All Stories

  1. Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei

    Article • PLoS Neglected Tropical Diseases, July 2020, PLOS

    Prof Mark C Field

  2. Pore timing: the evolutionary origins of the nucleus and nuclear pore complex

    Article • F1000Research, April 2019, Faculty of 1000, Ltd.

    Prof Mark C Field

  3. Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context inVSGexpression control

    Article • Cellular Microbiology, October 2013, Wiley

    Prof Mark C Field

  4. Molecular paleontology and complexity in the last eukaryotic common ancestor

    Article • Critical Reviews in Biochemistry and Molecular Biology, July 2013, Taylor & Francis

    Prof Mark C Field

  5. Cell density-dependent ectopic expression in bloodstream form Trypanosoma brucei

    Article • Experimental Parasitology, June 2013, Elsevier

    Prof Mark C Field

  6. Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy

    Article • Trends in Parasitology, May 2013, Elsevier

    Prof Mark C Field

  7. Evolution of modular intraflagellar transport from a coatomer-like progenitor

    Article • Proceedings of the National Academy of Sciences, April 2013, Proceedings of the National Academy of Sciences

    Prof Mark C Field

  8. Adaptin evolution in kinetoplastids and emergence of the variant surface glycoprotein coat in African trypanosomatids

    Article • Molecular Phylogenetics and Evolution, April 2013, Elsevier

    Prof Mark C Field

  9. A Cell-surface Phylome for African Trypanosomes

    Article • PLoS Neglected Tropical Diseases, March 2013, PLOS

    Prof Mark C Field

  10. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins

    Article • Molecular Biology of the Cell, March 2013, American Society for Cell Biology (ASCB)

    Prof Mark C Field

  11. TbFRP, a novel FYVE-domain containing phosphoinositide-binding Ras-like GTPase from trypanosomes

    Article • Experimental Parasitology, March 2013, Elsevier

    Prof Mark C Field

  12. Proteomic Analysis of Clathrin Interactions in Trypanosomes Reveals Dynamic Evolution of Endocytosis

    Article • Traffic, February 2013, Wiley

    Prof Mark C Field

  13. Differential Localization of the Two T. brucei Poly(A) Binding Proteins to the Nucleus and RNP Granules Suggests Binding to Distinct mRNA Pools

    Article • PLoS ONE, January 2013, PLOS

    Prof Mark C Field

  14. An automated graphics tool for comparative genomics: the Coulson plot generator

    Article • BMC Bioinformatics, January 2013, Springer Science + Business Media

    Prof Mark C Field

  15. Evidence for Recycling of Invariant Surface Transmembrane Domain Proteins in African Trypanosomes

    Article • Eukaryotic Cell, December 2012, ASM Journals

    Prof Mark C Field

  16. Pyrimidine Salvage in Trypanosoma brucei Bloodstream Forms and the Trypanocidal Action of Halogenated Pyrimidines

    Article • Molecular Pharmacology, November 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Prof Mark C Field

  17. Telomeres, tethers and trypanosomes

    Article • Nucleus, November 2012, Taylor & Francis

    Prof Mark C Field

  18. RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly

    Article • PLoS Genetics, October 2012, PLOS

    Prof Mark C Field

  19. Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes

    Article • Expert Reviews in Molecular Medicine, May 2012, Cambridge University Press

    Prof Mark C Field

  20. Terminal galactosylation of glycoconjugates in Plasmodium falciparum asexual blood stages and Trypanosoma brucei bloodstream trypomastigotes

    Article • Experimental Parasitology, April 2012, Elsevier

    Prof Mark C Field

  21. NUP-1 Is a Large Coiled-Coil Nucleoskeletal Protein in Trypanosomes with Lamin-Like Functions

    Article • PLoS Biology, March 2012, PLOS

    Prof Mark C Field

  22. Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases

    Article • Journal of Cell Science, February 2012, The Company of Biologists

    Prof Mark C Field

  23. Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species

    Article • Proceedings of the National Academy of Sciences, February 2012, Proceedings of the National Academy of Sciences

    Prof Mark C Field

  24. Proteomics on the rims: insights into the biology of the nuclear envelope and flagellar pocket of trypanosomes

    Article • Parasitology, February 2012, Cambridge University Press

    Prof Mark C Field

  25. High-throughput decoding of antitrypanosomal drug efficacy and resistance

    Article • Nature, January 2012, Springer Science + Business Media

    Prof Mark C Field

  26. Rab28 function in trypanosomes: interactions with retromer and ESCRT pathways

    Article • Journal of Cell Science, November 2011, The Company of Biologists

    Prof Mark C Field

  27. A Novel Rho-Like Protein TbRHP Is Involved in Spindle Formation and Mitosis in Trypanosomes

    Article • PLoS ONE, November 2011, PLOS

    Prof Mark C Field

  28. Specializations in a successful parasite: What makes the bloodstream-form African trypanosome so deadly?

    Article • Molecular and Biochemical Parasitology, October 2011, Elsevier

    Prof Mark C Field

  29. High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis

    Article • PLoS Pathogens, June 2011, PLOS

    Prof Mark C Field, Prof. Dr. ir. Benoit Stijlemans

  30. On a bender—BARs, ESCRTs, COPs, and finally getting your coat

    Article • The Journal of Cell Biology, June 2011, Rockefeller University Press

    Prof Mark C Field

  31. Rab11 Function in Trypanosoma brucei: Identification of Conserved and Novel Interaction Partners

    Article • Eukaryotic Cell, June 2011, ASM Journals

    Prof Mark C Field

  32. Ubiquitylation and Developmental Regulation of Invariant Surface Protein Expression in Trypanosomes

    Article • Eukaryotic Cell, May 2011, ASM Journals

    Prof Mark C Field

  33. Evolution of the Karyopherin-β Family of Nucleocytoplasmic Transport Factors; Ancient Origins and Continued Specialization

    Article • PLoS ONE, April 2011, PLOS

    Prof Mark C Field

  34. Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei

    Article • Journal of Cell Science, April 2011, The Company of Biologists

    Prof Mark C Field

  35. Trypanosoma brucei brucei: Endocytic recycling is important for mouse infectivity

    Article • Experimental Parasitology, April 2011, Elsevier

    Prof Mark C Field

  36. A Conserved Coatomer-related Complex Containing Sec13 and Seh1 Dynamically Associates With the Vacuole in Saccharomyces cerevisiae

    Article • Molecular & Cellular Proteomics, March 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  37. Rab23 is a flagellar protein in Trypanosoma brucei

    Article • BMC Research Notes, January 2011, Springer Science + Business Media

    Prof Mark C Field

  38. Regulation of Thromboxane Receptor Signaling at Multiple Levels by Oxidative Stress-Induced Stabilization, Relocation and Enhanced Responsiveness

    Article • PLoS ONE, September 2010, PLOS

    Prof Mark C Field

  39. Trypanosoma brucei: Trypanosome-specific endoplasmic reticulum proteins involved in variant surface glycoprotein expression

    Article • Experimental Parasitology, July 2010, Elsevier

    Prof Mark C Field

  40. Rab protein evolution and the history of the eukaryotic endomembrane system

    Article • Cellular and Molecular Life Sciences, June 2010, Springer Science + Business Media

    Prof Mark C Field

  41. The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility

    Article • Cell, March 2010, Elsevier

    Prof Mark C Field

  42. Chaperone Requirements for Biosynthesis of the Trypanosome Variant Surface Glycoprotein

    Article • PLoS ONE, January 2010, PLOS

    Prof Mark C Field

  43. Evidence that low endocytic activity is not directly responsible for human serum resistance in the insect form of African trypanosomes

    Article • BMC Research Notes, January 2010, Springer Science + Business Media

    Prof Mark C Field

  44. The trypanosome flagellar pocket

    Article • Nature Reviews Microbiology, October 2009, Nature

    Prof Mark C Field

  45. The Trypanosome Rab-Related Proteins RabX1 and RabX2 Play No Role in IntraCellular Trafficking but May Be Involved in Fly Infectivity

    Article • PLoS ONE, September 2009, PLOS

    Prof Mark C Field

  46. Evidence for a Shared Nuclear Pore Complex Architecture That Is Conserved from the Last Common Eukaryotic Ancestor

    Article • Molecular & Cellular Proteomics, June 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  47. Drug screening by crossing membranes: a novel approach to identification of trypanocides

    Article • Biochemical Journal, April 2009, Portland Press Ltd.

    Prof Mark C Field

  48. The Single ENTH-Domain Protein of Trypanosomes; Endocytic Functions and Evolutionary Relationship with Epsin

    Article • Traffic, March 2009, Wiley

    Prof Mark C Field

  49. First and last ancestors: reconstructing evolution of the endomembrane system with ESCRTs, vesicle coat proteins, and nuclear pore complexes

    Article • Current Opinion in Cell Biology, February 2009, Elsevier

    Prof Mark C Field

  50. Evolution of specificity in the eukaryotic endomembrane system

    Article • The International Journal of Biochemistry & Cell Biology, February 2009, Elsevier

    Prof Mark C Field

  51. Chapter 1 Macromolecular Trafficking and Immune Evasion in African Trypanosomes

    Article • January 2009, Elsevier

    Prof Mark C Field

  52. Ubiquitylation is Required for Degradation of Transmembrane Surface Proteins in Trypanosomes

    Article • Traffic, October 2008, Wiley

    Prof Mark C Field

  53. Evolution of the Multivesicular Body ESCRT Machinery; Retention Across the Eukaryotic Lineage

    Article • Traffic, October 2008, Wiley

    Prof Mark C Field

  54. Implications of the new eukaryotic systematics for parasitologists

    Article • Parasitology International, June 2008, Elsevier

    Prof Mark C Field

  55. How complex is GTPase signaling in trypanosomes?

    Article • Trends in Parasitology, June 2008, Elsevier

    Prof Mark C Field

  56. Phylogeny of endocytic components yields insight into the process of nonendosymbiotic organelle evolution

    Article • Proceedings of the National Academy of Sciences, January 2008, Proceedings of the National Academy of Sciences

    Prof Mark C Field

  57. The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages

    Article • BMC Genomics, January 2008, Springer Science + Business Media

    Prof Mark C Field

  58. Analysis of Small GTPase Function in Trypanosomes

    Article • January 2008, Elsevier

    Prof Mark C Field

  59. Dileucine signal-dependent and AP-1-independent targeting of a lysosomal glycoprotein in Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, December 2007, Elsevier

    Prof Mark C Field

  60. Activation of Endocytosis as an Adaptation to the Mammalian Host by Trypanosomes

    Article • Eukaryotic Cell, September 2007, ASM Journals

    Prof Mark C Field

  61. Evolution of the eukaryotic membrane-trafficking system: origin, tempo and mode

    Article • Journal of Cell Science, August 2007, The Company of Biologists

    Prof Mark C Field

  62. Intracellular Trafficking in the Trypanosomatids

    Article • Traffic, April 2007, Wiley

    Prof Mark C Field

  63. Article • BMC Evolutionary Biology, January 2007, Springer Science + Business Media

    Prof Mark C Field

  64. Chromosome-Wide Analysis of Gene Function by RNA Interference in the African Trypanosome

    Article • Eukaryotic Cell, September 2006, ASM Journals

    Prof Mark C Field

  65. TbVps34, the Trypanosome Orthologue of Vps34, Is Required for Golgi Complex Segregation

    Article • Journal of Biological Chemistry, July 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  66. Dramatic reorganisation of Trichomonas endomembranes during amoebal transformation: A possible role for G-proteins☆

    Article • Molecular and Biochemical Parasitology, July 2006, Elsevier

    Prof Mark C Field

  67. Electrical and optical performance of InAs/GaSb superlattice LWIR detectors

    Article • February 2006, SPIE

    Prof Mark C Field

  68. Trypanosoma brucei: TbRAB4 regulates membrane recycling and expression of surface proteins in procyclic forms

    Article • Experimental Parasitology, November 2005, Elsevier

    Prof Mark C Field

  69. Signalling the genome: the Ras-like small GTPase family of trypanosomatids

    Article • Trends in Parasitology, October 2005, Elsevier

    Prof Mark C Field

  70. Identification of a very large Rab GTPase family in the parasitic protozoan Trichomonas vaginalis

    Article • Molecular and Biochemical Parasitology, October 2005, Elsevier

    Prof Mark C Field

  71. ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome

    Article • Human Molecular Genetics, July 2005, Oxford University Press (OUP)

    Prof Mark C Field

  72. The Genome of the African Trypanosome Trypanosoma brucei

    Article • Science, July 2005, American Association for the Advancement of Science

    Professor Elodie Ghedin, Prof Mark C Field, Professor Fred R. Opperdoes

  73. An Evolutionarily Conserved Coiled-Coil Protein Implicated in Polycystic Kidney Disease Is Involved in Basal Body Duplication and Flagellar Biogenesis in Trypanosoma brucei

    Article • Molecular and Cellular Biology, May 2005, ASM Journals

    Prof Mark C Field

  74. Developmental Variation in Rab11-Dependent Trafficking in Trypanosoma brucei

    Article • Eukaryotic Cell, May 2005, ASM Journals

    Prof Mark C Field

  75. A bioinformatic analysis of the RAB genes of Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, May 2005, Elsevier

    Prof Mark C Field

  76. The role of alternative splicing and C-terminal amino acids in thromboxane receptor stabilization

    Article • Biochemical and Biophysical Research Communications, April 2005, Elsevier

    Prof Mark C Field

  77. Perturbation of local endogenous expression by insertion of Pol I expression constructs into the genome of Trypanosoma brucei

    Article • Experimental Parasitology, March 2005, Elsevier

    Prof Mark C Field

  78. Reconstitution of glycopeptide export in mixed detergent-solubilised and resealed microsomes depleted of lumenal components

    Article • Journal of Biochemical and Biophysical Methods, January 2005, Elsevier

    Prof Mark C Field

  79. Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite

    Article • Experimental Parasitology, January 2005, Elsevier

    Prof Mark C Field

  80. Both of the Rab5 subfamily small GTPases of Trypanosoma brucei are essential and required for endocytosis

    Article • Molecular and Biochemical Parasitology, November 2004, Elsevier

    Prof Mark C Field

  81. Intracellular Membrane Transport Systems in Trypanosoma brucei

    Article • Traffic, October 2004, Wiley

    Prof Mark C Field

  82. TbRAB1 and TbRAB2 mediate trafficking through the early secretory pathway of Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, October 2004, Elsevier

    Prof Mark C Field

  83. New Approaches to the Microscopic Imaging of Trypanosoma brucei

    Article • Microscopy and Microanalysis, October 2004, Cambridge University Press

    Prof Mark C Field

  84. Cytoplasmic Targeting Signals in Transmembrane Invariant Surface Glycoproteins of Trypanosomes

    Article • Journal of Biological Chemistry, September 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  85. TbRAB23; a nuclear-associated Rab protein from Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, August 2004, Elsevier

    Prof Mark C Field

  86. Rab4 Is an Essential Regulator of Lysosomal Trafficking in Trypanosomes

    Article • Journal of Biological Chemistry, July 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  87. The Single Dynamin-like Protein of Trypanosoma brucei Regulates Mitochondrial Division and Is Not Required for Endocytosis

    Article • Journal of Biological Chemistry, December 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  88. The Mechanism of Oxidative Stress Stabilization of the Thromboxane Receptor in COS-7 Cells

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  89. Clathrin-mediated endocytosis is essential in Trypanosoma brucei

    Article • The EMBO Journal, October 2003, Wiley

    Prof Mark C Field

  90. Rab5 and Rab11 mediate transferrin and anti-variant surface glycoprotein antibody recycling in Trypanosoma brucei

    Article • Biochemical Journal, September 2003, Portland Press Ltd.

    Prof Mark C Field

  91. Biochemical and genetic evidence for a family of heterotrimeric G-proteins in Trichomonas vaginalis

    Article • Molecular and Biochemical Parasitology, July 2003, Elsevier

    Prof Mark C Field

  92. RNAit: an automated web-based tool for the selection of RNAi targets in Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, April 2003, Elsevier

    Prof Mark C Field

  93. Endocytosis of a Glycosylphosphatidylinositol-anchored Protein via Clathrin-coated Vesicles, Sorting by Default in Endosomes, and Exocytosis via RAB11-positive Carriers

    Article • Molecular Biology of the Cell, February 2003, American Society for Cell Biology (ASCB)

    Prof Mark C Field

  94. Essential Roles for GPI-anchored Proteins in African Trypanosomes Revealed Using Mutants Deficient in GPI8

    Article • Molecular Biology of the Cell, December 2002, American Society for Cell Biology (ASCB)

    Prof Mark C Field

  95. The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system

    Article • Trends in Parasitology, December 2002, Elsevier

    Prof Mark C Field

  96. The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences

    Article • Trends in Parasitology, November 2002, Elsevier

    Prof Mark C Field

  97. Leishmania RAB7: characterisation of terminal endocytic stages in an intracellular parasite

    Article • Molecular and Biochemical Parasitology, August 2002, Elsevier

    Prof Mark C Field

  98. Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, July 2002, Elsevier

    Prof Mark C Field

  99. TbRAB18, a developmentally regulated Golgi GTPase from Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, April 2002, Elsevier

    Prof Mark C Field

  100. Differential Endocytic Functions ofTrypanosoma brucei Rab5 Isoforms Reveal a Glycosylphosphatidylinositol-specific Endosomal Pathway

    Article • Journal of Biological Chemistry, December 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  101. GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida

    Article • FEBS Letters, February 2001, Wiley

    Prof Mark C Field

  102. Export of a misprocessed GPI-anchored protein from the endoplasmic reticulum in vitro in an ATP- and cytosol-dependent manner

    Article • FEBS Letters, October 2000, Wiley

    Prof Mark C Field

  103. A Microsomal GTPase Is Required for Glycopeptide Export from the Mammalian Endoplasmic Reticulum

    Article • Journal of Biological Chemistry, July 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  104. Erratum to “Cell-cycle and developmental regulation of TbRAB31 localisation, a GTP-locked Rab protein from Trypanosoma brucei”[Mol. Biochem. Parasitol. 106 (2000) 21–35]

    Article • Molecular and Biochemical Parasitology, April 2000, Elsevier

    Prof Mark C Field

  105. Acylation-dependent Protein Export in Leishmania

    Article • Journal of Biological Chemistry, April 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  106. Cell-cycle and developmental regulation of TbRAB31 localisation, a GTP-locked Rab protein from Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, February 2000, Elsevier

    Prof Mark C Field

  107. The farnesyltransferase inhibitor manumycin A is a novel trypanocide with a complex mode of action including major effects on mitochondria

    Article • Molecular and Biochemical Parasitology, October 1999, Elsevier

    Prof Mark C Field

  108. GTPases in Protozoan Parasites: Tools for Cell Biology and Chemotherapy

    Article • Parasitology Today, September 1999, Elsevier

    Prof Mark C Field

  109. Complexity of Trypanosomatid Endocytosis Pathways Revealed by Rab4 and Rab5 Isoforms in Trypanosoma brucei

    Article • Journal of Biological Chemistry, November 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  110. Tandem Duplication of rab Genes Followed by Sequence Divergence and Acquisition of Distinct Functions in Trypanosoma brucei

    Article • Journal of Biological Chemistry, April 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field

  111. Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, November 1996, Elsevier

    Prof Mark C Field

  112. Leptomonas seymouri, Trypanosoma brucei:A Method for Isolating Trypanosomatid Nuclear Factors Which BindT. bruceiSingle-Stranded g-Rich Telomere Sequence

    Article • Experimental Parasitology, June 1996, Elsevier

    Prof Mark C Field

  113. Sequence divergence in a family of variant surface glycoprotein genes from trypanosomes: Coding region hypervariability and downstream recombinogenic repeats

    Article • Journal of Molecular Evolution, May 1996, Springer Science + Business Media

    Prof Mark C Field

  114. Trypanosoma brucei: Molecular Cloning of Homologues of Small GTP-Binding Proteins Involved in Vesicle Trafficking

    Article • Experimental Parasitology, November 1995, Elsevier

    Prof Mark C Field

  115. A homologue of the nuclear GTPase Ran/TC4 from Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, January 1995, Elsevier

    Prof Mark C Field

  116. Molecular species analysis of phospholipids from Trypanosoma brucei bloodstream and procyclic forms

    Article • Molecular and Biochemical Parasitology, March 1993, Elsevier

    Professor Peter Bütikofer, Prof Mark C Field

  117. Characterization of a glycosylphosphatidylinositol membrane protein anchor precursor in Leishmania mexicana

    Article • Molecular and Biochemical Parasitology, October 1991, Elsevier

    Prof Mark C Field