII-Polyol-...
Angewandte Chemie
October 1995
A practical method for preparing peroxynitrite solutions of low ionic strength and free...
Free Radical Biology and Medicine
January 1995
The kinetics of the oxidation of l-ascorbic acid by peroxynitrite
Free Radical Biology and Medicine
January 1995
Thermodynamic considerations on the formation of reactive species from hypochlorite, su...
FEBS Letters
June 1994
On the pH-dependent yield of hydroxyl radical products from peroxynitrite
Free Radical Biology and Medicine
March 1994
The hazard of hydroxyl radicals, a reply
Free Radical Biology and Medicine
February 1994
NO comments
Nature
January 1994
Chemistry of iron and copper in radical reactions
January 1994
The centennial of the Fenton reaction
Free Radical Biology and Medicine
December 1993
The nitration and hydroxylation of phenol and salicylic acid by peroxynitrite
Free Radical Biology and Medicine
November 1993
ALS, SOD and peroxynitrite
Nature
August 1993
Ferredoxin binding site on ferredoxin: NADP+ reductase. Differential chemical modificat...
European Journal of Biochemistry
August 1993
Binding of ferredoxin to ferredoxin: NADP<sup>+</sup>oxidoreductase: The role of carbox...
Protein Science
July 1993
Ab initio calculations on ONOOH and ONOO?
International Journal of Quantum Chemistry
March 1993
A thermodynamic appraisal of the radical sink hypothesis
Free Radical Biology and Medicine
January 1993
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
Chemical Research in Toxicology
November 1992
The quality of nutrition letters in free radical biology & medicine: A reply
Free Radical Biology and Medicine
October 1992
A small point
Free Radical Biology and Medicine
August 1992
The hydroxylation of tryptophan
Archives of Biochemistry and Biophysics
August 1992
The hydroxylation of phenylalanine and tyrosine: A comparison with salicylate and trypt...
Archives of Biochemistry and Biophysics
August 1992
Spirohydantoin inhibitors of aldose reductase inhibit iron- and copper-catalysed ascorb...
Biochemical Pharmacology
August 1991
The superoxide dismutase activities of two higher-valent manganese complexes, MnIV desf...
Archives of Biochemistry and Biophysics
August 1991
Reactions of Fe(II)-ATP and Fe(II)-citrate complexes with <i>t</i> -butyl hydroperoxide...
FEBS Letters
March 1991
TRANSITION METALS IN OXIDATIVE STRESS: AN OVERVIEW
January 1991
CATALYSIS OF OXYRADICAL REACTIONS BY IRON COMPLEXES
January 1991
Oxyradicals and multivitamin tablets
Free Radical Biology and Medicine
January 1991
Thermodynamic considerations on the generation of hydroxyl radicals from nitrous oxide—...
Free Radical Biology and Medicine
January 1991
Reactions of Fe(II)-ATP and Fe(II)-citrate complexes with <i>t</i> -butyl hydroperoxide...
FEBS Letters
November 1990
Oxyradical reactions: from bond-dissociation energies to reduction potentials
FEBS Letters
May 1990
Reactions of iron(II) nucleotide complexes with hydrogen peroxide
FEBS Letters
February 1990
What is in a name? Rules for radicals
Free Radical Biology and Medicine
January 1990
Catalysis of oxyradical reactions by iron
Free Radical Biology and Medicine
January 1990
[12] Distinction between hydroxyl radical and ferryl species
January 1990
The hydroxylation of the salicylate anion by a fenton reaction and Γ-radiolysis: A cons...
Free Radical Biology and Medicine
January 1990
Electron affinity of chlorine dioxide
The Journal of Physical Chemistry
December 1989
Hormesis
Science
October 1989
Electrostatic interactions of 4-carboxy-2,6-dinitrophenyllysine-modified cytochromes c ...
Biochimica et Biophysica Acta (BBA) - Bioenergetics
November 1988
The electron-transfer site of spinach plastocyanin
Biochemistry
August 1988
Reactions of iron(II) nitrilotriacetate and iron(II) ethylenediamine-N,N'-diacetate com...
Journal of the American Chemical Society
July 1988
Thermodynamics of reactions involving oxyradicals and hydrogen peroxide
Bioelectrochemistry and Bioenergetics
December 1987
Reduction potential of the carbon dioxide/carbon dioxide radical anion: a comparison wi...
The Journal of Physical Chemistry
July 1987
Effect of a dipole moment on the ionic strength dependence of electron-transfer reactio...
Journal of the American Chemical Society
April 1987
The reaction between ferrous polyaminocarboxylate complexes and hydrogen peroxide: An i...
Journal of Inorganic Biochemistry
March 1987
Effects of γ-irradiation on Isolated Rat Liver Mitochondria
International Journal of Radiation Biology and Related Studies in Physics Chemistry and...
January 1987
In vitro damage to rat lens by xanthine-xanthine oxidase: Protection by ascorbate
Experimental Eye Research
December 1986
Catalysis of superoxide dismutation by manganese aminopolycarboxylate complexes
Archives of Biochemistry and Biophysics
December 1986
Energetics of interconversion reactions of oxyradicals
Advances in Free Radical Biology & Medicine
January 1985
The reaction of ferrous EDTA with hydrogen peroxide: Evidence against hydroxyl radical ...
Journal of Free Radicals in Biology & Medicine
January 1985
The Radiation Chemistry of Cytochrome<i>c</i>
Israel Journal of Chemistry
January 1984
The oxidizing nature of the hydroxyl radical. A comparison with the ferryl ion (FeO2+)
The Journal of Physical Chemistry
January 1984
Is cytochrome c reactivity determined by dipole moment or by local charges?
Biophysical Chemistry
October 1983
CHEMIOSMOTIC ATPase MECHANISMS
Annals of the New York Academy of Sciences
December 1982
The reduction potential of the couple O<sub>3</sub> /O<sup>·−</sup> ...
FEBS Letters
April 1982
The Relation between the Dipole Moment of Cytochrome c and the Activity with Cytochrome...
January 1982
Basic issues in binding
Trends in Biochemical Sciences
January 1981
Use of singly modified cytochrome c derivatives to determine the site for electron tran...
Journal of the American Chemical Society
January 1981
Effect of a molecular dipole on the ionic strength dependence of a biomolecular rate co...
Biophysical Journal
March 1980
THE HABER-WEISS CYCLE
Photochemistry and Photobiology
October 1978
The electric potential field around cytochrome c and the effect of ionic strength on re...
Biochimica et Biophysica Acta (BBA) - Bioenergetics
September 1978
A tunnelling model to explain the reduction of ferricytochrome c by H and OH radicals
Biochimica et Biophysica Acta (BBA) - Bioenergetics
July 1978
EFFECTS OF ANIONS ON THE REACTION BETWEEN CYTOCHROME c AND CYTOCHROME c OXIDASE
January 1978
Mechanism of reactions involving singlet oxygen and the superoxide anion
FEBS Letters
November 1977
Mechanism of the reaction of hydrated electrons with ferrocytochrome c
Biochimica et Biophysica Acta (BBA) - Bioenergetics
February 1977
Erratum
Nature
November 1976
The kinetics of the reduction of cytochrome c by the superoxide anion radical
Biochimica et Biophysica Acta (BBA) - Bioenergetics
November 1976
Reactions involving singlet oxygen and the superoxide anion
Nature
July 1976
