All Stories

  1. Bioactive peptoids against vector-borne parasitic diseases

    Article • Bioorganic & Medicinal Chemistry Letters, February 2026, Elsevier

    Professor Paul W Denny

  2. Molecular diagnostics for cutaneous leishmaniasis: progress towards fulfilling the WHO target product profile

    Article • Parasitology, December 2025, Cambridge University Press

    Professor Paul W Denny

  3. INTERACT: Interactome Network Targeting via Enzyme Reactivity and Activity-based Chemoproteomic Tools

    Article • November 2025, openRxiv

    Professor Paul W Denny

  4. Profiling Serine Hydrolases in the Leishmania Host–Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

    Article • ChemBioChem, May 2025, Wiley

    Professor Paul W Denny

  5. Nanostructured Lipid Carrier for Intracellular Delivery of a Bis(pyridine-2-carboxamidine) DNA Minor Groove Binder Active against Leishmania

    Article • ACS Omega, February 2025, American Chemical Society (ACS)

    Professor Paul W Denny

  6. Simple accessible clemastine fumarate analogues as effective antileishmanials

    Article • RSC Medicinal Chemistry, January 2025, Royal Society of Chemistry

    Professor Paul W Denny

  7. BONCAT-iTRAQ Labelling Reveals Molecular Markers of Adaptive Responses in Toxoplasma gondii to Pyrimethamine Treatment

    Article • Pathogens, October 2024, MDPI AG

    Professor Paul W Denny

  8. Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach

    Article • ACS Infectious Diseases, July 2024, American Chemical Society (ACS)

    Professor Paul W Denny

  9. Rapid genotyping of Toxoplasma gondii isolates via Nanopore-based multi-locus sequencing

    Article • AMB Express, June 2024, Springer Science + Business Media

    Professor Paul W Denny

  10. Clemastine/tamoxifen hybrids as easily accessible antileishmanial drug leads

    Article • Organic & Biomolecular Chemistry, January 2024, Royal Society of Chemistry

    Professor Paul W Denny

  11. Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages

    Article • Microbiology Spectrum, December 2023, ASM Journals

    Professor Paul W Denny

  12. Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness

    Article • The FASEB Journal, October 2023, Wiley

    Professor Paul W Denny

  13. Disruption of the inositol phosphorylceramide synthase gene affects Trypanosoma cruzi differentiation and infection capacity

    Article • PLoS Neglected Tropical Diseases, September 2023, PLOS

    Professor Paul W Denny

  14. Assessment of Toxoplasma gondii lytic cycle and the impact of a gene deletion using 3D label-free optical diffraction holotomography

    Article • Frontiers in Cellular and Infection Microbiology, August 2023, Frontiers

    Professor Paul W Denny

  15. Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages

    Article • July 2023, openRxiv

    Professor Paul W Denny

  16. Editorial: Leishmania genome variability: Impacts on parasite evolution, parasitism and leishmaniases control

    Article • Frontiers in Cellular and Infection Microbiology, March 2023, Frontiers

    Professor Paul W Denny

  17. Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response

    Article • PLoS Neglected Tropical Diseases, September 2022, PLOS

    Professor Paul W Denny

  18. Genome deletions to overcome the directed loss of gene function in Leishmania

    Article • Frontiers in Cellular and Infection Microbiology, September 2022, Frontiers

    Professor Paul W Denny

  19. Illuminating Host-Parasite Interaction at the Cellular and Subcellular Levels with Infrared Microspectroscopy

    Article • Cells, February 2022, MDPI AG

    Carl W Stevenson, Assistant Professor Doctor alaa tariq abdulwahid alsandaqchi, Professor Paul W Denny

  20. Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana

    Article • Microbiology Spectrum, February 2022, ASM Journals

    Professor Paul W Denny

  21. Toxoplasma ceramide synthases: a curious case of gene duplication, divergence and key functionality

    Article • January 2022, openRxiv

    Professor Paul W Denny

  22. The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions

    Article • mBio, December 2021, ASM Journals

    Professor Roberto Docampo, Professor Paul W Denny

  23. Transcriptome-wide identification of coding and noncoding RNA-binding proteins defines the comprehensive RNA interactome of Leishmania mexicana

    Article • December 2021, openRxiv

    Professor Paul W Denny

  24. Amphotericin B resistance in Leishmania mexicana : Alterations to sterol metabolism, lipid transport and oxidative stress response

    Article • December 2021, openRxiv

    Professor Paul W Denny

  25. Chalcones identify cTXNPx as a potential antileishmanial drug target

    Article • PLoS Neglected Tropical Diseases, November 2021, PLOS

    Bartira Rossi-Bergmann, Professor Paul W Denny

  26. Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana

    Article • mSystems, June 2021, ASM Journals

    Professor Paul W Denny

  27. Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase

    Article • ACS Infectious Diseases, December 2020, American Chemical Society (ACS)

    Professor Paul W Denny

  28. How can proteomics overhaul our understanding of Leishmania biology?

    Article • Expert Review of Proteomics, December 2020, Taylor & Francis

    Professor Paul W Denny

  29. Apoptotic blebs from Leishmania major-infected macrophages as a new approach for cutaneous leishmaniasis vaccination

    Article • Microbial Pathogenesis, October 2020, Elsevier

    Professor Paul W Denny

  30. An investigation of the antileishmanial properties of semi-synthetic saponins

    Article • RSC Medicinal Chemistry, January 2020, Royal Society of Chemistry

    Professor Paul W Denny

  31. A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvation

    Article • PLoS Neglected Tropical Diseases, December 2019, PLOS

    Professor Paul W Denny

  32. Mining for natural product antileishmanials in a fungal extract library

    Article • International Journal for Parasitology Drugs and Drug Resistance, December 2019, Elsevier

    Professor Paul W Denny

  33. A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvation

    Article • July 2019, openRxiv

    Professor Paul W Denny

  34. The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity

    Article • Scientific Reports, May 2019, Springer Science + Business Media

    Professor Paul W Denny

  35. Expression levels of inositol phosphorylceramide synthase modulate plant responses to biotic and abiotic stress in Arabidopsis thaliana

    Article • PLOS One, May 2019, PLOS

    Professor Paul W Denny

  36. Lytic reactions of drugs with lipid membranes

    Article • Chemical Science, January 2019, Royal Society of Chemistry

    Professor Paul W Denny

  37. Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

    Article • International Journal for Parasitology Drugs and Drug Resistance, December 2018, Elsevier

    Professor Paul W Denny

  38. Yeast: bridging the gap between phenotypic and biochemical assays for high-throughput screening

    Article • Expert Opinion on Drug Discovery, October 2018, Taylor & Francis

    Professor Paul W Denny

  39. Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan Toxoplasma gondii

    Article • Genes, August 2018, MDPI AG

    Professor Paul W Denny

  40. Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

    Article • Scientific Reports, March 2018, Springer Science + Business Media

    Professor Paul W Denny

  41. Complex Interplay between Sphingolipid and Sterol Metabolism Revealed by Perturbations to the Leishmania Metabolome Caused by Miltefosine

    Article • Antimicrobial Agents and Chemotherapy, February 2018, ASM Journals

    Professor Paul W Denny

  42. Microbial protein targets: towards understanding and intervention

    Article • Parasitology, November 2017, Cambridge University Press

    Professor Paul W Denny

  43. Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art

    Article • Parasitology, August 2017, Cambridge University Press

    Professor Paul W Denny

  44. Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites

    Article • Journal of Biological Chemistry, July 2017, Elsevier

    Professor Paul W Denny

  45. Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis

    Article • Parasitology, June 2017, Cambridge University Press

    Professor Paul W Denny

  46. The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis – Corrigendum

    Article • Parasitology, June 2017, Cambridge University Press

    Professor Paul W Denny

  47. The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis

    Article • Parasitology, May 2017, Cambridge University Press

    Professor Paul W Denny

  48. An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

    Article • Journal of Visualized Experiments, November 2016, MyJove Corporation

    Professor Paul W Denny

  49. Enlarging the chemical space of anti-leishmanials: a structure–activity relationship study of peptoids against Leishmania mexicana, a causative agent of cutaneous leishmaniasis

    Article • MedChemComm, January 2016, Royal Society of Chemistry

    Professor Paul W Denny

  50. Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct

    Article • International Journal of Molecular Sciences, July 2015, MDPI AG

    Professor Paul W Denny

  51. The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides

    Article • Molecules, February 2015, MDPI AG

    Professor Paul W Denny

  52. Yeast as a Potential Vehicle for Neglected Tropical Disease Drug Discovery

    Article • SLAS DISCOVERY, January 2015, Elsevier

    Professor Paul W Denny

  53. Investigating the Anti‐leishmanial Effects of Linear Peptoids

    Article • ChemMedChem, December 2014, Wiley

    Professor Paul W Denny

  54. The utility of yeast as a tool for cell-based, target-directed high-throughput screening

    Article • Parasitology, April 2013, Cambridge University Press

    Professor Paul W Denny

  55. Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Professor Paul W Denny

  56. Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii

    Article • Molecular and Biochemical Parasitology, January 2013, Elsevier

    Professor Paul W Denny

  57. Endocytosis and Sphingolipid Scavenging inLeishmania mexicanaAmastigotes

    Article • Biochemistry Research International, January 2012, Hindawi Publishing Corporation

    Professor Paul W Denny

  58. Lipid Metabolism as a Therapeutic Target

    Article • Biochemistry Research International, January 2012, Wiley

    Professor Paul W Denny

  59. Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets

    Article • Biochemistry Research International, January 2012, Wiley

    Professor Paul W Denny

  60. Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa

    Article • Journal of Peptide Science, August 2011, Wiley

    Professor Paul W Denny

  61. Exploring Leishmania major Inositol Phosphorylceramide Synthase (LmjIPCS): Insights into the ceramide binding domain

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Professor Paul W Denny

  62. A plate-based assay system for analyses and screening of the Leishmania major inositol phosphorylceramide synthase

    Article • The International Journal of Biochemistry & Cell Biology, September 2010, Elsevier

    Professor Paul W Denny

  63. Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase

    Article • Plant Molecular Biology, March 2010, Springer Science + Business Media

    Professor Paul W Denny

  64. The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target

    Article • Molecular and Biochemical Parasitology, November 2009, Elsevier

    Professor Paul W Denny

  65. The Protozoan Inositol Phosphorylceramide Synthase

    Article • Journal of Biological Chemistry, September 2006, Elsevier

    Professor Paul W Denny

  66. An Evolutionarily Conserved Coiled-Coil Protein Implicated in Polycystic Kidney Disease Is Involved in Basal Body Duplication and Flagellar Biogenesis in Trypanosoma brucei

    Article • Molecular and Cellular Biology, May 2005, ASM Journals

    Prof Mark C Field, Professor Paul W Denny

  67. Direct transport across the plasma membrane of mammalian cells ofLeishmaniaHASPB as revealed by a CHO export mutant

    Article • Journal of Cell Science, February 2005, The Company of Biologists

    Professor Paul W Denny

  68. Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite

    Article • Experimental Parasitology, January 2005, Elsevier

    Prof Mark C Field, Professor Paul W Denny

  69. Rafts and sphingolipid biosynthesis in the kinetoplastid parasitic protozoa

    Article • Molecular Microbiology, July 2004, Wiley

    Professor Paul W Denny

  70. Sphingolipid‐free Leishmania are defective in membrane trafficking, differentiation and infectivity

    Article • Molecular Microbiology, March 2004, Wiley

    Professor Paul W Denny

  71. Ether Phospholipids and Glycosylinositolphospholipids Are Not Required for Amastigote Virulence or for Inhibition of Macrophage Activation by Leishmania major

    Article • Journal of Biological Chemistry, November 2003, Elsevier

    Professor Paul W Denny

  72. The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system

    Article • Trends in Parasitology, December 2002, Elsevier

    Prof Mark C Field, Belinda Hall, Professor Paul W Denny

  73. The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences

    Article • Trends in Parasitology, November 2002, Elsevier

    Prof Mark C Field, Belinda Hall, Professor Paul W Denny

  74. Leishmania RAB7: characterisation of terminal endocytic stages in an intracellular parasite

    Article • Molecular and Biochemical Parasitology, August 2002, Elsevier

    Prof Mark C Field, Professor Paul W Denny

  75. Phenotypic changes associated with deletion and overexpression of a stage-regulated gene family in Leishmania

    Article • Cellular Microbiology, August 2001, Hindawi Publishing Corporation

    Professor Paul W Denny

  76. Meeting Report: Molecular Parasitology XI, Woods Hole, USA, September 17–21, 2000

    Article • Protist, May 2001, Elsevier

    Professor Paul W Denny

  77. GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida

    Article • FEBS Letters, February 2001, Wiley

    Prof Mark C Field, Professor Paul W Denny

  78. The in vivo conformation of the plastid DNA of Toxoplasma gondii: implications for replication11Edited by N.-H. Chua

    Article • Journal of Molecular Biology, February 2001, Elsevier

    Professor Paul W Denny

  79. DRMs, secretion and lipid architecture in Trypanosomatidae

    Article • Biochemical Society Transactions, October 2000, Portland Press Ltd.

    Professor Paul W Denny

  80. Expression of the AM gene locus in infective stages of Leishmania

    Article • Molecular and Biochemical Parasitology, June 2000, Elsevier

    Professor Paul W Denny

  81. Acylation-dependent Protein Export in Leishmania

    Article • Journal of Biological Chemistry, April 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field, Professor Paul W Denny

  82. Evidence for a Single Origin of the 35 kb Plastid DNA in Apicomplexans

    Article • Protist, February 1998, Elsevier

    Professor Paul W Denny

  83. Thiostrepton binds to malarial plastid rRNA

    Article • FEBS Letters, April 1997, Wiley

    Professor Paul W Denny

  84. A Plastid of Probable Green Algal Origin in Apicomplexan Parasites

    Article • Science, March 1997, American Association for the Advancement of Science

    Professor Paul W Denny

  85. Complete Gene Map of the Plastid-like DNA of the Malaria ParasitePlasmodium falciparum

    Article • Journal of Molecular Biology, August 1996, Elsevier

    Professor Paul W Denny