All Stories

  1. Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

    Article • ACS Chemical Biology, May 2018, American Chemical Society (ACS)

    Professor Rodolfo Ippoliti, Elias Arner

  2. PPARs in Neurodegenerative and Neuroinflammatory Pathways

    Article • Current Alzheimer Research, February 2018, Bentham Science Publishers

    Professor Rodolfo Ippoliti

  3. Biocompatibility of composites based on chitosan, apatite, and graphene oxide for tissue applications

    Article • Journal of Biomedical Materials Research Part A, February 2018, Wiley

    Professor Rodolfo Ippoliti, Annamaria Cimini

  4. Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins

    Article • Toxins, February 2018, MDPI AG

    Professor Rodolfo Ippoliti

  5. N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy

    Article • Cancer Letters, January 2018, Elsevier

    Professor Rodolfo Ippoliti

  6. Targeted therapy of human glioblastoma via delivery of a toxin through a peptide directed to cell surface nucleolin

    Article • Journal of Cellular Physiology, December 2017, Wiley

    Jose Courty, Professor Mariarosa AB Melone, Professor Rodolfo Ippoliti, Annamaria Cimini

  7. EV20-Sap, a novel anti-HER-3 antibody-drug conjugate, displays promising antitumor activity in melanoma

    Article • Oncotarget, September 2017, Impact Journals, LLC

    Professor Rodolfo Ippoliti

  8. Energy metabolism in glioblastoma stem cells: PPARα a metabolic adaptor to intratumoral microenvironment

    Article • Oncotarget, July 2017, Impact Journals, LLC

    Professor Rodolfo Ippoliti

  9. PPARα Antagonist AA452 Triggers Metabolic Reprogramming and Increases Sensitivity to Radiation Therapy in Human Glioblastoma Primary Cells

    Article • Journal of Cellular Physiology, November 2016, Wiley

    Professor Rodolfo Ippoliti, Annamaria Cimini

  10. Roles of PPAR transcription factors in the energetic metabolic switch occurring during adult neurogenesis

    Article • Cell Cycle, November 2016, Taylor & Francis

    Professor Rodolfo Ippoliti, Professor Sandra Moreno

  11. Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera

    Article • Microbial Cell Factories, November 2016, Springer Science + Business Media

    Professor Rodolfo Ippoliti

  12. Uric Acid Amplifies Aβ Amyloid Effects Involved in the Cognitive Dysfunction/Dementia: Evidences From an Experimental Model In Vitro

    Article • Journal of Cellular Physiology, August 2016, Wiley

    Annamaria Cimini, Professor Rodolfo Ippoliti

  13. Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs

    Article • Journal of Cellular Physiology, June 2016, Wiley

    Professor Rodolfo Ippoliti

  14. A peroxiredoxin-based proteinaceous scaffold for the growth and differentiation of neuronal cells and tumour stem cells in the absence of prodifferentiation agents

    Article • Journal of Tissue Engineering and Regenerative Medicine, February 2016, Wiley

    Professor Rodolfo Ippoliti, Annamaria Cimini

  15. Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance

    Article • Stem Cells International, January 2016, Hindawi Publishing Corporation

    Professor Rodolfo Ippoliti

  16. Supramolecular self-assembly of graphene oxide and metal nanoparticles into stacked multilayers by means of a multitasking protein ring

    Article • Nanoscale, January 2016, Royal Society of Chemistry

    Professor Rodolfo Ippoliti

  17. The PPARβ/δ Agonist GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons: Role of PPARβ/δ in Neuronal Maturation

    Article • Journal of Cellular Physiology, November 2015, Wiley

    Annamaria Cimini, Professor Rodolfo Ippoliti

  18. Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model

    Article • Oncotarget, November 2015, Impact Journals, LLC

    Professor Rodolfo Ippoliti

  19. One ring (or two) to hold them all - on the structure and function of protein nanotubes

    Article • FEBS Journal, June 2015, Wiley

    Professor Andrea Bellelli, Professor Rodolfo Ippoliti

  20. PDZ Domain in the Engineering and Production of a Saporin Chimeric Toxin as a Tool for targeting Cancer Cells

    Article • Journal of Cellular Biochemistry, May 2015, Wiley

    Professor Rodolfo Ippoliti

  21. PPARβ/δ and γ in a Rat Model of Parkinson's Disease: Possible Involvement in PD Symptoms

    Article • Journal of Cellular Biochemistry, March 2015, Wiley

    Annamaria Cimini, Professor Rodolfo Ippoliti

  22. Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems

    Article • Microbial Cell Factories, January 2015, Springer Science + Business Media

    Professor Rodolfo Ippoliti

  23. A Long Journey to the Cytosol

    Article • April 2014, Wiley

    Professor Rodolfo Ippoliti

  24. Involvement of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in BDNF signaling during aging and in Alzheimer disease: Possible role of 4-hydroxynonenal (4-HNE)

    Article • Cell Cycle, March 2014, Taylor & Francis

    Professor Rodolfo Ippoliti, Professor Sandra Moreno

  25. Self-assembled protein nanotubes

    Article • Nanoscale, January 2014, Royal Society of Chemistry

    Professor Rodolfo Ippoliti

  26. Switching between the Alternative Structures and Functions of a 2-Cys Peroxiredoxin, by Site-Directed Mutagenesis

    Article • Journal of Molecular Biology, November 2013, Elsevier

    Professor Andrea Bellelli, Professor Rodolfo Ippoliti

  27. Engineering and production of saporin chimeric toxins against human glioblastoma

    Article • Current Opinion in Biotechnology, July 2013, Elsevier

    Professor Rodolfo Ippoliti

  28. Neuroprotective effects of PrxI over-expression in an in vitro human Alzheimer's disease model

    Article • Journal of Cellular Biochemistry, January 2013, Wiley

    Professor Rodolfo Ippoliti

  29. Dissecting the Entry Route of Saporin-based a-CD7 Immunotoxins in Human T-Cell Acute Lymphoblastic Leukaemia Cells

    Article • Antibodies, January 2013, MDPI AG

    Professor Rodolfo Ippoliti

  30. Current Status and Biomedical Applications of Ribosome-Inactivating Proteins

    Article • January 2013, Springer Science + Business Media

    Professor Rodolfo Ippoliti

  31. Hypoxia modulation of peroxisome proliferator‐activated receptors (PPARs) in human glioblastoma stem cells. Implications for therapy

    Article • Journal of Cellular Biochemistry, September 2012, Wiley

    Professor Rodolfo Ippoliti, Annamaria Cimini

  32. Physiological roles of ovotransferrin

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, March 2012, Elsevier

    Professor Rodolfo Ippoliti

  33. Distinct cellular responses induced by saporin and a transferrin-saporin conjugate in two different human glioblastoma cell lines

    Article • Journal of Cellular Physiology, December 2011, Wiley

    Professor Rodolfo Ippoliti

  34. Innovative Therapies against Human Glioblastoma Multiforme

    Article • ISRN Oncology, July 2011, Hindawi Publishing Corporation

    Professor Rodolfo Ippoliti

  35. Towards a Stem Architecture Description Language for Self-Adaptive Systems

    Article • September 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Rodolfo Ippoliti

  36. Ricin and Saporin: Plant Enzymes for the Research and the Clinics

    Article • Current Chemical Biology, May 2010, Bentham Science Publishers

    Professor Rodolfo Ippoliti

  37. Ricin and Saporin: Plant Enzymes for the Research and the Clinics

    Article • Current Chemical Biology, May 2010, Bentham Science Publishers

    Professor Rodolfo Ippoliti

  38. The role of the glycan moiety on the structure–function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves

    Article • Molecular BioSystems, January 2010, Royal Society of Chemistry

    Professor Rodolfo Ippoliti, Professor Antimo Di Maro, Rita Berisio

  39. Learning from the Cell Life-Cycle: A Self-adaptive Paradigm

    Article • January 2010, Springer Science + Business Media

    Professor Rodolfo Ippoliti

  40. Engineering a switchable toxin: the potential use of PDZ domains in the expression, targeting and activation of modified saporin variants

    Article • Protein Engineering Design and Selection, November 2009, Oxford University Press (OUP)

    Professor Rodolfo Ippoliti

  41. Pichia pastoris as a host for secretion of toxic saporin chimeras

    Article • The FASEB Journal, September 2009, Federation of American Societies For Experimental Biology (FASEB)

    Professor Rodolfo Ippoliti

  42. Molecular characterization of nitrite reductase gene (aniA) and gene product inNeisseria meningitidisisolates: IsaniA essential for meningococcal survival?

    Article • IUBMB Life, September 2008, Wiley

    Professor Rodolfo Ippoliti

  43. Multiple strategies for O2 transport: from simplicity to complexity

    Article • IUBMB Life, January 2007, Wiley

    Professor Rodolfo Ippoliti, Professor Andrea Bellelli

  44. Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells

    Article • FEBS Journal, September 2005, Wiley

    Professor Rodolfo Ippoliti

  45. The effect of AZT and chloroquine on the activities of ricin and a saporin–transferrin chimeric toxin

    Article • Biochemical Pharmacology, August 2005, Elsevier

    Professor Rodolfo Ippoliti

  46. GlutathioneS-transferase tissue profiling by reporter peptide monitoring

    Article • PROTEOMICS, February 2005, Wiley

    Professor Rodolfo Ippoliti

  47. Proteolytic activity of bovine lactoferrin

    Article • BioMetals, November 2004, Springer Science + Business Media

    Professor Rodolfo Ippoliti, Professor Fabio Polticelli

  48. Proteolytic activity of bovine lactoferrin

    Article • BioMetals, June 2004, Springer Science + Business Media

    Professor Rodolfo Ippoliti, Professor Fabio Polticelli

  49. Reductive activation of ricin and ricin A-chain immunotoxins by protein disulfide isomerase and thioredoxin reductase

    Article • Biochemical Pharmacology, May 2004, Elsevier

    Professor Rodolfo Ippoliti, Dr Giuseppe Bellisola, Phd Giulio Fracasso

  50. Role of immune sera in the in-vitro phagocytosis of Bordetella pertussis strains

    Article • Microbial Pathogenesis, March 2002, Elsevier

    Professor Rodolfo Ippoliti

  51. P-glycoprotein inserted in planar lipid bilayers formed by liposomes opened on amorphous carbon and Langmuir–Blodgett monolayer

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, February 2002, Elsevier

    Professor Rodolfo Ippoliti

  52. Article • The Histochemical Journal, January 2001, Springer Science + Business Media

    Professor Rodolfo Ippoliti

  53. Endocytosis of a chimera between human pro-urokinase and the plant toxin saporin: an unusual internalization mechanism

    Article • The FASEB Journal, July 2000, Federation of American Societies For Experimental Biology (FASEB)

    Professor Rodolfo Ippoliti

  54. The crystal structure of saporin SO6 fromSaponaria officinalisand its interaction with the ribosome

    Article • FEBS Letters, March 2000, Wiley

    Professor Rodolfo Ippoliti

  55. Modulation of mitochondrial respiration by nitric oxide: investigation by single cell fluorescence microscopy

    Article • The FASEB Journal, January 1999, Federation of American Societies For Experimental Biology (FASEB)

    Professor Rodolfo Ippoliti

  56. Targeting of saporin to Hodgkin's lymphoma cells by anti‐CD30 and anti‐CD25 bispecific antibodies

    Article • British Journal of Haematology, September 1998, Wiley

    Professor Rodolfo Ippoliti

  57. The effect of monensin and chloroquine on the endocytosis and toxicity of chimeric toxins

    Article • Cellular and Molecular Life Sciences, August 1998, Springer Science + Business Media

    Professor Rodolfo Ippoliti

  58. Crystallization and preliminary X-ray study of saporin, a ribosome-inactivating protein fromSaponaria officinalis

    Article • Acta Crystallographica Section D Biological Crystallography, July 1998, International Union of Crystallography

    Professor Rodolfo Ippoliti

  59. Covalent complex of microperoxidase with a 21-residue synthetic peptide as a maquette for low-molecular-mass redox proteins

    Article • Biochemical Journal, December 1997, Portland Press Ltd.

    Professor Rodolfo Ippoliti

  60. A saporin-insulin conjugate: Synthesis and biochemical characterization

    Article • Natural Toxins, July 1996, Wiley

    Professor Rodolfo Ippoliti, Professor Andrea Bellelli

  61. A chimeric saporin-transferrin conjugate compared to ricin toxin: role of the carrier in intracellular transport and toxicity.

    Article • The FASEB Journal, September 1995, Federation of American Societies For Experimental Biology (FASEB)

    Professor Rodolfo Ippoliti

  62. Intracellular dynamics of ricin followed by fluorescence microscopy on living cells reveals a rapid accumulation of the dimeric toxin in the Golgi apparatus

    Article • FEBS Letters, May 1994, Wiley

    Professor Rodolfo Ippoliti, Professor Andrea Bellelli

  63. Ligand binding and slow structural changes in chlorocruorin from Spirographis spallanzanii

    Article • Biochemistry, August 1993, American Chemical Society (ACS)

    Professor Rodolfo Ippoliti, Professor Andrea Bellelli

  64. Hemoglobin Dallas (α97(G4)Asn→Lys):functional characterization of a high oxygen affinity natural mutant

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, October 1992, Elsevier

    Professor Rodolfo Ippoliti

  65. A ribosomal protein is specifically recognized by saporin, a plant toxin which inhibits protein synthesis

    Article • FEBS Letters, February 1992, Wiley

    Professor Rodolfo Ippoliti, Professor Andrea Bellelli

  66. The amino acid sequence and oxygen-binding properties of the single hemoglobin of the cold-adapted Antarctic teleost Gymnodraco acuticeps

    Article • Archives of Biochemistry and Biophysics, January 1992, Elsevier

    Professor Rodolfo Ippoliti

  67. On the problem of immunological detection of antigens in skeletal remains

    Article • American Journal of Physical Anthropology, November 1991, Wiley

    Professor Rodolfo Ippoliti, Professor Andrea Bellelli

  68. Kinetic Evidences for Slow Structural Changes in the Chlorocruorin from Spirographis spallanzanii

    Article • January 1991, Springer Science + Business Media

    Professor Rodolfo Ippoliti, Professor Andrea Bellelli

  69. Effect of aromatic isothiocyanates on the functional properties of human hemoglobin

    Article • Biophysical Chemistry, August 1990, Elsevier

    Professor Rodolfo Ippoliti, Professor Andrea Bellelli, Professor Martino Bolognesi

  70. Cooperative ligand binding of crosslinked hemoglobins at very high temperatures

    Article • Journal of Molecular Biology, June 1990, Elsevier

    Professor Rodolfo Ippoliti, Professor Andrea Bellelli

  71. Binding and internalization of ricin labelled with fluorescein isothiocyanate

    Article • Biochemical and Biophysical Research Communications, June 1990, Elsevier

    Professor Rodolfo Ippoliti

  72. Human erythrocytes cross-linked with glutaraldehyde general properties and significance as a blood substitute

    Article • Biochemical and Biophysical Research Communications, October 1988, Elsevier

    Professor Rodolfo Ippoliti

  73. On the oxygen-linked anion-binding sites in human hemoglobin. Functional properties of human hemoglobin reacted with 4-isothiocyanatobenzenesulphonic acid and its hybrids

    Article • European Journal of Biochemistry, December 1986, Wiley

    Professor Rodolfo Ippoliti