All Stories

  1. Phylogenetic ancestry of Metamonada proteins points to a common origin of mitochondria in all eukaryotes
  2. Eukaryogenesis Meets Constructive Neutral Evolution?
  3. Stunning Intricacies of RNA Editing Complexes RECC , RESC , and REH2C
  4. Eukaryogenesis: Did an Oxidative Crucible Result in Misleading Bioinformatic Analyses?
  5. The Thing About Neurons
  6. Even Scientists Seem Unable to Change Their Minds
  7. Natural and artificial variations of the standard genetic code
  8. Eukaryogenesis From FECA to LECA: Radical Steps Along the Way
  9. Complex Interplay of Metabolic Substrates, Points of Entry into the Mitochondrial Electron Chain, and ROS Generation
  10. Dismissing Demographic Realities Because of Their Framing Is Unhelpful: The Human Population Size Is Really Problematic
  11. Safeguarding Scientific Accuracy in a Rapidly Changing World
  12. Calmly coasting towards complete collapse
  13. “Social Darwinism” revisited
  14. Let's talk about sex
  15. Are anti‐cancer patents intrinsically immoral?
  16. How mitochondrial cristae illuminate the important role of oxygen during eukaryogenesis
  17. The contours of evolution: In defence of Darwin's tree of life paradigm
  18. Mitochondrial genomes revisited: why do different lineages retain different genes?
  19. Trypanosomes as a magnifying glass for cell and molecular biology
  20. How did we let it come this far?
  21. Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes
  22. How mitochondria showcase evolutionary mechanisms and the importance of oxygen
  23. Neisseria meningitidis Sibling Small Regulatory RNAs Connect Metabolism with Colonization by Controlling Propionate Use
  24. Renewing L innaean taxonomy: a proposal to restructure the highest levels of the N atural S ystem
  25. How germline genes promote malignancy in cancer cells
  26. Airports: Flying in the face of science and common sense
  27. Eukaryotes were shaped by Oxygen
  28. Molecular characteristics of the multi‐functional FAO enzyme ACAD9 illustrate the importance of FADH 2 /NADH ratios for mitochondrial ROS formation
  29. Eukaryotic cellular intricacies shape mitochondrial proteomic complexity
  30. What are we doing, people? We have to challenge vested interests much more vigorously
  31. Getting updated on the brain: A review of “Livewired—The inside story of the ever‐changing brain” by David Eagleman
  32. Preventing the Matthew principle in science publishing
  33. Eukaryotes without oxygen? A review of “Mitochondria and anaerobic energy metabolism in eukaryotes” by William F. Martin, Aloysius G. M. Tielens and Marek Mentel
  34. Zombie ideas about early endosymbiosis: Which entry mechanisms gave us the “endo” in different endosymbionts?
  35. The sting of rejection
  36. Is There a Carcinogenic Risk Attached to Vitamin B 12 Deficient Diets and What Should We Do About It? Reviewing the Facts
  37. RNA Editing in Mitochondria and Plastids: Weird and Widespread
  38. Even The Guardian needs a guardian
  39. How neoteny shapes human society: Can we escape our formative years, and fight the wrong kind of populism?
  40. The Future of the World Wide Web: Wikipedia or Whatsapp?
  41. Comparing Early Eukaryotic Integration of Mitochondria and Chloroplasts in the Light of Internal ROS Challenges: Timing is of the Essence
  42. Debating Eukaryogenesis—Part 1: Does Eukaryogenesis Presuppose Symbiosis Before Uptake?
  43. Bad Faith Reasoning, Predictable Chaos, and the Truth
  44. Debating Eukaryogenesis—Part 2: How Anachronistic Reasoning Can Lure Us into Inventing Intermediates
  45. Is Popperian Falsification Useful in Biology?
  46. Dangerous Delusions about Darwinism
  47. Why Does the Web Seem to Bring Out the Best in Science but the Worst in Politics?
  48. Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes
  49. We Should Not Use the Term “Lamarckian” as It Is Often Used in Opposition to “Darwinian”
  50. On the Likelihood of Life Originating
  51. Stop the Assault on Truth
  52. Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway
  53. Let's Stop the Sloppy Use of “Lamarckian”
  54. Can All Major ROS Forming Sites of the Respiratory Chain Be Activated By High FADH2 /NADH Ratios?
  55. Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney
  56. A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
  57. Protease resistance of food proteins: a mixed picture for predicting allergenicity but a useful tool for assessing exposure
  58. Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism
  59. Impact Factors, Reads and Real Values
  60. How oxygen gave rise to eukaryotic sex
  61. Response to Ghiselli F et al. (2018)
  62. Dendritic Cells Potently Purge Latent HIV-1 in TCR-Activated Cells via the PI3K-Akt-mTOR Pathway: Implications for Shock and Killl Strategies and Reservoir Analysis
  63. Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions
  64. AML-specific cytotoxic antibodies in patients with durable graft versus leukemia responses
  65. Dendritic cells as natural latency reversing agent: A wake-up call for HIV-1
  66. In defence of the three-domains of life paradigm
  67. Evolution of peroxisomes illustrates symbiogenesis
  68. Regulation ofNeisseria meningitidiscytochromebc1components by NrrF, a Fur-controlled small noncoding RNA
  69. Unmiraculous? Yes. Ancient? Probably not. (Response to DOI 10.1002/bies.201700041)
  70. The Hfq regulon of Neisseria meningitidis
  71. sibling sRNAs from Neisseria
  72. Alternating terminal electron-acceptors at the basis of symbiogenesis: How oxygen ignited eukaryotic evolution
  73. Being right on Q: shaping eukaryotic evolution
  74. Abstract A061: Acute myeloid leukemia patients cured after allogeneic hematopoietic stem cell transplantation generate tumor-specific cytotoxic antibodies that kill AML blasts
  75. Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress
  76. What can we infer about the origin of sex in early eukaryotes?
  77. Abstract B052: Donor derived cytotoxic antibodies from transplanted AML patients targeting a cell surface expressed nuclear antigen
  78. Altered Loyalties of Neuronal Markers in Cultured Slices of Resected Human Brain Tissue
  79. Donor-Derived B Cells Produce Potent AML-Specific Antibodies That Recognize Novel Tumor-Specific Antigens and Mediate Graft-Versus-Leukemia Immunity
  80. Birth of the eukaryotes by a set of reactive innovations: New insights force us to relinquish gradual models
  81. Accuracy and Reproducibility in Quantification of Plasma Protein Concentrations by Mass Spectrometry without the Use of Isotopic Standards
  82. Sex is a ubiquitous, ancient, and inherent attribute of eukaryotic life
  83. Dendritic cell type-specific HIV-1 activation in effector T cells
  84. Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 Trans-Infection of CD4+ T-Lymphocytes
  85. Candidate prioritization for low-abundant differentially expressed proteins in 2D-DIGE datasets
  86. How Amino Acids and Peptides Shaped the RNA World
  87. Injury Response of Resected Human Brain TissueIn Vitro
  88. The road to rack and ruin: selecting deleterious mitochondrial DNA variants
  89. How to deal with oxygen radicals stemming from mitochondrial fatty acid oxidation
  90. How the mitochondrion was shaped by radical differences in substrates
  91. RNA Editing Types and Characteristics
  92. Interplay between viral Tat protein and c-Jun transcription factor in controlling LTR promoter activity in different human immunodeficiency virus type I subtypes
  93. Reconsidering ideas regarding the evolution of peroxisomes: the case for a mitochondrial connection
  94. Superior in vivo compatibility of hydrophilic polymer coated prosthetic vascular grafts
  95. A Realistic Model Under Which the Genetic Code is Optimal
  96. Dendritic Cell-induced Activation of Latent HIV-1 Provirus in Actively Proliferating Primary T Lymphocytes
  97. Brains have a gut feeling about fat storage
  98. Penetrating insights?
  99. Proteomic analysis of HIV–T cell interaction: an update
  100. Native Thrombocidin-1 and Unfolded Thrombocidin-1 Exert Antimicrobial Activity via Distinct Structural Elements
  101. Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response
  102. Does constructive neutral evolution play an important role in the origin of cellular complexity?
  103. The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation
  104. Oxygen radicals shaping evolution: Why fatty acid catabolism leads to peroxisomes while neurons do without it
  105. Proteome-wide Alterations inEscherichia coliTranslation Rates upon Anaerobiosis
  106. How honey kills bacteria
  107. Constructive neutral evolution cannot explain current kinetoplastid panediting patterns
  108. Identification of a novel anti-σE factor in Neisseria meningitidis
  109. Specific Human Astrocyte Subtype Revealed by Affinity Purified GFAP+1 Antibody; Unpurified Serum Cross-Reacts with Neurofilament-L in Alzheimer
  110. Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4+ T-lymphocytes
  111. Defining numbers in terms of their divisors
  112. Gaucher disease: a model disorder for biomarker discovery
  113. Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium
  114. Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium
  115. Molecular characterization and identification of proteins regulated by Hfq in Neisseria meningitidis
  116. P07-10. Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells
  117. Potential artefacts in proteome analysis of plasma of Gaucher patients due to protease abnormalities
  118. Differences in matrix composition between calvaria and long bone in mice suggest differences in biomechanical properties and resorption
  119. Intragenomic Variation in the Internal Transcribed Spacer 1 Region of Dientamoeba fragilis as a Molecular Epidemiological Marker
  120. Identification by UV Cross-Linking of Oligo(U)-Binding Proteins in Mitochondria of the Insect Trypanosomatid Crithidia fasciculata
  121. Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease
  122. Proteomic Studies Reveal Coordinated Changes in T-Cell Expression Patterns upon Infection with Human Immunodeficiency Virus Type 1
  123. Making Sense of Scrambled Genomes
  124. Evolutionary Aspects of RNA Editing
  125. Bile-salt stimulated lipase in human milk binds DC-SIGN and inhibits HIV-1 transmission
  126. TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase
  127. Evolution of Mammalian Chitinase(-Like) Members of Family 18 Glycosyl Hydrolases
  128. The mixed xylem sap proteome of Fusarium oxysporum-infected tomato plants
  129. 1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics
  130. Bile Salt-Stimulated Lipase from Human Milk Binds DC-SIGN and Inhibits Human Immunodeficiency Virus Type 1 Transfer to CD4+ T Cells
  131. Is kinetoplastid pan-editing the result of an evolutionary balancing act?
  132. Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity
  133. Proteomic analysis of high-density lipoprotein
  134. Carbohydrate Moieties of Microsporidian Polar Tube Proteins Are Targeted by Immunoglobulin G in Immunocompetent Individuals
  135. The N5-Glutamine S-Adenosyl-l-Methionine-Dependent Methyltransferase PrmC/HemK in Chlamydia trachomatis Methylates Class 1 Release Factors
  136. Major Histocompatibility Complex Class I Peptide Presentation after Salmonella enterica Serovar Typhimurium Infection Assessed via Stable Isotope Tagging of the B27-Presented Peptide Repertoire
  137. Role of the  -Glucanase Agn1p in Fission-Yeast Cell Separation
  138. Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry
  139. The ocular humoral immune response in health and disease
  140. Igm recognition of recombinant Toxoplasma gondii antigens by sera of acutely or latently infected humans
  141. Recombinant Enzyme Therapy for Fabry Disease: Absence of Editing of Human α-Galactosidase A mRNA
  142. Conserved regions of protein disulfide isomerase are targeted by natural IgA antibodies in humans
  143. Mass Spectrometric Identification of Isoforms of PR Proteins in Xylem Sap of Fungus-Infected Tomato
  144. Protein disulfide isomerase ofToxoplasma gondiiis targeted by mucosal IgA antibodies in humans
  145. Nano-Porn™: Assiduous Assessment of Proteins
  146. Cloning and characterization of two guide RNA-binding proteins from mitochondria of Crithidia fasciculata: gBP27, a novel protein, and gBP29, the orthologue of Trypanosoma brucei gBP21
  147. In VivoFunctional Analysis of the Human Mitochondrial DNA Polymerase POLG Expressed in Cultured Human Cells
  148. Chloramphenicol-sensitive mitochondrial translation in Trypanosoma brucei
  149. Trypanosoma brucei TBRGG1, a Mitochondrial Oligo(U)-binding Protein That Co-localizes with an in VitroRNA Editing Activity
  150. Assembly of cytochrome-c oxidase in cultured human cells
  151. Characterization of the respiratory chain from cultured Crithidia fasciculata
  152. Further Evidence for the Presence of Mitochondrially Encoded Subunits in Cytochrome c Oxidase of the Trypanosomatid Crithidia fasciculata
  153. Purification and characterization of cytochrome c oxidase from the insect trypanosomatid Crithidia fasciculata
  154. A homologue of the cysteine proteinase gene (ACP or Eh-CPp) of pathogenic Entamoeba histolytica is present in non-pathogenic E. dispar strains
  155. The sequence of a small subunit of cytochrome c oxidase from Crithidia fasciculata which is homologous to mammalian subunit IV
  156. Identification by UV Cross-Linking of Oligo(U)-Binding Proteins in Mitochondria of the Insect Trypanosomatid Crithidia fasciculata
  157. Implications of novel guide RNA features for the mechanism of RNA editing in Crithidia fasciculata.
  158. RNA editing in transcripts of the mitochondrial genes of the insect trypanosome Crithidia fasciculata.