All Stories

  1. Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes
  2. How mitochondria showcase evolutionary mechanisms and the importance of oxygen
  3. Neisseria meningitidis Sibling Small Regulatory RNAs Connect Metabolism with Colonization by Controlling Propionate Use
  4. Renewing L innaean taxonomy: a proposal to restructure the highest levels of the N atural S ystem
  5. How germline genes promote malignancy in cancer cells
  6. Airports: Flying in the face of science and common sense
  7. Eukaryotes were shaped by Oxygen
  8. Molecular characteristics of the multi‐functional FAO enzyme ACAD9 illustrate the importance of FADH 2 /NADH ratios for mitochondrial ROS formation
  9. Eukaryotic cellular intricacies shape mitochondrial proteomic complexity
  10. What are we doing, people? We have to challenge vested interests much more vigorously
  11. Getting updated on the brain: A review of “Livewired—The inside story of the ever‐changing brain” by David Eagleman
  12. Preventing the Matthew principle in science publishing
  13. Eukaryotes without oxygen? A review of “Mitochondria and anaerobic energy metabolism in eukaryotes” by William F. Martin, Aloysius G. M. Tielens and Marek Mentel
  14. Zombie ideas about early endosymbiosis: Which entry mechanisms gave us the “endo” in different endosymbionts?
  15. The sting of rejection
  16. Is There a Carcinogenic Risk Attached to Vitamin B 12 Deficient Diets and What Should We Do About It? Reviewing the Facts
  17. RNA Editing in Mitochondria and Plastids: Weird and Widespread
  18. Even The Guardian needs a guardian
  19. How neoteny shapes human society: Can we escape our formative years, and fight the wrong kind of populism?
  20. The Future of the World Wide Web: Wikipedia or Whatsapp?
  21. Comparing Early Eukaryotic Integration of Mitochondria and Chloroplasts in the Light of Internal ROS Challenges: Timing is of the Essence
  22. Debating Eukaryogenesis—Part 1: Does Eukaryogenesis Presuppose Symbiosis Before Uptake?
  23. Bad Faith Reasoning, Predictable Chaos, and the Truth
  24. Debating Eukaryogenesis—Part 2: How Anachronistic Reasoning Can Lure Us into Inventing Intermediates
  25. Is Popperian Falsification Useful in Biology?
  26. Dangerous Delusions about Darwinism
  27. Why Does the Web Seem to Bring Out the Best in Science but the Worst in Politics?
  28. Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes
  29. We Should Not Use the Term “Lamarckian” as It Is Often Used in Opposition to “Darwinian”
  30. On the Likelihood of Life Originating
  31. Stop the Assault on Truth
  32. Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway
  33. Let's Stop the Sloppy Use of “Lamarckian”
  34. Can All Major ROS Forming Sites of the Respiratory Chain Be Activated By High FADH2 /NADH Ratios?
  35. Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney
  36. A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
  37. Protease resistance of food proteins: a mixed picture for predicting allergenicity but a useful tool for assessing exposure
  38. Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism
  39. Impact Factors, Reads and Real Values
  40. How oxygen gave rise to eukaryotic sex
  41. Response to Ghiselli F et al. (2018)
  42. Dendritic Cells Potently Purge Latent HIV-1 in TCR-Activated Cells via the PI3K-Akt-mTOR Pathway: Implications for Shock and Killl Strategies and Reservoir Analysis
  43. Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions
  44. AML-specific cytotoxic antibodies in patients with durable graft versus leukemia responses
  45. Dendritic cells as natural latency reversing agent: A wake-up call for HIV-1
  46. In defence of the three-domains of life paradigm
  47. Evolution of peroxisomes illustrates symbiogenesis
  48. Regulation ofNeisseria meningitidiscytochromebc1components by NrrF, a Fur-controlled small noncoding RNA
  49. Unmiraculous? Yes. Ancient? Probably not. (Response to DOI 10.1002/bies.201700041)
  50. The Hfq regulon of Neisseria meningitidis
  51. sibling sRNAs from Neisseria
  52. Alternating terminal electron-acceptors at the basis of symbiogenesis: How oxygen ignited eukaryotic evolution
  53. Being right on Q: shaping eukaryotic evolution
  54. Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress
  55. What can we infer about the origin of sex in early eukaryotes?
  56. Altered Loyalties of Neuronal Markers in Cultured Slices of Resected Human Brain Tissue
  57. Donor-Derived B Cells Produce Potent AML-Specific Antibodies That Recognize Novel Tumor-Specific Antigens and Mediate Graft-Versus-Leukemia Immunity
  58. Birth of the eukaryotes by a set of reactive innovations: New insights force us to relinquish gradual models
  59. Accuracy and Reproducibility in Quantification of Plasma Protein Concentrations by Mass Spectrometry without the Use of Isotopic Standards
  60. Sex is a ubiquitous, ancient, and inherent attribute of eukaryotic life
  61. Dendritic cell type-specific HIV-1 activation in effector T cells
  62. Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 Trans-Infection of CD4+ T-Lymphocytes
  63. Candidate prioritization for low-abundant differentially expressed proteins in 2D-DIGE datasets
  64. How Amino Acids and Peptides Shaped the RNA World
  65. Injury Response of Resected Human Brain TissueIn Vitro
  66. The road to rack and ruin: selecting deleterious mitochondrial DNA variants
  67. How to deal with oxygen radicals stemming from mitochondrial fatty acid oxidation
  68. How the mitochondrion was shaped by radical differences in substrates
  69. Interplay between viral Tat protein and c-Jun transcription factor in controlling LTR promoter activity in different human immunodeficiency virus type I subtypes
  70. Reconsidering ideas regarding the evolution of peroxisomes: the case for a mitochondrial connection
  71. Superior in vivo compatibility of hydrophilic polymer coated prosthetic vascular grafts
  72. A Realistic Model Under Which the Genetic Code is Optimal
  73. Dendritic Cell-induced Activation of Latent HIV-1 Provirus in Actively Proliferating Primary T Lymphocytes
  74. Brains have a gut feeling about fat storage
  75. Penetrating insights?
  76. Proteomic analysis of HIV–T cell interaction: an update
  77. Native Thrombocidin-1 and Unfolded Thrombocidin-1 Exert Antimicrobial Activity via Distinct Structural Elements
  78. Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response
  79. Does constructive neutral evolution play an important role in the origin of cellular complexity?
  80. The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation
  81. Oxygen radicals shaping evolution: Why fatty acid catabolism leads to peroxisomes while neurons do without it
  82. Proteome-wide Alterations inEscherichia coliTranslation Rates upon Anaerobiosis
  83. How honey kills bacteria
  84. Constructive neutral evolution cannot explain current kinetoplastid panediting patterns
  85. Identification of a novel anti-σE factor in Neisseria meningitidis
  86. Specific Human Astrocyte Subtype Revealed by Affinity Purified GFAP+1 Antibody; Unpurified Serum Cross-Reacts with Neurofilament-L in Alzheimer
  87. Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4+ T-lymphocytes
  88. Defining numbers in terms of their divisors
  89. Gaucher disease: a model disorder for biomarker discovery
  90. Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium
  91. Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium
  92. Molecular characterization and identification of proteins regulated by Hfq in Neisseria meningitidis
  93. P07-10. Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells
  94. Potential artefacts in proteome analysis of plasma of Gaucher patients due to protease abnormalities
  95. Differences in matrix composition between calvaria and long bone in mice suggest differences in biomechanical properties and resorption
  96. Intragenomic Variation in the Internal Transcribed Spacer 1 Region of Dientamoeba fragilis as a Molecular Epidemiological Marker
  97. Identification by UV Cross-Linking of Oligo(U)-Binding Proteins in Mitochondria of the Insect Trypanosomatid Crithidia fasciculata
  98. Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease
  99. Proteomic Studies Reveal Coordinated Changes in T-Cell Expression Patterns upon Infection with Human Immunodeficiency Virus Type 1
  100. Making Sense of Scrambled Genomes
  101. Evolutionary Aspects of RNA Editing
  102. Bile-salt stimulated lipase in human milk binds DC-SIGN and inhibits HIV-1 transmission
  103. TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase
  104. Evolution of Mammalian Chitinase(-Like) Members of Family 18 Glycosyl Hydrolases
  105. The mixed xylem sap proteome of Fusarium oxysporum-infected tomato plants
  106. 1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics
  107. Bile Salt-Stimulated Lipase from Human Milk Binds DC-SIGN and Inhibits Human Immunodeficiency Virus Type 1 Transfer to CD4+ T Cells
  108. Is kinetoplastid pan-editing the result of an evolutionary balancing act?
  109. Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity
  110. Proteomic analysis of high-density lipoprotein
  111. Carbohydrate Moieties of Microsporidian Polar Tube Proteins Are Targeted by Immunoglobulin G in Immunocompetent Individuals
  112. The N5-Glutamine S-Adenosyl-l-Methionine-Dependent Methyltransferase PrmC/HemK in Chlamydia trachomatis Methylates Class 1 Release Factors
  113. Major Histocompatibility Complex Class I Peptide Presentation after Salmonella enterica Serovar Typhimurium Infection Assessed via Stable Isotope Tagging of the B27-Presented Peptide Repertoire
  114. Role of the  -Glucanase Agn1p in Fission-Yeast Cell Separation
  115. Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry
  116. The ocular humoral immune response in health and disease
  117. Igm recognition of recombinant Toxoplasma gondii antigens by sera of acutely or latently infected humans
  118. Recombinant Enzyme Therapy for Fabry Disease: Absence of Editing of Human α-Galactosidase A mRNA
  119. Conserved regions of protein disulfide isomerase are targeted by natural IgA antibodies in humans
  120. Mass Spectrometric Identification of Isoforms of PR Proteins in Xylem Sap of Fungus-Infected Tomato
  121. Protein disulfide isomerase ofToxoplasma gondiiis targeted by mucosal IgA antibodies in humans
  122. Nano-Porn™: Assiduous Assessment of Proteins
  123. Cloning and characterization of two guide RNA-binding proteins from mitochondria of Crithidia fasciculata: gBP27, a novel protein, and gBP29, the orthologue of Trypanosoma brucei gBP21
  124. In VivoFunctional Analysis of the Human Mitochondrial DNA Polymerase POLG Expressed in Cultured Human Cells
  125. Chloramphenicol-sensitive mitochondrial translation in Trypanosoma brucei
  126. Trypanosoma brucei TBRGG1, a Mitochondrial Oligo(U)-binding Protein That Co-localizes with an in VitroRNA Editing Activity
  127. Assembly of cytochrome-c oxidase in cultured human cells
  128. Characterization of the respiratory chain from cultured Crithidia fasciculata
  129. Further Evidence for the Presence of Mitochondrially Encoded Subunits in Cytochrome c Oxidase of the Trypanosomatid Crithidia fasciculata
  130. Purification and characterization of cytochrome c oxidase from the insect trypanosomatid Crithidia fasciculata
  131. A homologue of the cysteine proteinase gene (ACP or Eh-CPp) of pathogenic Entamoeba histolytica is present in non-pathogenic E. dispar strains
  132. The sequence of a small subunit of cytochrome c oxidase from Crithidia fasciculata which is homologous to mammalian subunit IV
  133. Identification by UV Cross-Linking of Oligo(U)-Binding Proteins in Mitochondria of the Insect Trypanosomatid Crithidia fasciculata
  134. Implications of novel guide RNA features for the mechanism of RNA editing in Crithidia fasciculata.
  135. RNA editing in transcripts of the mitochondrial genes of the insect trypanosome Crithidia fasciculata.