All Stories

  1. Human Helicase DDX5 is Hijacked by SARS-CoV-2 Nsp13 Helicase to Enhance RNA Unwinding
  2. Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284
  3. Crystal structure and biophysical characterisation of the enterococcal foldase PpiC, a cross‐opsonic antigen against gram‐positive nosocomial pathogens
  4. A Self-Assembling Cross-Protective Antigen Against Multiple Gram-Positive Nosocomial Pathogens
  5. Discovery of p-Trifluoromethylbenzohydrazide Derivatives as Potent Antiviral Agents against Monkeypox Virus
  6. Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in Acinetobacter baumannii
  7. Structural studies of KCTD1 and its disease-causing mutant P20S provide insights into the protein function and misfunction
  8. A rationally designed antigen elicits protective antibodies against multiple nosocomial Gram-positive pathogens
  9. HtpG—A Major Virulence Factor and a Promising Vaccine Antigen against Mycobacterium tuberculosis
  10. Klebsiella phage KP34gp57 capsular depolymerase structure and function: from a serendipitous finding to the design of active mini-enzymes against K. pneumoniae
  11. Virulence Factors in Mycobacterium tuberculosis Infection: Structural and Functional Studies
  12. Structural Basis of PE_PGRS Polymorphism, a Tool for Functional Modulation
  13. Unveiling CD59-Antibody Interactions to Design Paratope-Mimicking Peptides for Complement Modulation
  14. A Structural View at Vaccine Development against M. tuberculosis
  15. Molecular Immunology in Bacterial Vaccine Discovery
  16. Understanding Molecular Actors of SARS-CoV-2 Virulence to Tackle COVID-19 Outbreak
  17. Conformational stability of ageritin, a metal binding ribotoxin-like protein of fungal origin
  18. PGRS domain structures: Doomed to sail the mycomembrane
  19. Structure based design of effective HtpG-derived vaccine antigens against M. tuberculosis
  20. Resveratrol Reverts Tolerance and Restores Susceptibility to Chlorhexidine and Benzalkonium in Gram-Negative Bacteria, Gram-Positive Bacteria and Yeasts
  21. Structural and Binding Properties of the Active Cell Wall Hydrolase RipA from M. tuberculosis, a Promising Biosensing Molecule for Early Warning Bacterial Detection
  22. Structure-Based Development of SARS-CoV-2 Spike Interactors
  23. Structural and Biochemical Characterization of Endo-β-1,4-glucanase from Dictyoglomus thermophilum, a Hyperthermostable and Halotolerant Cellulase
  24. Inhibition of AdeB, AceI, and AmvA Efflux Pumps Restores Chlorhexidine and Benzalkonium Susceptibility in Acinetobacter baumannii ATCC 19606
  25. Protein with negative surface charge distribution, Bnr1, shows characteristics of a DNA‐mimic protein and may be involved in the adaptation of Burkholderia cenocepacia
  26. A global analysis of conservative and non-conservative mutations in SARS-CoV-2 detected in the first year of the COVID-19 world-wide diffusion
  27. AlphaFold-Predicted Structures of KCTD Proteins Unravel Previously Undetected Relationships among the Members of the Family
  28. A structure-based approach for the development of a bicyclic peptide acting as a miniaturized anti-CD55 antibody
  29. Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation
  30. PE_PGRS3 ensures provision of the vital phospholipids cardiolipin and phosphatidylinositols by promoting the interaction betweenM. tuberculosisand host cells
  31. Thinking Outside the Bug: Targeting Outer Membrane Proteins for Burkholderia Vaccines
  32. PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response
  33. Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral Proteins
  34. Structural features of HtpGMtb and HtpG-ESAT6Mtb vaccine antigens against tuberculosis: Molecular determinants of antigenic synergy and cytotoxicity modulation
  35. PE_PGRS proteins ofMycobacterium tuberculosis: A specialized molecular task force at the forefront of host–pathogen interaction
  36. Structural and Functional Studies of a Klebsiella Phage Capsule Depolymerase Tailspike: Mechanistic Insights into Capsular Degradation
  37. A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping
  38. The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima
  39. Molecular Biomarkers of Disease for Diagnosis and Drug Development
  40. Binding and enzymatic properties of Ageritin, a fungal ribotoxin with novel zinc-dependent function
  41. Structural and dynamic studies provide insights into specificity and allosteric regulation of ribonuclease as, a key enzyme in mycobacterial virulence
  42. Streptococcal Collagen-like Protein 1 Binds Wound Fibronectin: Implications in Pathogen Targeting
  43. Molecular Biomarkers of Disease for Diagnosis and Drug Development
  44. The Cell Wall Hydrolytic NlpC/P60 Endopeptidases in Mycobacterial Cytokinesis: A Structural Perspective
  45. Adaptation of the group A Streptococcus adhesin Scl1 to bind fibronectin type III repeats within wound‐associated extracellular matrix: implications for cancer therapy
  46. Structural and enzymatic properties of Ageritin, a novel metal-dependent ribotoxin-like protein with antitumor activity
  47. Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection
  48. Phage-Borne Depolymerases Decrease Klebsiella pneumoniae Resistance to Innate Defense Mechanisms
  49. Collagen degradation in tuberculosis pathogenesis: the biochemical consequences of hosting an undesired guest
  50. Domain swapping dissection in Thermotoga maritima arginine binding protein: How structural flexibility may compensate destabilization
  51. PASTA sequence composition is a predictive tool for protein class identification
  52. Surface-exposed loops and an acidic patch in the Scl1 protein of group A Streptococcus enable Scl1 binding to wound-associated fibronectin
  53. The novel thermostable cellulose-degrading enzyme DtCel5H from Dictyoglomus thermophilum: crystallization and X-ray crystallographic analysis
  54. A structural overview of mycobacterial adhesins: Key biomarkers for diagnostics and therapeutics
  55. Chemistry of Peptidoglycan in Mycobacterium tuberculosis Life Cycle: An off-the-wall Balance of Synthesis and Degradation
  56. Structural Versatility of Hepatitis C Virus Proteins: Implications for the Design of Novel Anti-HCV Intervention Strategies
  57. Molecular Players in Tuberculosis Drug Development: Another Break in the Cell Wall
  58. Defense Against Pathogens: Structural Insights into the Mechanism of Chitin Induced Activation of Innate Immunity
  59. Editorial: Molecular Scenarios Behind Infectious Diseases
  60. PASTA in Penicillin Binding Proteins and Serine/Threonine Kinases: A Recipe of Structural, Dynamic and Binding Properties
  61. Collagen‐like proteins of pathogenic streptococci
  62. Capsule-Targeting Depolymerase, Derived from Klebsiella KP36 Phage, as a Tool for the Development of Anti-Virulent Strategy
  63. a key bactrial protein that can serve as a vaccine
  64. Use of Hydrolytic Enzymes for Algal Biomass Treatment
  65. Unique Footprint in the scl1.3 Locus Affects Adhesion and Biofilm Formation of the Invasive M3-Type Group A Streptococcus
  66. Structural and dynamic features of PASTA domains with different functional roles
  67. Structure and dynamics of the multi-domain resuscitation promoting factor RpfB from Mycobacterium tuberculosis
  68. Identification of an OmpW homologue in Burkholderia pseudomallei, a protective vaccine antigen against melioidosis
  69. The structure of Resuscitation promoting factor B from M. tuberculosis reveals unexpected ubiquitin-like domains
  70. MAbs against cyclic Epitope I of HCV E2
  71. NMR Structure and Dynamics of the Resuscitation Promoting Factor RpfC Catalytic Domain
  72. A product of RpfB and RipA joint enzymatic action promotes the resuscitation of dormant mycobacteria
  73. Differential thermodynamic behaviours of the extra-cellular regions of two Ser/Thr PrkC kinases revealed by calorimetric studies
  74. Exit from Mycobacterial Dormancy: A Structural Perspective
  75. Antimicrobial Peptides as an Opportunity Against Bacterial Diseases
  76. Structure and Function of RNase AS: A Novel Virulence Factor From Mycobacterium tuberculosis
  77. Editorial (Thematic Issue: Molecular Determinants of Bacterial Diseases)
  78. Chemistry of Lipid A: At the Heart of Innate Immunity
  79. Mutational and structural study of RipA, a key enzyme inMycobacterium tuberculosiscell division: evidence for theL-to-Dinversion of configuration of the catalytic cysteine
  80. A Loose Domain Swapping Organization Confers a Remarkable Stability to the Dimeric Structure of the Arginine Binding Protein from Thermotoga maritima
  81. Structure and Function of RNase AS, a Polyadenylate-Specific Exoribonuclease Affecting Mycobacterial Virulence In Vivo
  82. Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein fromMycobacterium tuberculosis
  83. The Crystal Structure of the Streptococcal Collagen-like Protein 2 Globular Domain from Invasive M3-type Group A Streptococcus Shows Significant Similarity to Immunomodulatory HIV Protein gp41
  84. Chitin-induced activation of immune signaling by the rice receptor CEBiP relies on a unique sandwich-type dimerization
  85. Conformational Modifications of gB from Herpes Simplex Virus Type 1 Analyzed by Synthetic Peptides
  86. Crystallization and preliminary X-ray crystallographic analysis of the variable domain of Scl2.3, a streptococcal collagen-like protein from invasive M3-typeStreptococcus pyogenes
  87. Structures of free and inhibited forms of theL,D-transpeptidase LdtMt1fromMycobacterium tuberculosis
  88. Carbohydrate Recognition by RpfB from Mycobacterium tuberculosis Unveiled by Crystallographic and Molecular Dynamics Analyses
  89. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of theL,D-transpeptidase LdtMt1fromMycobacterium tuberculosis
  90. Molecular determinants of inactivation of the resuscitation promoting factor B fromMycobacterium tuberculosis
  91. Interplay between Peptide Bond Geometrical Parameters in Nonglobular Structural Contexts
  92. Polyproline and Triple Helix Motifs in Host-Pathogen Recognition
  93. Bacterial Cell Division Regulation by Ser/Thr Kinases: A Structural Perspective
  94. Editorial (Hot Topic: Learning from Pathogens: Exploiting Host-Pathogen Liaison for Therapeutic Development)
  95. Editorial (Hot Topic: Cell Processes in Bacterial Diseases)
  96. Structural and Dynamic Properties of Incomplete Immunoglobulin-like Fold Domains
  97. Structural and enzymatic properties of an in vivo proteolytic form of PD-S2, type 1 ribosome-inactivating protein from seeds of Phytolacca dioica L.
  98. Enhanced Crystallizability by Protein Engineering Approaches: A General Overview
  99. Mapping key interactions in the dimerization process of HBHA fromMycobacterium tuberculosis, insights into bacterial agglutination
  100. Chemical Basis of Peptidoglycan Discrimination by PrkC, a Key Kinase Involved in Bacterial Resuscitation from Dormancy
  101. Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms ofThermotoga maritimaarginine-binding protein
  102. Heparin-binding hemagglutinin HBHA from Mycobacterium tuberculosis affects actin polymerisation
  103. Role of Hydration in Collagen Recognition by Bacterial Adhesins
  104. X-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureus
  105. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB fromMycobacterium tuberculosis
  106. Dynamical properties of cold shock protein A from Mycobacterium tuberculosis
  107. Expression, Purification, Crystallization and Preliminary X-Ray Crystallographic Analysis of the Peptidoglycan Binding Region of the Ser/Thr Kinase PrkC from Staphylococcus aureus
  108. Structure and Functional Regulation of RipA, a Mycobacterial Enzyme Essential for Daughter Cell Separation
  109. Nobel Prize in Chemistry 2009: When Biology Turns into Chemistry
  110. Elongation Factors EFIA and EF-Tu: Their Role in Translation and Beyond
  111. Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis : Implications for bacterial agglutination
  112. The role of the glycan moiety on the structure–function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves
  113. Type 1 Ribosome-Inactivating Proteins from the Ombú Tree (Phytolacca dioica L.)
  114. Expression, Purification, Crystallization and Preliminary X-Ray Crystallographic Analysis of the Resuscitation Promoting Factor Interacting Protein RipA from M. tuberculosis
  115. Crystal structure of PD-L1, a ribosome inactivating protein fromPhytolacca dioicaL. Leaves with the property to induce DNA cleavage
  116. Comment onMicrofibrillar structure of type I collagenin situby Orgelet al.(2006),Proc. Natl Acad. Sci. USA,103, 9001–9005
  117. Crystal structure of the collagen triple helix model [(Pro-Pro-Gly)10]3
  118. Molecular dynamics studies of the P pilus rod subunit PapA
  119. Ribosome's mode of function: myths, facts and recent results
  120. Role of side chains in collagen triple helix stabilization and partner recognition
  121. Phase behavior and crystallogenesis under counter-diffusion conditions of the collagen-model peptide (Pro–Pro–Gly)10
  122. Crystal Structure of the Resuscitation-Promoting Factor ΔDUFRpfB from M. tuberculosis
  123. Conformational states and association mechanism of Yersinia pestis Caf1 subunits
  124. Role of hydration in collagen triple helix stabilization
  125. Contribution of dipole-dipole interactions to the stability of the collagen triple helix
  126. Evidence for an Elongated Dimeric Structure of Heparin-Binding Hemagglutinin from Mycobacterium tuberculosis
  127. Atomic resolution (1.1 Å) structure of the ribosome-inactivating protein PD-L4 fromPhytolacca dioicaL. leaves
  128. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor fromMycobacterium tuberculosis
  129. A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis
  130. Crystallization and Preliminary X-Ray Diffraction Analysis of PD-L1, a Highly Glycosylated Ribosome Inactivating Protein with DNase Activity
  131. Fate of prions in soil: Interaction of a recombinant ovine prion protein with synthetic humic-like mineral complexes
  132. Crystallization and Preliminary X-Ray Diffraction Analysis of PD-L4, a Ribosome Inactivating Protein from Phytolacca dioica L. leaves
  133. 23S rRNA 2058A→G Alteration Mediates Ketolide Resistance in Combination with Deletion in L22
  134. Polyproline Helices in Protein Structures: A Statistical Survey
  135. The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH
  136. Limited tendency of α-helical residues to form disulfide bridges: a structural explanation
  137. A crevice adjoining the ribosome tunnel: Hints for cotranslational folding
  138. Functional aspects of ribosomal architecture: symmetry, chirality and regulation
  139. Imino Acids and Collagen Triple Helix Stability:  Characterization of Collagen-like Polypeptides Containing Hyp-Hyp-Gly Sequence Repeats
  140. Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism
  141. Characterization of collagen-like heterotrimers: Implications for triple-helix stability
  142. Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease
  143. Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
  144. Ribosomal crystallography: Peptide bond formation and its inhibition
  145. Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants
  146. On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes. Delivered on 20 October 2002 at the 28th FEBS Meeting in Istanbul
  147. Structural insight into the role of the ribosomal tunnel in cellular regulation
  148. Structural Basis of the Ribosomal Machinery for Peptide Bond Formation, Translocation, and Nascent Chain Progression
  149. Crystallization of the collagen-like polypeptide (PPG)10 aboard the International Space Station. 2. Comparison of crystal quality by X-ray diffraction
  150. Recent Progress on Collagen Triple Helix Structure, Stability and Assembly
  151. Atomic resolution structures of ribonuclease A at six pH values
  152. Video observation of protein crystal growth in the advanced protein crystallization facility aboard the space shuttle mission STS-95
  153. Atomic resolution structure of a mutant of the spectrin SH3 domain
  154. Structural bases of collagen stabilization induced by proline hydroxylation
  155. Effects of microgravity on the crystal quality of a collagen-like polypeptide
  156. Protein titration in the crystal state
  157. Crystallization of multiple forms of bovine seminal ribonuclease in the liganded and unliganded state
  158. Thermodynamic Analysis of α-spectrin SH3 and Two of Its Circular Permutants with Different Loop Lengths:  Discerning the Reasons for Rapid Folding in Proteins,
  159. X-ray crystallographic determination of a collagen-like peptide with the repeating sequence (Pro-Pro-Gly)
  160. Protein Crystal Growth in the Advanced Protein Crystallization Facility on the LMS Mission: a Comparison of Sulfolobus solfataricus Alcohol Dehydrogenase Crystals Grown on the Ground and in Microgravity