Professor Hiroshi Yamazaki

All Stories

Humanized-Liver TK-NOG Mice Lacking Plasma Carboxylesterase 1c Improve the Prediction of Human Carboxylesterase 1-Mediated Drug Metabolism

Article • Drug Metabolism and Disposition, March 2026, Elsevier

Professor Hiroshi Yamazaki
Novel cytochrome P450 2J isoforms in tree shrews are functional drug-metabolising enzymes involved in ebastine and astemizole oxidation

Article • Xenobiotica, January 2026, Taylor & Francis

Professor Hiroshi Yamazaki
Investigation of genetic polymorphisms in pig cytochromes P450 1A2, 2A19, 2C33, 2D25, and 3A22 to elucidate inter-individual variability of hepatic drug oxidations

Article • Biochemical Pharmacology, December 2025, Elsevier

Professor Hiroshi Yamazaki
Prediction of Human Hepatic Clearance with HepaSH Monolayers for Low-Turnover Compounds

Article • Drug Metabolism and Disposition, November 2025, Elsevier

Professor Hiroshi Yamazaki
Japanese medicinal drug labeling for use in the clinical setting as informed by pharmacogenomic data on cytochrome P450 enzymes obtained from in silico studies

Article • Drug Metabolism and Pharmacokinetics, October 2025, Elsevier

Professor Hiroshi Yamazaki
Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs

Article • Drug Metabolism and Disposition, September 2025, Elsevier

Professor Hiroshi Yamazaki
Tyrosine kinase inhibitors, nilotinib and radotinib, suppress both catalytic function and mRNA expression of human cytochrome P450 2J2 and 2C8

Article • Drug Metabolism and Pharmacokinetics, August 2025, Elsevier

Professor Hiroshi Yamazaki
Prediction of Internal Exposures after Virtual Oral Doses of Disparate Chemicals in Rats and Humans Using Simplified Physiologically Based Pharmacokinetic Models with In Silico-Generated Input Parameters

Article • Chemical Research in Toxicology, July 2025, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Investigation of pilocarpine oxidative and hydrolytic metabolism in chimeric mice with humanized liver

Article • Drug Metabolism and Pharmacokinetics, June 2025, Elsevier

Professor Hiroshi Yamazaki
Contribution of Japanese scientists to drug metabolism and disposition

Article • Drug Metabolism and Disposition, May 2025, Elsevier

Professor Hiroshi Yamazaki
Novel dog hepatic cytochrome P450 3A293 oxidizes endogenous testosterone and estradiol

Article • Biochemical Pharmacology, May 2025, Elsevier

Professor Hiroshi Yamazaki
Substrate inhibition potential of arachidonic acid on 14,15-epoxidation, a biological drug developmental target, mediated by recombinant human cytochrome P450 2J2 and 2C8 enzymes

Article • Drug Metabolism and Pharmacokinetics, April 2025, Elsevier

Professor Hiroshi Yamazaki
Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity

Article • Biochemical Pharmacology, October 2024, Elsevier

Professor Hiroshi Yamazaki
Kinetics of the inhibition of CYP3A4 and CYP2C19 activity by jabara juice and identification of the responsible inhibitory components

Article • Journal of Pharmaceutical Sciences, October 2024, Elsevier

Professor Hiroshi Yamazaki
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities

Article • Xenobiotica, August 2024, Taylor & Francis

Professor Hiroshi Yamazaki
Investigation of Functional Cytochrome P450 4A Enzymes in Liver and Kidney of Pigs, Cats, Tree Shrews, and Dogs in Comparison with the Metabolic Capacity of Human P450 4A11

Article • Drug Metabolism and Disposition, July 2024, Elsevier

Professor Hiroshi Yamazaki
QuinuclidineN-Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs

Article • Drug Metabolism and Disposition, May 2024, Elsevier

Professor Hiroshi Yamazaki
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells

Article • Chemical Research in Toxicology, April 2024, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources

Article • Drug Metabolism and Pharmacokinetics, April 2024, Elsevier

Professor Hiroshi Yamazaki
Transcript abundance of hepatic drug-metabolizing enzymes in two dog breeds compared with 14 species including humans

Article • Drug Metabolism and Pharmacokinetics, April 2024, Elsevier

Professor Hiroshi Yamazaki
Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan

Article • Drug Metabolism and Disposition, January 2024, Elsevier

Professor Hiroshi Yamazaki
Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman

Article • Acute Medicine & Surgery, January 2024, Wiley

Professor Hiroshi Yamazaki
Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole

Article • Drug Metabolism and Disposition, December 2023, Elsevier

Professor Hiroshi Yamazaki
Simple confirmation methods for rare but impaired variants of human flavin-containing monooxygenase 3 (FMO3) found in an updated genome resource databank

Article • Drug Metabolism and Pharmacokinetics, December 2023, Elsevier

Professor Hiroshi Yamazaki
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver

Article • Xenobiotica, November 2023, Taylor & Francis

Professor Hiroshi Yamazaki
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol

Article • Xenobiotica, November 2023, Taylor & Francis

Professor Hiroshi Yamazaki
A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis – A potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir

Article • Journal of Infection and Chemotherapy, November 2023, Elsevier

Professor Hiroshi Yamazaki
Pharmacokinetic Models Scaled Up from Humanized Liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated andN-Demethylated Metabolites in Pediatric Patients Genotyped for CytochromeP450 2D6

Article • Drug Metabolism and Disposition, October 2023, Elsevier

Professor Hiroshi Yamazaki
Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection

Article • Journal of Pharmaceutical Health Care and Sciences, October 2023, Springer Science + Business Media

Professor Hiroshi Yamazaki
Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1

Article • Chemical Research in Toxicology, October 2023, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation

Article • Xenobiotica, July 2023, Taylor & Francis

Professor Hiroshi Yamazaki
A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria

Article • Drug Metabolism and Pharmacokinetics, June 2023, Elsevier

Professor Hiroshi Yamazaki
HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes

Article • Biochemical and Biophysical Research Communications, June 2023, Elsevier

Professor Hiroshi Yamazaki
Roles of human cytochrome P450 3A4/5 in dexamethasone 6β-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin

Article • Drug Metabolism and Pharmacokinetics, June 2023, Elsevier

Professor Hiroshi Yamazaki
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro

Article • Xenobiotica, May 2023, Taylor & Francis

Professor Hiroshi Yamazaki
Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources

Article • Drug Metabolism and Disposition, April 2023, Elsevier

Professor Hiroshi Yamazaki
High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database

Article • Drug Metabolism and Pharmacokinetics, April 2023, Elsevier

Professor Hiroshi Yamazaki
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs

Article • Xenobiotica, March 2023, Taylor & Francis

Professor Hiroshi Yamazaki
Novel Cytochrome P450 2C94 Functionally Metabolizes Diclofenac and Omeprazole in Dogs

Article • Drug Metabolism and Disposition, February 2023, Elsevier

Professor Hiroshi Yamazaki
Newly Identified Tree ShrewCytochrome P4502A13 is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to DogCytochrome P4502A13 and PigCytochrome P4502A19

Article • Drug Metabolism and Disposition, January 2023, Elsevier

Professor Hiroshi Yamazaki
The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers

Article • Drug Metabolism and Disposition, January 2023, Elsevier

Professor Hiroshi Yamazaki
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22

Article • Xenobiotica, January 2023, Taylor & Francis

Professor Hiroshi Yamazaki
A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs

Article • Xenobiotica, November 2022, Taylor & Francis

Professor Hiroshi Yamazaki
Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria

Article • Drug Metabolism and Pharmacokinetics, October 2022, Elsevier

Professor Hiroshi Yamazaki
Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats

Article • Biochemical Pharmacology, August 2022, Elsevier

Professor Hiroshi Yamazaki
Correction to “An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats”

Article • Chemical Research in Toxicology, July 2022, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2

Article • Xenobiotica, July 2022, Taylor & Francis

Professor Hiroshi Yamazaki
Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes

Article • Xenobiotica, July 2022, Taylor & Francis

Professor Hiroshi Yamazaki
Plasma and synovial fluid concentrations of linezolid in patients with knee osteoarthritis infected with Staphylococcus aureus

Article • Journal of Pharmaceutical Health Care and Sciences, July 2022, Springer Science + Business Media

Professor Hiroshi Yamazaki
A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) Reveals a Functional Role of Newly Identified CYP3A98 in Small Intestine

Article • Drug Metabolism and Disposition, June 2022, Elsevier

Professor Hiroshi Yamazaki
Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes

Article • Drug Metabolism and Disposition, June 2022, Elsevier

Professor Hiroshi Yamazaki
Molecular and Functional Characterization of N-Acetyltransferases in Common Marmosets and Pigs

Article • Drug Metabolism and Disposition, June 2022, Elsevier

Professor Hiroshi Yamazaki
Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies

Article • Annals of Hematology, June 2022, Springer Science + Business Media

Professor Hiroshi Yamazaki
Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes

Article • Drug Metabolism and Disposition, June 2022, Elsevier

Professor Hiroshi Yamazaki
Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers

Article • Drug Metabolism and Pharmacokinetics, June 2022, Elsevier

Professor Hiroshi Yamazaki
Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo

Article • Drug Metabolism and Pharmacokinetics, June 2022, Elsevier

Professor Hiroshi Yamazaki
Systematic identification and characterization of cynomolgus macaque solute carrier transporters

Article • Drug Metabolism and Pharmacokinetics, April 2022, Elsevier

Professor Hiroshi Yamazaki
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes

Article • Xenobiotica, March 2022, Taylor & Francis

Professor Hiroshi Yamazaki
Plasma Concentration Profiles for Hepatotoxic Pyrrolizidine Alkaloid Senkirkine in Humans Extrapolated from Rat Data Sets Using a Simplified Physiologically Based Pharmacokinetic Model

Article • Drug Metabolism and Bioanalysis Letters, March 2022, Bentham Science Publishers

Professor Hiroshi Yamazaki
Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13

Article • Xenobiotica, February 2022, Taylor & Francis

Professor Hiroshi Yamazaki
An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals

Article • Drug Metabolism and Pharmacokinetics, February 2022, Elsevier

Professor Hiroshi Yamazaki
Cloning and tissue expression of ATP-binding cassette transporters in cynomolgus macaques

Article • Drug Metabolism and Pharmacokinetics, February 2022, Elsevier

Professor Hiroshi Yamazaki
A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects

Article • Drug Metabolism and Pharmacokinetics, December 2021, Elsevier

Professor Hiroshi Yamazaki
Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes

Article • Drug Metabolism and Pharmacokinetics, December 2021, Elsevier

Professor Hiroshi Yamazaki
Pharmacokinetics of caffeine self-administered in overdose in a Japanese patient admitted to hospital

Article • Journal of Pharmaceutical Health Care and Sciences, October 2021, Springer Science + Business Media

Professor Hiroshi Yamazaki
Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes

Article • Drug Metabolism and Pharmacokinetics, October 2021, Elsevier

Professor Hiroshi Yamazaki
Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning

Article • Biochemical Pharmacology, October 2021, Elsevier

Professor Hiroshi Yamazaki
An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats

Article • Chemical Research in Toxicology, September 2021, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital

Article • Journal of Pharmaceutical Health Care and Sciences, September 2021, Springer Science + Business Media

Professor Hiroshi Yamazaki
UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers

Article • Xenobiotica, September 2021, Taylor & Francis

Professor Hiroshi Yamazaki
Roles of cytochrome P450 2A6 in the oxidation of flavone, 4′-hydroxyflavone, and 4′-, 3′-, and 2′-methoxyflavones by human liver microsomes

Article • Xenobiotica, August 2021, Taylor & Francis

Professor Hiroshi Yamazaki
Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital

Article • Journal of Pharmaceutical Health Care and Sciences, August 2021, Springer Science + Business Media

Professor Hiroshi Yamazaki
Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 1

Article • Drug Metabolism and Pharmacokinetics, August 2021, Elsevier

Professor Hiroshi Yamazaki
Feasibility of physiologically based pharmacokinetic simulations for assessing pediatric patients after accidental drug ingestion: A case study of a 1.4-year-old girl who ingested alprazolam

Article • Drug Metabolism and Pharmacokinetics, August 2021, Elsevier

Professor Hiroshi Yamazaki
Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: insights into future personalized treatments

Article • Journal of Pharmaceutical Health Care and Sciences, July 2021, Springer Science + Business Media

Professor Hiroshi Yamazaki
Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans

Article • Drug Metabolism and Disposition, June 2021, Elsevier

Professor Hiroshi Yamazaki
Evaluation of domain of unknown function 1220 (DUF1220) for detection of human genome by quantitative polymerase chain reaction: Potential use in assessing the biodistribution of transplanted therapeutic human cells

Article • Drug Metabolism and Pharmacokinetics, June 2021, Elsevier

Professor Hiroshi Yamazaki
Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources

Article • Drug Metabolism and Pharmacokinetics, June 2021, Elsevier

Professor Hiroshi Yamazaki
Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants

Article • Current Drug Metabolism, April 2021, Bentham Science Publishers

Professor Hiroshi Yamazaki
Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models

Article • Xenobiotica, April 2021, Taylor & Francis

Professor Hiroshi Yamazaki
In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice

Article • Drug Metabolism and Pharmacokinetics, April 2021, Elsevier

Professor Hiroshi Yamazaki
Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes

Article • Xenobiotica, February 2021, Taylor & Francis

Professor Hiroshi Yamazaki
Pharmacokinetics of duloxetine self-administered in overdose with quetiapine and other antipsychotic drugs in a Japanese patient admitted to hospital

Article • Journal of Pharmaceutical Health Care and Sciences, February 2021, Springer Science + Business Media

Professor Hiroshi Yamazaki
Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques

Article • Xenobiotica, January 2021, Taylor & Francis

Professor Hiroshi Yamazaki
Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19

Article • Xenobiotica, January 2021, Taylor & Francis

Professor Hiroshi Yamazaki
Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan

Article • Current Drug Metabolism, December 2020, Bentham Science Publishers

Professor Hiroshi Yamazaki, Dr Kanae Mure
Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential

Article • Chemical Research in Toxicology, December 2020, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic modeling

Article • Drug Metabolism and Pharmacokinetics, December 2020, Elsevier

Professor Hiroshi Yamazaki
Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3)

Article • Drug Metabolism and Pharmacokinetics, December 2020, Elsevier

Professor Hiroshi Yamazaki
Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling

Article • Xenobiotica, November 2020, Taylor & Francis

Professor Hiroshi Yamazaki
Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model

Article • Chemical Research in Toxicology, November 2020, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2′-, 3′-, 4′- and 6-hydroxyflavanones by human cytochrome P450 enzymes

Article • Xenobiotica, October 2020, Taylor & Francis

Professor Hiroshi Yamazaki
Expression of functional sulfotransferases (SULT) 1A1, 1A3, 1B1, 1C2, 1E1, and 2A1 in common marmosets

Article • Biochemical Pharmacology, October 2020, Elsevier

Professor Hiroshi Yamazaki
Molecular cloning, sequence analysis, and tissue distribution of marmoset monoamine oxidases A and B

Article • Drug Metabolism and Pharmacokinetics, October 2020, Elsevier

Professor Hiroshi Yamazaki
Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital

Article • Journal of Pharmaceutical Health Care and Sciences, September 2020, Springer Science + Business Media

Professor Hiroshi Yamazaki
Genetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques

Article • Xenobiotica, August 2020, Taylor & Francis

Professor Hiroshi Yamazaki
Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B1

Article • Drug Metabolism and Pharmacokinetics, August 2020, Elsevier

Professor Hiroshi Yamazaki
Molecular characterization of UDP-glucuronosyltransferases 3A and 8A in cynomolgus macaques

Article • Drug Metabolism and Pharmacokinetics, August 2020, Elsevier

Professor Hiroshi Yamazaki
Novel variants in outer protein surface of flavin-containing monooxygenase 3 found in an Argentinian case with impaired capacity for trimethylamine N-oxygenation

Article • Drug Metabolism and Pharmacokinetics, August 2020, Elsevier

Professor Hiroshi Yamazaki
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data

Article • Drug Metabolism and Pharmacokinetics, August 2020, Elsevier

Professor Hiroshi Yamazaki
Regional distributions of UDP-glucuronosyltransferase activities toward estradiol and serotonin in the liver and small intestine of cynomolgus macaques

Article • Drug Metabolism and Pharmacokinetics, August 2020, Elsevier

Professor Hiroshi Yamazaki
Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations

Article • Xenobiotica, July 2020, Taylor & Francis

Professor Hiroshi Yamazaki
Genetic variants of N-acetyltransferases 1 and 2 (NAT1 and NAT2) in cynomolgus and rhesus macaques

Article • Biochemical Pharmacology, July 2020, Elsevier

Professor Hiroshi Yamazaki
Interleukin-1β and tumor necrosis factor-α affect cytochrome P450 expression in cynomolgus macaque hepatocytes

Article • Drug Metabolism and Pharmacokinetics, June 2020, Elsevier

Professor Hiroshi Yamazaki
Human Aldehyde Oxidase 1-mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes

Article • Drug Metabolism and Disposition, May 2020, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Preference forO-demethylation reactions in the oxidation of 2′-, 3′-, and 4′-methoxyflavones by human cytochrome P450 enzymes

Article • Xenobiotica, April 2020, Taylor & Francis

Professor Hiroshi Yamazaki
Systematic characterization of glutathione S-transferases in common marmosets

Article • Biochemical Pharmacology, April 2020, Elsevier

Professor Hiroshi Yamazaki
Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment

Article • Xenobiotica, January 2020, Taylor & Francis

Professor Hiroshi Yamazaki
Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model

Article • The Journal of Toxicological Sciences, January 2020, Japanese Society of Toxicology

Professor Hiroshi Yamazaki
The marmoset cytochrome P450 superfamily: Sequence/phylogenetic analyses, genomic structure, and catalytic function

Article • Biochemical Pharmacology, January 2020, Elsevier

Professor Hiroshi Yamazaki
Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4′- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice

Article • Chemical Research in Toxicology, December 2019, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver

Article • Xenobiotica, November 2019, Taylor & Francis

Professor Hiroshi Yamazaki
Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes

Article • Xenobiotica, November 2019, Taylor & Francis

Professor Hiroshi Yamazaki
Expression levels of microRNAs that are potential cytochrome P450 regulators in cynomolgus macaques

Article • Xenobiotica, November 2019, Taylor & Francis

Professor Hiroshi Yamazaki
Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling

Article • Biopharmaceutics & Drug Disposition, November 2019, Wiley

Professor Hiroshi Yamazaki
Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver

Article • Xenobiotica, September 2019, Taylor & Francis

Professor Hiroshi Yamazaki
Molecular and functional characterization of cytosolic sulfotransferases in cynomolgus macaque

Article • Biochemical Pharmacology, August 2019, Elsevier

Professor Hiroshi Yamazaki
Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques

Article • Biochemical Pharmacology, May 2019, Elsevier

Professor Hiroshi Yamazaki
Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

Article • Current Drug Metabolism, April 2019, Bentham Science Publishers

Professor Hiroshi Yamazaki, Yasuhiro Uno
Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes

Article • Chemical Research in Toxicology, April 2019, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Functional characterization for polymorphic organic anion transporting polypeptides (OATP/SLCO1B1, 1B3, 2B1) of monkeys recombinantly expressed with various OATP probes

Article • Biopharmaceutics & Drug Disposition, February 2019, Wiley

Professor Hiroshi Yamazaki
Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques

Article • Drug Metabolism and Pharmacokinetics, February 2019, Elsevier

Professor Hiroshi Yamazaki
Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate

Article • Chemical Research in Toxicology, January 2019, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Pharmacokinetics and metabolism of pemafibrate, a novel selective peroxisome proliferator‐activated receptor‐alpha modulator, in rats and monkeys

Article • Biopharmaceutics & Drug Disposition, January 2019, Wiley

Professor Hiroshi Yamazaki
Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6

Article • Xenobiotica, December 2018, Taylor & Francis

Professor Hiroshi Yamazaki
Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver

Article • Xenobiotica, December 2018, Taylor & Francis

Professor Hiroshi Yamazaki
Plasma and Hepatic Concentrations of Chemicals after Virtual Oral Administrations Extrapolated Using Rat Plasma Data and Simple Physiologically Based Pharmacokinetic Models

Article • Chemical Research in Toxicology, December 2018, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Novel variants and haplotypes of human flavin-containing monooxygenase 3 gene associated with Japanese subjects suffering from trimethylaminuria

Article • Xenobiotica, November 2018, Taylor & Francis

Professor Hiroshi Yamazaki
Prediction of Human Distribution Volumes of Compounds in Various Elimination Phases Using Physiologically Based Pharmacokinetic Modeling and Experimental Pharmacokinetics in Animals

Article • Drug Metabolism and Disposition, November 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Cytochrome P450 1A1, 2C9, 2C19, and 3A4 Polymorphisms Account for Interindividual Variability of Toxicological Drug Metabolism in Cynomolgus Macaques

Article • Chemical Research in Toxicology, November 2018, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Molecular and Functional Characterization of N-Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque

Article • Chemical Research in Toxicology, October 2018, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

Article • Xenobiotica, September 2018, Taylor & Francis

Professor Hiroshi Yamazaki
Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney

Article • Journal of Medical Primatology, September 2018, Wiley

Professor Hiroshi Yamazaki
In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans

Article • Xenobiotica, September 2018, Taylor & Francis

Professor Hiroshi Yamazaki
Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques

Article • Xenobiotica, September 2018, Taylor & Francis

Professor Hiroshi Yamazaki, Yasuhiro Uno
Pharmacokinetics of anticoagulants apixaban, dabigatran, edoxaban, and rivaroxaban in elderly Japanese patients with atrial fibrillation treated in one general hospital

Article • Xenobiotica, September 2018, Taylor & Francis

Professor Hiroshi Yamazaki, Minoru Kogiku
Genetic Variants of Glutathione S-Transferase GSTT1 and GSTT2 in Cynomolgus Macaques: Identification of GSTT Substrates and Functionally Relevant Alleles

Article • Chemical Research in Toxicology, August 2018, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Oxidation of flavanone and flavone by cytochrome P450 2A6

Article • Xenobiotica, July 2018, Taylor & Francis

Haruna Nagayoshi, Professor Hiroshi Yamazaki
Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanized livers

Article • Xenobiotica, July 2018, Taylor & Francis

Professor Hiroshi Yamazaki
Suitable albumin concentrations for enhanced drug oxidation activities mediated by human liver microsomal cytochrome P450 2C9 and other forms predicted with unbound fractions and partition/distribution coefficients of model substrates

Article • Xenobiotica, June 2018, Taylor & Francis

Professor Hiroshi Yamazaki
Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate

Article • Xenobiotica, May 2018, Taylor & Francis

Professor Hiroshi Yamazaki
Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

Article • Xenobiotica, April 2018, Taylor & Francis

Professor Hiroshi Yamazaki
Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure

Article • Pest Management Science, February 2018, Wiley

Professor Hiroshi Yamazaki
Polymorphisms of cytochrome P450 2B6 (CYP2B6 ) in cynomolgus and rhesus macaques

Article • Journal of Medical Primatology, February 2018, Wiley

Professor Hiroshi Yamazaki
Marmoset cytochrome P450 2B6, a propofol hydroxylase expressed in liver

Article • Xenobiotica, February 2018, Taylor & Francis

Professor Hiroshi Yamazaki, Yasuhiro Uno
Improved Intranasal Retentivity and Transnasal Absorption Enhancement by PEGylated Poly-l-ornithine

Article • Pharmaceuticals, January 2018, MDPI AG

Professor Hiroshi Yamazaki
Cytochrome P450 2A6 and Other Human P450 Enzymes in the Oxidation of Flavone and Flavanone

Article • Xenobiotica, January 2018, Taylor & Francis

Professor Hiroshi Yamazaki
Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies

Article • Biopharmaceutics & Drug Disposition, December 2017, Wiley

Professor Hiroshi Yamazaki
Molecular cloning and tissue distribution of a novel marmoset ABC transporter

Article • Biopharmaceutics & Drug Disposition, December 2017, Wiley

Professor Hiroshi Yamazaki, Yasuhiro Uno
The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage

Article • Chemical Research in Toxicology, August 2017, American Chemical Society (ACS)

Professor Hiroshi Yamazaki, Professor Norio Shibata
Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques

Article • Journal of Veterinary Pharmacology and Therapeutics, July 2017, Wiley

Professor Hiroshi Yamazaki, Yasuhiro Uno
Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19

Article • Xenobiotica, July 2017, Taylor & Francis

Professor Hiroshi Yamazaki, Yasuhiro Uno
Marmoset pulmonary cytochrome P450 2F1 oxidizes biphenyl and 7-ethoxycoumarin and hepatic human P450 substrates

Article • Xenobiotica, July 2017, Taylor & Francis

Professor Hiroshi Yamazaki, Yasuhiro Uno
Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants

Article • Xenobiotica, July 2017, Taylor & Francis

Professor Hiroshi Yamazaki
Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

Article • Biopharmaceutics & Drug Disposition, July 2017, Wiley

Professor Hiroshi Yamazaki, Yasuhiro Uno
Hepatic expression of cytochrome P450 enzymes in non-human primate species

Article • Journal of Medical Primatology, June 2017, Wiley

Professor Hiroshi Yamazaki, Yasuhiro Uno
Functional characterization and tissue expression of marmoset cytochrome P450 2E1

Article • Biopharmaceutics & Drug Disposition, June 2017, Wiley

Professor Hiroshi Yamazaki, Yasuhiro Uno
Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines

Article • Xenobiotica, May 2017, Taylor & Francis

Professor Hiroshi Yamazaki, Yasuhiro Uno
Regio- and Stereo-Selective Oxidation of a Cardiovascular Drug, Metoprolol, Mediated by Cytochrome P450 2D and 3A Enzymes in Marmoset Livers

Article • Drug Metabolism and Disposition, May 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Molecular Cloning and Characterization of Marmoset Aldehyde Oxidase

Article • Drug Metabolism and Disposition, May 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Ratio of serum levels of AGEs to soluble RAGE is correlated with trimethylamine-N-oxide in non-diabetic subjects

Article • International Journal of Food Sciences and Nutrition, April 2017, Taylor & Francis

Professor Hiroshi Yamazaki
Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase

Article • Drug Metabolism and Disposition, March 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone

Article • Drug Metabolism and Disposition, February 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
A Case of Delayed Emergence After Propofol Anesthesia

Article • A & A Case Reports, December 2016, Wolters Kluwer Health

Professor Hiroshi Yamazaki
Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes

Article • Biochemical Pharmacology, December 2016, Elsevier

Professor Hiroshi Yamazaki
Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice

Article • Xenobiotica, November 2016, Taylor & Francis

Professor Hiroshi Yamazaki
Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets

Article • Biochemical Pharmacology, November 2016, Elsevier

Professor Hiroshi Yamazaki
Differences in Toxicological and Pharmacological Responses Mediated by Polymorphic Cytochromes P450 and Related Drug-Metabolizing Enzymes

Article • Chemical Research in Toxicology, October 2016, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide

Article • Biopharmaceutics & Drug Disposition, October 2016, Wiley

Yasuhiro Uno, Professor Hiroshi Yamazaki
Physiologically based pharmacokinetic-pharmacodynamic modeling to predict concentrations and actions of sodium-dependent glucose transporter 2 inhibitor canagliflozin in human intestines and renal tubules

Article • Biopharmaceutics & Drug Disposition, September 2016, Wiley

Professor Hiroshi Yamazaki
Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2′,5′-Tetrachlorobiphenyl

Article • Drug Metabolism and Disposition, September 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
In vivoindividual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9

Article • Biopharmaceutics & Drug Disposition, September 2016, Wiley

Professor Hiroshi Yamazaki, Yasuhiro Uno
Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry

Article • Chemical Research in Toxicology, July 2016, American Chemical Society (ACS)

Professor Hiroshi Yamazaki, Professor Norio Shibata
Systematic approach to optimize a pretreatment method for ultrasensitive liquid chromatography with tandem mass spectrometry analysis of multiple target compounds in biological samples

Article • Journal of Separation Science, July 2016, Wiley

Professor Hiroshi Yamazaki
Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues

Article • Xenobiotica, July 2016, Taylor & Francis

Professor Hiroshi Yamazaki
Simulation of human plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling

Article • Xenobiotica, July 2016, Taylor & Francis

Professor Hiroshi Yamazaki
Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology

Article • Chemical Research in Toxicology, July 2016, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors

Article • Biopharmaceutics & Drug Disposition, July 2016, Wiley

Professor Hiroshi Yamazaki, Yasuhiro Uno
Structure–Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6

Article • Chemical Research in Toxicology, May 2016, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing

Article • Biopharmaceutics & Drug Disposition, May 2016, Wiley

Professor Hiroshi Yamazaki, Yasuhiro Uno
Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population

Article • Gastroenterology, May 2016, Elsevier

Professor Hiroshi Yamazaki
Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers

Article • Drug Metabolism and Disposition, April 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine

Article • Drug Metabolism and Disposition, April 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling

Article • Xenobiotica, February 2016, Taylor & Francis

Professor Hiroshi Yamazaki
Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model

Article • Scientific Reports, February 2016, Springer Science + Business Media

Professor Hiroshi Yamazaki
Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine

Article • Xenobiotica, February 2016, Taylor & Francis

Professor Hiroshi Yamazaki
Individual differences inin vitroandin vivometabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3

Article • Human Psychopharmacology Clinical and Experimental, February 2016, Wiley

Professor Hiroshi Yamazaki
Individual differences inin vitroandin vivometabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5

Article • Human Psychopharmacology Clinical and Experimental, February 2016, Wiley

Professor Hiroshi Yamazaki
Functional polymer‐dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes

Article • Hepatology Research, February 2016, Wiley

Professor Hiroshi Yamazaki
In vitroinhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight intoin vitroandin vivodiscrepancy of metabolite formation in humans

Article • Xenobiotica, December 2015, Taylor & Francis

Professor Hiroshi Yamazaki
Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling

Article • Xenobiotica, December 2015, Taylor & Francis

Professor Hiroshi Yamazaki
Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances

Article • Biopharmaceutics & Drug Disposition, December 2015, Wiley

Professor Hiroshi Yamazaki, Yasuhiro Uno
Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria

Article • Molecular Genetics and Metabolism Reports, December 2015, Elsevier

Professor Hiroshi Yamazaki
Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion ( CYP2A6 * 4 ) by real-time polymerase chain reaction platforms

Article • Data in Brief, December 2015, Elsevier

Professor Hiroshi Yamazaki
Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1

Article • Drug Metabolism and Disposition, October 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Point mutation of cytochrome P450 2A6 (a polymorphic variant CYP2A6.25) confers new substrate specificity towards flavonoids

Article • Biopharmaceutics & Drug Disposition, August 2015, Wiley

Professor Hiroshi Yamazaki
Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13

Article • Xenobiotica, August 2015, Taylor & Francis

Professor Hiroshi Yamazaki
Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates,S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole

Article • Drug Metabolism and Disposition, July 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus)

Article • Xenobiotica, June 2015, Taylor & Francis

Professor Hiroshi Yamazaki
Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays

Article • Drug Metabolism Letters, June 2015, Bentham Science Publishers

Professor Hiroshi Yamazaki
Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling

Article • Xenobiotica, June 2015, Taylor & Francis

Professor Hiroshi Yamazaki
Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling

Article • Regulatory Toxicology and Pharmacology, June 2015, Elsevier

Professor Hiroshi Yamazaki
Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase

Article • Drug Metabolism and Disposition, May 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling

Article • Environmental Toxicology and Pharmacology, May 2015, Elsevier

Professor Hiroshi Yamazaki
Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo

Article • Biochemical Pharmacology, May 2015, Elsevier

Professor Hiroshi Yamazaki
Substrate Selectivities and Catalytic Activities of Marmoset Liver Cytochrome P450 2A6 Differed from Those of Human P450 2A6

Article • Drug Metabolism and Disposition, April 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan

Article • Xenobiotica, March 2015, Taylor & Francis

Professor Hiroshi Yamazaki
Activation and Deactivation of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine by Cytochrome P450 Enzymes and Flavin-Containing Monooxygenases in Common Marmosets (Callithrix jacchus)

Article • Drug Metabolism and Disposition, March 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Oral L-Carnitine Supplementation Increases Trimethylamine-N-oxide but Reduces Markers of Vascular Injury in Hemodialysis Patients

Article • Journal of Cardiovascular Pharmacology, March 2015, Wolters Kluwer Health

Professor Hiroshi Yamazaki
CYP2D44 polymorphisms in cynomolgus and rhesus macaques

Article • Molecular Biology Reports, February 2015, Springer Science + Business Media

Professor Hiroshi Yamazaki
Regioselective hydroxylation of steroid hormones by human cytochromes P450

Article • Drug Metabolism Reviews, February 2015, Taylor & Francis

Professor Hiroshi Yamazaki
Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes

Article • Chemical Research in Toxicology, February 2015, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans

Article • Drug Metabolism and Pharmacokinetics, February 2015, Elsevier

Professor Hiroshi Yamazaki
Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9

Article • Drug Metabolism and Pharmacokinetics, February 2015, Elsevier

Professor Hiroshi Yamazaki
Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes

Article • Clinica Chimica Acta, February 2015, Elsevier

Professor Hiroshi Yamazaki
Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers

Article • Drug Metabolism and Pharmacokinetics, February 2015, Elsevier

Professor Hiroshi Yamazaki
Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling

Article • Biopharmaceutics & Drug Disposition, January 2015, Wiley

Professor Hiroshi Yamazaki
Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

Article • Toxicology Research, January 2015, Oxford University Press (OUP)

Professor Hiroshi Yamazaki
Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients

Article • Biochemical Pharmacology, January 2015, Elsevier

Professor Hiroshi Yamazaki
Fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations

Article • The Journal of Toxicological Sciences, January 2015, Japanese Society of Toxicology

Professor Hiroshi Yamazaki
Intravenous Administration of Apomorphine Does NOT Induce Long QT Syndrome: Experimental Evidence fromIn VivoCanine Models

Article • Basic & Clinical Pharmacology & Toxicology, November 2014, Wiley

Professor Hiroshi Yamazaki
Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam andR-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys usingin vitro–in vivocorrelation

Article • Xenobiotica, November 2014, Taylor & Francis

Professor Hiroshi Yamazaki
Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes

Article • Regulatory Toxicology and Pharmacology, November 2014, Elsevier

Professor Hiroshi Yamazaki
Azithromycin Can Prolong QT Interval and Suppress Ventricular Contraction, but Will Not Induce Torsade de Pointes

Article • Cardiovascular Toxicology, October 2014, Springer Science + Business Media

Professor Hiroshi Yamazaki
Evaluation of 89 Compounds for Identification of Substrates for Cynomolgus Monkey CYP2C76, a New Bupropion/Nifedipine Oxidase

Article • Drug Metabolism and Disposition, October 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling

Article • Regulatory Toxicology and Pharmacology, October 2014, Elsevier

Professor Hiroshi Yamazaki
CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques

Article • Biochemical Pharmacology, September 2014, Elsevier

Professor Hiroshi Yamazaki
Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine

Article • Xenobiotica, August 2014, Taylor & Francis

Professor Hiroshi Yamazaki
Polymorphisms of CYP2D17 in Cynomolgus and Rhesus Macaques: an Evidence of the Genetic Basis for the Variability of CYP2D-Dependent Drug Metabolism

Article • Drug Metabolism and Disposition, July 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs

Article • Biochemical Pharmacology, July 2014, Elsevier

Professor Hiroshi Yamazaki
Qualitative De Novo Analysis of Full Length cDNA and Quantitative Analysis of Gene Expression for Common Marmoset (Callithrix jacchus) Transcriptomes Using Parallel Long-Read Technology and Short-Read Sequencing

Article • PLOS One, June 2014, PLOS

Professor Hiroshi Yamazaki
Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig

Article • Biopharmaceutics & Drug Disposition, May 2014, Wiley

Professor Hiroshi Yamazaki
Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine

Article • Clinical Kidney Journal, May 2014, Oxford University Press (OUP)

Professor Hiroshi Yamazaki
Effect of Ketoconazole on the Pharmacokinetics of the Dipeptidyl Peptidase-4 Inhibitor Teneligliptin: An Open-Label Study in Healthy White Subjects in Germany

Article • Clinical Therapeutics, May 2014, Elsevier

Professor Hiroshi Yamazaki
Relationships between flavin‐containing mono‐oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population

Article • British Journal of Clinical Pharmacology, April 2014, Wiley

Professor Hiroshi Yamazaki
Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs

Article • Xenobiotica, March 2014, Taylor & Francis

Professor Hiroshi Yamazaki
Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys

Article • Xenobiotica, March 2014, Taylor & Francis

Professor Hiroshi Yamazaki
Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450

Article • Drug Metabolism and Disposition, February 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Thalidomide Increases Human Hepatic Cytochrome P450 3A Enzymes by Direct Activation of the Pregnane X Receptor

Article • Chemical Research in Toxicology, February 2014, American Chemical Society (ACS)

Professor Hiroshi Yamazaki, Professor Norio Shibata
Voriconazole Metabolism, Toxicity, and the Effect of Cytochrome P450 2C19 Genotype

Article • The Journal of Infectious Diseases, January 2014, Oxford University Press (OUP)

Professor Hiroshi Yamazaki
Drug-induced Liver Toxicity Studies: Research into Human Metabolites Clarifies Their Role in Drug Development

Article • Drug Metabolism and Pharmacokinetics, January 2014, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Comparison of Catalytic Properties of Cytochromes P450 3A4 and 3A5 by Molecular Docking Simulation

Article • Drug Metabolism Letters, December 2013, Bentham Science Publishers

Professor Hiroshi Yamazaki
Human Cytochrome P450 Oxidation of 5-Hydroxythalidomide and Pomalidomide, an Amino Analogue of Thalidomide

Article • Chemical Research in Toxicology, December 2013, American Chemical Society (ACS)

Professor Hiroshi Yamazaki, Professor Norio Shibata
The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice

Article • Xenobiotica, September 2013, Taylor & Francis

Professor Hiroshi Yamazaki
Systematic identification and characterization of glutathione S-transferases in cynomolgus macaque

Article • Biochemical Pharmacology, September 2013, Elsevier

Professor Hiroshi Yamazaki
Pitavastatin as an In Vivo Probe for Studying Hepatic Organic Anion Transporting Polypeptide-Mediated Drug–Drug Interactions in Cynomolgus Monkeys

Article • Drug Metabolism and Disposition, August 2013, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans

Article • Xenobiotica, July 2013, Taylor & Francis

Professor Hiroshi Yamazaki
Characterization of Microsomal Glutathione S-Transferases MGST1, MGST2, and MGST3 in Cynomolgus Macaque

Article • Drug Metabolism and Disposition, June 2013, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation

Article • Xenobiotica, June 2013, Taylor & Francis

Professor Hiroshi Yamazaki
Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque

Article • Biochemical Pharmacology, June 2013, Elsevier

Professor Hiroshi Yamazaki
Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities

Article • Biochemical Pharmacology, June 2013, Elsevier

Professor Hiroshi Yamazaki
Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline

Article • Xenobiotica, May 2013, Taylor & Francis

Professor Hiroshi Yamazaki
Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling

Article • Regulatory Toxicology and Pharmacology, April 2013, Elsevier

Professor Hiroshi Yamazaki
Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition

Article • Chemical Research in Toxicology, March 2013, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Metabolic Activation of Polycyclic Aromatic Hydrocarbons and Aryl and Heterocyclic Amines by Human Cytochromes P450 2A13 and 2A6

Article • Chemical Research in Toxicology, March 2013, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
In Vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice

Article • Chemical Research in Toxicology, March 2013, American Chemical Society (ACS)

Professor Hiroshi Yamazaki, Professor Norio Shibata
Cardiohemodynamic and Electrophysiological Effects of Anti-influenza Drug Oseltamivir In Vivo and In Vitro

Article • Cardiovascular Toxicology, February 2013, Springer Science + Business Media

Professor Hiroshi Yamazaki
Clinical Evidence of Pharmacokinetic Changes in Thalidomide Therapy

Article • Drug Metabolism and Pharmacokinetics, January 2013, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Cytochrome P450 Metabolic Activities in the Small Intestine of Cynomolgus Macaques Bred in Cambodia, China, and Indonesia

Article • Drug Metabolism and Pharmacokinetics, January 2013, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Drug Interactions Mediated by Drug-Metabolizing Enzymes

Article • Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, January 2013, Japanese Society of Clinical Pharmacology and Therapeutics

Professor Hiroshi Yamazaki
Mechanism-based Inhibition of CYP1A1 and CYP3A4 by the Furanocoumarin Chalepensin

Article • Drug Metabolism and Pharmacokinetics, January 2013, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
The <i>CYP3A4</i> intron 6 C>T polymorphism (<i>CYP3A4*22</i>) is associated with reduced CYP3A4 protein level and function in human liver microsomes

Article • The Journal of Toxicological Sciences, January 2013, Japanese Society of Toxicology

Professor Hiroshi Yamazaki
Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation

Article • Biochemical Pharmacology, December 2012, Elsevier

Professor Hiroshi Yamazaki
Variants in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population

Article • Molecular Genetics and Metabolism, November 2012, Elsevier

Professor Hiroshi Yamazaki
Intravenous and oral administrations of DD2 [7-Amino-2-(sulfanylmethyl)heptanoic acid] produce thrombolysis through inhibition of plasma TAFIa in rats with tissue factor-induced microthrombosis

Article • Thrombosis Research, October 2012, Elsevier

Professor Hiroshi Yamazaki
A rapid multiplex PCR assay that can reliably discriminate the cytochrome P450 2D6 whole-gene deletion allele from 2D6*10 alleles

Article • Clinica Chimica Acta, October 2012, Elsevier

Professor Hiroshi Yamazaki
Comparison of Cytochrome P450 2C Subfamily Members in Terms of Drug Oxidation Rates and Substrate Inhibition

Article • Current Drug Metabolism, September 2012, Bentham Science Publishers

Professor Hiroshi Yamazaki
Note to readers

Article • Biochemical Pharmacology, August 2012, Elsevier

Professor Hiroshi Yamazaki
Cytochrome P450 2A6 Phenotyping Based on Dietary Caffeine Intake in a Japanese Population of Non-smokers

Article • Drug Metabolism Letters, June 2012, Bentham Science Publishers

Professor Hiroshi Yamazaki
In Vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites Derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG Mice

Article • Chemical Research in Toxicology, January 2012, American Chemical Society (ACS)

Professor Hiroshi Yamazaki, Professor Norio Shibata
CYP2C76 Non-synonymous Variants in Cynomolgus and Rhesus Macaques

Article • Drug Metabolism and Pharmacokinetics, January 2012, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Expression Profile of Hepatic Genes in Cynomolgus Macaques Bred in Cambodia, China, and Indonesia: Implications for Cytochrome P450 Genes

Article • Drug Metabolism and Pharmacokinetics, January 2012, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs

Article • The Journal of Toxicological Sciences, January 2012, Japanese Society of Toxicology

Professor Hiroshi Yamazaki
Different Metabolites of Human Hepatotoxic Pyrazolopyrimidine Derivative 5‐n‐Butyl‐Pyrazolo[1,5‐a]Pyrimidine Produced by Human, Rat and Monkey Cytochrome P450 1A2 and Liver Microsomes

Article • Basic & Clinical Pharmacology & Toxicology, November 2011, Wiley

Professor Hiroshi Yamazaki
Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients

Article • Journal of Clinical Pharmacy and Therapeutics, August 2011, Hindawi Publishing Corporation

Professor Hiroshi Yamazaki
Immunochemical Detection of Cytochrome P450 Enzymes in Liver Microsomes of 27 Cynomolgus Monkeys

Article • Journal of Pharmacology and Experimental Therapeutics, August 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Human Liver Enzymes Responsible for Metabolic Elimination of Tyramine, a Vasopressor Agent from Daily Food

Article • Drug Metabolism Letters, August 2011, Bentham Science Publishers

Professor Hiroshi Yamazaki
Spectral Modification and Catalytic Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by Four Chemopreventive Organoselenium Compounds

Article • Chemical Research in Toxicology, July 2011, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Metabolism of P450 Probe Substrates by Cynomolgus Monkey CYP2C76

Article • Basic & Clinical Pharmacology & Toxicology, July 2011, Wiley

Professor Hiroshi Yamazaki
Mechanism‐based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo

Article • British Journal of Pharmacology, June 2011, Wiley

Professor Hiroshi Yamazaki
Comparison of Cytochrome P450 2D6 and Variants in Terms of Drug Oxidation Rates and Substrate Inhibition

Article • Current Drug Metabolism, June 2011, Bentham Science Publishers

Professor Hiroshi Yamazaki
Direct genotyping of Cytochrome P450 2A6 whole gene deletion from human blood samples by the SmartAmp method

Article • Clinica Chimica Acta, June 2011, Elsevier

Professor Hiroshi Yamazaki
Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation

Article • PLOS One, May 2011, PLOS

Professor Hiroshi Yamazaki
Developmental variations in metabolic capacity of flavin‐containing mono‐oxygenase 3 in childhood

Article • British Journal of Clinical Pharmacology, March 2011, Wiley

Professor Hiroshi Yamazaki
Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function

Article • Drug Metabolism Reviews, February 2011, Taylor & Francis

Professor Hiroshi Yamazaki
Newly Identified CYP2C93 Is a Functional Enzyme in Rhesus Monkey, but Not in Cynomolgus Monkey

Article • PLOS One, February 2011, PLOS

Professor Hiroshi Yamazaki
In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG Mice

Article • Chemical Research in Toxicology, February 2011, American Chemical Society (ACS)

Professor Hiroshi Yamazaki, Professor Norio Shibata
CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey

Article • Biochemical Pharmacology, February 2011, Elsevier

Professor Hiroshi Yamazaki
Sorafenib and Sunitinib, Two Anticancer Drugs, Inhibit CYP3A4-Mediated and Activate CY3A5-Mediated Midazolam 1′-Hydroxylation

Article • Drug Metabolism and Disposition, January 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Comparison of the Inhibitory Profiles of Itraconazole and Cimetidine in Cytochrome P450 3A4 Genetic Variants

Article • Drug Metabolism and Disposition, January 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
A Newly Developed DNA Microarray Is Useful to Assess Induction of Cytochromes P450 in the Cynomolgus Monkey

Article • Drug Metabolism and Pharmacokinetics, January 2011, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
CYP1B1 is Polymorphic in Cynomolgus and Rhesus Macaques

Article • Journal of Veterinary Medical Science, January 2011, Japanese Society of Veterinary Science

Professor Hiroshi Yamazaki
Cynomolgus Macaque CYP4 Isoforms Are Functional,Metabolizing Arachidonic Acid

Article • Journal of Veterinary Medical Science, January 2011, Japanese Society of Veterinary Science

Professor Hiroshi Yamazaki
Discovery of Genetic Variants in CYP1D1: Implication for Functional Integrity of CYP1D1 in Cynomolgus Macaques and Rhesus Macaques

Article • Drug Metabolism and Pharmacokinetics, January 2011, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Drug Metabolism and Toxicity in Chimeric Mice with Humanized Liver

Article • JOURNAL OF HEALTH SCIENCE, January 2011, Pharmaceutical Society of Japan

Professor Hiroshi Yamazaki
Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system

Article • Journal of Bioscience and Bioengineering, January 2011, Elsevier

Professor Hiroshi Yamazaki
Expression of Cytochromes P450 in Fetal, Infant, and Juvenile Liver of Cynomolgus Macaques

Article • Drug Metabolism and Pharmacokinetics, January 2011, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Human Cytochrome P450 1A1 Is a Novel Target Gene of Liver X Receptor α

Article • Drug Metabolism and Pharmacokinetics, January 2011, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Individual Differences in Pharmacokinetics and Pharmacodynamics of Anesthetic Agent Propofol with Regard to CYP2B6 and UGT1A9 Genotype and Patient Age

Article • Drug Metabolism and Pharmacokinetics, January 2011, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig

Article • Journal of Pharmacological Sciences, January 2011, Japanese Pharmacological Society

Professor Hiroshi Yamazaki
Species Difference between Cynomolgus Monkeys and Humans on Cytochromes P450 2D and 3A-Dependent Drug Oxidation Activities in Liver Microsomes

Article • JOURNAL OF HEALTH SCIENCE, January 2011, Pharmaceutical Society of Japan

Professor Hiroshi Yamazaki
CYP2G2, Pseudogenized in Human, Is Expressed in Nasal Mucosa of Cynomolgus Monkey and Encodes a Functional Drug-Metabolizing Enzyme

Article • Drug Metabolism and Disposition, December 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Structure−Function Relationships of Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 Flavonoid Derivatives

Article • Chemical Research in Toxicology, November 2010, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

Article • Regulatory Toxicology and Pharmacology, November 2010, Elsevier

Professor Hiroshi Yamazaki
Methodologies for Investigating Drug Metabolism at the Early Drug Discovery Stage: Prediction of Hepatic Drug Clearance and P450 Contribution

Article • Current Drug Metabolism, October 2010, Bentham Science Publishers

Professor Hiroshi Yamazaki
Human Blood Concentrations of Cotinine, a Biomonitoring Marker for Tobacco Smoke, Extrapolated from Nicotine Metabolism in Rats and Humans and Physiologically Based Pharmacokinetic Modeling

Article • International Journal of Environmental Research and Public Health, September 2010, MDPI AG

Professor Hiroshi Yamazaki
A novel CYP2A26 identified in cynomolgus monkey liver metabolizes coumarin

Article • Xenobiotica, August 2010, Taylor & Francis

Professor Hiroshi Yamazaki
Limited effects of frequent CYP2D6*36-*10 tandem duplication allele on in vivo dextromethorphan metabolism in a Japanese population

Article • European Journal of Clinical Pharmacology, August 2010, Springer Science + Business Media

Professor Hiroshi Yamazaki
Biomonitoring of Urinary Cotinine Concentrations Associated with Plasma Levels of Nicotine Metabolites after Daily Cigarette Smoking in a Male Japanese Population

Article • International Journal of Environmental Research and Public Health, July 2010, MDPI AG

Professor Hiroshi Yamazaki
Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys

Article • Drug Metabolism and Disposition, June 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Cynomolgus Monkey CYP2D44 Newly Identified in Liver, Metabolizes Bufuralol, and Dextromethorphan

Article • Drug Metabolism and Disposition, May 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Potential impact of cytochrome P450 3A5 in human liver on drug interactions with triazoles

Article • British Journal of Clinical Pharmacology, May 2010, Wiley

Professor Hiroshi Yamazaki
Human Liver Microsomal Cytochrome P450 3A Enzymes Involved in Thalidomide 5-Hydroxylation and Formation of a Glutathione Conjugate

Article • Chemical Research in Toxicology, May 2010, American Chemical Society (ACS)

Professor Hiroshi Yamazaki, Professor Norio Shibata
Genetic Variants of CYP3A4 and CYP3A5 in Cynomolgus and Rhesus Macaques

Article • Drug Metabolism and Disposition, February 2010, Elsevier

Professor Hiroshi Yamazaki
Comparison of Cytochrome P450 3A Enzymes in Cynomolgus Monkeys and Humans

Article • Drug Metabolism and Pharmacokinetics, January 2010, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Comparison of the Contributions of Cytochromes P450 3A4 and 3A5 in Drug Oxidation Rates and Substrate Inhibition

Article • JOURNAL OF HEALTH SCIENCE, January 2010, Pharmaceutical Society of Japan

Professor Hiroshi Yamazaki
Identification and Characterization of CYP2C18 in the Cynomolgus Macaque (Macaca fascicularis)

Article • Journal of Veterinary Medical Science, January 2010, Japanese Society of Veterinary Science

Professor Hiroshi Yamazaki
Effects of Histidine-Tag on Recombinant Human Cytochrome P450 3A5 Catalytic Activity in Reconstitution Systems

Article • Drug Metabolism Letters, December 2009, Bentham Science Publishers

Professor Hiroshi Yamazaki
Cloning, Expression, and Characterization of CYP3A43 in Cynomolgus Macaque (Macaca fascicularis)

Article • Drug Metabolism Letters, December 2009, Bentham Science Publishers

Professor Hiroshi Yamazaki
Approach for in Vivo Protein Binding of 5-n-Butyl-pyrazolo[1,5-a]pyrimidine Bioactivated in Chimeric Mice with Humanized Liver by Two-Dimensional Electrophoresis with Accelerator Mass Spectrometry

Article • Chemical Research in Toxicology, November 2009, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Article • Xenobiotica, October 2009, Taylor & Francis

Professor Hiroshi Yamazaki
Oxidation of Endobiotics Mediated by Xenobiotic-Metabolizing Forms of Human Cytochrome P450

Article • Current Drug Metabolism, September 2009, Bentham Science Publishers

Professor Hiroshi Yamazaki
Reverse Type I Binding Spectra of Human Cytochrome P450 1B1 Induced by Flavonoid, Stilbene, Pyrene, Naphthalene, Phenanthrene, and Biphenyl Derivatives That Inhibit Catalytic Activity: A Structure−Function Relationship Study

Article • Chemical Research in Toxicology, June 2009, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Two Novel CYP2D6*10 Haplotypes As Possible Causes of a Poor Metabolic Phenotype in Japanese

Article • Drug Metabolism and Disposition, April 2009, Elsevier

Professor Hiroshi Yamazaki
Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding

Article • Xenobiotica, March 2009, Taylor & Francis

Professor Hiroshi Yamazaki
Human Cytochrome P450 1A2 Involvement in the Formation of Reactive Metabolites from a Species-Specific Hepatotoxic Pyrazolopyrimidine Derivative, 5-n-Butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidine

Article • Chemical Research in Toxicology, January 2009, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Bonitos with Low Content of Malodorous Trimethylamine as Palliative Care for Self-reported Japanese Trimethylaminuria Subjects

Article • Drug Metabolism and Pharmacokinetics, January 2009, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Cytochrome P450-depedent Drug Oxidation Activity of Liver Microsomes from Microminipigs, A Possible New Animal Model for Humans in Non-clinical Studies

Article • Drug Metabolism and Pharmacokinetics, January 2009, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Dose-dependent Effects of Cigarette Smoke on Blood Biomarkers in Healthy Japanese Volunteers: Observations from Smoking and Non-smoking

Article • JOURNAL OF HEALTH SCIENCE, January 2009, Pharmaceutical Society of Japan

Professor Hiroshi Yamazaki
Genetic Polymorphisms of Glycine N-acyltransferase in Japanese Individuals

Article • Drug Metabolism and Pharmacokinetics, January 2009, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Identification and Characterization of CYP2B6 cDNA in Cynomolgus Macaques (Macaca fascicularis)

Article • Journal of Veterinary Medical Science, January 2009, Japanese Society of Veterinary Science

Professor Hiroshi Yamazaki
Inter-individual Variation in Flavin-containing Monooxygenase 3 in Livers from Japanese: Correlation with Hepatic Transcription Factors

Article • Drug Metabolism and Pharmacokinetics, January 2009, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Pharmacokinetic Investigation of Increased Efficacy Against Malignant Gliomas of Carboplatin Combined With Hyperbaric Oxygenation

Article • Neurologia medico-chirurgica, January 2009, Japan Neurosurgical Society

Professor Hiroshi Yamazaki
Increased distribution of carboplatin, an anti-cancer agent, to rat brains with the aid of hyperbaric oxygenation

Article • Xenobiotica, November 2008, Taylor & Francis

Professor Hiroshi Yamazaki
Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5

Article • Drug Metabolism and Disposition, October 2008, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Interaction of Polycyclic Aromatic Hydrocarbons with Human Cytochrome P450 1B1 in Inhibiting Catalytic Activity

Article • Chemical Research in Toxicology, October 2008, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Increased transendothelial permeability of anti-cancer agent carboplatin with the aid of hyperbaric oxygenation

Article • Xenobiotica, October 2008, Taylor & Francis

Professor Hiroshi Yamazaki
Effects of Enzyme Sources on Midazolam 1-Hydroxylation Activity Catalyzed by Recombinant Cytochrome P450 3A4 in Combination with NADPH-Cytochrome P450 Reductase

Article • Drug Metabolism Letters, August 2008, Bentham Science Publishers

Professor Hiroshi Yamazaki
Heterotropic Cooperativity in Oxidation Mediated by Cytochrome P450

Article • Current Drug Metabolism, June 2008, Bentham Science Publishers

Professor Hiroshi Yamazaki
Human Cytochrome P450 2A13 Efficiently Metabolizes Chemicals in Air Pollutants: Naphthalene, Styrene, and Toluene

Article • Chemical Research in Toxicology, February 2008, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Limited frequency of the CYP2C19*17 allele and its minor role in a Japanese population

Article • British Journal of Clinical Pharmacology, January 2008, Wiley

Professor Hiroshi Yamazaki
Comparison of Kinetic Parameters for Drug Oxidation Rates and Substrate Inhibition Potential Mediated by Cytochrome P450 3A4 and 3A5

Article • Current Drug Metabolism, January 2008, Bentham Science Publishers

Professor Hiroshi Yamazaki
Complex Mechanism Underlying Transcriptional Control of the Haplotyped Flavin-containing Monooxygenase 3 (FMO3) Gene in Japanese: Different Regulation between Mutations in 5′-Upstream Distal Region and Common Element in Proximal Region

Article • Drug Metabolism and Pharmacokinetics, January 2008, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Individual Differences in Toxicological Response Caused by a Diversity of Chemicals: Observations in Japan

Article • Chemical Research in Toxicology, January 2008, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3)

Article • Pharmacogenetics and Genomics, October 2007, Wolters Kluwer Health

Professor Hiroshi Yamazaki
Involvement of human cytochrome P450 2B6 in theω- and 4-hydroxylation of the anesthetic agent propofol

Article • Xenobiotica, July 2007, Taylor & Francis

Professor Hiroshi Yamazaki
Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes

Article • Drug Metabolism and Disposition, June 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Genetic Polymorphism of the Flavin-Containing Monooxygenase 3 (FMO3) Associated with Trimethylaminuria (Fish Odor Syndrome): Observations from Japanese Patients

Article • Current Drug Metabolism, June 2007, Bentham Science Publishers

Professor Hiroshi Yamazaki
Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes

Article • Biochemical Pharmacology, June 2007, Elsevier

Professor Hiroshi Yamazaki
Pharmacokinetics of Antifungal Agent Micafungin in Critically Ill Patients Receiving Continuous Hemodialysis Filtration

Article • YAKUGAKU ZASSHI, May 2007, Pharmaceutical Society of Japan

Professor Hiroshi Yamazaki
Different Mechanisms for Inhibition of Human Cytochromes P450 1A1, 1A2, and 1B1 by Polycyclic Aromatic Inhibitors

Article • Chemical Research in Toxicology, February 2007, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Transient trimethylaminuria related to menstruation

Article • BMC Medical Genetics, January 2007, Springer Science + Business Media

Professor Hiroshi Yamazaki
Effects of Propofol Analogs on Glucuronidation of Propofol, an Anesthetic Drug, by Human Liver Microsomes

Article • Drug Metabolism Letters, January 2007, Bentham Science Publishers

Professor Hiroshi Yamazaki
Genetic Polymorphism of Bile acid CoA: Amino acid N-acyltransferase in Japanese Individuals

Article • Drug Metabolism and Pharmacokinetics, January 2007, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort

Article • Drug Metabolism and Pharmacokinetics, January 2007, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population

Article • Molecular Genetics and Metabolism, January 2007, Elsevier

Professor Hiroshi Yamazaki
Effect of Genetic Variants of the Human Flavin-Containing Monooxygenase 3 on N- and S-Oxygenation Activities

Article • Drug Metabolism and Disposition, December 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
CYP2A13 expressed in human bladder metabolically activates 4‐aminobiphenyl

Article • International Journal of Cancer, October 2006, Wiley

Professor Hiroshi Yamazaki
Rat Cytochrome P450 2C11 in Liver Microsomes Involved in Oxidation of Anesthetic Agent Propofol and Deactivated by Prior Treatment with Propofol

Article • Drug Metabolism and Disposition, August 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Prediction ofin vivodrug clearance fromin vitrodata. II: Potential inter-ethnic differences

Article • Xenobiotica, June 2006, Taylor & Francis

Professor Hiroshi Yamazaki
Species differences in hydrolase activities toward OT-7100 responsible for different bioavailability in rats, dogs, monkeys and humans

Article • Xenobiotica, April 2006, Taylor & Francis

Professor Hiroshi Yamazaki
Activities of Rat Cytochrome P450 3A and 2C Isoforms are Increased In Vivo by Magnesium Sulfate as Evidenced by Enhanced Oxidation of Bupivacaine and Testosterone in Liver Microsomes

Article • Drug Metabolism and Pharmacokinetics, January 2006, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais

Article • Drug Metabolism and Pharmacokinetics, January 2006, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations

Article • Xenobiotica, January 2006, Taylor & Francis

Professor Hiroshi Yamazaki
Three Novel Single Nucleotide Polymorphisms of the FMO3 Gene in a Japanese Population

Article • Drug Metabolism and Pharmacokinetics, January 2006, Japanese Society for the Study of Xenobiotics

Professor Hiroshi Yamazaki
Mild trimethylaminuria observed in a Japanese cohort with liver damage

Article • The American Journal of Medicine, July 2005, Elsevier

Professor Hiroshi Yamazaki
CYP2A6 IS A PRINCIPAL ENZYME INVOLVED IN HYDROXYLATION OF 1,7-DIMETHYLXANTHINE, A MAIN CAFFEINE METABOLITE, IN HUMANS

Article • Drug Metabolism and Disposition, June 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas

Article • Carcinogenesis, June 2005, Oxford University Press (OUP)

Professor Hiroshi Yamazaki
Sexual behaviour and high risk human papillomavirus infections in Japanese women

Article • Sexually Transmitted Infections, June 2005, BMJ

Professor Hiroshi Yamazaki
Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108

Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, March 2005, Elsevier

Professor Hiroshi Yamazaki
High prevalence of cytochrome P 450 2A6*1A alleles in a black African population of Ghana

Article • European Journal of Clinical Pharmacology, January 2005, Springer Science + Business Media

Professor Hiroshi Yamazaki
Ethnic differences between Japanese and Caucasians in the expression levels of mRNAs for CYP3A4, CYP3A5 and CYP3A7: lack of co-regulation of the expression of CYP3A in Japanese livers

Article • Xenobiotica, January 2005, Taylor & Francis

Professor Hiroshi Yamazaki
Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens

Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, August 2004, Elsevier

Professor Hiroshi Yamazaki
Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers

Article • Carcinogenesis, June 2004, Oxford University Press (OUP)

Professor Hiroshi Yamazaki
Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients

Article • Life Sciences, April 2004, Elsevier

Professor Hiroshi Yamazaki
Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes

Article • Biochemical Pharmacology, April 2004, Elsevier

Professor Hiroshi Yamazaki
Identification of a Novel Polymorphic Enhancer of the Human CYP3A4 Gene

Article • Molecular Pharmacology, January 2004, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
Effects of cytochrome b5 on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7

Article • Biochemical Pharmacology, December 2003, Elsevier

Professor Hiroshi Yamazaki
Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9)

Article • Pharmacogenetics, November 2003, Wolters Kluwer Health

Professor Hiroshi Yamazaki
Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes

Article • Xenobiotica, January 2003, Taylor & Francis

Professor Hiroshi Yamazaki
A population phenotyping study of three drug‐metabolizing enzymes in Kyushu, Japan, with use of the caffeine test

Article • Clinical Pharmacology & Therapeutics, August 2002, Wiley

Professor Hiroshi Yamazaki
Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay

Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, August 2002, Elsevier

Professor Hiroshi Yamazaki
Hepatocyte Nuclear Factor-1α Is a Causal Factor Responsible for Interindividual Differences in the Expression of UDP-Glucuronosyltransferase 2B7 mRNA in Human Livers

Article • Drug Metabolism and Disposition, June 2002, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
A novel mutant allele of the CYP2A6 gene (CYP2A6*11) found in a cancer patient who showed poor metabolic phenotype towards tegafur

Article • Pharmacogenetics, June 2002, Wolters Kluwer Health

Professor Hiroshi Yamazaki
Identification of catalase in human livers as a factor that enhances phenytoin dihydroxy metabolite formation by human liver microsomes

Article • Biochemical Pharmacology, June 2002, Elsevier

Professor Hiroshi Yamazaki
Evaluation of Approach to Predict the Contribution of Multiple Cytochrome P450s in Drug Metabolism Using Relative Activity Factor: Effects of the Differences in Expression Levels of NADPH–Cytochrome P450 Reductase and Cytochrome b5 in the Expression Sy...

Article • Journal of Pharmaceutical Sciences, April 2002, Elsevier

Professor Hiroshi Yamazaki
Roles of NADPH-P450 Reductase and Apo- and Holo-Cytochrome b5 on Xenobiotic Oxidations Catalyzed by 12 Recombinant Human Cytochrome P450s Expressed in Membranes of Escherichia coli

Article • Protein Expression and Purification, April 2002, Elsevier

Professor Hiroshi Yamazaki
Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females

Article • Pharmacogenetics, April 2002, Wolters Kluwer Health

Professor Hiroshi Yamazaki
Formation of a Novel Quinone Epoxide Metabolite of Troglitazone with Cytotoxic to HepG2 Cells

Article • Drug Metabolism and Disposition, February 2002, American Society for Pharmacology & Experimental Therapeutics (ASPET)

Professor Hiroshi Yamazaki
P450 and carcinogenesis.

Article • Folia Pharmacologica Japonica, January 2002, Japanese Pharmacological Society

Professor Hiroshi Yamazaki
Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells

Article • Life Sciences, December 2001, Elsevier

Professor Hiroshi Yamazaki
Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay

Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, October 2001, Elsevier

Professor Hiroshi Yamazaki
Stimulation of Cytochrome P450 Reactions by Apo-cytochromeb 5

Article • Journal of Biological Chemistry, August 2001, Elsevier

Professor Hiroshi Yamazaki
Nicotine metabolism and CYP2A6 allele frequencies in Koreans

Article • Pharmacogenetics, June 2001, Wolters Kluwer Health

Professor Hiroshi Yamazaki
Characterization of (??)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6

Article • Pharmacogenetics, March 2001, Wolters Kluwer Health

Professor Hiroshi Yamazaki
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport

Article • European Journal of Pharmaceutical Sciences, February 2001, Elsevier

Professor Hiroshi Yamazaki
Cooperativity ofα-naphthoflavone in cytochrome P450 3A-dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human

Article • Xenobiotica, January 2001, Taylor & Francis

Professor Hiroshi Yamazaki
Article • Pharmaceutical Research, January 2001, Springer Science + Business Media

Professor Hiroshi Yamazaki
Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans

Article • Clinical Pharmacology & Therapeutics, January 2001, Wiley

Professor Hiroshi Yamazaki
Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1

Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, December 2000, Elsevier

Professor Hiroshi Yamazaki
Characterization of liver microsomal 7-ethoxycoumarin O -deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene

Article • Archives of Toxicology, September 2000, Springer Science + Business Media

Professor Hiroshi Yamazaki
A new PCR-based assay amplifies the E6–E7 genes of most mucosal human papillomaviruses (HPV)

Article • Virus Research, April 2000, Elsevier

Professor Hiroshi Yamazaki
Inhibitory effects of amiodarone and its N‐deethylated metabolite on human cytochrome P450 activities: Prediction of in vivo drug interactions

Article • British Journal of Clinical Pharmacology, March 2000, Wiley

Professor Hiroshi Yamazaki
Article • Pharmaceutical Research, January 2000, Springer Science + Business Media

Professor Hiroshi Yamazaki
Phospholipase D Activity of Cytochrome P450 in Human Liver Endoplasmic Reticulum

Article • Archives of Biochemistry and Biophysics, July 1999, Elsevier

Professor Hiroshi Yamazaki
Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002

Article • Carcinogenesis, June 1999, Oxford University Press (OUP)

Professor Hiroshi Yamazaki
Molecular Cloning of a Novel Human Collectin from Liver (CL-L1)

Article • Journal of Biological Chemistry, May 1999, Elsevier

Professor Hiroshi Yamazaki
Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

Article • Archives of Toxicology, April 1999, Springer Science + Business Media

Professor Hiroshi Yamazaki
Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes

Article • Xenobiotica, January 1999, Taylor & Francis

Professor Hiroshi Yamazaki
Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes

Article • Journal of Chromatography B Biomedical Sciences and Applications, January 1999, Elsevier

Professor Hiroshi Yamazaki
Selectivity of Polycyclic Inhibitors for Human Cytochrome P450s 1A1, 1A2, and 1B1

Article • Chemical Research in Toxicology, August 1998, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Comparative Studies on the Catalytic Roles of Cytochrome P450 2C9 and Its Cys- and Leu-Variants in the Oxidation of Warfarin, Flurbiprofen, and Diclofenac by Human Liver Microsomes

Article • Biochemical Pharmacology, July 1998, Elsevier

Professor Hiroshi Yamazaki
Activation and detoxication of aflatoxin B1

Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, June 1998, Elsevier

Professor Hiroshi Yamazaki
Roles of Cytochromes P450 1A2 and 3A4 in the Oxidation of Estradiol and Estrone in Human Liver Microsomes

Article • Chemical Research in Toxicology, May 1998, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Linkage between the distribution of mutations in theCYP2C18andCYP2C19genes in the Japanese and Caucasian

Article • Xenobiotica, January 1998, Taylor & Francis

Professor Hiroshi Yamazaki
Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes

Article • Xenobiotica, January 1998, Taylor & Francis

Professor Hiroshi Yamazaki
Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers

Article • Biochemical Pharmacology, December 1997, Elsevier

Professor Hiroshi Yamazaki
Progesterone and Testosterone Hydroxylation by Cytochromes P450 2C19, 2C9, and 3A4 in Human Liver Microsomes

Article • Archives of Biochemistry and Biophysics, October 1997, Elsevier

Professor Hiroshi Yamazaki
Aflatoxin B1 8,9-Epoxide Hydrolysis in the Presence of Rat and Human Epoxide Hydrolase

Article • Chemical Research in Toxicology, June 1997, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Reconstitution of Recombinant Cytochrome P450 2C10(2C9) and Comparison with Cytochrome P450 3A4 and Other Forms: Effects of Cytochrome P450–P450 and Cytochrome P450–b5Interactions

Article • Archives of Biochemistry and Biophysics, June 1997, Elsevier

Professor Hiroshi Yamazaki
Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans

Article • Archives of Toxicology, April 1997, Springer Science + Business Media

Professor Hiroshi Yamazaki
Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4???-hydroxylation activities in livers of Japanese and Caucasian populations

Article • Pharmacogenetics, April 1997, Wolters Kluwer Health

Professor Hiroshi Yamazaki
Lack of Electron Transfer from Cytochrome b5 in Stimulation of Catalytic Activities of Cytochrome P450 3A4

Article • Journal of Biological Chemistry, November 1996, Elsevier

Professor Hiroshi Yamazaki
Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes

Article • Biochemical Pharmacology, July 1996, Elsevier

Professor Hiroshi Yamazaki
High Rates of Substrate Hydroxylation by Human Cytochrome P450 3A4 in Reconstituted Membranous Vesicles: Influence of Membrane Charge

Article • Biochemical and Biophysical Research Communications, April 1996, Elsevier

Professor Hiroshi Yamazaki
Recombinant Human Cytochrome P450 1A2 and an N-Terminal-Truncated Form: Construction, Purification, Aggregation Properties, and Interactions with Flavodoxin, Ferredoxin, and NADPH-Cytochrome P450 Reductase

Article • Archives of Biochemistry and Biophysics, March 1996, Elsevier

Professor Hiroshi Yamazaki
7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes

Article • Biochemical Pharmacology, February 1996, Elsevier

Professor Hiroshi Yamazaki
A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5–5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system

Article • Carcinogenesis, January 1996, Oxford University Press (OUP)

Professor Hiroshi Yamazaki
Activation and Inactivation of Carcinogenic Dihaloalkanes and Other Compounds by Glutathione S-Transferase 5-5 in Salmonella typhimurium Tester Strain NM5004

Article • Chemical Research in Toxicology, January 1996, American Chemical Society (ACS)

Professor Hiroshi Yamazaki
Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

Article • Archives of Biochemistry and Biophysics, January 1996, Elsevier

Professor Hiroshi Yamazaki
Mutagenic Activation of 3-Methoxy-4-aminoazobenzene by Mouse Renal Cytochrome-P450 CYP4B1: Cloning and Characterization of Mouse CYP4B1

Article • Archives of Biochemistry and Biophysics, August 1995, Elsevier

Professor Hiroshi Yamazaki
Development of high sensitive umu test system: rapid detection of genotoxicity of promutagenic aromatic amines by Salmonella typhimurium strain NM2009 possessing high O-acetyltransferase activity

Article • Mutation Research/Environmental Mutagenesis and Related Subjects, April 1995, Elsevier

Professor Hiroshi Yamazaki
Volume 317, Number 2 (1995), in the article "Expression of Cytochrome P450-3A5 in Escherichia-Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities," by Elizabeth M. J. Gillam, Zu...

Article • Archives of Biochemistry and Biophysics, April 1995, Elsevier

Professor Hiroshi Yamazaki
Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

Article • Archives of Biochemistry and Biophysics, March 1995, Elsevier

Professor Hiroshi Yamazaki
Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7α- and coumarin 7-hydroxylations

Article • Biochemical Pharmacology, October 1994, Elsevier

Professor Hiroshi Yamazaki
Fluorescencein situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1

Article • The Japanese Journal of Human Genetics, September 1994, Springer Science + Business Media

Professor Hiroshi Yamazaki
Differential roles of cytochromes P450 2D1, 2C11, and 1A1/2 in the hydroxylation of bufuralol by rat liver microsomes

Article • Biochemical Pharmacology, June 1994, Elsevier

Professor Hiroshi Yamazaki
Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes

Article • Biochemical Pharmacology, February 1994, Elsevier

Professor Hiroshi Yamazaki
Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens

Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, December 1992, Elsevier

Professor Hiroshi Yamazaki
Use of a newly developed tester strain Salmonella typhimurium NM2009 for the study of metabolic activation of carcinogenic aromatic amines by rat liver microsomal cytochrome P-450 enzymes

Article • Mutation Research/Environmental Mutagenesis and Related Subjects, October 1992, Elsevier

Professor Hiroshi Yamazaki
Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescencein situ hybridization

Article • The Japanese Journal of Human Genetics, June 1992, Springer Science + Business Media

Professor Hiroshi Yamazaki
Cytochrome P-450 forms and its inducibility by PCB isomers in black-headed gulls and black-tailed gulls

Article • Marine Pollution Bulletin, June 1992, Elsevier

Professor Hiroshi Yamazaki
The evaluation of genotoxic activities of disinfectants and their metabolites by umu test

Article • Mutation Research Letters, November 1988, Elsevier

Professor Hiroshi Yamazaki
Mutagenicity of N-nitrosodiethanolamine in the Salmonella/microsome test

Article • Mutation Research Letters, October 1987, Elsevier

Professor Hiroshi Yamazaki
Activation of carcinogenic N-nitrosopropylamines to mutagens by lung and pancreas S9 fractions from various animal species and man

Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, May 1986, Elsevier

Professor Hiroshi Yamazaki
Genotoxicity of carcinogenic N-nitrosopropylamine derivatives in the hepatocyte primary culture/DNA-repair test

Article • Mutation Research Letters, November 1985, Elsevier

Professor Hiroshi Yamazaki
Inhibitory effect of organic solvents on the mutagenicity of N-nitrosodialkylamines in Salmonella

Article • Mutation Research Letters, April 1985, Elsevier

Professor Hiroshi Yamazaki

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