All Stories

  1. Plasma Concentration Profiles for Hepatotoxic Pyrrolizidine Alkaloid Senkirkine in Humans Extrapolated from Rat Data Sets Using a Simplified Physiologically Based Pharmacokinetic Model

    Article • Drug Metabolism and Bioanalysis Letters, March 2022, Bentham Science Publishers

    Professor Hiroshi Yamazaki

  2. Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan

    Article • Current Drug Metabolism, December 2020, Bentham Science Publishers

    Professor Hiroshi Yamazaki, Dr Kanae Mure

  3. Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver

    Article • Xenobiotica, September 2019, Taylor & Francis

    Professor Hiroshi Yamazaki

  4. Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

    Article • Current Drug Metabolism, April 2019, Bentham Science Publishers

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  5. Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6

    Article • Xenobiotica, December 2018, Taylor & Francis

    Professor Hiroshi Yamazaki

  6. Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver

    Article • Xenobiotica, December 2018, Taylor & Francis

    Professor Hiroshi Yamazaki

  7. Novel variants and haplotypes of human flavin-containing monooxygenase 3 gene associated with Japanese subjects suffering from trimethylaminuria

    Article • Xenobiotica, November 2018, Taylor & Francis

    Professor Hiroshi Yamazaki

  8. In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

    Article • Xenobiotica, September 2018, Taylor & Francis

    Professor Hiroshi Yamazaki

  9. Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney

    Article • Journal of Medical Primatology, September 2018, Wiley

    Professor Hiroshi Yamazaki

  10. In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans

    Article • Xenobiotica, September 2018, Taylor & Francis

    Professor Hiroshi Yamazaki

  11. Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques

    Article • Xenobiotica, September 2018, Taylor & Francis

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  12. Pharmacokinetics of anticoagulants apixaban, dabigatran, edoxaban, and rivaroxaban in elderly Japanese patients with atrial fibrillation treated in one general hospital

    Article • Xenobiotica, September 2018, Taylor & Francis

    Professor Hiroshi Yamazaki, Minoru Kogiku

  13. Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure

    Article • Pest Management Science, February 2018, Wiley

    Professor Hiroshi Yamazaki

  14. Polymorphisms of cytochrome P450 2B6 (CYP2B6 ) in cynomolgus and rhesus macaques

    Article • Journal of Medical Primatology, February 2018, Wiley

    Professor Hiroshi Yamazaki

  15. Marmoset cytochrome P450 2B6, a propofol hydroxylase expressed in liver

    Article • Xenobiotica, February 2018, Taylor & Francis

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  16. Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies

    Article • Biopharmaceutics & Drug Disposition, December 2017, Wiley

    Professor Hiroshi Yamazaki

  17. Molecular cloning and tissue distribution of a novel marmoset ABC transporter

    Article • Biopharmaceutics & Drug Disposition, December 2017, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  18. Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques

    Article • Journal of Veterinary Pharmacology and Therapeutics, July 2017, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  19. Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19

    Article • Xenobiotica, July 2017, Taylor & Francis

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  20. Marmoset pulmonary cytochrome P450 2F1 oxidizes biphenyl and 7-ethoxycoumarin and hepatic human P450 substrates

    Article • Xenobiotica, July 2017, Taylor & Francis

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  21. Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants

    Article • Xenobiotica, July 2017, Taylor & Francis

    Professor Hiroshi Yamazaki

  22. Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

    Article • Biopharmaceutics & Drug Disposition, July 2017, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  23. Hepatic expression of cytochrome P450 enzymes in non-human primate species

    Article • Journal of Medical Primatology, June 2017, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  24. Functional characterization and tissue expression of marmoset cytochrome P450 2E1

    Article • Biopharmaceutics & Drug Disposition, June 2017, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  25. Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines

    Article • Xenobiotica, May 2017, Taylor & Francis

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  26. Regio- and Stereo-Selective Oxidation of a Cardiovascular Drug, Metoprolol, Mediated by Cytochrome P450 2D and 3A Enzymes in Marmoset Livers

    Article • Drug Metabolism and Disposition, May 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  27. Molecular Cloning and Characterization of Marmoset Aldehyde Oxidase

    Article • Drug Metabolism and Disposition, May 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  28. Ratio of serum levels of AGEs to soluble RAGE is correlated with trimethylamine-N-oxide in non-diabetic subjects

    Article • International Journal of Food Sciences and Nutrition, April 2017, Taylor & Francis

    Professor Hiroshi Yamazaki

  29. Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase

    Article • Drug Metabolism and Disposition, March 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  30. Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone

    Article • Drug Metabolism and Disposition, February 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  31. Physiologically based pharmacokinetic-pharmacodynamic modeling to predict concentrations and actions of sodium-dependent glucose transporter 2 inhibitor canagliflozin in human intestines and renal tubules

    Article • Biopharmaceutics & Drug Disposition, September 2016, Wiley

    Professor Hiroshi Yamazaki

  32. In vivoindividual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9

    Article • Biopharmaceutics & Drug Disposition, September 2016, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  33. Systematic approach to optimize a pretreatment method for ultrasensitive liquid chromatography with tandem mass spectrometry analysis of multiple target compounds in biological samples

    Article • Journal of Separation Science, July 2016, Wiley

    Professor Hiroshi Yamazaki

  34. Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors

    Article • Biopharmaceutics & Drug Disposition, July 2016, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  35. Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing

    Article • Biopharmaceutics & Drug Disposition, May 2016, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  36. Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers

    Article • Drug Metabolism and Disposition, April 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  37. A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine

    Article • Drug Metabolism and Disposition, April 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  38. Individual differences inin vitroandin vivometabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3

    Article • Human Psychopharmacology Clinical and Experimental, February 2016, Wiley

    Professor Hiroshi Yamazaki

  39. Individual differences inin vitroandin vivometabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5

    Article • Human Psychopharmacology Clinical and Experimental, February 2016, Wiley

    Professor Hiroshi Yamazaki

  40. Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances

    Article • Biopharmaceutics & Drug Disposition, December 2015, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  41. Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1

    Article • Drug Metabolism and Disposition, October 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  42. Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates,S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole

    Article • Drug Metabolism and Disposition, July 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  43. Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays

    Article • Drug Metabolism Letters, June 2015, Bentham Science Publishers

    Professor Hiroshi Yamazaki

  44. Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase

    Article • Drug Metabolism and Disposition, May 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  45. Substrate Selectivities and Catalytic Activities of Marmoset Liver Cytochrome P450 2A6 Differed from Those of Human P450 2A6

    Article • Drug Metabolism and Disposition, April 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  46. Activation and Deactivation of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine by Cytochrome P450 Enzymes and Flavin-Containing Monooxygenases in Common Marmosets (Callithrix jacchus)

    Article • Drug Metabolism and Disposition, March 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  47. Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling

    Article • Biopharmaceutics & Drug Disposition, January 2015, Wiley

    Professor Hiroshi Yamazaki

  48. Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

    Article • Toxicology Research, January 2015, Oxford University Press (OUP)

    Professor Hiroshi Yamazaki

  49. Evaluation of 89 Compounds for Identification of Substrates for Cynomolgus Monkey CYP2C76, a New Bupropion/Nifedipine Oxidase

    Article • Drug Metabolism and Disposition, October 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Hiroshi Yamazaki

  50. Comparison of Catalytic Properties of Cytochromes P450 3A4 and 3A5 by Molecular Docking Simulation

    Article • Drug Metabolism Letters, December 2013, Bentham Science Publishers

    Professor Hiroshi Yamazaki