All Stories

  1. 2.1 Electrophilic Fluorinating Agents

    Article • January 2026, Thieme Publishing Group

    Professor Norio Shibata

  2. High-valent sulfur fluorides as reactivity switches for PFAS-free benzene–azepine skeletal editing

    Article • Chemical Science, January 2026, Royal Society of Chemistry

    Professor Norio Shibata

  3. N -Difluoroacetylation of Sulfoximines by TFEDMA

    Article • Organic Letters, October 2025, American Chemical Society (ACS)

    Professor Norio Shibata

  4. Cu-Catalyzed SF 4 -Alkynylation of Quinolones, Chromones and Cyclohexenones

    Article • Organic Letters, October 2025, American Chemical Society (ACS)

    Professor Norio Shibata

  5. From Refrigerant to Reagent: Repurposing HFC-125 into Inorganic and Organic Fluorinating Agents

    Article • Organic Letters, September 2025, American Chemical Society (ACS)

    Professor Norio Shibata

  6. Recent Advances on Catalytic Asymmetric Synthesis of Molecules Bearing a Fluorine-Containing Stereogenic Carbon Center (2015–2024)

    Article • Chemical Reviews, August 2025, American Chemical Society (ACS)

    Professor Norio Shibata

  7. Room-temperature defluorination of PTFE and PFAS via sodium dispersion

    Article • Nature Communications, July 2025, Springer Science + Business Media

    Professor Norio Shibata

  8. Mechanochemical pathway for converting fluoropolymers to fluorochemicals

    Article • Nature Chemistry, June 2025, Springer Science + Business Media

    Professor Norio Shibata

  9. Synthesis of Silylmethyl gem-Difluoroalkenes via Room-Temperature Catalytic Defluorosilylation of Trifluoromethylalkenes

    Article • The Journal of Organic Chemistry, June 2025, American Chemical Society (ACS)

    Professor Norio Shibata

  10. Breaking the Strongest Organic Bonds by Water: Defluorosubstitutions at the Air–Water Interface of Microdroplets

    Article • Journal of the American Chemical Society, June 2025, American Chemical Society (ACS)

    Professor Norio Shibata

  11. Repurposing HFC-125 to tetrafluoroethylene: A step toward a more sustainable fluoropolymer feedstock strategy

    Article • iScience, June 2025, Elsevier

    Professor Norio Shibata

  12. Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications

    Article • Chemical Reviews, April 2025, American Chemical Society (ACS)

    Professor Norio Shibata

  13. How Temperature Change Affects the Lattice Parameters, Molecular Conformation, and Reaction Cavity in Enantiomeric and Racemic Crystals of Thalidomide

    Article • Journal of the American Chemical Society, March 2025, American Chemical Society (ACS)

    Professor Norio Shibata

  14. Discovering Key Activation Hotspots in the M2 Muscarinic Receptor

    Article • Journal of the American Chemical Society, March 2025, American Chemical Society (ACS)

    Professor Norio Shibata

  15. Radical trifluoromethoxylation of fluorinated alkenes for accessing difluoro(trifluoromethoxy)methyl groups

    Article • Chemical Science, January 2025, Royal Society of Chemistry

    Professor Norio Shibata

  16. Chemoselective Cu-catalyzed acylsilylation of vinyl arenes using silylboronates and acyl fluorides

    Article • Chemical Science, January 2025, Royal Society of Chemistry

    Professor Norio Shibata

  17. Sequential Michael addition, cross-coupling and [3 + 2] cycloaddition reactions within the coordination sphere of chiral Ni(ii) Schiff base complexes derived from dehydroamino acids: pathways to the asymmetric synthesis of structurally diver...

    Article • RSC Advances, January 2025, Royal Society of Chemistry

    Professor Norio Shibata

  18. Synthesis of Ngai Reagent and Longer Carbon Chain Variants for Perfluoroalkoxylations

    Article • Organic Letters, December 2024, American Chemical Society (ACS)

    Professor Norio Shibata

  19. Stereodivergent Hydrohalogenation of SCF3 Alkynes and Cross- Coupling Reactions

    Article • Organic Letters, October 2024, American Chemical Society (ACS)

    Professor Norio Shibata

  20. TBHP Promotes Cross-Dehydrogenative Coupling of SF4 Alkynes with Tetrahydroisoquinolines under Copper Catalysis

    Article • Organic Letters, August 2024, American Chemical Society (ACS)

    Professor Norio Shibata

  21. Mechanochemical Deoxyfluorination of Carboxylic Acids to Acyl Fluorides and Successive Mechanochemical Amide Bond Formation

    Article • ACS Sustainable Chemistry & Engineering, February 2024, American Chemical Society (ACS)

    Professor Norio Shibata

  22. Cross Dehydrogenative Coupling of SF4-Alkyne with Tetrahydroisoquinolines

    Article • Organic Letters, February 2024, American Chemical Society (ACS)

    Professor Norio Shibata

  23. Transition‐Metal‐Free Approach for Z‐Vinyl Fluorides by Hydrofluorination of Alkynes bearing SF4 and SF5 Groups

    Article • Angewandte Chemie, January 2024, Wiley

    Professor Norio Shibata

  24. Transition‐Metal‐Free Approach for Z‐Vinyl Fluorides by Hydrofluorination of Alkynes bearing SF4 and SF5 Groups

    Article • Angewandte Chemie, January 2024, Wiley

    Professor Norio Shibata

  25. A silylboronate-mediated strategy for cross-coupling of alkyl fluorides with aryl alkanes: mechanistic insights and scope expansion

    Article • Chemical Science, January 2024, Royal Society of Chemistry

    Professor Norio Shibata

  26. Cross-coupling of organic fluorides with allenes: a silyl-radical-relay pathway for the construction of α-alkynyl-substituted all-carbon quaternary centres

    Article • Chemical Science, January 2024, Royal Society of Chemistry

    Professor Norio Shibata

  27. Halo-perfluoroalkoxylation of gem-difluoroalkenes with short-lived alkali metal perfluoroalkoxides in triglyme

    Article • Chemical Science, January 2024, Royal Society of Chemistry

    Professor Norio Shibata

  28. Expanding the Frontier of Linear Drug Design: Cu‐Catalyzed Csp–Csp3‐Coupling of Electron‐Deficient SF4‐Alkynes with Alkyl Iodides

    Article • Advanced Science, December 2023, Wiley

    Professor Norio Shibata

  29. Preface to the Special Issue on Fluorine Chemistry

    Article • The Chemical Record, August 2023, Wiley

    Professor Norio Shibata

  30. Regio‐ and Z‐Selective Alkyne Hydroamination and Hydrophenoxylation using Tetrafluoro‐λ6‐Sulfanyl Alkynes under Superbasic, Naked Anion Conditions

    Article • Angewandte Chemie, July 2023, Wiley

    Professor Norio Shibata

  31. Regio‐ and Z‐Selective Alkyne Hydroamination and Hydrophenoxylation using Tetrafluoro‐λ6‐Sulfanyl Alkynes under Superbasic, Naked Anion Conditions

    Article • Angewandte Chemie, July 2023, Wiley

    Professor Norio Shibata

  32. Current State of Microflow Trifluoromethylation Reactions

    Article • The Chemical Record, June 2023, Wiley

    Professor Norio Shibata

  33. Fluorinated Vilsmeier Reagent: TFEDMA‐mediated Synthesis of Aryl‐cyanides and Aryl‐amides via the Activation of Oximes†

    Article • Asian Journal of Organic Chemistry, May 2023, Wiley

    Professor Norio Shibata

  34. N‐Fluoro Ammonium Salts of Cinchona Alkaloids in Enantioselective Electrophilic Fluorination

    Article • The Chemical Record, April 2023, Wiley

    Professor Norio Shibata

  35. Elemental Sulfur-Mediated Transformation of Carboxylic Acids to Acyl Fluorides by Electrophilic Fluorinating Reagent, Selectfluor

    Article • Organic Letters, April 2023, American Chemical Society (ACS)

    Professor Norio Shibata

  36. Transition-metal-free silylboronate-mediated cross-couplings of organic fluorides with amines

    Article • Nature Communications, April 2023, Springer Science + Business Media

    Professor Norio Shibata

  37. Synthesis, Characterization, and Study of Catalytic Activity of Chiral Cu(II) and Ni(II) Salen Complexes in the α-Amino Acid C-α Alkylation Reaction

    Article • Molecules, January 2023, MDPI AG

    Professor Norio Shibata, Vladimir Larionov

  38. Synthesis of triarylmethanes by silyl radical-mediated cross-coupling of aryl fluorides and arylmethanes

    Article • Chemical Science, January 2023, Royal Society of Chemistry

    Professor Norio Shibata

  39. Lenalidomide Derivative and PROTAC for Controlling Neosubstrate Degradation

    Article • November 2022, Research Square

    Professor Masaru Tanokura, Professor Norio Shibata

  40. KHMDS/Triglyme Cryptate as an Alternative to Phosphazene Base in Stereodivergent Pentafluoroethylation of N-Sulfinylimines Using HFC-125

    Article • The Journal of Organic Chemistry, October 2022, American Chemical Society (ACS)

    Professor Norio Shibata

  41. Unusual Photoisomerization Pathway in a Near-Infrared Light Absorbing Enzymerhodopsin

    Article • The Journal of Physical Chemistry Letters, October 2022, American Chemical Society (ACS)

    Professor Norio Shibata

  42. Etherification of Fluoroarenes with Alkoxyboronic Acid Pinacol Esters via C–F Bond Cleavage

    Article • Organic Letters, July 2022, American Chemical Society (ACS)

    Professor Norio Shibata

  43. Synthesis of Pyridine–SF4–Isoxazolines Using the Functionality of trans-Tetrafluoro-λ6-sulfanyl Rodlike Linkers

    Article • Organic Letters, April 2022, American Chemical Society (ACS)

    Professor Norio Shibata

  44. Regioselective Synthesis of Pyridine-SF4-Methyl Ketones via Hydration of Pyridine-SF4-Alkynes

    Article • Organic Letters, April 2022, American Chemical Society (ACS)

    Professor Norio Shibata

  45. Ethynyl-SF4-Pyridines: Reagents for SF4-Alkynylation to Carbonyl Compounds

    Article • The Journal of Organic Chemistry, April 2022, American Chemical Society (ACS)

    Professor Norio Shibata

  46. Enantio‐, Diastereo‐ and Regioselective Synthesis of Chiral Cyclic and Acyclic gem‐Difluoromethylenes by Palladium‐Catalyzed [4+2] Cycloaddition

    Article • Angewandte Chemie, April 2022, Wiley

    Professor Norio Shibata

  47. Enantio‐, Diastereo‐ and Regioselective Synthesis of Chiral Cyclic and Acyclic gem‐Difluoromethylenes by Palladium‐Catalyzed [4+2] Cycloaddition

    Article • Angewandte Chemie, April 2022, Wiley

    Professor Norio Shibata

  48. Synthesis of an Eccentric Electron-Deficient Fluorinated Motif, Tetrafluoro-λ6-sulfanyl gem-Difluorocyclopropenes

    Article • Organic Letters, February 2022, American Chemical Society (ACS)

    Professor Norio Shibata

  49. A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues

    Article • Nature Communications, January 2022, Springer Science + Business Media

    Professor Norio Shibata

  50. Construction of poly-N-heterocyclic scaffolds via the controlled reactivity of Cu-allenylidene intermediates

    Article • Communications Chemistry, November 2021, Springer Science + Business Media

    Professor Norio Shibata

  51. Catalyst-free carbosilylation of alkenes using silyl boronates and organic fluorides via selective C-F bond activation

    Article • Nature Communications, June 2021, Springer Science + Business Media

    Professor Norio Shibata

  52. Diastereodivergent Synthesis of Chiral 4-Fluoropyrrolidines (exo and exo′) Based on the Cu(II)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition

    Article • The Journal of Organic Chemistry, June 2021, American Chemical Society (ACS)

    Professor Norio Shibata

  53. Pentafluoroethylation of Carbonyl Compounds Using HFC-125 in a Flow Microreactor System

    Article • The Journal of Organic Chemistry, June 2021, American Chemical Society (ACS)

    Professor Norio Shibata

  54. Synthesis of Tetra‐Substituted Trifluoromethyl‐3,1‐Benzoxazines by Transition‐Metal‐Catalyzed Decarboxylative Cyclization of N‐Benzoyl Benzoxazinones

    Article • ChemistryOpen, May 2021, Wiley

    Professor Norio Shibata

  55. Pentafluoroethylation of Carbonyl Compounds by HFC-125 via the Encapsulation of the K Cation with Glymes

    Article • The Journal of Organic Chemistry, March 2021, American Chemical Society (ACS)

    Professor Norio Shibata

  56. Synthesis of Difluoromethanesulfinate Esters by the Difluoromethanesulfinylation of Alcohols

    Article • Organic Letters, March 2021, American Chemical Society (ACS)

    Professor Norio Shibata

  57. Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system

    Article • Beilstein Journal of Organic Chemistry, February 2021, Beilstein Institut

    Professor Norio Shibata

  58. Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF

    Article • The EMBO Journal, January 2021, Springer Science + Business Media

    Professor Norio Shibata

  59. Acyl Fluorides from Carboxylic Acids, Aldehydes, or Alcohols under Oxidative Fluorination

    Article • Organic Letters, January 2021, American Chemical Society (ACS)

    Professor Norio Shibata

  60. Transition‐Metal Free Catalytic Synthesis of Trifluoromethyl Indolines by [4+1] Cycloaddition of Trifluoromethyl Benzoxazinones with Sulfur Ylides

    Article • Helvetica Chimica Acta, January 2021, Wiley

    Professor Norio Shibata

  61. Vibrational analysis of acetylcholine binding to the M2 receptor

    Article • RSC Advances, January 2021, Royal Society of Chemistry

    Professor Norio Shibata

  62. Deoxyfluorination of acyl fluorides to trifluoromethyl compounds by FLUOLEAD®/Olah’s reagent under solvent-free conditions

    Article • Beilstein Journal of Organic Chemistry, December 2020, Beilstein Institut

    Professor Norio Shibata

  63. Modular Synthesis of Medium-Sized Fluorinated and Nonfluorinated Heterocyclic Lactones by Sequential CN-Bond-Cleaving Ring Expansion under Pd Catalysis

    Article • ACS Catalysis, November 2020, American Chemical Society (ACS)

    Professor Norio Shibata

  64. Synthesis of Chiral gem-Difluoromethylene Compounds by Enantioselective Ethoxycarbonyldifluoromethylation of MBH Fluorides via Silicon-Assisted C–F Bond Activation

    Article • The Journal of Organic Chemistry, November 2020, American Chemical Society (ACS)

    Professor Norio Shibata

  65. Design and Synthesis of a Chiral Halogen-Bond Donor with a Sp3-Hybridized Carbon–Iodine Moiety in a Chiral Fluorobissulfonyl Scaffold

    Article • Molecules, October 2020, MDPI AG

    Professor Norio Shibata

  66. An IMiD-induced SALL4 degron system for selective degradation of target proteins

    Article • Communications Biology, September 2020, Springer Science + Business Media

    Professor Norio Shibata

  67. Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide

    Article • Nature Communications, September 2020, Springer Science + Business Media

    Professor Masaru Tanokura, Professor Norio Shibata

  68. Current Contributions of Organofluorine Compounds to the Agrochemical Industry

    Article • iScience, September 2020, Elsevier

    Professor Norio Shibata

  69. Diastereoselective Synthesis of Enantioenriched Trifluoromethylated Ethylenediamines and Isoindolines Containing Two Stereogenic Carbon Centers by Nucleophilic Trifluoromethylation Using HFC-23

    Article • The Journal of Organic Chemistry, May 2020, American Chemical Society (ACS)

    Professor Norio Shibata

  70. Pd-catalyzed fluoro-carbonylation of aryl, vinyl, and heteroaryl iodides using 2-(difluoromethoxy)-5-nitropyridine

    Article • Communications Chemistry, May 2020, Springer Science + Business Media

    Professor Norio Shibata

  71. Contribution of Organofluorine Compounds to Pharmaceuticals

    Article • ACS Omega, April 2020, American Chemical Society (ACS)

    Professor Norio Shibata

  72. Two Catalytic Annulation Modes via Cu-Allenylidenes with Sulfur Ylides that Are Dominated by the Presence or Absence of Trifluoromethyl Substituents

    Article • iScience, April 2020, Elsevier

    Professor Norio Shibata

  73. Synthesis of Both Enantiomers of Nine‐Membered CF3‐Substituted Heterocycles Using a Single Chiral Ligand: Palladium‐Catalyzed Decarboxylative Ring Expansion with Kinetic Resolution

    Article • Angewandte Chemie, March 2020, Wiley

    Professor Norio Shibata

  74. Synthesis of Both Enantiomers of Nine‐Membered CF3‐Substituted Heterocycles Using a Single Chiral Ligand: Palladium‐Catalyzed Decarboxylative Ring Expansion with Kinetic Resolution

    Article • Angewandte Chemie, March 2020, Wiley

    Professor Norio Shibata

  75. Synthesis of Highly Functionalized 12-Membered Trifluoromethyl Heterocycles via a Nondecarboxylative Pd-Catalyzed [6 + 6] Annulation

    Article • ACS Catalysis, January 2020, American Chemical Society (ACS)

    Professor Norio Shibata

  76. Pyridine tetrafluoro-λ6-sulfanyl chlorides: spontaneous addition to alkynes and alkenes in the presence or absence of photo-irradiation

    Article • Organic Chemistry Frontiers, January 2020, Royal Society of Chemistry

    Professor Norio Shibata

  77. Selective synthesis of spirobiindanes, alkenyl chlorides, and monofluoroalkenes from unactivated gem-difluoroalkanes controlled by aluminum-based Lewis acids

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Professor Norio Shibata

  78. Studies of Halogen Bonding Induced by Pentafluorosulfanyl Aryl Iodides: A Potential Group of Halogen Bond Donors in a Rational Drug Design

    Article • Molecules, October 2019, MDPI AG

    Professor Norio Shibata

  79. Studies of Halogen Bonding Induced by Pentafluorosulfanyl Aryl Iodides: A Potential Group of Halogen Bond Donors in a Rational Drug Design

    Article • August 2019, MDPI AG

    Professor Norio Shibata

  80. Enantioselective Benzylation and Allylation of α-Trifluoromethoxy Indanones under Phase-Transfer Catalysis

    Article • Molecules, July 2019, MDPI AG

    Professor Norio Shibata

  81. Enantioselective Benzylation and Allylation of α-Trifluoromethoxy Indanones under Phase-Transfer Catalysis

    Article • July 2019, MDPI AG

    Professor Norio Shibata

  82. Activation of Saturated Fluorocarbons to Synthesize Spirobiindanes, Monofluoroalkenes, and Indane Derivatives

    Article • iScience, July 2019, Elsevier

    Professor Norio Shibata

  83. Cover Feature: Catalytic Desymmetrization of 1,3‐Difluoropropan‐2‐ols via C−F Bond Activation Using a Phosphazene Base Affords Monofluoromethyl‐Substituted Epoxides (Asian J. Org. Chem. 5/2019)

    Article • Asian Journal of Organic Chemistry, May 2019, Wiley

    Professor Norio Shibata

  84. The story of SF5-substituted pyridines

    Article • Phosphorus Sulfur and Silicon and the Related Elements, April 2019, Taylor & Francis

    Professor Norio Shibata

  85. Catalytic Desymmetrization of 1,3‐Difluoropropan‐2‐ols via C−F Bond Activation Using a Phosphazene Base Affords Monofluoromethyl‐Substituted Epoxides

    Article • Asian Journal of Organic Chemistry, April 2019, Wiley

    Professor Norio Shibata

  86. Front Cover: Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines (ChemistryOpen 4/2019)

    Article • ChemistryOpen, March 2019, Wiley

    Professor Norio Shibata

  87. Pd-Catalyzed Decarboxylative Cyclization of Trifluoromethyl Vinyl Benzoxazinanones with Sulfur Ylides: Access to Trifluoromethyl Dihydroquinolines

    Article • Organic Letters, February 2019, American Chemical Society (ACS)

    Professor Norio Shibata

  88. Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines

    Article • ChemistryOpen, February 2019, Wiley

    Professor Norio Shibata

  89. Asymmetric Electrophilic Difluoromethylthiolation of Indanone-Based β-Keto Esters Using Difluoromethanesulfonyl Hypervalent Iodonium Ylides

    Article • Molecules, January 2019, MDPI AG

    Professor Norio Shibata

  90. Synthesis of aryl and heteroaryl tetrafluoro-λ6-sulfanyl chlorides from diaryl disulfides using trichloroisocyanuric acid and potassium fluoride

    Article • Organic Chemistry Frontiers, January 2019, Royal Society of Chemistry

    Professor Norio Shibata

  91. Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers

    Article • Scientific Reports, November 2018, Springer Science + Business Media

    Professor Norio Shibata

  92. Synthesis of Chiral Nonracemic α-Difluoromethylthio Compounds with Tetrasubstituted Stereogenic Centers via a Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation

    Article • Organic Letters, November 2018, American Chemical Society (ACS)

    Professor Norio Shibata

  93. Defluorosilylation of fluoroarenes and fluoroalkanes

    Article • Nature Communications, October 2018, Springer Science + Business Media

    Professor Norio Shibata

  94. Super-Sensitive Protonation Behavior of Trifluoroethoxy-Substituted Phthalocyanines and Their Application to Solvent Discrimination

    Article • ACS Omega, September 2018, American Chemical Society (ACS)

    Professor Norio Shibata

  95. Direct nucleophilic trifluoromethylation of carbonyl compounds by potent greenhouse gas, fluoroform: Improving the reactivity of anionoid trifluoromethyl species in glymes

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Professor Norio Shibata

  96. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

    Article • Nature Communications, July 2018, Springer Science + Business Media

    PhD Isao Naguro, Professor Norio Shibata

  97. Fluorobissulfonylmethyl Iodides: An Efficient Scaffold for Halogen Bonding Catalysts with an sp3-Hybridized Carbon–Iodine Moiety

    Article • ACS Catalysis, June 2018, American Chemical Society (ACS)

    Professor Norio Shibata

  98. Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

    Article • Chemical Reviews, April 2018, American Chemical Society (ACS)

    Professor Norio Shibata, Dr Jianlin Han

  99. Highly Diastereoselective Synthesis of Trifluoromethyl Indolines by Interceptive Benzylic Decarboxylative Cycloaddition of Nonvinyl, Trifluoromethyl Benzoxazinanones with Sulfur Ylides under Palladium Catalysis

    Article • Organic Letters, February 2018, American Chemical Society (ACS)

    Professor Norio Shibata

  100. Synthesis of fluoro-functionalized diaryl-λ3-iodonium salts and their cytotoxicity against human lymphoma U937 cells

    Article • Beilstein Journal of Organic Chemistry, February 2018, Beilstein Institut

    Professor Norio Shibata

  101. Synthesis of Aryl Triflones through the Trifluoromethanesulfonylation of Benzynes

    Article • ChemistryOpen, February 2018, Wiley

    Professor Norio Shibata

  102. Structural basis of thalidomide enantiomer binding to cereblon

    Article • Scientific Reports, January 2018, Springer Science + Business Media

    Professor Norio Shibata

  103. Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides

    Article • Beilstein Journal of Organic Chemistry, January 2018, Beilstein Institut

    Professor Norio Shibata

  104. Front Cover: Trifluoroethoxy‐Coated Subphthalocyanines Attract Small Arenes in Their π‐Concave Cavity (ChemPlusChem 3/2018)

    Article • ChemPlusChem, January 2018, Wiley

    Professor Norio Shibata

  105. Trifluoroethoxy‐Coated Subphthalocyanines Attract Small Arenes in Their π‐Concave Cavity

    Article • ChemPlusChem, January 2018, Wiley

    Professor Norio Shibata

  106. Anionic Triflyldiazomethane: Generation and Its Application for Synthesis of Pyrazole-3-triflones via [3 + 2] Cycloaddition Reaction

    Article • Organic Letters, January 2018, American Chemical Society (ACS)

    Professor Norio Shibata

  107. Access to benzo-fused nine-membered heterocyclic alkenes with a trifluoromethyl carbinol moiety via a double decarboxylative formal ring-expansion process under palladium catalysis

    Article • Chemical Science, January 2018, Royal Society of Chemistry

    Professor Norio Shibata

  108. An eccentric rod-like linear connection of two heterocycles: synthesis of pyridine trans-tetrafluoro-λ6-sulfanyl triazoles

    Article • Chemical Science, January 2018, Royal Society of Chemistry

    Professor Norio Shibata

  109. Asymmetric synthesis of α-trifluoromethoxy ketones with a tetrasubstituted α-stereogenic centre via the palladium-catalyzed decarboxylative allylic alkylation of allyl enol carbonates

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Professor Norio Shibata

  110. Design and synthesis of galactose-conjugated fluorinated and non-fluorinated proline oligomers: towards antifreeze molecules

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Professor Norio Shibata

  111. Highly C-selective difluoromethylation of β-ketoesters by using TMSCF2Br/lithium hydroxide/N,N,N-trimethylhexadecan-1-ammonium bromide

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Professor Norio Shibata

  112. Stereodivergent trifluoromethylation of N-sulfinylimines by fluoroform with either organic-superbase or organometallic-base

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Professor Norio Shibata

  113. Stille cross-coupling of secondary and tertiary α-(trifluoromethyl)-benzyl chlorides with allylstannanes

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Professor Norio Shibata

  114. Synthesis of pyridine trans-tetrafluoro-λ6-sulfane derivatives via radical addition

    Article • Organic Chemistry Frontiers, January 2018, Royal Society of Chemistry

    Professor Norio Shibata

  115. The CF3-DAST-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones/lactams/lactones and its extension to deacylative pentafluorophenylthiolation

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Professor Norio Shibata

  116. Trifluoroethoxy‐Coated Subphthalocyanines Attract Small Arenes in Their π‐Concave Cavity

    Article • ChemPlusChem, December 2017, Wiley

    Professor Norio Shibata

  117. Recent advancements in the synthesis of pentafluorosulfanyl (SF5)-containing heteroaromatic compounds

    Article • Tetrahedron Letters, December 2017, Elsevier

    Professor Norio Shibata

  118. Intramolecular Aminotrifluoromethanesulfinyloxylation of ω-Aminoalkenes by CF3SO2Na/Pd(OAc)2/PhI(OAc)2/ t BuOCl/PivOH System

    Article • Synlett, November 2017, Thieme Publishing Group

    Professor Norio Shibata

  119. Synthesis of Sulfur Perfluorophenyl Compounds Using a Pentafluorobenzenesulfonyl Hypervalent Iodonium Ylide

    Article • The Journal of Organic Chemistry, September 2017, American Chemical Society (ACS)

    Professor Norio Shibata

  120. Electrophilic Triflyl-arylation and Triflyl-pyridylation by Unsymmetrical Aryl/Pyridyl-λ3-iodonium Salts: Synthesis of Aryl and Pyridyl Triflones

    Article • The Journal of Organic Chemistry, September 2017, American Chemical Society (ACS)

    Professor Norio Shibata

  121. The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage

    Article • Chemical Research in Toxicology, August 2017, American Chemical Society (ACS)

    Professor Hiroshi Yamazaki, Professor Norio Shibata

  122. Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others

    Article • PLOS One, August 2017, PLOS

    Professor Norio Shibata

  123. Trifluoroethoxy-Coated Phthalocyanine Catalyzes Perfluoroalkylation of Alkenes under Visible-Light Irradiation

    Article • Molecules, July 2017, MDPI AG

    Professor Norio Shibata

  124. New utility of electrophilic trifluoromethylthiolation reagents for the synthesis of a variety of triflones

    Article • Journal of Fluorine Chemistry, June 2017, Elsevier

    Professor Norio Shibata

  125. Operationally Convenient and Scalable Asymmetric Synthesis of (2S)‐ and (2R)‐α‐(Methyl)cysteine Derivatives through Alkylation of Chiral Alanine Schiff Base NiII Complexes

    Article • European Journal of Organic Chemistry, April 2017, Wiley

    Professor Norio Shibata

  126. Trifluoroethoxy‐Coated Subphthalocyanine affects Trifluoromethylation of Alkenes and Alkynes even under Low‐Energy Red‐Light Irradiation

    Article • ChemistryOpen, February 2017, Wiley

    Professor Norio Shibata

  127. Construction of Fluorinated Benzoxathiin Skeleton by Successive Perfluorophenylthiolation/Cyclization of Activated α-Methylene Ketones by Perfluorophenyl Diethylaminosulfur Difluoride

    Article • Organic Letters, February 2017, American Chemical Society (ACS)

    Professor Norio Shibata

  128. Difluoromethylthiolation of Phenols and Related Compounds with a HF2CSO2Na/Ph2PCl/Me3SiCl System

    Article • Organic Letters, February 2017, American Chemical Society (ACS)

    Professor Norio Shibata

  129. Catalytic Asymmetric 1,3‐Dipolar Cycloaddition of β‐Fluoroalkylated α,β‐Unsaturated 2‐Pyridylsulfones with Nitrones for Chiral Fluoroalkylated Isoxazolidines and γ‐Amino Alcohols

    Article • Angewandte Chemie, January 2017, Wiley

    Professor Norio Shibata

  130. Asymmetric synthesis of α-deuterated α-amino acids

    Article • Organic & Biomolecular Chemistry, January 2017, Royal Society of Chemistry

    Professor Norio Shibata

  131. Diastereoselective synthesis of fluoroisosteric analogues of antiparasitic pyrrolobenzoxazine alkaloids from tryptophan by successive fluorination–cyclization and a Meisenheimer-type rearrangement

    Article • Organic Chemistry Frontiers, January 2017, Royal Society of Chemistry

    Professor Norio Shibata

  132. IF5 affects the final stage of the Cl–F exchange fluorination in the synthesis of pentafluoro-λ6-sulfanyl-pyridines, pyrimidines and benzenes with electron-withdrawing substituents

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Professor Norio Shibata

  133. Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity

    Article • The Journal of Toxicological Sciences, January 2017, Japanese Society of Toxicology

    Professor Norio Shibata

  134. SF5-Pyridylaryl-λ3-iodonium salts and their utility as electrophilic reagents to access SF5-pyridine derivatives in the late-stage of synthesis

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Professor Norio Shibata

  135. Silver-induced self-immolative Cl–F exchange fluorination of arylsulfur chlorotetrafluorides: synthesis of arylsulfur pentafluorides

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Professor Norio Shibata

  136. Synthesis of chiral (tetrazolyl)methyl-containing acrylates via silicon-induced organocatalytic kinetic resolution of Morita–Baylis–Hillman fluorides

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Professor Norio Shibata

  137. Perfluoroalkyl Analogues of Diethylaminosulfur Trifluoride: Reagents for Perfluoroalkylthiolation of Active Methylene Compounds under Mild Conditions

    Article • Organic Letters, November 2016, American Chemical Society (ACS)

    Professor Norio Shibata

  138. Alkynyl Cinchona Catalysts affect Enantioselective Trifluoromethylation for Efavirenz under Metal-Free Conditions

    Article • Organic Letters, October 2016, American Chemical Society (ACS)

    Professor Norio Shibata

  139. Importance of a Fluorine Substituent for the Preparation of meta‐ and para‐Pentafluoro‐λ6‐sulfanyl‐Substituted Pyridines

    Article • Angewandte Chemie, August 2016, Wiley

    Professor Norio Shibata

  140. Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry

    Article • Chemical Research in Toxicology, July 2016, American Chemical Society (ACS)

    Professor Hiroshi Yamazaki, Professor Norio Shibata

  141. Direct Fluoro‐aminosulfenylation of Active Methylenes by Dialkylaminosulfur Trifluorides under Catalyst‐Free Conditions

    Article • Asian Journal of Organic Chemistry, July 2016, Wiley

    Professor Norio Shibata

  142. Asymmetric Desymmetrization via Metal‐Free C−F Bond Activation: Synthesis of 3,5‐Diaryl‐5‐fluoromethyloxazolidin‐2‐ones with Quaternary Carbon Centers

    Article • Angewandte Chemie, June 2016, Wiley

    Professor Norio Shibata

  143. Difluoromethanesulfonyl hypervalent iodonium ylides for electrophilic difluoromethylthiolation reactions under copper catalysis

    Article • Royal Society Open Science, May 2016, Royal Society Publishing

    Professor Norio Shibata

  144. Novel Use of CF3SO2Cl for the Metal-Free Electrophilic Trifluoromethylthiolation

    Article • Organic Letters, April 2016, American Chemical Society (ACS)

    Professor Norio Shibata

  145. Organocatalytic Enantioselective Nucleophilic Alkynylation of Allyl Fluorides Affording Chiral Skipped Ene‐ynes

    Article • Angewandte Chemie, April 2016, Wiley

    Professor Norio Shibata

  146. Activation of Trifluoromethylthio Moiety by Appending Iodonium Ylide under Copper Catalysis for Electrophilic Trifluoromethylation Reaction

    Article • Chinese Journal of Chemistry, March 2016, Wiley

    Professor Norio Shibata

  147. 2‐Diazo‐1‐phenyl‐2‐((trifluoromethyl)sulfonyl)ethan‐1‐one: Another Utility for Electrophilic Trifluoromethylthiolation Reactions

    Article • ChemistryOpen, January 2016, Wiley

    Professor Norio Shibata

  148. Methyl NFSI: atom-economical alternative to NFSI shows higher fluorination reactivity under Lewis acid-catalysis and non-catalysis

    Article • Green Chemistry, January 2016, Royal Society of Chemistry

    Professor Norio Shibata

  149. Design, synthesis and optical properties of unsymmetrical subphthalocyanine trimer connected by phloroglucinol via axial positions

    Article • Dalton Transactions, January 2016, Royal Society of Chemistry

    Professor Norio Shibata

  150. Successive C–C bond cleavage, fluorination, trifluoromethylthio- and pentafluorophenylthiolation under metal-free conditions to provide compounds with dual fluoro-functionalization

    Article • Chemical Science, January 2016, Royal Society of Chemistry

    Professor Norio Shibata

  151. Flow trifluoromethylation of carbonyl compounds by Ruppert–Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016

    Article • RSC Advances, January 2016, Royal Society of Chemistry

    Professor Norio Shibata

  152. Synthesis of fluorinated donepezil by palladium-catalyzed decarboxylative allylation of α-fluoro-β-keto ester with tri-substituted heterocyclic alkene and the self-disproportionation of its enantiomers

    Article • RSC Advances, January 2016, Royal Society of Chemistry

    Professor Norio Shibata

  153. Enantiomerization of Allylic Trifluoromethyl Sulfoxides Studied by HPLC Analysis and DFT Calculations

    Article • Chirality, December 2015, Wiley

    Professor Norio Shibata

  154. Stereoselective Synthesis of β-Lactam-triflones under Catalyst-Free Conditions

    Article • Organic Letters, November 2015, American Chemical Society (ACS)

    Professor Norio Shibata

  155. Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice

    Article • Chemical Research in Toxicology, October 2015, American Chemical Society (ACS)

    Professor Norio Shibata

  156. Enantioselective Trichloromethylation of MBH‐Fluorides with Chloroform Based on Silicon‐assisted C−F Activation and Carbanion Exchange Induced by a Ruppert–Prakash Reagent

    Article • Angewandte Chemie, October 2015, Wiley

    Professor Norio Shibata

  157. Corrigendum: Regioisomer-Free C 4h β-Tetrakis(tert -butyl)metallo-phthalocyanines: Regioselective Synthesis and Spectral Investigations

    Article • ChemistryOpen, September 2015, Wiley

    Professor Norio Shibata

  158. Organocatalyzed Trifluoromethylation of Ketones and Sulfonyl Fluorides by Fluoroform under a Superbase System

    Article • ChemistryOpen, August 2015, Wiley

    Professor Norio Shibata

  159. Synthesis of Phthalocyanines with a Pentafluorosulfanyl Substituent at Peripheral Positions

    Article • ChemistryOpen, July 2015, Wiley

    Professor Norio Shibata

  160. Difluoromethylation of Terminal Alkynes by Fluoroform

    Article • Organic Letters, July 2015, American Chemical Society (ACS)

    Professor Norio Shibata

  161. Carbene-Induced Intra- vs Intermolecular Transfer-Fluoromethylation of Aryl Fluoromethylthio Compounds under Rhodium Catalysis

    Article • ACS Catalysis, July 2015, American Chemical Society (ACS)

    Professor Norio Shibata

  162. Design, synthesis, spectral investigations and biological activity of fluorinated phthalocyanine conjugated with galactose and comparison to its non-fluorinated counterpart

    Article • Journal of Fluorine Chemistry, June 2015, Elsevier

    Professor Norio Shibata

  163. Synthesis of Diaryliodonium Salts Having Pentafluorosulfanylarenes and Their Application to Electrophilic Pentafluorosulfanylarylation of C-, O-, N-, and S-Nucleophiles

    Article • Organic Letters, May 2015, American Chemical Society (ACS)

    Professor Norio Shibata

  164. Synthesis of Billard–Langlois Reagents and their Derivatives by Copper‐Catalyzed N‐Trifluoromethylthiolation of Arylamines with a Trifluoromethanesulfonyl Hypervalent Iodonium Ylide

    Article • Asian Journal of Organic Chemistry, April 2015, Wiley

    Professor Norio Shibata

  165. Trifluoromethyl Sulfoxides from Allylic Alcohols and Electrophilic SCF3 Donor by [2,3]-Sigmatropic Rearrangement

    Article • Organic Letters, April 2015, American Chemical Society (ACS)

    Professor Norio Shibata

  166. Catalytic Trifluoromethylation of Aryl- and Vinylboronic Acids by 2-Cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium Triflate

    Article • Organic Letters, March 2015, American Chemical Society (ACS)

    Professor Norio Shibata

  167. Catalytic Asymmetric Synthesis of Enantioenriched Heterocycles Bearing a CCF3 Stereogenic Center

    Article • Chemistry - A European Journal, March 2015, Wiley

    Professor Norio Shibata, Francis Verpoort

  168. Pentafluorosulfanyl (SF5) in dyes: C3-Regioselective synthesis of α-mono-substituted subphthalocyanine with SF5-phenyl group

    Article • Journal of Fluorine Chemistry, March 2015, Elsevier

    Professor Norio Shibata

  169. Trifluoromethylthiolation of Allylsilanes and Silyl Enol Ethers with Trifluoromethanesulfonyl Hypervalent Iodonium Ylide under Copper Catalysis

    Article • Organic Letters, February 2015, American Chemical Society (ACS)

    Professor Norio Shibata

  170. Copper-Catalyzed Regioselective Trifluoromethylthiolation of Pyrroles by Trifluoromethanesulfonyl Hypervalent Iodonium Ylide

    Article • Organic Letters, February 2015, American Chemical Society (ACS)

    Professor Norio Shibata

  171. Self-disproportionation of enantiomers of thalidomide and its fluorinated analogue via gravity-driven achiral chromatography: mechanistic rationale and implications

    Article • Chemical Science, January 2015, Royal Society of Chemistry

    Professor Norio Shibata, Professor Toru Asahi

  172. Synthesis and optical properties of subphthalocyanine homo- and heterodimers axially connected via a hydroquinone linker

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Professor Norio Shibata

  173. Reactions of allyl alcohols and boronic acids with trifluoromethanesulfonyl hypervalent iodonium ylide under copper-catalysis

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Professor Norio Shibata

  174. Synthesis and property of novel phthalocyanine having a 3,5-bis-pentafluorosulfanylphenyl group on the α-peripheral position

    Article • Journal of Fluorine Chemistry, December 2014, Elsevier

    Professor Norio Shibata

  175. Regioisomer-Free C 4h β-Tetrakis(tert -butyl)metallo-phthalocyanines: Regioselective Synthesis and Spectral Investigations

    Article • ChemistryOpen, November 2014, Wiley

    Professor Norio Shibata

  176. Synthesis and optical properties of trifluoroethoxy-substituted double-decker phthalocyanines

    Article • Journal of Porphyrins and Phthalocyanines, October 2014, World Scientific Pub Co Pte Lt

    Professor Norio Shibata

  177. Sterically Demanding Unsymmetrical Diaryl‐λ3‐iodanes for Electrophilic Pentafluorophenylation and an Approach to α‐Pentafluorophenyl Carbonyl Compounds with an All‐Carbon Stereocenter

    Article • ChemistryOpen, September 2014, Wiley

    Professor Norio Shibata

  178. Synthetic Methods for Compounds Having CF3–S Units on Carbon by Trifluoromethylation, Trifluoromethylthiolation, Triflylation, and Related Reactions

    Article • Chemical Reviews, August 2014, American Chemical Society (ACS)

    Professor Norio Shibata

  179. Asymmetric Synthesis of Agrochemically Attractive Trifluoromethylated Dihydroazoles and Related Compounds under Organocatalysis

    Article • The Chemical Record, August 2014, Wiley

    Professor Norio Shibata

  180. Studies on the C/O-regioselectivity in Electrophilic Fluoromethylations of β-Ketoesters based on Thermodynamics by Ab initio Calculations

    Article • Bulletin of the Korean Chemical Society, June 2014, Korean Chemical Society

    Professor Norio Shibata

  181. (S)-(Trifluoromethyl)diphenylsulfonium Triflate

    Article • May 2014, Wiley

    Professor Norio Shibata

  182. Asymmetric Synthesis of Efavirenz via Organocatalyzed Enantioselective Trifluoromethylation

    Article • Asian Journal of Organic Chemistry, March 2014, Wiley

    Professor Norio Shibata

  183. Bis(pentafluorosulfanyl)phenyl Azide as an Expeditious Tool for Click Chemistry toward Antitumor Pharmaceuticals

    Article • ChemMedChem, March 2014, Wiley

    Professor Norio Shibata

  184. Thalidomide Increases Human Hepatic Cytochrome P450 3A Enzymes by Direct Activation of the Pregnane X Receptor

    Article • Chemical Research in Toxicology, February 2014, American Chemical Society (ACS)

    Professor Hiroshi Yamazaki, Professor Norio Shibata

  185. Diastereoselective Additive Trifluoromethylation/Halogenation of Isoxazole Triflones: Synthesis of All-Carbon-Functionalized Trifluoromethyl Isoxazoline Triflones

    Article • ChemistryOpen, February 2014, Wiley

    Professor Norio Shibata

  186. S‐((Phenylsulfonyl)difluoromethyl)thiophenium Salts: Carbon‐Selective Electrophilic Difluoromethylation of β‐Ketoesters, β‐Diketones, and Dicyanoalkylidenes

    Article • Angewandte Chemie, January 2014, Wiley

    Professor Norio Shibata

  187. S‐((Phenylsulfonyl)difluoromethyl)thiophenium Salts: Carbon‐Selective Electrophilic Difluoromethylation of β‐Ketoesters, β‐Diketones, and Dicyanoalkylidenes

    Article • Angewandte Chemie, January 2014, Wiley

    Professor Norio Shibata

  188. Asymmetric Mannich reaction between (S)-N-(tert-butanesulfinyl)-3,3,3-trifluoroacetaldimine and malonic acid derivatives. Stereodivergent synthesis of (R)- and (S)-3-amino-4,4,4-trifluorobutanoic acids

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Vadim Soloshonok, Dr Jose Luis Aceña, Professor Norio Shibata

  189. NH-type of chiral Ni(ii) complexes of glycine Schiff base: design, structural evaluation, reactivity and synthetic applications

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Vadim Soloshonok, Dr Jose Luis Aceña, Professor Norio Shibata, Dr Jianlin Han

  190. A phthalocyanine–subphthalocyanine heterodinuclear dimer: comparison of spectroscopic properties with those of homodinuclear dimers of constituting units

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Professor Norio Shibata

  191. Iodoarene-catalyzed fluorination and aminofluorination by an Ar-I/HF·pyridine/mCPBA system

    Article • Chemical Science, January 2014, Royal Society of Chemistry

    Professor Norio Shibata, Prof. Dr. Toshifumi Dohi

  192. An aza-Michael addition protocol to fluoroalkylated β-amino acid derivatives and enantiopure trifluoromethylated N-heterocycles

    Article • Green Chemistry, January 2014, Royal Society of Chemistry

    Professor Norio Shibata

  193. Direct nucleophilic difluoromethylation of aromatic isoxazoles activated by electron-withdrawing groups using (difluoromethyl)trimethylsilane

    Article • ScienceOpen Research, January 2014, ScienceOpen

    Professor Norio Shibata

  194. Human Cytochrome P450 Oxidation of 5-Hydroxythalidomide and Pomalidomide, an Amino Analogue of Thalidomide

    Article • Chemical Research in Toxicology, December 2013, American Chemical Society (ACS)

    Professor Hiroshi Yamazaki, Professor Norio Shibata

  195. Kinetic Resolution of Allyl Fluorides by Enantioselective Allylic Trifluoromethylation Based on Silicon‐Assisted CF Bond Cleavage

    Article • Angewandte Chemie, November 2013, Wiley

    Professor Norio Shibata

  196. Redox chemistry of trifluoromethyl sulfonium salts as CF3 radical sources

    Article • Journal of Fluorine Chemistry, November 2013, Elsevier

    Professor Norio Shibata

  197. Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system

    Article • Beilstein Journal of Organic Chemistry, October 2013, Beilstein Institut

    Professor Norio Shibata

  198. Stereoselective Synthesis of Vinyl Triflones and Heteroaryl Triflones through Anionic O→Cvinyl and N→Cvinyl Trifluoromethanesulfonyl Migration Reactions

    Article • Angewandte Chemie, October 2013, Wiley

    Professor Norio Shibata

  199. Enantioselective Synthesis of 5‐Trifluoromethyl‐2‐isoxazolines and Their N‐Oxides by [Hydroxy(tosyloxy)iodo]benzene‐Mediated Oxidative N–O Coupling

    Article • European Journal of Organic Chemistry, September 2013, Wiley

    Professor Norio Shibata

  200. Chiral N‐Fluorodibenzenesulfonimide Analogues for Enantioselective Electrophilic Fluorination and Oxidative Fluorination

    Article • European Journal of Organic Chemistry, September 2013, Wiley

    Professor Norio Shibata

  201. Cinchona alkaloid/TMAF combination: Enantioselective trifluoromethylation of aryl aldehydes

    Article • Journal of Fluorine Chemistry, August 2013, Elsevier

    Professor Norio Shibata

  202. Highly Enantioselective Monofluoromethylation of C2-Arylindoles Using FBSM under Chiral Phase-Transfer Catalysis

    Article • Organic Letters, June 2013, American Chemical Society (ACS)

    Professor Norio Shibata

  203. Trifluoromethanesulfonyl Hypervalent Iodonium Ylide for Copper-Catalyzed Trifluoromethylthiolation of Enamines, Indoles, and β-Keto Esters

    Article • Journal of the American Chemical Society, June 2013, American Chemical Society (ACS)

    Professor Norio Shibata

  204. Phthalocyanine with Trifluoroethoxy Substituents for Organic Solar Cells

    Article • Japanese Journal of Applied Physics, May 2013, Institute of Physics Publishing

    Professor Yasuhiko HAYASHI, Professor Norio Shibata

  205. Benzenesulfenyl Chloride

    Article • April 2013, Wiley

    Dr Ramon Rios, Professor Norio Shibata

  206. Efficient Access to Trifluoromethyl Diarylpyrrolines and their N‐Oxides through Enantioselective Conjugate Addition of Nitromethane to β,β‐Disubstituted Enones

    Article • Angewandte Chemie, April 2013, Wiley

    Professor Norio Shibata

  207. In Vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice

    Article • Chemical Research in Toxicology, March 2013, American Chemical Society (ACS)

    Professor Hiroshi Yamazaki, Professor Norio Shibata

  208. SelectiveO-Difluoromethylation of 1,3-Diones by Bromodifluoromethylating Reagents

    Article • Organic Letters, February 2013, American Chemical Society (ACS)

    Professor Norio Shibata

  209. Remote Anionic Fries Rearrangement of Sulfonates: Regioselective Synthesis of Indole Triflones

    Article • Organic Letters, January 2013, American Chemical Society (ACS)

    Professor Norio Shibata

  210. Enantioselective Synthesis of Epoxides Having a Tetrasubstituted Trifluoromethylated Carbon Center: Methylhydrazine‐Induced Aerobic Epoxidation of β,β‐Disubstituted Enones

    Article • Angewandte Chemie, January 2013, Wiley

    Professor Norio Shibata

  211. Transition-metal-free oxidative trifluoromethylation of unsymmetrical biaryls with trifluoromethanesulfinate

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Professor Norio Shibata

  212. A sterically demanding organo-superbase avoids decomposition of a naked trifluoromethyl carbanion directly generated from fluoroform

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Professor Norio Shibata

  213. Enantioselective monofluoromethylation of aldehydes with 2-fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide catalyzed by a bifunctional cinchona alkaloid-derived thiourea–titanium complex

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Professor Norio Shibata

  214. Efficient direct ester condensation between equimolar amounts of carboxylic acids and alcohols catalyzed by trifluoromethanesulfonic acid (TfOH) in Solkane365mfc

    Article • RSC Advances, January 2013, Royal Society of Chemistry

    Professor Norio Shibata

  215. New Approaches to the Regioselective Synthesis of Heteroaryl Triflones

    Article • Journal of Synthetic Organic Chemistry Japan, January 2013, The Society of Synthetic Organic Chemistry, Japan

    Professor Norio Shibata

  216. CF Bond Activation of Unactivated Aliphatic Fluorides: Synthesis of Fluoromethyl‐3,5‐diaryl‐2‐oxazolidinones by Desymmetrization of 2‐Aryl‐1,3‐difluoropropan‐2‐ols

    Article • Angewandte Chemie, November 2012, Wiley

    Professor Norio Shibata

  217. 3,5-Bis(pentafluorosulfanyl)phenylboronic acid: A new organocatalyst for Conia-ene carbocyclization of 1,3-dicarbonyl compounds having terminal alkynes

    Article • Journal of Fluorine Chemistry, November 2012, Elsevier

    Professor Norio Shibata

  218. N-2-Iodobenzylcinchoninium bromide is effective for catalytic enantioselective trifluoromethylation of azomethine imines in Solkane® 365mfc

    Article • Journal of Fluorine Chemistry, November 2012, Elsevier

    Professor Norio Shibata

  219. Decarboxylative Allylation of Trifluoroethyl Sulfones and Approach to Difluoromethyl Compounds

    Article • Organic Letters, October 2012, American Chemical Society (ACS)

    Professor Norio Shibata

  220. Regioselective Synthesis of Pyrazole Triflones Based on Triflyl Alkyne Cycloadditions

    Article • Organic Letters, October 2012, American Chemical Society (ACS)

    Professor Norio Shibata

  221. Enantioselective Aza‐Morita–Baylis–Hillman Reactions of Acrylonitrile Catalyzed by Palladium(II) Pincer Complexes having C2‐Symmetric Chiral Bis(imidazoline) Ligands

    Article • Angewandte Chemie, September 2012, Wiley

    Professor Norio Shibata

  222. Design and Photonic Properties of Novel Fluorinated Copolymers Bearing Phthalocyanine Side Groups

    Article • Macromolecular Chemistry and Physics, July 2012, Wiley

    Professor Norio Shibata

  223. Enantioselective Synthesis of AG‐041R by using N‐Heteroarenesulfonyl Cinchona Alkaloid Amides as Organocatalysts

    Article • Chemistry - A European Journal, June 2012, Wiley

    Professor Norio Shibata

  224. Enantioselective Synthesis of Imidazolines with Quaternary Stereocenters by Organocatalytic Reaction of N-(Heteroarenesulfonyl)imines with Isocyanoacetates

    Article • Organic Letters, June 2012, American Chemical Society (ACS)

    Professor Norio Shibata

  225. Regioselective Synthesis of Heteroaryl Triflones by LDA (Lithium Diisopropylamide)-Mediated Anionic Thia-Fries Rearrangement

    Article • Organic Letters, April 2012, American Chemical Society (ACS)

    Professor Norio Shibata

  226. Fundamental Study on Organic Solar Cells Based on Soluble Zinc Phthalocyanine

    Article • Japanese Journal of Applied Physics, April 2012, Japan Society of Applied Physics

    Professor Yasuhiko HAYASHI, Professor Norio Shibata

  227. Organocatalytic Asymmetric Synthesis of Trifluoromethyl‐substituted Diarylpyrrolines: Enantioselective Conjugate Cyanation of β‐Aryl‐β‐trifluoromethyl‐disubstituted Enones

    Article • Angewandte Chemie, April 2012, Wiley

    Professor Norio Shibata

  228. Enantioselective 5‐endo‐dig Carbocyclization of β‐Ketoesters with Internal Alkynes Employing a Four‐Component Catalyst System

    Article • Angewandte Chemie, March 2012, Wiley

    Professor Norio Shibata

  229. Suzuki–Miyaura Cross‐Coupling Reactions in a Solkane365/227/Ethanol Blend at Ambient Temperature

    Article • European Journal of Organic Chemistry, February 2012, Wiley

    Professor Norio Shibata

  230. In Vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites Derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG Mice

    Article • Chemical Research in Toxicology, January 2012, American Chemical Society (ACS)

    Professor Hiroshi Yamazaki, Professor Norio Shibata

  231. Synthesis of Isoxazole Triflones

    Article • European Journal of Organic Chemistry, January 2012, Wiley

    Professor Norio Shibata

  232. Organic base-catalyzed stereodivergent synthesis of (R)- and (S)-3-amino-4,4,4-trifluorobutanoic acids

    Article • Chemical Communications, January 2012, Royal Society of Chemistry

    Vadim Soloshonok, Professor Norio Shibata

  233. Partially saturated fluorinated heterocycles: diastereo- and enantioselective synthesis of β-trifluoromethyl-pyrroline carboxylates

    Article • Chemical Communications, January 2012, Royal Society of Chemistry

    Professor Norio Shibata

  234. Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines

    Article • Chemical Communications, January 2012, Royal Society of Chemistry

    Professor Norio Shibata

  235. Efficient synthesis of unsymmetrical S-(bromodifluoromethyl)diarylsulfonium salts for electrophilic bromodifluoromethylating reagents

    Article • New Journal of Chemistry, January 2012, Royal Society of Chemistry

    Professor Norio Shibata

  236. 5.9 Oxidation: C–X Bond Formation (X=Halogen, S, Se)

    Article • January 2012, Elsevier

    Professor Norio Shibata

  237. Direct Enantioselective Three‐Component Kabachnik–Fields Reaction Catalyzed by Chiral Bis(imidazoline)‐Zinc(II) Catalysts

    Article • Advanced Synthesis & Catalysis, December 2011, Wiley

    Professor Norio Shibata

  238. Enantioselective Reaction of Imines and Benzyl Nitriles Using Palladium Pincer Complexes with C2‐Symmetric Chiral Bis(imidazoline)s

    Article • Advanced Synthesis & Catalysis, December 2011, Wiley

    Professor Norio Shibata

  239. Organocatalytic Enantioselective Decarboxylative Addition of Malonic Acids Half Thioesters to Isatins

    Article • Advanced Synthesis & Catalysis, November 2011, Wiley

    Professor Norio Shibata

  240. A New Synthetic Approach to Efavirenz through Enantioselective Trifluoromethylation by Using the Ruppert–Prakash Reagent

    Article • European Journal of Organic Chemistry, September 2011, Wiley

    Professor Norio Shibata

  241. Asymmetric Allylic Monofluoromethylation and Methylation of Morita–Baylis–Hillman Carbonates with FBSM and BSM by Cooperative Cinchona Alkaloid/FeCl2 Catalysis

    Article • Angewandte Chemie, September 2011, Wiley

    Professor Norio Shibata

  242. Synthesis of Indole and Biindolyl Triflones: Trifluoromethanesulfonylation of Indoles with Tf2O/TTBP (2,4,6-tri-tert-butylpyridine) System

    Article • Organic Letters, August 2011, American Chemical Society (ACS)

    Professor Norio Shibata

  243. Trifluoromethylation of Aromatic Isoxazoles: Regio‐ and Diastereoselective Route to 5‐Trifluoromethyl‐2‐isoxazolines

    Article • Angewandte Chemie, August 2011, Wiley

    Professor Norio Shibata

  244. Construction of Trifluoromethyl‐Bearing Quaternary Carbon Centers by Intramolecular Decarboxylative Allylation of α‐Trifluoromethyl β‐Keto Esters

    Article • Advanced Synthesis & Catalysis, August 2011, Wiley

    Professor Norio Shibata

  245. Organocatalyzed Regio- and Enantioselective Allylic Trifluoromethylation of Morita–Baylis–Hillman Adducts Using Ruppert–Prakash Reagent

    Article • Organic Letters, June 2011, American Chemical Society (ACS)

    Professor Norio Shibata

  246. Cu-Mediated Chemoselective Trifluoromethylation of Benzyl Bromides Using Shelf-Stable Electrophilic Trifluoromethylating Reagents

    Article • Organic Letters, June 2011, American Chemical Society (ACS)

    Professor Norio Shibata

  247. ChemInform Abstract: Inherent Oxygen Preference in Enolate Monofluoromethylation and a Synthetic Entry to Monofluoromethyl Ethers.

    Article • ChemInform, April 2011, Wiley

    Professor Norio Shibata

  248. Fluorothalidomide: A Characterization of Maternal and Developmental Toxicity in Rabbits and Mice

    Article • Toxicological Sciences, April 2011, Oxford University Press (OUP)

    Professor Norio Shibata

  249. N-Fluoro-(3,5-di-tert-butyl-4-methoxy)benzenesulfonimide (NFBSI): A sterically demanding electrophilic fluorinating reagent for enantioselective fluorination

    Article • Journal of Fluorine Chemistry, March 2011, Elsevier

    Professor Norio Shibata

  250. Robust synthesis of trifluoromethionine and its derivatives by reductive trifluoromethylation of amino acid disulfides by CF3I/Na/Liq.NH3 system

    Article • Journal of Fluorine Chemistry, March 2011, Elsevier

    Professor Norio Shibata

  251. In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG Mice

    Article • Chemical Research in Toxicology, February 2011, American Chemical Society (ACS)

    Professor Hiroshi Yamazaki, Professor Norio Shibata

  252. Catalyst-free and catalytic Friedel–Crafts alkylations of indoles in Solkane® 365mfc, an environmentally benign alternative solvent

    Article • Green Chemistry, January 2011, Royal Society of Chemistry

    Professor Norio Shibata

  253. Organic reaction in Solkane® 365 mfc: homocoupling reaction of terminal alkynes

    Article • Green Chemistry, January 2011, Royal Society of Chemistry

    Professor Norio Shibata

  254. Asymmetric synthesis of chiral trifluoromethylated heliotridane via highly catalytic asymmetric Friedel–Crafts alkylation with β-trifluoromethylated acrylates and pyrroles

    Article • New Journal of Chemistry, January 2011, Royal Society of Chemistry

    Professor Norio Shibata

  255. Influence of new fullerene derivatives with fluorocarbon substituent on performance of polymer solar cells

    Article • Physics Procedia, January 2011, Elsevier

    Professor Yasuhiko HAYASHI, Professor Norio Shibata

  256. Inherent Oxygen Preference in Enolate Monofluoromethylation and a Synthetic Entry to Monofluoromethyl Ethers

    Article • Angewandte Chemie, December 2010, Wiley

    Professor Norio Shibata

  257. Asymmetric Synthesis of Both Mirror Images of 3′-Fluorothalidomide by Enantiodivergent Fluorination Using a Single, Cinchona Alkaloid

    Article • Organic Letters, December 2010, American Chemical Society (ACS)

    Professor Norio Shibata

  258. Poly[(3-hexylthiophene)-block-(3-semifluoroalkylthiophene)] for Polymer Solar Cells

    Article • International Journal of Molecular Sciences, December 2010, MDPI AG

    Professor Yasuhiko HAYASHI, Professor Norio Shibata

  259. Cinchona Alkaloid-Catalyzed Asymmetric Trifluoromethylation of Alkynyl Ketones with Trimethylsilyl Trifluoromethane

    Article • Organic Letters, October 2010, American Chemical Society (ACS)

    Professor Norio Shibata

  260. Expeditious Synthesis of Trifluoromethylated Heterocycles: Noncatalytic 1,3-Dipolar Cyclization of Azomethine Imines with (α-Trifluoromethyl)acrylates

    Article • Synthesis, August 2010, Thieme Publishing Group

    Professor Norio Shibata

  261. Enantioselective Synthesis of Trifluoromethyl‐Substituted 2‐Isoxazolines: Asymmetric Hydroxylamine/Enone Cascade Reaction

    Article • Angewandte Chemie, July 2010, Wiley

    Professor Norio Shibata

  262. Enantioselective Friedel−Crafts Reaction of β-Trifluoromethylated Acrylates with Pyrroles and Its Application to the Synthesis of Trifluorinated Heliotridane

    Article • Organic Letters, July 2010, American Chemical Society (ACS)

    Professor Norio Shibata

  263. Enantioselective Aldol Reaction using Recyclable Montmorillonite‐Entrapped N‐(2‐Thiophenesulfonyl)prolinamide

    Article • Advanced Synthesis & Catalysis, July 2010, Wiley

    Professor Norio Shibata

  264. Enantioselective desymmetrization of meso-N-(heteroarenesulfonyl)aziridines with TMSN3 catalyzed by chiral Lewis acids

    Article • Tetrahedron Letters, July 2010, Elsevier

    Professor Norio Shibata

  265. Trifluoroethoxy‐Coating Improves the Axial Ligand Substitution of Subphthalocyanine

    Article • Chemistry - A European Journal, June 2010, Wiley

    Professor Norio Shibata

  266. Cinchona Alkaloid/TiIV‐Catalyzed Enantioselective Enamine–Trifluoropyruvate Condensation–Cyclization Reaction and Its Application to Drug‐like Heterocycles

    Article • Chemistry - A European Journal, June 2010, Wiley

    Professor Norio Shibata

  267. Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective

    Article • Beilstein Journal of Organic Chemistry, June 2010, Beilstein Institut

    Professor Norio Shibata

  268. Human Liver Microsomal Cytochrome P450 3A Enzymes Involved in Thalidomide 5-Hydroxylation and Formation of a Glutathione Conjugate

    Article • Chemical Research in Toxicology, May 2010, American Chemical Society (ACS)

    Professor Hiroshi Yamazaki, Professor Norio Shibata

  269. Perfluoroisopropyl Zinc Phthalocyanines Conjugated with Deoxyribonucleosides: Synthesis, Photophysical Properties and In Vitro Photodynamic Activities

    Article • European Journal of Organic Chemistry, May 2010, Wiley

    Professor Norio Shibata

  270. Solubility of trifluoroethoxyphthalocyanines and -subphthalocyanines in liquid and supercritical carbon dioxide

    Article • Journal of Fluorine Chemistry, May 2010, Elsevier

    Professor Norio Shibata

  271. ChemInform Abstract: Catalytic Enantioselective Hydrophosphonylation of Ketimines Using Cinchona Alkaloids.

    Article • ChemInform, April 2010, Wiley

    Professor Norio Shibata

  272. Corrigendum to “Cytotoxic effect of amide derivatives of trifluoromethionine against the enteric protozoan parasite Entamoeba histolytica” [Int. J. Antimicrob. Agents 31 (2010) 56–61]

    Article • International Journal of Antimicrobial Agents, April 2010, Elsevier

    Professor Norio Shibata

  273. Self-disproportionation of enantiomers of heterocyclic compounds having a tertiary trifluoromethyl alcohol center on chromatography with a non-chiral system

    Article • Journal of Fluorine Chemistry, April 2010, Elsevier

    Professor Norio Shibata

  274. ChemInform Abstract: Solkane® 365mfc Is an Environmentally Benign Alternative Solvent for Trifluoromethylation Reactions.

    Article • ChemInform, March 2010, Wiley

    Professor Norio Shibata

  275. ChemInform Abstract: Synthesis of Fluorinated Allenes via Palladium‐Catalyzed Monofluoromethylation Using FBSM.

    Article • ChemInform, March 2010, Wiley

    Professor Norio Shibata

  276. Evaluation of stability difference between asymmetric homochiral dimer in (S)-thalidomide crystal and symmetric heterochiral dimer in (RS)-thalidomide crystal

    Article • Phase Transitions, March 2010, Taylor & Francis

    Professor Norio Shibata

  277. Synthesis of Benzene-centered Trinuclear Phthalocyanines by Triple-click Chemistry

    Article • Chemistry Letters, February 2010, Oxford University Press (OUP)

    Professor Norio Shibata

  278. 2‐Fluoro‐1,3‐benzodithiole‐1,1,3,3‐tetraoxide: A Reagent for Nucleophilic Monofluoromethylation of Aldehydes

    Article • Angewandte Chemie, February 2010, Wiley

    Professor Norio Shibata

  279. Copper‐Catalyzed Enantioselective Three‐Component Synthesis of Optically Active Propargylamines from Aldehydes, Amines, and Aliphatic Alkynes

    Article • Chemistry - A European Journal, February 2010, Wiley

    Professor Norio Shibata

  280. Enantioselective Friedel−Crafts Reaction of β-Trifluoromethylated Acrylates with Pyrroles and Its Application to the Synthesis of Trifluorinated Heliotridane

    Article • Organic Letters, February 2010, American Chemical Society (ACS)

    Professor Norio Shibata

  281. Efficient Access to Extended Yagupolskii–Umemoto‐Type Reagents: Triflic Acid Catalyzed Intramolecular Cyclization of ortho‐Ethynylaryltrifluoromethylsulfanes

    Article • Angewandte Chemie, January 2010, Wiley

    Professor Norio Shibata

  282. Asymmetric Syntheses Using Heteroarenesulfonyl Groups as a Highly Functional Protecting-activating Group

    Article • Journal of Synthetic Organic Chemistry Japan, January 2010, The Society of Synthetic Organic Chemistry, Japan

    Professor Norio Shibata

  283. Cytotoxic effect of amide derivatives of trifluoromethionine against the enteric protozoan parasite Entamoeba histolytica

    Article • International Journal of Antimicrobial Agents, January 2010, Elsevier

    Professor Norio Shibata

  284. Synthesis and Configurational Stability of (S)- and (R)-Deuteriothalidomides

    Article • Chemical and Pharmaceutical Bulletin, January 2010, Pharmaceutical Society of Japan

    Professor Norio Shibata

  285. Catalytic Enantioselective Hydrophosphonylation of Ketimines Using Cinchona Alkaloids

    Article • Journal of the American Chemical Society, December 2009, American Chemical Society (ACS)

    Professor Norio Shibata

  286. Synthesis, photophysical and electrochemical properties of perfluoroisopropyl substituted binuclear phthalocyanine conjugated with a butadiyne linker

    Article • Journal of Fluorine Chemistry, December 2009, Elsevier

    Professor Norio Shibata

  287. Asymmetric synthesis of α-fluoro-α-sulfenyl-β-ketoesters using DBFOX–Ph/Ni(II) complex

    Article • Journal of Fluorine Chemistry, November 2009, Elsevier

    Professor Norio Shibata

  288. Design and Synthesis of Thalidomide–Deoxyribonucleoside Chimeras

    Article • Chemistry Letters, October 2009, Oxford University Press (OUP)

    Professor Norio Shibata

  289. Construction of Nonadjacent Stereocenters Containing a Trifluoromethylated Carbon by Organocatalyzed Michael Addition of β-Ketoesters to 2-(Trifluoromethyl)acrylate

    Article • Chemistry Letters, October 2009, Oxford University Press (OUP)

    Professor Norio Shibata

  290. Dihydroquinidine Acetate

    Article • September 2009, Wiley

    Professor Norio Shibata

  291. Dihydroquinine Acetate

    Article • September 2009, Wiley

    Professor Norio Shibata

  292. A DBFOX‐Ph‐Based Combinatorial Catalyst for Enantioselective Fluorination of Aryl Acetyl and 3‐Butenoyl Thiazolidinones

    Article • Chemistry - An Asian Journal, August 2009, Wiley

    Professor Norio Shibata

  293. Catalytic Enantioselective Trifluoromethylation of Azomethine Imines with Trimethyl(trifluoromethyl)silane

    Article • Angewandte Chemie, August 2009, Wiley

    Professor Norio Shibata

  294. Synthesis of novel C2-symmetric chiral crown ethers and their application to enantioselective trifluoromethylation of aldehydes and ketones

    Article • Journal of Fluorine Chemistry, August 2009, Elsevier

    Professor Norio Shibata

  295. First Enantioselective Synthesis of (R)‐Convolutamydine B and E with N‐(Heteroarenesulfonyl)prolinamides

    Article • Chemistry - A European Journal, July 2009, Wiley

    Professor Norio Shibata

  296. Synthesis, configurational stability and stereochemical biological evaluations of (S)- and (R)-5-hydroxythalidomides

    Article • Bioorganic & Medicinal Chemistry Letters, July 2009, Elsevier

    Professor Norio Shibata

  297. Organocatalytic Enantioselective Aza-Friedel-Crafts Alkylation of Pyrroles with N-(Heteroarenesulfonyl)imines

    Article • Synlett, June 2009, Thieme Publishing Group

    Professor Norio Shibata

  298. Dihydroquinidine Acetate

    Article • March 2009, Wiley

    Professor Norio Shibata

  299. Dihydroquinine Acetate

    Article • March 2009, Wiley

    Professor Norio Shibata

  300. Synthesis and spectroscopic investigation of trifluoroethoxy-coated phthalocyanine linked with fullerene

    Article • Journal of Fluorine Chemistry, March 2009, Elsevier

    Professor Yasuhiko HAYASHI, Professor Norio Shibata

  301. Thalidomide protects against ischemic neuronal damage induced by focal cerebral ischemia in mice

    Article • Neuroscience, March 2009, Elsevier

    Professor Norio Shibata

  302. New diarylmethanofullerene derivatives and their properties for organic thin-film solar cells

    Article • Beilstein Journal of Organic Chemistry, February 2009, Beilstein Institut

    Professor Yasuhiko HAYASHI, Professor Norio Shibata

  303. A Dynamic Kinetic Asymmetric Transformation in the α‐Hydroxylation of Racemic Malonates and Its Application to Biologically Active Molecules

    Article • Angewandte Chemie, January 2009, Wiley

    Professor Norio Shibata

  304. Enantioselective electrophilic trifluoromethylation of β-keto esters with Umemoto reagents induced by chiral nonracemic guanidines

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Professor Norio Shibata

  305. Synthesis of fluorinated allenes via palladium-catalyzed monofluoromethylation using FBSM

    Article • Chemical Communications, January 2009, Royal Society of Chemistry

    Professor Norio Shibata

  306. Solkane® 365mfc is an environmentally benign alternative solvent for trifluoromethylation reactions

    Article • Green Chemistry, January 2009, Royal Society of Chemistry

    Professor Norio Shibata

  307. Synthesis of trifluoroethoxy-coated binuclear phthalocyanines with click spacers and investigation of their clamshell behaviour

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Professor Norio Shibata

  308. Recent advances in enantioselective trifluoromethylation reactions

    Article • Tetrahedron Asymmetry, December 2008, Elsevier

    Professor Norio Shibata

  309. Catalytic Enantioselective Michael Addition of 1‐Fluorobis(phenylsulfonyl)methane to α,β‐Unsaturated Ketones Catalyzed by Cinchona Alkaloids

    Article • Angewandte Chemie, September 2008, Wiley

    Professor Norio Shibata

  310. ChemInform Abstract: Fluorinated Johnson Reagent for Transfer‐Trifluoromethylation to Carbon Nucleophiles.

    Article • ChemInform, September 2008, Wiley

    Professor Norio Shibata

  311. Enantioselective Synthesis of (R)‐Convolutamydine A with New N‐Heteroarylsulfonylprolinamides

    Article • Chemistry - A European Journal, September 2008, Wiley

    Professor Norio Shibata

  312. ChemInform Abstract: Recent Advances in Enantioselective Trifluoromethylation Reactions

    Article • ChemInform, July 2008, Wiley

    Professor Norio Shibata

  313. Novel Enantiocomplementary C2‐Symmetric Chiral Bis(imidazoline) Ligands: Highly Enantioselective Friedel–Crafts Alkylation of Indoles with Ethyl 3,3,3‐Trifluoropyruvate

    Article • Advanced Synthesis & Catalysis, July 2008, Wiley

    Professor Norio Shibata

  314. Fluorinated Johnson Reagent for Transfer‐Trifluoromethylation to Carbon Nucleophiles

    Article • European Journal of Organic Chemistry, June 2008, Wiley

    Professor Norio Shibata

  315. Catalytic and Highly Enantioselective Reactions of α‐Sulfonyl Carbanions with Chiral Bis(oxazoline)s

    Article • Chemistry - A European Journal, June 2008, Wiley

    Professor Norio Shibata

  316. Organocatalytic Enantioselective Hydrophosphonylation of Sulfonylimines having a Heteroarenesulfonyl Group as a Novel Stereocontroller

    Article • Advanced Synthesis & Catalysis, May 2008, Wiley

    Professor Norio Shibata

  317. DBFOX-Ph/metal complexes: Evaluation as catalysts for enantioselective fluorination of 3-(2-arylacetyl)-2-thiazolidinones

    Article • Beilstein Journal of Organic Chemistry, May 2008, Beilstein Institut

    Professor Norio Shibata

  318. Cinchona Alkaloid Catalyzed Enantioselective Fluorination of Allyl Silanes, Silyl Enol Ethers, and Oxindoles

    Article • Angewandte Chemie, May 2008, Wiley

    Professor Norio Shibata

  319. Enantioselective CC Bond Formation to Sulfonylimines through Use of the 2‐Pyridinesulfonyl Group as a Novel Stereocontroller

    Article • Chemistry - A European Journal, February 2008, Wiley

    Professor Norio Shibata

  320. Enzymatic resolution and evaluation of enantiomers of cis-5′-hydroxythalidomide

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Professor Norio Shibata

  321. Synthesis of covalently linked binuclear clamshell phthalocyanine by double-click reaction

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Professor Norio Shibata

  322. Synthesis and properties of trifluoroethoxy-coated binuclear phthalocyanine

    Article • Chemical Communications, January 2008, Royal Society of Chemistry

    Professor Norio Shibata

  323. Highly Enantioselective Reactions of Configurationally Labile Epimeric Diamine Complexes of Lithiated S‐Benzyl Thiocarbamates

    Article • Chemistry - An Asian Journal, December 2007, Wiley

    Professor Norio Shibata

  324. Desymmetrization‐like Catalytic Enantioselective Fluorination of Malonates and Its Application to Pharmaceutically Attractive Molecules

    Article • Angewandte Chemie, December 2007, Wiley

    Professor Norio Shibata

  325. Asymmetric lithiation of 2-alkynyl aryl sulfides—Enantio- and diastereoselective formation of allenyl aryl sulfides and their application in nickel-catalyzed cross-coupling reactions

    Article • Tetrahedron Letters, December 2007, Elsevier

    Professor Norio Shibata

  326. Cinchona‐Alkaloid‐Catalyzed Enantioselective Direct Aldol‐Type Reaction of Oxindoles with Ethyl Trifluoropyruvate

    Article • Angewandte Chemie, November 2007, Wiley

    Professor Norio Shibata

  327. Highly Enantioselective Reactions of α‐Sulfonyl Carbanions of Trifluoromethyl Sulfones

    Article • Angewandte Chemie, September 2007, Wiley

    Professor Norio Shibata

  328. Ammonium bromides/KF catalyzed trifluoromethylation of carbonyl compounds with (trifluoromethyl)trimethylsilane and its application in the enantioselective trifluoromethylation reaction

    Article • Tetrahedron, August 2007, Elsevier

    Professor Norio Shibata

  329. Cinchona Alkaloids/TMAF Combination-Catalyzed Nucleophilic Enantioselective Trifluoromethylation of Aryl Ketones

    Article • Organic Letters, August 2007, American Chemical Society (ACS)

    Professor Norio Shibata

  330. DNA‐Mediated Enantioselective Carbon—Fluorine Bond Formation

    Article • ChemInform, July 2007, Wiley

    Professor Norio Shibata

  331. Enantioselective Mannich-type reaction of sulfonylimines having 2-pyridylsulfonyl group as a novel stereocontroller

    Article • Tetrahedron Letters, July 2007, Elsevier

    Professor Norio Shibata

  332. New approaches to enantioselective fluorination: Cinchona alkaloids combinations and chiral ligands/metal complexes

    Article • Journal of Fluorine Chemistry, May 2007, Elsevier

    Professor Norio Shibata

  333. Cinchona Alkaloid-Catalyzed Enantioselective Monofluoromethylation Reaction Based on Fluorobis(phenylsulfonyl)methane Chemistry Combined with a Mannich-type Reaction

    Article • Journal of the American Chemical Society, April 2007, American Chemical Society (ACS)

    Professor Norio Shibata

  334. DNA-Mediated Enantioselective Carbon-Fluorine Bond Formation

    Article • Synlett, April 2007, Thieme Publishing Group

    Professor Norio Shibata

  335. Synthesis and Spectral Properties of a Deoxyribose-Phthalocyanine ­Conjugate Using a Sonogashira Coupling Reaction

    Article • Synlett, February 2007, Thieme Publishing Group

    Professor Norio Shibata

  336. Design, Synthesis, and Spectroscopic Investigation of Zinc Dodecakis(trifluoroethoxy)phthalocyanines Conjugated with Deoxyribonucleosides

    Article • Angewandte Chemie, December 2006, Wiley

    Professor Norio Shibata

  337. Efficient Synthesis of Bicyclic α-Hydroxy-α-trifluoromethyl-γ-lactams

    Article • Synlett, December 2006, Thieme Publishing Group

    Professor Norio Shibata

  338. Lewis Acid-Catalyzed Enantioselective Hydroxylation Reactions of Oxindoles and β-Keto Esters Using DBFOX Ligand

    Article • Journal of the American Chemical Society, December 2006, American Chemical Society (ACS)

    Professor Norio Shibata

  339. Enantioselective Strecker-type reaction to sulfonylimines having a 2-pyridylsulfonyl group as a novel stereocontroller

    Article • Tetrahedron Letters, October 2006, Elsevier

    Professor Norio Shibata

  340. Enantioselective Fluorination Mediated by Cinchona Alkaloids/Selectfluor Combinations: A Catalytic Approach.

    Article • ChemInform, August 2006, Wiley

    Professor Norio Shibata

  341. Fluorobis(phenylsulfonyl)methane: A Fluoromethide Equivalent and Palladium‐Catalyzed Enantioselective Allylic Monofluoromethylation

    Article • Angewandte Chemie, July 2006, Wiley

    Professor Norio Shibata

  342. Enantioselective fluorination mediated by cinchona alkaloids/selectfluor combinations: A catalytic approach

    Article • Journal of Fluorine Chemistry, May 2006, Elsevier

    Professor Norio Shibata

  343. Remote asymmetric trifluoromethylation induced by chiral sulfinyl group: synthesis of enantiomerically pure 1-(2-naphthyl)-2,2,2-trifluoroethanol

    Article • Tetrahedron Letters, February 2006, Elsevier

    Professor Norio Shibata

  344. Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes

    Article • Chemical Communications, January 2006, Royal Society of Chemistry

    Professor Norio Shibata

  345. Tri-tert-butylphosphine is an Efficient Promoter for the Trifluoromethylation Reactions of Aldehydes, Ketones, Imides and Imines

    Article • Synlett, January 2006, Thieme Publishing Group

    Professor Norio Shibata

  346. Enantioselective nucleophilic addition to N-(2-pyridylsulfonyl)imines by use of dynamically induced chirality

    Article • Tetrahedron Letters, December 2005, Elsevier

    Professor Norio Shibata

  347. Highly Enantioselective Catalytic Fluorination and Chlorination Reactions of Carbonyl Compounds Capable of Two‐Point Binding

    Article • Angewandte Chemie, June 2005, Wiley

    Professor Norio Shibata

  348. Cinchona Alkaloid/Sulfinyl Chloride Combinations. Enantioselective Sulfinylating Agents of Alcohols.

    Article • ChemInform, May 2005, Wiley

    Professor Norio Shibata

  349. Cinchona Alkaloid/Sulfinyl Chloride Combinations:  Enantioselective Sulfinylating Agents of Alcohols [J. Am. Chem. Soc. 2005, 127, 1374−1375].

    Article • Journal of the American Chemical Society, March 2005, American Chemical Society (ACS)

    Professor Norio Shibata

  350. Cinchona Alkaloid/Sulfinyl Chloride Combinations:  Enantioselective Sulfinylating Agents of Alcohols

    Article • Journal of the American Chemical Society, January 2005, American Chemical Society (ACS)

    Professor Norio Shibata

  351. Cinchona Alkaloid-Sulfinyl Chloride Combinations: Catalytic Enantio­selective Sulfinylation of Alcohols

    Article • Synlett, January 2005, Thieme Publishing Group

    Professor Norio Shibata

  352. Enantioselective synthesis of chiral sulfinates using chiral diamines

    Article • Chirality, January 2005, Wiley

    Professor Norio Shibata

  353. Asymmetric Synthesis of Axially Chiral cis-Arylmethylenebicyclo[3.3.0]octanes Using α-Thio- and α-Selenoorganolithium Compounds

    Article • Chemistry Letters, December 2004, Oxford University Press (OUP)

    Professor Norio Shibata

  354. First Enantio‐Flexible Fluorination Reaction Using Metal‐Bis(oxazoline) Complexes.

    Article • ChemInform, November 2004, Wiley

    Professor Norio Shibata

  355. 20-Deoxy-20-fluorocamptothecin: Design and Synthesis of Camptothecin Isostere

    Article • Synlett, October 2004, Thieme Publishing Group

    Professor Norio Shibata

  356. Chiral discrimination between thalidomide enantiomers using a solid surface with two-dimensional chirality

    Article • Chirality, January 2004, Wiley

    Professor Norio Shibata

  357. Enantioselective Fluorination Mediated by N-Fluoroammonium Salts of Cinchona Alkaloids:  First Enantioselective Synthesis of BMS-204352 (MaxiPost)

    Article • The Journal of Organic Chemistry, February 2003, American Chemical Society (ACS)

    Professor Norio Shibata

  358. ChemInform Abstract: Synthesis of Nonpolar Peptide Nucleic Acid Monomers Containing Fluoroaromatics.

    Article • ChemInform, November 2001, Wiley

    Professor Norio Shibata

  359. Enantioselective Fluorination Mediated by Cinchona Alkaloid Derivatives/Selectfluor Combinations:  Reaction Scope and Structural Information forN-Fluorocinchona Alkaloids

    Article • Journal of the American Chemical Society, June 2001, American Chemical Society (ACS)

    Professor Norio Shibata

  360. A Fundamentally New Approach to Enantioselective Fluorination Based on Cinchona Alkaloid Derivatives/Selectfluor Combination

    Article • Journal of the American Chemical Society, October 2000, American Chemical Society (ACS)

    Professor Norio Shibata

  361. Novel Methods for the Facile Construction of 3,3-Disubstituted and 3,3-Spiro-2H,4H-benzo[e]1,2-thiazine-1,1-diones:  Synthesis of (11S,12R,14R)-2-Fluoro-14-methyl-11-(methylethyl)spiro[4H-benzo[e]...

    Article • The Journal of Organic Chemistry, October 2000, American Chemical Society (ACS)

    Professor Norio Shibata

  362. ChemInform Abstract: (R)‐ and (S)‐3‐Fluorothalidomides: Isosteric Analogues of Thalidomide.

    Article • ChemInform, February 2000, Wiley

    Professor Norio Shibata

  363. Application of the Ugi four-component condensation reaction for the synthesis of α,α- and α,β-dipeptides substituted with fluoroarylalkyl pendent groups†

    Article • Journal of the Chemical Society Perkin Transactions 1, January 2000, Royal Society of Chemistry

    Professor Norio Shibata

  364. N-Fluoro-3-cyclohexyl-3-methyl-2,3- dihydrobenzo[1,2-d]isothiazole 1,1-Dioxide:  An Efficient Agent for Electrophilic Asymmetric Fluorination of Enolates

    Article • The Journal of Organic Chemistry, July 1999, American Chemical Society (ACS)

    Professor Norio Shibata

  365. ChemInform Abstract: Research on the Correlation Between the Pummerer Reaction and Penicillin Biosynthesis

    Article • ChemInform, April 1999, Wiley

    Professor Norio Shibata

  366. Synthesis of γ-fluoro-α-methyl-α-amino acids. A new alkylation procedure for ester imines

    Article • Tetrahedron, May 1998, Elsevier

    Professor Norio Shibata

  367. Structure of isopenicillinN synthase complexed with substrate and the mechanism ofpenicillin formation

    Article • Nature, June 1997, Springer Science + Business Media

    Professor Norio Shibata

  368. Resin-bound peptide libraries showing specific metal ion binding

    Article • Bioorganic & Medicinal Chemistry Letters, February 1997, Elsevier

    Professor Norio Shibata

  369. An expeditious synthesis of (2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol, a key building block of HIV protease inhibitors

    Article • Tetrahedron Letters, January 1997, Elsevier

    Professor Norio Shibata

  370. Highly asymmetric Pummerer-type reaction induced by ethoxy vinyl esters

    Article • Tetrahedron Asymmetry, January 1997, Elsevier

    Professor Norio Shibata

  371. Electrophilic sulfenylation in a stereocontrolled synthesis of protected (2R,3R)-3-mercaptoaspartic acid from -aspartic acid

    Article • Tetrahedron, September 1996, Elsevier

    Professor Norio Shibata

  372. Adipoyl-6-aminopenicillanic acid is a substrate for deacetoxycephalosporin C synthase (DAOCS)

    Article • Bioorganic & Medicinal Chemistry Letters, July 1996, Elsevier

    Professor Norio Shibata

  373. A highly asymmetric Pummerer-type cyclization of chiral, non-racemic β-amidosulfoxides induced by O-silylated ketene acetals

    Article • Tetrahedron Letters, January 1995, Elsevier

    Professor Norio Shibata

  374. A novel diastereoselective synthesis of chiral, non-racemic unsymmetrical thioacetals using silicon-induced Pummerer-type reaction

    Article • Tetrahedron Letters, January 1995, Elsevier

    Professor Norio Shibata

  375. Enantioselective pummerer-type rearrangement by reaction of O-silylated ketene acetal with enantiopure α-substituted sulfoxides

    Article • Tetrahedron Letters, December 1994, Elsevier

    Professor Norio Shibata

  376. Pummerer-type Cyclization of Arnstein Tripeptide Analogs Induced by O-Silylated Ketene Acetals: Studies of Penicillin Biosynthesis

    Article • Journal of the American Chemical Society, June 1994, American Chemical Society (ACS)

    Professor Norio Shibata

  377. A novel asymmetric pummerer reaction induced by ethoxy vinyl ester

    Article • Tetrahedron Letters, May 1994, Elsevier

    Professor Norio Shibata

  378. Mechanistic studies of Pummerer reaction in acyclic sulfoxides induced by O-silylated ketene acetals

    Article • Tetrahedron Letters, April 1994, Elsevier

    Professor Norio Shibata

  379. The first highly asymmetric pummerer-type reaction in chiral acyclic sulfoxides: Chemistry of O-silylated ketene acetals

    Article • Tetrahedron Letters, June 1993, Elsevier

    Professor Norio Shibata

  380. A Novel Method for the Alkoxylation of Azetidin-2-ones at the 4-Position.

    Article • Chemical and Pharmaceutical Bulletin, January 1992, Pharmaceutical Society of Japan

    Professor Norio Shibata

  381. An Efficient Synthesis of 4-Heterofunction-Substituted 3-(1-Hydroxy)ethylazetidin-2-ones from 3-(1-Hydroxy)ethyl-4-phenylsulfinylazetidin-2-one by Reaction with Silylated Heteronucleophiles.

    Article • Chemical and Pharmaceutical Bulletin, January 1992, Pharmaceutical Society of Japan

    Professor Norio Shibata

  382. Chemistry of O-Silylated Ketene Acetals: A Stereoselective Synthesis of Optically Active Carbapenem Antibiotics, (+)-Thienamycin and (+)-PS-5.

    Article • Chemical and Pharmaceutical Bulletin, January 1992, Pharmaceutical Society of Japan

    Professor Norio Shibata

  383. A novel substitution reaction of 4-sulfinylazetidin-2-one with silylated heteronucleophiles: an efficient synthesis of 4-heterofunction substituted 3-(1-hydroxy)ethylazetidin-2-ones

    Article • Tetrahedron Letters, May 1991, Elsevier

    Professor Norio Shibata

  384. Chemistry of O-Silylated Ketene Acetals: A Mild and Convenient Synthesis of .BETA.-Lactam Antibiotics.

    Article • Chemical and Pharmaceutical Bulletin, January 1991, Pharmaceutical Society of Japan

    Professor Norio Shibata

  385. Chemistry of O-silylated ketene acetals: a stereoselective synthesis of chiral thienamycin intermediate

    Article • Journal of the Chemical Society Chemical Communications, January 1990, Royal Society of Chemistry

    Professor Norio Shibata

  386. Chemistry of O-silylated ketene acetals: A novel intramolecular Pummerer-type reaction of .OMEGA.-carbamoylsulfoxides leading to .ALPHA.-thiolactams.

    Article • Chemical and Pharmaceutical Bulletin, January 1990, Pharmaceutical Society of Japan

    Professor Norio Shibata

  387. Chemistry of O -silylated ketene acetals: Biomimetic synthesis of cis -β-lactams

    Article • Tetrahedron Letters, January 1989, Elsevier

    Professor Norio Shibata

  388. Novel transformation of azabicyclothionocarbonate to azaspirolactone.

    Article • Chemical and Pharmaceutical Bulletin, January 1989, Pharmaceutical Society of Japan

    Professor Norio Shibata

  389. Synthesis of Thalidomide

    Article • Springer Science + Business Media

    Professor Norio Shibata