All Stories

  1. Sodium ion influx regulates liquidity of biomolecular condensates in hyperosmotic stress response

    Article • Cell Reports, April 2023, Elsevier

    PhD Isao Naguro

  2. Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation

    Article • Journal of Biological Chemistry, February 2023, Elsevier

    PhD Isao Naguro

  3. HES1 contributes to high salt stress response as an enhancer of NFAT5-DNA binding

    Article • October 2022, Cold Spring Harbor Laboratory Press

    PhD Isao Naguro

  4. mTOR-AKT Signaling in Cellular Clock Resetting Triggered by Osmotic Stress

    Article • Antioxidants & Redox Signaling, October 2022, Mary Ann Liebert Inc

    PhD Isao Naguro

  5. DNA damage response signaling to mitochondria drives senescence

    Article • September 2022, Cold Spring Harbor Laboratory Press

    PhD Isao Naguro

  6. Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via PDH regulation

    Article • June 2022, Cold Spring Harbor Laboratory Press

    PhD Isao Naguro

  7. Sodium ion regulates liquidity of biomolecular condensates in hyperosmotic stress response

    Article • June 2022, Cold Spring Harbor Laboratory Press

    PhD Isao Naguro

  8. NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress

    Article • Cell Death Discovery, April 2022, Springer Science + Business Media

    PhD Isao Naguro

  9. ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes

    Article • Scientific Reports, November 2021, Springer Science + Business Media

    PhD Isao Naguro

  10. Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process

    Article • Placenta, November 2021, Elsevier

    PhD Isao Naguro

  11. Functional cooperation between ASK1 and p21Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes

    Article • Cell Death Discovery, April 2021, Springer Science + Business Media

    PhD Isao Naguro

  12. The mitochondrial Ca 2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis

    Article • EMBO Reports, April 2021, Springer Science + Business Media

    PhD Isao Naguro

  13. ASK1 suppresses NK cell‐mediated intravascular tumor cell clearance in lung metastasis

    Article • Cancer Science, March 2021, Wiley

    PhD Isao Naguro

  14. Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

    Article • Nature Communications, March 2021, Springer Science + Business Media

    PhD Isao Naguro

  15. Molecular functions of ASK family in diseases caused by stress-induced inflammation and apoptosis

    Article • The Journal of Biochemistry, December 2020, Oxford University Press (OUP)

    PhD Isao Naguro

  16. The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression

    Article • Nature Communications, December 2020, Springer Science + Business Media

    PhD Isao Naguro

  17. FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells

    Article • Current Biology, December 2020, Elsevier

    Motoyuki Ogawa, PhD Isao Naguro

  18. Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)

    Article • April 2020, Cold Spring Harbor Laboratory Press

    PhD Isao Naguro

  19. Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu,Zn-superoxide dismutase

    Article • Journal of Biological Chemistry, March 2020, Elsevier

    PhD Isao Naguro

  20. ASK1 promotes uterine inflammation leading to pathological preterm birth

    Article • Scientific Reports, February 2020, Springer Science + Business Media

    PhD Isao Naguro

  21. Osmotic gradient induces stable dome morphogenesis on extracellular matrix

    Article • Journal of Cell Science, January 2020, The Company of Biologists

    PhD Isao Naguro

  22. Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, September 2019, Elsevier

    PhD Isao Naguro

  23. In Situ Single‐Cell Western Blot on Adherent Cell Culture

    Article • Angewandte Chemie, August 2019, Wiley

    PhD Isao Naguro

  24. Staphylococcus aureus aggregation in the plasma fraction of silkworm hemolymph

    Article • PLOS One, May 2019, PLOS

    PhD Isao Naguro

  25. Functional Analysis of Apoptosis Signal-regulating Kinase Family in a Murine Model of Tumor Metastasis

    Article • YAKUGAKU ZASSHI, May 2019, Pharmaceutical Society of Japan

    PhD Isao Naguro

  26. β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2018, Elsevier

    PhD Isao Naguro

  27. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

    Article • Nature Communications, July 2018, Springer Science + Business Media

    PhD Isao Naguro, Professor Norio Shibata

  28. ASK family kinases mediate cellular stress and redox signaling to circadian clock

    Article • Proceedings of the National Academy of Sciences, March 2018, Proceedings of the National Academy of Sciences

    PhD Isao Naguro

  29. A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress

    Article • Cell Reports, March 2018, Elsevier

    PhD Isao Naguro

  30. ASK family and cancer

    Article • Advances in Biological Regulation, December 2017, Elsevier

    PhD Isao Naguro

  31. mASKing cancer cells in a tumor microenvironment

    Article • Cell Cycle, November 2017, Taylor & Francis

    PhD Isao Naguro

  32. TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1

    Article • Cell Reports, November 2017, Elsevier

    PhD Isao Naguro

  33. Cold stress‐induced ferroptosis involves the ASK1‐p38 pathway

    Article • EMBO Reports, September 2017, EMBO

    PhD Isao Naguro, Kazuki Hattori

  34. Involvement of apoptosis signal-regulating kinase-1 in house dust mite-induced allergic asthma in mice

    Article • Allergology International, September 2017, Elsevier

    PhD Isao Naguro

  35. ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets

    Article • Cell Death and Differentiation, July 2017, Nature

    PhD Isao Naguro

  36. KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation

    Article • PLOS One, September 2016, PLOS

    PhD Isao Naguro

  37. Mitogen-activated protein kinases as key players in osmotic stress signaling

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, September 2016, Elsevier

    PhD Isao Naguro

  38. The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction

    Article • eLife, August 2016, eLife

    PhD Isao Naguro

  39. ASK1 signalling regulates brown and beige adipocyte function

    Article • Nature Communications, April 2016, Springer Science + Business Media

    PhD Isao Naguro

  40. The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress

    Article • EBioMedicine, March 2016, Elsevier

    PhD Isao Naguro

  41. Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway

    Article • Scientific Reports, January 2016, Springer Science + Business Media

    PhD Isao Naguro

  42. The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis

    Article • Human Molecular Genetics, November 2015, Oxford University Press (OUP)

    PhD Isao Naguro

  43. A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants

    Article • Neurobiology of Disease, October 2015, Elsevier

    PhD Isao Naguro

  44. In vivo gene manipulation reveals the impact of stress‐responsive MAPK pathways on tumor progression

    Article • Cancer Science, May 2015, Wiley

    PhD Isao Naguro

  45. Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis

    Article • Journal of Biological Chemistry, April 2015, Elsevier

    PhD Isao Naguro

  46. The DEAH-Box RNA Helicase DHX15 Activates NF-κB and MAPK Signaling Downstream of MAVS During Antiviral Responses

    Article • Science Signaling, April 2014, American Association for the Advancement of Science

    PhD Isao Naguro

  47. Apoptosis signal-regulating kinase 1 as a therapeutic target

    Article • Expert Opinion on Therapeutic Targets, March 2014, Taylor & Francis

    PhD Isao Naguro

  48. Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses

    Article • Science Signaling, January 2014, American Association for the Advancement of Science

    PhD Isao Naguro

  49. SOD1 as a Molecular Switch for Initiating the Homeostatic ER Stress Response under Zinc Deficiency

    Article • Molecular Cell, October 2013, Elsevier

    PhD Isao Naguro

  50. Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling

    Article • Advances in Biological Regulation, January 2013, Elsevier

    PhD Isao Naguro

  51. ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney

    Article • Nature Communications, December 2012, Springer Science + Business Media

    PhD Isao Naguro

  52. A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis‐linked SOD1 mutants

    Article • Annals of Neurology, November 2012, Wiley

    PhD Isao Naguro

  53. p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors

    Article • Journal of Cell Science, September 2011, The Company of Biologists

    PhD Isao Naguro

  54. Apoptosis Signaling Kinases: From Stress Response to Health Outcomes

    Article • Antioxidants & Redox Signaling, August 2011, Mary Ann Liebert Inc

    PhD Isao Naguro

  55. CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

    Article • The EMBO Journal, June 2010, Springer Science + Business Media

    PhD Isao Naguro

  56. The roles of ASK family proteins in stress responses and diseases

    Article • Cell Communication and Signaling, April 2009, Springer Science + Business Media

    PhD Isao Naguro

  57. Stress-Activated MAP Kinase Cascades in Cellular Senescence

    Article • Current Medicinal Chemistry, April 2009, Bentham Science Publishers

    PhD Isao Naguro

  58. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

    Article • The EMBO Journal, February 2009, Springer Science + Business Media

    PhD Isao Naguro

  59. Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

    Article • Journal of Biological Chemistry, March 2008, Elsevier

    PhD Isao Naguro

  60. Apoptosis Signal-Regulating Kinase 1 in Stress and Immune Response

    Article • The Annual Review of Pharmacology and Toxicology, February 2008, Annual Reviews

    PhD Isao Naguro

  61. Apoptosis Signal-regulating Kinase (ASK) 2 Functions as a Mitogen-activated Protein Kinase Kinase Kinase in a Heteromeric Complex with ASK1

    Article • Journal of Biological Chemistry, March 2007, Elsevier

    PhD Isao Naguro

  62. Multiple transcripts of Ca2+ channel α1-subunits and a novel spliced variant of the α1C-subunit in rat ductus arteriosus

    Article • AJP Heart and Circulatory Physiology, April 2006, American Physiological Society

    PhD Isao Naguro

  63. Calcium signaling via voltage‐dependent L‐type Ca2+ channels

    Article • Signal Transduction, December 2004, Wiley

    PhD Isao Naguro

  64. Ser1901 of α1C subunit is required for the PKA‐mediated enhancement of L‐type Ca2+ channel currents but not for the negative shift of activation

    Article • FEBS Letters, January 2001, Wiley

    PhD Isao Naguro