All Stories

  1. Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry
  2. PPARs in Neurodegenerative and Neuroinflammatory Pathways
  3. Biocompatibility of composites based on chitosan, apatite, and graphene oxide for tissue applications
  4. Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins
  5. N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy
  6. Targeted therapy of human glioblastoma via delivery of a toxin through a peptide directed to cell surface nucleolin
  7. EV20-Sap, a novel anti-HER-3 antibody-drug conjugate, displays promising antitumor activity in melanoma
  8. Energy metabolism in glioblastoma stem cells: PPARα a metabolic adaptor to intratumoral microenvironment
  9. PPARα Antagonist AA452 Triggers Metabolic Reprogramming and Increases Sensitivity to Radiation Therapy in Human Glioblastoma Primary Cells
  10. Roles of PPAR transcription factors in the energetic metabolic switch occurring during adult neurogenesis
  11. Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera
  12. Uric Acid Amplifies Aβ Amyloid Effects Involved in the Cognitive Dysfunction/Dementia: Evidences From an Experimental Model In Vitro
  13. Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs
  14. A peroxiredoxin-based proteinaceous scaffold for the growth and differentiation of neuronal cells and tumour stem cells in the absence of prodifferentiation agents
  15. Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance
  16. Supramolecular self-assembly of graphene oxide and metal nanoparticles into stacked multilayers by means of a multitasking protein ring
  17. The PPARβ/δ Agonist GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons: Role of PPARβ/δ in Neuronal Maturation
  18. Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model
  19. One ring (or two) to hold them all - on the structure and function of protein nanotubes
  20. PDZ Domain in the Engineering and Production of a Saporin Chimeric Toxin as a Tool for targeting Cancer Cells
  21. PPARβ/δ and γ in a Rat Model of Parkinson's Disease: Possible Involvement in PD Symptoms
  22. Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems
  23. A Long Journey to the Cytosol
  24. Involvement of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in BDNF signaling during aging and in Alzheimer disease: Possible role of 4-hydroxynonenal (4-HNE)
  25. Self-assembled protein nanotubes
  26. Switching between the Alternative Structures and Functions of a 2-Cys Peroxiredoxin, by Site-Directed Mutagenesis
  27. Engineering and production of saporin chimeric toxins against human glioblastoma
  28. Neuroprotective effects of PrxI over-expression in an in vitro human Alzheimer's disease model
  29. Dissecting the Entry Route of Saporin-based a-CD7 Immunotoxins in Human T-Cell Acute Lymphoblastic Leukaemia Cells
  30. Current Status and Biomedical Applications of Ribosome-Inactivating Proteins
  31. Hypoxia modulation of peroxisome proliferator‐activated receptors (PPARs) in human glioblastoma stem cells. Implications for therapy
  32. Physiological roles of ovotransferrin
  33. Distinct cellular responses induced by saporin and a transferrin-saporin conjugate in two different human glioblastoma cell lines
  34. Innovative Therapies against Human Glioblastoma Multiforme
  35. Towards a Stem Architecture Description Language for Self-Adaptive Systems
  36. Ricin and Saporin: Plant Enzymes for the Research and the Clinics
  37. Ricin and Saporin: Plant Enzymes for the Research and the Clinics
  38. The role of the glycan moiety on the structure–function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves
  39. Learning from the Cell Life-Cycle: A Self-adaptive Paradigm
  40. Engineering a switchable toxin: the potential use of PDZ domains in the expression, targeting and activation of modified saporin variants
  41. Pichia pastoris as a host for secretion of toxic saporin chimeras
  42. Molecular characterization of nitrite reductase gene (aniA) and gene product inNeisseria meningitidisisolates: IsaniA essential for meningococcal survival?
  43. Multiple strategies for O2 transport: from simplicity to complexity
  44. Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells
  45. The effect of AZT and chloroquine on the activities of ricin and a saporin–transferrin chimeric toxin
  46. GlutathioneS-transferase tissue profiling by reporter peptide monitoring
  47. Proteolytic activity of bovine lactoferrin
  48. Proteolytic activity of bovine lactoferrin
  49. Reductive activation of ricin and ricin A-chain immunotoxins by protein disulfide isomerase and thioredoxin reductase
  50. Role of immune sera in the in-vitro phagocytosis of Bordetella pertussis strains
  51. P-glycoprotein inserted in planar lipid bilayers formed by liposomes opened on amorphous carbon and Langmuir–Blodgett monolayer
  52. Endocytosis of a chimera between human pro-urokinase and the plant toxin saporin: an unusual internalization mechanism
  53. The crystal structure of saporin SO6 fromSaponaria officinalisand its interaction with the ribosome
  54. Modulation of mitochondrial respiration by nitric oxide: investigation by single cell fluorescence microscopy
  55. Targeting of saporin to Hodgkin's lymphoma cells by anti‐CD30 and anti‐CD25 bispecific antibodies
  56. The effect of monensin and chloroquine on the endocytosis and toxicity of chimeric toxins
  57. Crystallization and preliminary X-ray study of saporin, a ribosome-inactivating protein fromSaponaria officinalis
  58. Covalent complex of microperoxidase with a 21-residue synthetic peptide as a maquette for low-molecular-mass redox proteins
  59. A saporin-insulin conjugate: Synthesis and biochemical characterization
  60. A chimeric saporin-transferrin conjugate compared to ricin toxin: role of the carrier in intracellular transport and toxicity.
  61. Intracellular dynamics of ricin followed by fluorescence microscopy on living cells reveals a rapid accumulation of the dimeric toxin in the Golgi apparatus
  62. Ligand binding and slow structural changes in chlorocruorin from Spirographis spallanzanii
  63. Hemoglobin Dallas (α97(G4)Asn→Lys):functional characterization of a high oxygen affinity natural mutant
  64. A ribosomal protein is specifically recognized by saporin, a plant toxin which inhibits protein synthesis
  65. The amino acid sequence and oxygen-binding properties of the single hemoglobin of the cold-adapted Antarctic teleost Gymnodraco acuticeps
  66. On the problem of immunological detection of antigens in skeletal remains
  67. Kinetic Evidences for Slow Structural Changes in the Chlorocruorin from Spirographis spallanzanii
  68. Effect of aromatic isothiocyanates on the functional properties of human hemoglobin
  69. Cooperative ligand binding of crosslinked hemoglobins at very high temperatures
  70. Binding and internalization of ricin labelled with fluorescein isothiocyanate
  71. Human erythrocytes cross-linked with glutaraldehyde general properties and significance as a blood substitute
  72. On the oxygen-linked anion-binding sites in human hemoglobin. Functional properties of human hemoglobin reacted with 4-isothiocyanatobenzenesulphonic acid and its hybrids