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  1. Common modifications of selenocysteine in selenoproteins
  2. Author Correction: Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system
  3. Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system
  4. Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades
  5. Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate
  6. Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase
  7. NADPH-dependent and -independent disulfide reductase systems
  8. Selenium and selenoproteins in (redox) signaling, diseases, and animal models - 200 year anniversary issue
  9. Selenium research in biochemistry and biophysics - 200 year anniversary issue
  10. Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways
  11. Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry
  12. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
  13. The A to Z of modulated cell patterning by mammalian thioredoxin reductases
  14. Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
  15. Overexpression of Recombinant Selenoproteins in E. coli
  16. Selective Evaluation of Thioredoxin Reductase Enzymatic Activities
  17. Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells
  18. Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H 2 O 2 exposure
  19. Molecular Mechanisms of Regulated Cell Pattering by the Mammalian Thioredoxin System
  20. Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase
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  22. Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy
  23. Rutin protects against H 2 O 2 -triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress
  24. Erratum: APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase
  25. Cross Talk in HEK293 Cells Between Nrf2, HIF, and NF-κB Activities upon Challenges with Redox Therapeutics Characterized with Single-Cell Resolution
  26. Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depletedEscherichia coliHost Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation
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  28. Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER
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  30. Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms
  31. Selenoprotein Gene Nomenclature
  32. Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors
  33. Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance
  34. Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake
  35. Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness
  36. Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells
  37. Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads
  38. Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities
  39. A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems
  40. Selenium Research (Se2017)
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  44. Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications
  45. TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System
  46. Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells
  47. Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver
  48. The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death
  49. Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury
  50. Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2
  51. Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase
  52. Redox active motifs in selenoproteins
  53. The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death
  54. Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures
  55. Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1
  56. ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis
  57. A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification
  58. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase
  59. Wobble decoding by the Escherichia coli selenocysteine insertion machinery
  60. Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling
  61. Redox activation of Fe(III)–thiosemicarbazones and Fe(III)–bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping
  62. BBA General Subjects – Changing of the Guard at the Publishing Palace
  63. Multilevel Regulation of 2-Cys Peroxiredoxin Reaction Cycle byS-Nitrosylation
  64. Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death
  65. The Rare TXNRD1_v3 (“v3”) Splice Variant of Human Thioredoxin Reductase 1 Protein Is Targeted to Membrane Rafts byN-Acylation and Induces Filopodia Independently of Its Redox Active Site Integrity
  66. Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells
  67. Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury
  68. Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase
  69. HER2-Positive Tumors Imaged Within 1 Hour Using a Site-Specifically 11C-Labeled Sel-Tagged Affibody Molecule
  70. Combining [11C]-AnxA5 PET Imaging with Serum Biomarkers for Improved Detection in Live Mice of Modest Cell Death in Human Solid Tumor Xenografts
  71. Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase
  72. Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1
  73. Biochemical Discrimination between Selenium and Sulfur 2: Mechanistic Investigation of the Selenium Specificity of Human Selenocysteine Lyase
  74. Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase
  75. Thioredoxin Reductase Inhibition Induces Nrf2mediated Antioxidant Responses in Murine Transformed Clara Cells
  76. Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay
  77. Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors
  78. Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans
  79. History of Selenium Research
  80. Human Protein Atlas of redox systems — What can be learnt?
  81. Noble metal targeting of thioredoxin reductase — covalent complexes with thioredoxin and thioredoxin-related protein of 14kDa triggered by cisplatin
  82. Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning
  83. The Selenium-independent Inherent Pro-oxidant NADPH Oxidase Activity of Mammalian Thioredoxin Reductase and Its Selenium-dependent Direct Peroxidase Activities
  84. Selenoproteins—What unique properties can arise with selenocysteine in place of cysteine?
  85. The Interactions of Thioredoxin Reductase with Quinones and Acrolein: Covalent Adducts and Stimulation of NADPH Oxidase Activity
  86. High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy
  87. Special issue on selenoprotein expression and function
  88. Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis
  89. The human thioredoxin reductase-1 splice variant TXNRD1_v3 is an atypical inducer of cytoplasmic filaments and cell membrane filopodia
  90. Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions
  91. Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice
  92. Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1
  93. Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1
  94. Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity
  95. Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1
  96. The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation
  97. Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates
  98. Cell Death by SecTRAPs: Thioredoxin Reductase as a Prooxidant Killer of Cells
  99. Induction of Cell Membrane Protrusions by the N-terminal Glutaredoxin Domain of a Rare Splice Variant of Human Thioredoxin Reductase 1
  100. Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target
  101. Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target
  102. Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney
  103. The thioredoxin system in cancer
  104. The thioredoxin system in cancer—introduction to a thematic volume of Seminars in Cancer Biology
  105. Titration and Conditional Knockdown of the prfB Gene in Escherichia coli: Effects on Growth and Overproduction of the Recombinant Mammalian Selenoprotein Thioredoxin Reductase
  106. Selenolthiol and Dithiol C-Terminal Tetrapeptide Motifs for One-Step Purification and Labeling of Recombinant Proteins Produced in E. coli
  107. Studies of an active site mutant of the selenoprotein thioredoxin reductase: The Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme
  108. Tagging recombinant proteins with a Sel-tag for purification, labeling with electrophilic compounds or radiolabeling with 11C
  109. Interactions of Nitroaromatic Compounds with the Mammalian Selenoprotein Thioredoxin Reductase and the Relation to Induction of Apoptosis in Human Cancer Cells
  110. Selenocysteine in proteins—properties and biotechnological use
  111. Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
  112. Thioredoxin reductase 1
  113. A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation
  114. Overexpression of Enzymatically Active Human Cytosolic and Mitochondrial Thioredoxin Reductase in HEK-293 Cells
  115. Exploiting the 21st amino acid—purifying and labeling proteins by selenolate targeting
  116. Assessment of Production Conditions for Efficient Use of Escherichia coli in High-Yield Heterologous Recombinant Selenoprotein Synthesis
  117. Expression of selenocysteine-containing glutathione S-transferase in Escherichia coli
  118. Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins
  119. Evidence for intriguingly complex transcription of human thioredoxin reductase 1
  120. Regulation of the Mammalian Selenoprotein Thioredoxin Reductase 1 in Relation to Cellular Phenotype, Growth, and Signaling Events
  121. Interactions of Quinones with Thioredoxin Reductase
  122. Active sites of thioredoxin reductases: Why selenoproteins?
  123. Selenocysteine Insertion and Reactivity: Mammalian Thioredoxin Reductases in Relation to Cellular Redox Signaling
  124. Rapid Induction of Cell Death by Selenium-compromised Thioredoxin Reductase 1 but Not by the Fully Active Enzyme Containing Selenocysteine
  125. Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase
  126. The Mammalian Cytosolic Selenoenzyme Thioredoxin Reductase Reduces Ubiquinone
  127. Recombinant Expression of Mammalian Selenocysteine-Containing Thioredoxin Reductase and Other Selenoproteins in Escherichia coli
  128. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordbe...
  129. Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis -diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex
  130. The Core Promoter of Human Thioredoxin Reductase 1
  131. Measurement of Thioredoxin and Thioredoxin Reductase
  132. Physiological functions of thioredoxin and thioredoxin reductase
  133. Truncated Thioredoxin Is a Mitogenic Cytokine for Resting Human Peripheral Blood Mononuclear Cells and Is Present in Human Plasma
  134. Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence
  135. Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′ untranslated region
  136. Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′ untranslated region
  137. High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA , selB and selC genes 1 1Edited by M. Gottesman
  138. Preparation and assay of mammalian thioredoxin and thioredoxin reductase
  139. Superoxide production by dinitrophenyl- derivatized thioredoxin reductase - a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes
  140. Mammalian Thioredoxin Reductase Is Irreversibly Inhibited by Dinitrohalobenzenes by Alkylation of Both the Redox Active Selenocysteine and Its Neighboring Cysteine Residue
  141. Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue
  142. Efficient Reduction of Lipoamide and Lipoic Acid by Mammalian Thioredoxin Reductase
  143. On the Phosphorylation of 2-chlorodeoxy-adenosine (CdA) and Its Correlation with Clinical Response in Leukemia Treatment
  144. 1-Chloro-2,4-dinitrobenzene Is an Irreversible Inhibitor of Human Thioredoxin Reductase
  145. Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues
  146. Mammalian deoxyribonucleoside kinases
  147. Mitochondrial Versus Cytosolic Activities of Deoxyribonucleoside Salvage Enzymes
  148. Phosphorylation of 2-chlorodeoxyadenosine (CdA) in extracts of peripheral blood mononuclear cells of leukaemic patients
  149. Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy
  150. Deoxycytidine and 2′,3′-Dideoxycytidine Metabolism in Human Monocyte-Derived Macrophages: A Study of Both Anabolic and Catabolic Pathways
  151. Catabolism of Deoxycytidine in Human Peripheral Blood Mononuclear Cells and Its Interference with the Determination of in Situ Thymidylate Synthase Activity
  152. Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues
  153. Deoxycytidine kinase is constitutively expressed in human lymphocytes: Consequences for compartmentation effects, unscheduled dna synthesis, and viral replication in resting cells
  154. Maximal flux responses after multiple challenges with vasopressin
  155. Biotechnology of selenocysteine
  156. Thioredoxin System