All Stories

  1. Membrane Transporters Involved in Iron Trafficking: Physiological and Pathological Aspects
  2. Antioxidant Capacity and NF-kB-Mediated Anti-Inflammatory Activity of Six Red Uruguayan Grape Pomaces
  3. In Silico Analysis of the Structural Dynamics and Substrate Recognition Determinants of the Human Mitochondrial Carnitine/Acylcarnitine SLC25A20 Transporter
  4. A computational study of the structure and function of human Zrt and Irt-like proteins metal transporters: An elevator-type transport mechanism predicted by AlphaFold2
  5. Molecular Characterization of Kunitz-Type Protease Inhibitors from Blister Beetles (Coleoptera, Meloidae)
  6. Insulin-Degrading Enzyme Is a Non Proteasomal Target of Carfilzomib and Affects the 20S Proteasome Inhibition by the Drug
  7. FGDB: a comprehensive graph database of ligand fragments from the Protein Data Bank
  8. Modelling of the Citrus CCD4 Family Members: In Silico Analysis of Membrane Binding and Substrate Preference
  9. Computational studies of the mitochondrial carrier family SLC25. Present status and future perspectives
  10. In Silico Analysis of Huntingtin Homologs in Lower Eukaryotes
  11. Kinetic inequivalence between α and β subunits of ligand dissociation from ferrous nitrosylated human haptoglobin:hemoglobin complexes. A comparison with O2 and CO dissociation
  12. Structural determinants of ligands recognition by the human mitochondrial basic amino acids transporter SLC25A29. Insights from molecular dynamics simulations of the c-state
  13. DockingApp RF: A State-of-the-Art Novel Scoring Function for Molecular Docking in a User-Friendly Interface to AutoDock Vina
  14. Haptoglobin and the related haptoglobin protein: the N-terminus makes the difference
  15. Binding of direct oral anticoagulants to the FA1 site of human serum albumin
  16. Dynamical Behavior of the Human Ferroportin Homologue from Bdellovibrio bacteriovorus: Insight into the Ligand Recognition Mechanism
  17. Structural Basis of Drug Recognition by Human Serum Albumin
  18. Computational Methods for the Identification of Molecular Targets of Toxic Food Additives. Butylated Hydroxytoluene as a Case Study
  19. Contaminations in (meta)genome data: An open issue for the scientific community
  20. Uncovering the structure and function of Pseudomonas aeruginosa periplasmic proteins by an in silico approach
  21. Neonicotinoid trapping by the FA1 site of human serum albumin
  22. Computational methods and tools for binding site recognition between proteins and small molecules: from classical geometrical approaches to modern machine learning strategies
  23. Fragment-Based Ligand-Protein Contact Statistics: Application to Docking Simulations
  24. Oxygen dissociation from ferrous oxygenated human hemoglobin:haptoglobin complexes confirms that in the R-state α and β chains are functionally heterogeneous
  25. Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase
  26. No Lanthanides‐based Catalysis in Eukaryotes
  27. Protein-ligand binding site detection as an alternative route to molecular docking and drug repurposing
  28. An improved structural model of the human iron exporter ferroportin. Insight into the role of pathogenic mutations in hereditary hemochromatosis type 4
  29. LIBRA-WA: a web application for ligand binding site detection and protein function recognition
  30. Neuroglobin and friends
  31. DockingApp: a user friendly interface for facilitated docking simulations with AutoDock Vina
  32. Nitrophorins and nitrobindins: structure and function
  33. In silico study of the structure and function of Streptococcus mutans plasmidic proteins
  34. The key role played by charge in the interaction of cytochrome c with cardiolipin
  35. Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin
  36. Peptidomimetic Targeting of Cavβ2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac FunctionClinical Perspective
  37. The plastoquinol–plastoquinone exchange mechanism in photosystem II: insight from molecular dynamics simulations
  38. Stability of spermine oxidase to thermal and chemical denaturation: comparison with bovine serum amine oxidase
  39. Selective binding of estrogen receptor α to ubiquitin chains
  40. Molecular Evolution of Alternative Oxidase Proteins: A Phylogenetic and Structure Modeling Approach
  41. Nitrobindin: An Ubiquitous Family of Allβ-Barrel Heme-proteins
  42. Resveratrol and its methoxy-derivatives as modulators of DNA damage induced by ionising radiation
  43. The human iron exporter ferroportin. Insight into the transport mechanism by molecular modeling
  44. Molecular models of human visual pigments: insight into the atomic bases of spectral tuning
  45. All- trans -retinoic acid and retinol binding to the FA1 site of human serum albumin competitively inhibits heme-Fe(III) association
  46. A bacterial homologue of the human iron exporter ferroportin
  47. Different disulfide bridge connectivity drives alternative folds in highly homologousBrassicaceaetrypsin inhibitors
  48. Enhanced heme accessibility in horse heart mini-myoglobin: Insights from molecular modelling and reactivity studies
  49. LIBRA: LIgand Binding site Recognition Application
  50. Functional and Spectroscopic Characterization of Chlamydomonas reinhardtii Truncated Hemoglobins
  51. Pacific oyster polyamine oxidase: a protein missing link in invertebrate evolution
  52. Cardiolipin-cytochromeccomplex: Switching cytochromecfrom an electron-transfer shuttle to a myoglobin- and a peroxidase-like heme-protein
  53. Imatinib binding to human serum albumin modulates heme association and reactivity
  54. The Glu 216 /Ser 218 pocket is a major determinant of spermine oxidase substrate specificity
  55. Role of Intermediate States in Protein Folding and Misfolding
  56. Cardiolipin modulates allosterically the nitrite reductase activity of horse heart cytochrome c
  57. A structural model of human ferroportin and of its iron binding site
  58. Role of Cardiolipin in Mitochondrial Diseases and Apoptosis
  59. Structure/Function/Dynamics of Photosystem II Plastoquinone Binding Sites
  60. Polar Localization of PhoN2, a Periplasmic Virulence-Associated Factor of Shigella flexneri, Is Required for Proper IcsA Exposition at the Old Bacterial Pole
  61. Role of Intermediate States in Protein Folding and Misfolding
  62. ASSIST: a fast versatile local structural comparison tool
  63. Non-covalent and covalent modifications modulate the reactivity of monomeric mammalian globins
  64. Role of Lysines in Cytochrome c –Cardiolipin Interaction
  65. Structure–Function Relationships in the Evolutionary Framework of Spermine Oxidase
  66. Reactivity of the human hemoglobin “Dark side”
  67. Design and biophysical characterization of atrazine-sensing peptides mimicking the Chlamydomonas reinhardtii plastoquinone binding niche
  68. Cyanide binding to human plasma heme–hemopexin: A comparative study
  69. A Knowledge Discovery Methodology for Semantic Categorization of Unstructured Textual Sources
  70. GA/GB fold switching may modulate fatty acid transfer from human serum albumin to bacteria
  71. GA/GB Fold switching may modulate fatty acid transfer from human serum albumin to bacteria
  72. Recombinant expression and insecticidal properties of a Conus ventricosus conotoxin-GST fusion protein
  73. Conversion of cytochrome c into a peroxidase: Inhibitory mechanisms and implication for neurodegenerative diseases
  74. Do Natural Proteins Differ from Random Sequences Polypeptides? Natural vs. Random Proteins Classification Using an Evolutionary Neural Network
  75. Cupricyclins, Novel Redox-Active Metallopeptides Based on Conotoxins Scaffold
  76. Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine
  77. Resveratrol acts as a topoisomerase II poison in human glioma cells
  78. Automatic Protein Abbreviations Discovery and Resolution from Full-Text Scientific Papers: The PRAISED Framework
  79. Molecular evolution of the polyamine oxidase gene family in Metazoa
  80. The effects of ATP and sodium chloride on the cytochrome c–cardiolipin interaction: The contrasting behavior of the horse heart and yeast proteins
  81. PS1-045. The conserved acidic cluster domain of HIV-1 Nef is required to induces a proinflammatory state in primary macrophages: involvement of TNF alpha Receptor Associated Factor 2
  82. HIV-1 Nef Induces Proinflammatory State in Macrophages through Its Acidic Cluster Domain: Involvement of TNF Alpha Receptor Associated Factor 2
  83. Spermine oxidase: ten years after
  84. A framework for semi-automatic identification, disambiguation and storage of protein-related abbreviations in scientific literature
  85. Xenosensors CAR and PXR at Work: Impact on Statin Metabolism
  86. Cardiolipin drives cytochrome c proapoptotic and antiapoptotic actions
  87. The structure of maize polyamine oxidase K300M mutant in complex with the natural substrates provides a snapshot of the catalytic mechanism of polyamine oxidation
  88. Directed Evolution and In Silico Analysis of Reaction Centre Proteins Reveal Molecular Signatures of Photosynthesis Adaptation to Radiation Pressure
  89. Computational Biology, Protein Engineering, and Biosensor Technology: a Close Cooperation for Herbicides Monitoring
  90. Experimentation of an automatic resolution method for protein abbreviations in full-text papers
  91. An Automatic Identification and Resolution System for Protein-Related Abbreviations in Scientific Papers
  92. Cytochromes: Reactivity of the “dark side” of the heme
  93. Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm
  94. Probing mammalian spermine oxidase enzyme–substrate complex through molecular modeling, site-directed mutagenesis and biochemical characterization
  95. Role of External Loops of Human Ceruloplasmin in Copper Loading by ATP7B and Ccc2p
  96. Extended cardiolipin anchorage to cytochrome c: a model for protein–mitochondrial membrane binding
  97. In silico Structural Study of Random Amino Acid Sequence Proteins Not Present in Nature
  98. Structure-based design of novelChlamydomonas reinhardtiiD1-D2 photosynthetic proteins for herbicide monitoring
  99. ATP Acts as a Regulatory Effector in Modulating Structural Transitions of Cytochrome c : Implications for Apoptotic Activity †
  100. Spermine Metabolism and Anticancer Therapy
  101. Cupryphans, metal-binding, redox active, redesigned conopeptides
  102. Massive non-natural proteins structure prediction using grid technologies
  103. Structural determinants of trypsin affinity and specificity for cationic inhibitors
  104. Dominant Mutants of Ceruloplasmin Impair the Copper Loading Machinery in Aceruloplasminemia
  105. Never born proteins as a test case for ab initio protein structures prediction
  106. Human haptoglobin structure and function - a molecular modelling study
  107. S-Glutathionylation of metallothioneins by nitrosative/oxidative stress
  108. The R215W mutation in NBS1 impairs γ-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients
  109. Characterization of a Lysine-Specific Histone Demethylase from Arabidopsis thaliana†
  110. Conus ventricosusvenom peptides profiling by HPLC-MS: A new insight in the intraspecific variation
  111. Probing the Effect of Mutations on Cytochrome c Stability
  112. Nanoscopic and Redox Characterization of Engineered Horse Cytochrome c Chemisorbed on a Bare Gold Electrode
  113. The Pseudomonas Quorum-Sensing Regulator RsaL Belongs to the Tetrahelical Superclass of H-T-H Proteins
  114. The Production ofde novo Folded Proteins by a Stepwise Chain Elongation: A Model for Prebiotic Chemical Evolution of Macromolecular Sequences
  115. Investigation ofde novo Totally Random Biosequences, Part II
  116. Heterologous Expression and Biochemical Characterization of a Polyamine Oxidase from Arabidopsis Involved in Polyamine Back Conversion
  117. Nitrosative/oxidative modifications and ageing
  118. Inhibition of polyamine and spermine oxidases by polyamine analogues
  119. The Quorum-Sensing Negative Regulator RsaL of Pseudomonas aeruginosa Binds to the lasI Promoter
  120. Lys300 Plays a Major Role in the Catalytic Mechanism of Maize Polyamine Oxidase †
  121. Structural Consensus Rules for Cysteine Protease Inhibition by NO(-Donors)
  122. Mitochondrial type I nitric oxide synthase physically interacts with cytochrome c oxidase
  123. Two short protein domains are responsible for the nuclear localization of the mouse spermine oxidase µ isoform
  124. Allosteric modulation of monomeric proteins
  125. Probing the Cruzain S2Recognition Subsite:  A Kinetic and Binding Energy Calculation Study†
  126. Proteolytic activity of bovine lactoferrin
  127. 1H NMR relaxometric characterization of bovine lactoferrin
  128. Proteolytic activity of bovine lactoferrin
  129. Interleukin-1β up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis
  130. Solution structure of the cyclic peptide contryphan-Vn, a Ca2+-dependent K+channel modulator
  131. Molecular Basis for the Binding of Competitive Inhibitors of Maize Polyamine Oxidase †
  132. Mouse spermine oxidase gene splice variants
  133. The Rhodococcus sp. Cocaine Esterase: A Bacterial Candidate for Novel Pharmacokinetic-based Therapies for Cocaine Abuse
  134. AtCYS1, a cystatin from Arabidopsis thaliana, suppresses hypersensitive cell death
  135. Contryphan-Vn: a modulator of Ca2+-dependent K+ channels
  136. Heterologous Expression and Characterization of Mouse Spermine Oxidase
  137. Heme, chlorophyll, and bilins: Methods and protocols: Smith, A. G., Witty, M. (eds.)
  138. Contryphan-Vn: A Novel Peptide from the Venom of the Mediterranean Snail Conus ventricosus
  139. A barley polyamine oxidase isoform with distinct structural features and subcellular localization
  140. Inhibition of Cysteine Protease Activity by NO-donors
  141. Modulation of the catalytic activity of cruzipain, the major cysteine proteinase from Trypanosoma cruzi , by temperature and pH
  142. Time-resolved X-ray crystallography: uncovering reaction intermediates in biochemical processes
  143. Structural determinants of mini-protein stability
  144. Inhibition ofSaccharomyces cerevisiaePhosphomannose Isomerase by the NO-donor S-nitroso-acetyl-penicillamine
  145. Structural determinants of mini-protein stability
  146. Time-resolved X-ray crystallography: uncovering reaction intermediates in biochemical processes
  147. Characterization of five new low-molecular-mass trypsin inhibitors from white mustard (Sinapis alba L.) seed
  148. Modulation of the Nitric Oxide Pathway by Copper in Glial Cells
  149. A Chimeric Mini-Trypsin Inhibitor Derived from the Oil Rape Proteinase Inhibitor Type III
  150. Re-Evaluation of Amino Acid Sequence and Structural Consensus Rules for Cysteine-Nitric Oxide Reactivity
  151. Serine proteinase inhibition by the active site titrant N α-(N,N-dimethylcarbamoyl)-α-azaornithine p-nitrophenyl ester
  152. The T-Knot Motif Revisited
  153. Nitric Oxide Inhibits the HIV-1 Reverse Transcriptase Activity
  154. Structure/Function Relationships in Ceruloplasmin
  155. Role of the electrostatic loop charged residues in Cu, Zn superoxide dismutase
  156. Effect of Val 73 → Trp Mutation on the Reaction of “Cambialistic” Superoxide Dismutase fromPropionibacterium shermaniiwith Hydrogen Peroxide
  157. Effect of Lys175 mutation on structure function properties of Propionibacterium shermanii superoxide dismutase
  158. Characterization of Cu,Zn Superoxide Dismutase from the Bathophile Fish, Lampanyctus crocodilus
  159. Amino Acid Sequence of Chicken Cu, Zn-Containing Superoxide Dismutase and Identification of Glutathionyl Adducts at Exposed Cysteine Residues
  160. Identification of the residues responsible for the alkaline inhibition of Cu, Zn superoxide dismutase: A site-directed mutagenesis approach
  161. Effect of Lys→Arg mutation on the thermal stability of Cu,Zn superoxide dismutase: influence on the monomer–dimer equilibrium
  162. Low-temperature optical spectroscopy of cobalt in Cu,Co superoxide dismutase: a structural dynamics study of the solvent-unaccessible metal site
  163. Identification of the Residues Responsible for the Alkaline Inhibition of the Activity of Cu,Zn Superoxide Dismutase: A Study of Native and Chemically Modified Enzymes
  165. Modulation of the Catalytic Rate of Cu,Zn Superoxide Dismutase in Single and Double Mutants of Conserved Positively and Negatively Charged Residues
  166. Modelling the three-dimensional structure and the electrostatic potential field of two Cu,Zn superoxide dismutase variants from tomato leaves
  167. Low-Temperature Optical Spectroscopy of Native and Azide-Reacted Bovine Cu,Zn Superoxide Dismutase. A Structural Dynamics Study
  168. Simulation of superoxide-superoxide dismutase association rate for six natural variants. Comparison with the experimental catalytic rate
  169. Mutation of Lys-120 and Lys-134 drastically reduces the catalytic rate of Cu,Zn superoxide dismutase
  170. Crystal structure of the cyanide-inhibited Xenopus laevis Cu,Zn superoxide dismutase at 98 K
  171. Crystallographic Study of Azide-inhibited Bovine Cu,Zn Superoxide Dismutase
  172. Crystallization and Preliminary Crystallographic Analysis of Recombinant Xenopus laevis Cu, Zn Superoxide Dismutase b
  173. Electrostatic Recognition in Redox Copper Proteins: A 1H NMR Study of the Protonation Behavior of His 19 in Oxidized and Reduced Cu,Zn Superoxide Dismutase
  174. An electrostatic enzyme-substrate recognition: the case of Cu, Zn superoxide dismutase
  175. Evolutionary conservativeness of electric field in the Cu,Zn superoxide dismutase active site
  176. Involvement of the Copper in the Inhibition of Cu, Zn Superoxide Dismutase Activity at high pH
  177. The Cu,Zn superoxide dismutase isoenzymes of Xenopus laevis: Purification, identification of a heterodimer and differential heat sensitivity
  178. Substitution of arginine for lysine 134 alters electrostatic parameters of the active site in shark Cu,Zn superoxide dismutase
  179. Porting Biological Applications in Grid: An Experience within the EUChinaGRID Framework