All Stories

  1. Development of novel analogs of the TRi-1 and TRi-2 selenoprotein thioredoxin reductase inhibitors with initial assessment of their cytotoxicity profiles

    Article • Free Radical Biology and Medicine, December 2025, Elsevier

    Elias Arner

  2. Anti-Tumoral Treatment with Thioredoxin Reductase 1 Inhibitor Auranofin Fosters Regulatory T Cell and B16F10 Expansion in Mice

    Article • Antioxidants, November 2025, MDPI AG

    Elias Arner

  3. Patient-derived TXNIP-deficient primary cells exhibit NRF2 activation linked to upregulation of glyoxalase 1 (GLO1)

    Article • Free Radical Biology and Medicine, November 2025, Elsevier

    Elias Arner

  4. Bicyclic Selenenyl Sulfides with Tuned Bioreductive Step Rates Reveal Constraints for Probes Targeting Thioredoxin Reductase

    Article • Angewandte Chemie, July 2025, Wiley

    Elias Arner

  5. Bicyclic Selenenyl Sulfides with Tuned Bioreductive Step Rates Reveal Constraints for Probes Targeting Thioredoxin Reductase

    Article • Angewandte Chemie, July 2025, Wiley

    Elias Arner

  6. Cellular activity of the cytosolic selenoprotein thioredoxin reductase 1 (TXNRD1) is modulated by copper and zinc levels in the cell culture medium

    Article • Journal of Trace Elements in Medicine and Biology, April 2025, Elsevier

    Elias Arner

  7. Bicyclic selenenyl sulfides tune stepwise rates of thiol/selenol addition, resolution, and cyclisation, to reveal cellular constraints for bioreductive probes targeting mammalian thioredoxin reductase

    Article • February 2025, American Chemical Society (ACS)

    Elias Arner

  8. Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system

    Article • Current Opinion in Chemical Biology, December 2024, Elsevier

    Elias Arner

  9. TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation

    Article • The EMBO Journal, May 2024, Springer Science + Business Media

    Elias Arner

  10. Ancient Loss of Catalytic Selenocysteine Spurred Convergent Adaptation in a Mammalian Oxidoreductase

    Article • Genome Biology and Evolution, March 2024, Oxford University Press (OUP)

    Elias Arner

  11. Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology

    Article • Journal of the American Chemical Society, February 2024, American Chemical Society (ACS)

    Elias Arner

  12. Arsenic exposure and increased C-reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children

    Article • Redox Biochemistry and Chemistry, December 2023, Elsevier

    Elias Arner

  13. TXNL1 has dual functions as a redox active thioredoxin-like protein as well as an ATP- and redox-independent chaperone

    Article • Redox Biology, November 2023, Elsevier

    Elias Arner

  14. Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells

    Article • Redox Biology, November 2023, Elsevier

    Elias Arner

  15. Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant

    Article • Redox Biology, August 2023, Elsevier

    Elias Arner

  16. Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4

    Article • Redox Biology, July 2023, Elsevier

    Elias Arner

  17. Novel gold(III)-dithiocarbamate complex targeting bacterial thioredoxin reductase: antimicrobial activity, synergy, toxicity, and mechanistic insights

    Article • Frontiers in Microbiology, June 2023, Frontiers

    Raquel Soengas, Elias Arner

  18. The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1

    Article • Redox Biology, June 2023, Elsevier

    Elias Arner

  19. Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides

    Article • Redox Biology, February 2023, Elsevier

    Elias Arner

  20. Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Elias Arner

  21. Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases

    Article • Free Radical Biology and Medicine, September 2022, Elsevier

    Elias Arner

  22. Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress

    Article • Journal for ImmunoTherapy of Cancer, June 2022, BMJ

    Elias Arner

  23. Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

    Article • eLife, May 2022, eLife

    Elias Arner

  24. Selective cellular probes for mammalian thioredoxin reductase TrxR1: Rational design of RX1, a modular 1,2-thiaselenane redox probe

    Article • Chem, May 2022, Elsevier

    Elias Arner

  25. Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus

    Article • Redox Biology, May 2022, Elsevier

    Elias Arner

  26. Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically

    Article • Nature Communications, April 2022, Springer Science + Business Media

    Elias Arner

  27. Development of a chemical probe that selectively images the activity of mammalian Thioredoxin Reductase 1

    Article • Free Radical Biology and Medicine, February 2022, Elsevier

    Elias Arner

  28. Thioredoxin Reductase Inhibition for Cancer Therapy

    Article • The Annual Review of Pharmacology and Toxicology, January 2022, Annual Reviews

    Elias Arner

  29. Thioredoxin and glutathione reductases

    Article • January 2022, Elsevier

    Elias Arner

  30. Expressing recombinant selenoproteins using redefinition of a single UAG codon in an RF1-depleted E. coli host strain

    Article • January 2022, Elsevier

    Elias Arner

  31. Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin

    Article • Redox Biology, December 2021, Elsevier

    Elias Arner

  32. Evaluation of dithiothreitol-oxidizing capacity (DOC) as a serum biomarker for chronic hepatitis B in patients exhibiting normal alanine aminotransferase levels: a pilot study towards better monitoring of disease

    Article • EClinicalMedicine, December 2021, Elsevier

    Elias Arner

  33. Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities

    Article • Orphanet Journal of Rare Diseases, October 2021, Springer Science + Business Media

    Elias Arner

  34. Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein

    Article • Redox Biology, October 2021, Elsevier

    Elias Arner

  35. Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif

    Article • Journal of the American Chemical Society, June 2021, American Chemical Society (ACS)

    Elias Arner

  36. In Memoriam Arne Holmgren (1940–2020)

    Article • Free Radical Biology and Medicine, May 2021, Elsevier

    Elias Arner

  37. Comment on “Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity”

    Article • Science Advances, April 2021, American Association for the Advancement of Science

    Elias Arner

  38. Development of Therapies for Rare Genetic Disorders of GPX4: Roadmap and Opportunities

    Article • April 2021, MDPI AG

    Elias Arner

  39. Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif

    Article • March 2021, American Chemical Society (ACS)

    Elias Arner

  40. System-wide identification and prioritization of enzyme substrates by thermal analysis

    Article • Nature Communications, February 2021, Springer Science + Business Media

    Akos Vegvari, Elias Arner

  41. Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H2O2 Together with Bicarbonate

    Article • Antioxidants, January 2021, MDPI AG

    Elias Arner

  42. Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases

    Article • Oxidative Medicine and Cellular Longevity, January 2021, Wiley

    Elias Arner

  43. To inhibit TrxR1 is to inactivate STAT3–Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors

    Article • Redox Biology, September 2020, Elsevier

    Elias Arner

  44. Identification and targeting of selective vulnerability rendered by tamoxifen resistance

    Article • Breast Cancer Research, July 2020, Springer Science + Business Media

    Elias Arner

  45. Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

    Article • Neurotherapeutics, July 2020, Elsevier

    Professor Fredrik Piehl, Elias Arner

  46. Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin

    Article • Redox Biology, May 2020, Elsevier

    Elias Arner

  47. Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

    Article • Science Advances, March 2020, American Association for the Advancement of Science

    Elias Arner

  48. Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase

    Article • Inorganic Chemistry, February 2020, American Chemical Society (ACS)

    Elias Arner

  49. Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis

    Article • ACS Infectious Diseases, January 2020, American Chemical Society (ACS)

    Elias Arner

  50. Effects of Mammalian Thioredoxin Reductase Inhibitors

    Article • January 2020, Springer Science + Business Media

    Elias Arner

  51. Perspectives of TrxR1-based cancer therapies

    Article • January 2020, Elsevier

    Elias Arner

  52. Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone

    Article • Redox Biology, January 2020, Elsevier

    Elias Arner

  53. Common modifications of selenocysteine in selenoproteins

    Article • Essays in Biochemistry, December 2019, Portland Press Ltd.

    Elias Arner

  54. Author Correction: Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

    Article • Scientific Reports, November 2019, Springer Science + Business Media

    Elias Arner

  55. Which Antioxidant System Shapes Intracellular H2O2 Gradients?

    Article • Antioxidants & Redox Signaling, September 2019, Mary Ann Liebert Inc

    Elias Arner

  56. Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

    Article • Scientific Reports, July 2019, Springer Science + Business Media

    Elias Arner

  57. Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

    Article • Biochimie, July 2019, Elsevier

    Elias Arner

  58. Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades

    Article • Journal of Biological Chemistry, June 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  59. TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy

    Article • Proceedings of the National Academy of Sciences, May 2019, Proceedings of the National Academy of Sciences

    Elias Arner

  60. Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

    Article • Diabetes, February 2019, American Diabetes Association

    Elias Arner

  61. ProPerDP: A Protein Persulfide Detection Protocol

    Article • January 2019, Springer Science + Business Media

    Elias Arner

  62. Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 2018, Elsevier

    Elias Arner

  63. NADPH-dependent and -independent disulfide reductase systems

    Article • Free Radical Biology and Medicine, November 2018, Elsevier

    Elias Arner

  64. Selenium and selenoproteins in (redox) signaling, diseases, and animal models - 200 year anniversary issue

    Article • Free Radical Biology and Medicine, November 2018, Elsevier

    Elias Arner

  65. Selenium research in biochemistry and biophysics - 200 year anniversary issue

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 2018, Elsevier

    Elias Arner

  66. Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways

    Article • Bone Marrow Transplantation, October 2018, Wiley

    Elias Arner

  67. Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

    Article • ACS Chemical Biology, May 2018, American Chemical Society (ACS)

    Professor Rodolfo Ippoliti, Elias Arner

  68. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

    Article • Science Translational Medicine, February 2018, American Association for the Advancement of Science

    Elias Arner

  69. The A to Z of modulated cell patterning by mammalian thioredoxin reductases

    Article • Free Radical Biology and Medicine, February 2018, Elsevier

    Elias Arner

  70. Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

    Article • Cell, January 2018, Elsevier

    Elias Arner

  71. H2O2, Thioredoxin, and Signaling

    Article • October 2017, Taylor & Francis

    Elias Arner

  72. Overexpression of Recombinant Selenoproteins in E. coli

    Article • September 2017, Springer Science + Business Media

    Elias Arner

  73. Selective Evaluation of Thioredoxin Reductase Enzymatic Activities

    Article • September 2017, Springer Science + Business Media

    Elias Arner

  74. Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells

    Article • Redox Biology, August 2017, Elsevier

    Elias Arner

  75. Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H 2 O 2 exposure

    Article • Journal of Biological Chemistry, July 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  76. Molecular Mechanisms of Regulated Cell Pattering by the Mammalian Thioredoxin System

    Article • Free Radical Biology and Medicine, July 2017, Elsevier

    Elias Arner

  77. Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

    Article • Cell Reports, June 2017, Elsevier

    Elias Arner

  78. Mark Your Calendar

    Article • Chemistry International, May 2017, De Gruyter

    Michael Shaver, Professor Miguel Angel Garcia-Garibay, Dr Tomas Elbert, Elias Arner

  79. Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy

    Article • Free Radical Biology and Medicine, May 2017, Elsevier

    Elias Arner, Professor Lutz Schomburg

  80. Rutin protects against H 2 O 2 -triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, May 2017, Elsevier

    Elias Arner

  81. Erratum: APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

    Article • Cell Death and Disease, April 2017, Springer Science + Business Media

    Elias Arner

  82. Cross Talk in HEK293 Cells Between Nrf2, HIF, and NF-κB Activities upon Challenges with Redox Therapeutics Characterized with Single-Cell Resolution

    Article • Antioxidants & Redox Signaling, February 2017, Mary Ann Liebert Inc

    Elias Arner, Professor Fredrik Piehl

  83. Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depletedEscherichia coliHost Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation

    Article • Journal of Biological Chemistry, February 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  84. Mark Your Calendar

    Article • Chemistry International, January 2017, De Gruyter

    Dr John B Unsworth, Dr Alexander Haliassos, Michael Shaver, Dr Tomas Elbert, Professor Miguel Angel Garcia-Garibay, Elias Arner

  85. Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER

    Article • The EMBO Journal, January 2017, EMBO

    Elias Arner

  86. Mark Your Calendar

    Article • Chemistry International, January 2017, De Gruyter

    Dr Ilya Kuselman, Dr John B Unsworth, Michael Shaver, Dr Alexander Haliassos, Elias Arner

  87. Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy

    Article • January 2017, Elsevier

    Elias Arner

  88. Thioredoxin System

    Article • January 2017, Springer Science + Business Media

    Elias Arner

  89. Selenium Metabolism in Herbivores and Higher Trophic Levels Including Mammals

    Article • January 2017, Springer Science + Business Media

    Elias Arner

  90. Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms

    Article • Free Radical Biology and Medicine, October 2016, Elsevier

    Elias Arner

  91. Selenoprotein Gene Nomenclature

    Article • Journal of Biological Chemistry, September 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner, Professor Lutz Schomburg, Josef Köhrle

  92. Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors

    Article • Scientific Reports, September 2016, Springer Science + Business Media

    Elias Arner

  93. Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance

    Article • Free Radical Biology and Medicine, August 2016, Elsevier

    Elias Arner

  94. Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake

    Article • EJNMMI Research, July 2016, Springer Science + Business Media

    Elias Arner

  95. Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness

    Article • Scientific Reports, June 2016, Springer Science + Business Media

    Elias Arner

  96. Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

    Article • Molecular Pharmaceutics, June 2016, American Chemical Society (ACS)

    Professor Guido R Haenen, Elias Arner

  97. Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

    Article • Oncotarget, May 2016, Impact Journals, LLC

    Elias Arner

  98. Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities

    Article • Free Radical Biology and Medicine, May 2016, Elsevier

    Elias Arner

  99. A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems

    Article • Science Advances, January 2016, American Association for the Advancement of Science

    Dr Péter Nagy, Elias Arner

  100. Selenium Research (Se2017)

    Article • Chemistry International, January 2016, De Gruyter

    Elias Arner

  101. Mark Your Calendar

    Article • Chemistry International, January 2016, De Gruyter

    Professor Kostas D Demadis, Dr Ilya Kuselman, Robert Belford, Elias Arner

  102. Mark Your Calendar

    Article • Chemistry International, January 2016, De Gruyter

    Dr Ilya Kuselman, Elias Arner

  103. Mark Your Calendar

    Article • Chemistry International, January 2016, De Gruyter

    Dr Ilya Kuselman, Elias Arner

  104. Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications

    Article • Physiological Reviews, January 2016, American Physiological Society

    Elias Arner

  105. Thioredoxin Reductase 1 as an Anticancer Drug Target

    Article • January 2016, Springer Science + Business Media

    Elias Arner

  106. TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System

    Article • Antioxidants & Redox Signaling, October 2015, Mary Ann Liebert Inc

    Elias Arner

  107. Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells

    Article • Oncotarget, May 2015, Impact Journals, LLC

    Elias Arner

  108. Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

    Article • Nature Communications, March 2015, Springer Science + Business Media

    Elias Arner

  109. The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death

    Article • Cell Death and Disease, January 2015, Springer Science + Business Media

    Elias Arner

  110. Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 2014, Elsevier

    Elias Arner

  111. Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2

    Article • Cell Death and Disease, May 2014, Springer Science + Business Media

    Elias Arner

  112. Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase

    Article • Proceedings of the National Academy of Sciences, April 2014, Proceedings of the National Academy of Sciences

    Elias Arner

  113. Redox active motifs in selenoproteins

    Article • Proceedings of the National Academy of Sciences, April 2014, Proceedings of the National Academy of Sciences

    Elias Arner

  114. The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

    Article • Molecular Pharmacology, April 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Elias Arner

  115. Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures

    Article • Acta Oto-Laryngologica, April 2014, Taylor & Francis

    Elias Arner

  116. Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

    Article • Free Radical Biology and Medicine, April 2014, Elsevier

    Elias Arner

  117. ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

    Article • Cell Death and Differentiation, January 2014, Springer Science + Business Media

    Elias Arner

  118. The selenoprotein thioredoxin reductase as a key regulator of cellular signaling pathways

    Article • October 2013, Taylor & Francis

    Elias Arner

  119. A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification

    Article • Free Radical Biology and Medicine, October 2013, Elsevier

    Elias Arner

  120. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

    Article • Cell Death and Disease, October 2013, Springer Science + Business Media

    Elias Arner

  121. Wobble decoding by the Escherichia coli selenocysteine insertion machinery

    Article • Nucleic Acids Research, August 2013, Oxford University Press (OUP)

    Elias Arner

  122. Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling

    Article • Proceedings of the National Academy of Sciences, July 2013, Proceedings of the National Academy of Sciences

    Dr. Jeroen Frijhoff, Elias Arner

  123. Redox activation of Fe(III)–thiosemicarbazones and Fe(III)–bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping

    Article • Free Radical Biology and Medicine, July 2013, Elsevier

    Elias Arner

  124. BBA General Subjects – Changing of the Guard at the Publishing Palace

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, June 2013, Elsevier

    Elias Arner

  125. Multilevel Regulation of 2-Cys Peroxiredoxin Reaction Cycle byS-Nitrosylation

    Article • Journal of Biological Chemistry, March 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  126. Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, March 2013, Elsevier

    Elias Arner

  127. The Rare TXNRD1_v3 (“v3”) Splice Variant of Human Thioredoxin Reductase 1 Protein Is Targeted to Membrane Rafts byN-Acylation and Induces Filopodia Independently of Its Redox Active Site Integrity

    Article • Journal of Biological Chemistry, February 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  128. Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells

    Article • Biochemical and Biophysical Research Communications, January 2013, Elsevier

    Elias Arner

  129. Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury

    Article • Antioxidants & Redox Signaling, November 2012, Mary Ann Liebert Inc

    Elias Arner

  130. Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase

    Article • Biochemical Journal, October 2012, Portland Press Ltd.

    Elias Arner

  131. HER2-Positive Tumors Imaged Within 1 Hour Using a Site-Specifically 11C-Labeled Sel-Tagged Affibody Molecule

    Article • Journal of Nuclear Medicine, August 2012, Society of Nuclear Medicine

    Elias Arner

  132. Combining [11C]-AnxA5 PET Imaging with Serum Biomarkers for Improved Detection in Live Mice of Modest Cell Death in Human Solid Tumor Xenografts

    Article • PLOS One, August 2012, PLOS

    Elias Arner

  133. Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase

    Article • Biochemical Pharmacology, March 2012, Elsevier

    Elias Arner

  134. Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1

    Article • Free Radical Biology and Medicine, February 2012, Elsevier

    Elias Arner

  135. Biochemical Discrimination between Selenium and Sulfur 2: Mechanistic Investigation of the Selenium Specificity of Human Selenocysteine Lyase

    Article • PLOS One, January 2012, PLOS

    Elias Arner

  136. Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase

    Article • PLOS One, January 2012, PLOS

    Elias Arner

  137. Thioredoxin Reductase Inhibition Induces Nrf2mediated Antioxidant Responses in Murine Transformed Clara Cells

    Article • Free Radical Biology and Medicine, November 2011, Elsevier

    Elias Arner

  138. Redox Pioneer: Professor Arne Holmgren

    Article • Antioxidants & Redox Signaling, August 2011, Mary Ann Liebert Inc

    Elias Arner

  139. Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay

    Article • Free Radical Biology and Medicine, May 2011, Elsevier

    Elias Arner

  140. Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors

    Article • Free Radical Biology and Medicine, March 2011, Elsevier

    Elias Arner

  141. Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans

    Article • Proceedings of the National Academy of Sciences, January 2011, Proceedings of the National Academy of Sciences

    Elias Arner

  142. History of Selenium Research

    Article • January 2011, Springer Science + Business Media

    Elias Arner

  143. Human Protein Atlas of redox systems — What can be learnt?

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, January 2011, Elsevier

    Elias Arner

  144. Noble metal targeting of thioredoxin reductase — covalent complexes with thioredoxin and thioredoxin-related protein of 14kDa triggered by cisplatin

    Article • Free Radical Biology and Medicine, December 2010, Elsevier

    Elias Arner

  145. Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning

    Article • The FASEB Journal, September 2010, Federation of American Societies For Experimental Biology (FASEB)

    Elias Arner

  146. The Selenium-independent Inherent Pro-oxidant NADPH Oxidase Activity of Mammalian Thioredoxin Reductase and Its Selenium-dependent Direct Peroxidase Activities

    Article • Journal of Biological Chemistry, May 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  147. Selenoproteins—What unique properties can arise with selenocysteine in place of cysteine?

    Article • Experimental Cell Research, May 2010, Elsevier

    Elias Arner

  148. The Interactions of Thioredoxin Reductase with Quinones and Acrolein: Covalent Adducts and Stimulation of NADPH Oxidase Activity

    Article • Free Radical Biology and Medicine, January 2010, Elsevier

    Elias Arner

  149. High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy

    Article • Free Radical Biology and Medicine, December 2009, Elsevier

    Elias Arner

  150. Special issue on selenoprotein expression and function

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 2009, Elsevier

    Elias Arner

  151. p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA

    Article • Cell Cycle, November 2009, Taylor & Francis

    Elias Arner

  152. Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis

    Article • Journal of Medicinal Chemistry, October 2009, American Chemical Society (ACS)

    Elias Arner

  153. The human thioredoxin reductase-1 splice variant TXNRD1_v3 is an atypical inducer of cytoplasmic filaments and cell membrane filopodia

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, October 2009, Elsevier

    Elias Arner

  154. Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, June 2009, Elsevier

    Elias Arner

  155. Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice

    Article • Allergy, June 2009, Wiley

    Elias Arner

  156. Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1

    Article • Experimental Cell Research, May 2009, Elsevier

    Professor Ola Hermanson, Elias Arner

  157. Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1

    Article • Free Radical Biology and Medicine, April 2009, Elsevier

    Elias Arner

  158. Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

    Article • JNCI Journal of the National Cancer Institute, December 2008, Oxford University Press (OUP)

    Elias Arner

  159. Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1

    Article • Journal of Biological Chemistry, December 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  160. The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation

    Article • Biochemical Pharmacology, October 2008, Elsevier

    Elias Arner

  161. Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates

    Article • Free Radical Biology and Medicine, August 2008, Elsevier

    Elias Arner

  162. Cell Death by SecTRAPs: Thioredoxin Reductase as a Prooxidant Killer of Cells

    Article • PLOS One, April 2008, PLOS

    Elias Arner

  163. Induction of Cell Membrane Protrusions by the N-terminal Glutaredoxin Domain of a Rare Splice Variant of Human Thioredoxin Reductase 1

    Article • Journal of Biological Chemistry, November 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  164. Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

    Article • PLoS Medicine, August 2007, PLOS

    Elisabeth Davioud-Charvet, Elias Arner

  165. Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

    Article • PLoS Medicine, June 2007, PLOS

    Elisabeth Davioud-Charvet, Elias Arner

  166. Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney

    Article • Archives of Biochemistry and Biophysics, March 2007, Elsevier

    Elias Arner

  167. The thioredoxin system in cancer

    Article • Seminars in Cancer Biology, December 2006, Elsevier

    Elias Arner

  168. The thioredoxin system in cancer—introduction to a thematic volume of Seminars in Cancer Biology

    Article • Seminars in Cancer Biology, December 2006, Elsevier

    Elias Arner

  169. Titration and Conditional Knockdown of the prfB Gene in Escherichia coli: Effects on Growth and Overproduction of the Recombinant Mammalian Selenoprotein Thioredoxin Reductase

    Article • Applied and Environmental Microbiology, November 2006, ASM Journals

    Elias Arner

  170. Selenolthiol and Dithiol C-Terminal Tetrapeptide Motifs for One-Step Purification and Labeling of Recombinant Proteins Produced in E. coli

    Article • ChemBioChem, October 2006, Wiley

    Elias Arner

  171. Studies of an active site mutant of the selenoprotein thioredoxin reductase: The Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme

    Article • Free Radical Biology and Medicine, August 2006, Elsevier

    Elias Arner

  172. Tagging recombinant proteins with a Sel-tag for purification, labeling with electrophilic compounds or radiolabeling with 11C

    Article • Nature Protocols, July 2006, Springer Science + Business Media

    Elias Arner

  173. Interactions of Nitroaromatic Compounds with the Mammalian Selenoprotein Thioredoxin Reductase and the Relation to Induction of Apoptosis in Human Cancer Cells

    Article • Journal of Biological Chemistry, December 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  174. Selenocysteine in proteins—properties and biotechnological use

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2005, Elsevier

    Elias Arner

  175. Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds

    Article • Free Radical Biology and Medicine, September 2005, Elsevier

    Elias Arner

  176. Thioredoxin reductase 1

    Article • AfCS-Nature Molecule Pages, August 2005, Springer Science + Business Media

    Elias Arner

  177. A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation

    Article • European Journal of Biochemistry, June 2005, Wiley

    Elias Arner

  178. Overexpression of Enzymatically Active Human Cytosolic and Mitochondrial Thioredoxin Reductase in HEK-293 Cells

    Article • Journal of Biological Chemistry, October 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  179. Exploiting the 21st amino acid—purifying and labeling proteins by selenolate targeting

    Article • Nature Chemical Biology, September 2004, Springer Science + Business Media

    Elias Arner

  180. Assessment of Production Conditions for Efficient Use of Escherichia coli in High-Yield Heterologous Recombinant Selenoprotein Synthesis

    Article • Applied and Environmental Microbiology, September 2004, ASM Journals

    Elias Arner, Alexios Vlamis

  181. Expression of selenocysteine-containing glutathione S-transferase in Escherichia coli

    Article • Biochemical and Biophysical Research Communications, August 2004, Elsevier

    Elias Arner

  182. Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins

    Article • Free Radical Biology and Medicine, July 2004, Elsevier

    Elias Arner

  183. Evidence for intriguingly complex transcription of human thioredoxin reductase 1

    Article • Free Radical Biology and Medicine, March 2004, Elsevier

    Elias Arner

  184. Regulation of the Mammalian Selenoprotein Thioredoxin Reductase 1 in Relation to Cellular Phenotype, Growth, and Signaling Events

    Article • Antioxidants & Redox Signaling, February 2004, Mary Ann Liebert Inc

    Elias Arner

  185. Interactions of Quinones with Thioredoxin Reductase

    Article • Journal of Biological Chemistry, November 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  186. Active sites of thioredoxin reductases: Why selenoproteins?

    Article • Proceedings of the National Academy of Sciences, October 2003, Proceedings of the National Academy of Sciences

    Elias Arner

  187. Selenocysteine Insertion and Reactivity: Mammalian Thioredoxin Reductases in Relation to Cellular Redox Signaling

    Article • July 2003, World Scientific Pub Co Pte Lt

    Elias Arner

  188. Rapid Induction of Cell Death by Selenium-compromised Thioredoxin Reductase 1 but Not by the Fully Active Enzyme Containing Selenocysteine

    Article • Journal of Biological Chemistry, February 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  189. Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase

    Article • BioFactors, January 2003, Wiley

    Elias Arner

  190. The Mammalian Cytosolic Selenoenzyme Thioredoxin Reductase Reduces Ubiquinone

    Article • Journal of Biological Chemistry, November 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  191. Recombinant Expression of Mammalian Selenocysteine-Containing Thioredoxin Reductase and Other Selenoproteins in Escherichia coli

    Article • January 2002, Elsevier

    Elias Arner

  192. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordbe...

    Article • Free Radical Biology and Medicine, December 2001, Elsevier

    Elias Arner

  193. Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis -diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex

    Article • Free Radical Biology and Medicine, November 2001, Elsevier

    Elias Arner, Tetsuro Sasada

  194. The Core Promoter of Human Thioredoxin Reductase 1

    Article • Journal of Biological Chemistry, May 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  195. Measurement of Thioredoxin and Thioredoxin Reductase

    Article • May 2001, Wiley

    Elias Arner

  196. Physiological functions of thioredoxin and thioredoxin reductase

    Article • European Journal of Biochemistry, October 2000, Wiley

    Elias Arner

  197. Truncated Thioredoxin Is a Mitogenic Cytokine for Resting Human Peripheral Blood Mononuclear Cells and Is Present in Human Plasma

    Article • Journal of Biological Chemistry, September 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  198. Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

    Article • Proceedings of the National Academy of Sciences, May 2000, Proceedings of the National Academy of Sciences

    Elias Arner

  199. Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′ untranslated region

    Article • Biochemical Journal, May 2000, Portland Press Ltd.

    Elias Arner

  200. Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′ untranslated region

    Article • Biochemical Journal, May 2000, Portland Press Ltd.

    Elias Arner

  201. High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA , selB and selC genes 1 1Edited by M. Gottesman

    Article • Journal of Molecular Biology, October 1999, Elsevier

    Elias Arner

  202. Preparation and assay of mammalian thioredoxin and thioredoxin reductase

    Article • January 1999, Elsevier

    Elias Arner

  203. Superoxide production by dinitrophenyl- derivatized thioredoxin reductase - a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes

    Article • BioFactors, January 1999, Wiley

    Elias Arner

  204. Mammalian Thioredoxin Reductase Is Irreversibly Inhibited by Dinitrohalobenzenes by Alkylation of Both the Redox Active Selenocysteine and Its Neighboring Cysteine Residue

    Article • Journal of Biological Chemistry, May 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  205. Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue

    Article • Journal of Biological Chemistry, April 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  206. Efficient Reduction of Lipoamide and Lipoic Acid by Mammalian Thioredoxin Reductase

    Article • Biochemical and Biophysical Research Communications, August 1996, Elsevier

    Elias Arner

  207. On the Phosphorylation of 2-chlorodeoxy-adenosine (CdA) and Its Correlation with Clinical Response in Leukemia Treatment

    Article • Leukemia & Lymphoma, January 1996, Taylor & Francis

    Elias Arner

  208. 1-Chloro-2,4-dinitrobenzene Is an Irreversible Inhibitor of Human Thioredoxin Reductase

    Article • Journal of Biological Chemistry, February 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner

  209. Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues

    Article • European Journal of Cancer, January 1995, Elsevier

    Elias Arner

  210. Mammalian deoxyribonucleoside kinases

    Article • Pharmacology & Therapeutics, January 1995, Elsevier

    Elias Arner

  211. Mitochondrial Versus Cytosolic Activities of Deoxyribonucleoside Salvage Enzymes

    Article • January 1995, Springer Science + Business Media

    Elias Arner

  212. Phosphorylation of 2-chlorodeoxyadenosine (CdA) in extracts of peripheral blood mononuclear cells of leukaemic patients

    Article • British Journal of Haematology, August 1994, Wiley

    Elias Arner

  213. Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy

    Article • Advances in Enzyme Regulation, January 1994, Elsevier

    Elias Arner

  214. Deoxycytidine and 2′,3′-Dideoxycytidine Metabolism in Human Monocyte-Derived Macrophages: A Study of Both Anabolic and Catabolic Pathways

    Article • Biochemical and Biophysical Research Communications, December 1993, Elsevier

    Elias Arner

  215. Catabolism of Deoxycytidine in Human Peripheral Blood Mononuclear Cells and Its Interference with the Determination of in Situ Thymidylate Synthase Activity

    Article • Analytical Biochemistry, April 1993, Elsevier

    Elias Arner

  216. Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues

    Article • Biochemical and Biophysical Research Communications, October 1992, Elsevier

    Elias Arner

  217. Deoxycytidine kinase is constitutively expressed in human lymphocytes: Consequences for compartmentation effects, unscheduled dna synthesis, and viral replication in resting cells

    Article • Experimental Cell Research, October 1988, Elsevier

    Elias Arner

  218. Maximal flux responses after multiple challenges with vasopressin

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 1984, Elsevier

    Elias Arner

  219. Biotechnology of selenocysteine

    Article • Springer Science + Business Media

    Elias Arner

  220. Thioredoxin System

    Article • Springer Science + Business Media

    Elias Arner