All Stories

  1. Eukaryogenesis Meets Constructive Neutral Evolution?
  2. Stunning Intricacies of RNA Editing Complexes RECC , RESC , and REH2C
  3. Eukaryogenesis: Did an Oxidative Crucible Result in Misleading Bioinformatic Analyses?
  4. The Thing About Neurons
  5. Even Scientists Seem Unable to Change Their Minds
  6. Natural and artificial variations of the standard genetic code
  7. Eukaryogenesis From FECA to LECA: Radical Steps Along the Way
  8. Complex Interplay of Metabolic Substrates, Points of Entry into the Mitochondrial Electron Chain, and ROS Generation
  9. Dismissing Demographic Realities Because of Their Framing Is Unhelpful: The Human Population Size Is Really Problematic
  10. Safeguarding Scientific Accuracy in a Rapidly Changing World
  11. Calmly coasting towards complete collapse
  12. “Social Darwinism” revisited
  13. Let's talk about sex
  14. Are anti‐cancer patents intrinsically immoral?
  15. How mitochondrial cristae illuminate the important role of oxygen during eukaryogenesis
  16. The contours of evolution: In defence of Darwin's tree of life paradigm
  17. Mitochondrial genomes revisited: why do different lineages retain different genes?
  18. Trypanosomes as a magnifying glass for cell and molecular biology
  19. How did we let it come this far?
  20. Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes
  21. How mitochondria showcase evolutionary mechanisms and the importance of oxygen
  22. Neisseria meningitidis Sibling Small Regulatory RNAs Connect Metabolism with Colonization by Controlling Propionate Use
  23. Renewing L innaean taxonomy: a proposal to restructure the highest levels of the N atural S ystem
  24. How germline genes promote malignancy in cancer cells
  25. Airports: Flying in the face of science and common sense
  26. Eukaryotes were shaped by Oxygen
  27. Molecular characteristics of the multi‐functional FAO enzyme ACAD9 illustrate the importance of FADH 2 /NADH ratios for mitochondrial ROS formation
  28. Eukaryotic cellular intricacies shape mitochondrial proteomic complexity
  29. What are we doing, people? We have to challenge vested interests much more vigorously
  30. Getting updated on the brain: A review of “Livewired—The inside story of the ever‐changing brain” by David Eagleman
  31. Preventing the Matthew principle in science publishing
  32. Eukaryotes without oxygen? A review of “Mitochondria and anaerobic energy metabolism in eukaryotes” by William F. Martin, Aloysius G. M. Tielens and Marek Mentel
  33. Zombie ideas about early endosymbiosis: Which entry mechanisms gave us the “endo” in different endosymbionts?
  34. The sting of rejection
  35. Is There a Carcinogenic Risk Attached to Vitamin B 12 Deficient Diets and What Should We Do About It? Reviewing the Facts
  36. RNA Editing in Mitochondria and Plastids: Weird and Widespread
  37. Even The Guardian needs a guardian
  38. How neoteny shapes human society: Can we escape our formative years, and fight the wrong kind of populism?
  39. The Future of the World Wide Web: Wikipedia or Whatsapp?
  40. Comparing Early Eukaryotic Integration of Mitochondria and Chloroplasts in the Light of Internal ROS Challenges: Timing is of the Essence
  41. Debating Eukaryogenesis—Part 1: Does Eukaryogenesis Presuppose Symbiosis Before Uptake?
  42. Bad Faith Reasoning, Predictable Chaos, and the Truth
  43. Debating Eukaryogenesis—Part 2: How Anachronistic Reasoning Can Lure Us into Inventing Intermediates
  44. Is Popperian Falsification Useful in Biology?
  45. Dangerous Delusions about Darwinism
  46. Why Does the Web Seem to Bring Out the Best in Science but the Worst in Politics?
  47. Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes
  48. We Should Not Use the Term “Lamarckian” as It Is Often Used in Opposition to “Darwinian”
  49. On the Likelihood of Life Originating
  50. Stop the Assault on Truth
  51. Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway
  52. Let's Stop the Sloppy Use of “Lamarckian”
  53. Can All Major ROS Forming Sites of the Respiratory Chain Be Activated By High FADH2 /NADH Ratios?
  54. Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney
  55. A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
  56. Protease resistance of food proteins: a mixed picture for predicting allergenicity but a useful tool for assessing exposure
  57. Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism
  58. Impact Factors, Reads and Real Values
  59. How oxygen gave rise to eukaryotic sex
  60. Response to Ghiselli F et al. (2018)
  61. Dendritic Cells Potently Purge Latent HIV-1 in TCR-Activated Cells via the PI3K-Akt-mTOR Pathway: Implications for Shock and Killl Strategies and Reservoir Analysis
  62. Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions
  63. AML-specific cytotoxic antibodies in patients with durable graft versus leukemia responses
  64. Dendritic cells as natural latency reversing agent: A wake-up call for HIV-1
  65. In defence of the three-domains of life paradigm
  66. Evolution of peroxisomes illustrates symbiogenesis
  67. Regulation ofNeisseria meningitidiscytochromebc1components by NrrF, a Fur-controlled small noncoding RNA
  68. Unmiraculous? Yes. Ancient? Probably not. (Response to DOI 10.1002/bies.201700041)
  69. The Hfq regulon of Neisseria meningitidis
  70. sibling sRNAs from Neisseria
  71. Alternating terminal electron-acceptors at the basis of symbiogenesis: How oxygen ignited eukaryotic evolution
  72. Being right on Q: shaping eukaryotic evolution
  73. Abstract A061: Acute myeloid leukemia patients cured after allogeneic hematopoietic stem cell transplantation generate tumor-specific cytotoxic antibodies that kill AML blasts
  74. Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress
  75. What can we infer about the origin of sex in early eukaryotes?
  76. Abstract B052: Donor derived cytotoxic antibodies from transplanted AML patients targeting a cell surface expressed nuclear antigen
  77. Altered Loyalties of Neuronal Markers in Cultured Slices of Resected Human Brain Tissue
  78. Donor-Derived B Cells Produce Potent AML-Specific Antibodies That Recognize Novel Tumor-Specific Antigens and Mediate Graft-Versus-Leukemia Immunity
  79. Birth of the eukaryotes by a set of reactive innovations: New insights force us to relinquish gradual models
  80. Accuracy and Reproducibility in Quantification of Plasma Protein Concentrations by Mass Spectrometry without the Use of Isotopic Standards
  81. Sex is a ubiquitous, ancient, and inherent attribute of eukaryotic life
  82. Dendritic cell type-specific HIV-1 activation in effector T cells
  83. Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 Trans-Infection of CD4+ T-Lymphocytes
  84. Candidate prioritization for low-abundant differentially expressed proteins in 2D-DIGE datasets
  85. How Amino Acids and Peptides Shaped the RNA World
  86. Injury Response of Resected Human Brain TissueIn Vitro
  87. The road to rack and ruin: selecting deleterious mitochondrial DNA variants
  88. How to deal with oxygen radicals stemming from mitochondrial fatty acid oxidation
  89. How the mitochondrion was shaped by radical differences in substrates
  90. RNA Editing Types and Characteristics
  91. Interplay between viral Tat protein and c-Jun transcription factor in controlling LTR promoter activity in different human immunodeficiency virus type I subtypes
  92. Reconsidering ideas regarding the evolution of peroxisomes: the case for a mitochondrial connection
  93. Superior in vivo compatibility of hydrophilic polymer coated prosthetic vascular grafts
  94. A Realistic Model Under Which the Genetic Code is Optimal
  95. Dendritic Cell-induced Activation of Latent HIV-1 Provirus in Actively Proliferating Primary T Lymphocytes
  96. Brains have a gut feeling about fat storage
  97. Penetrating insights?
  98. Proteomic analysis of HIV–T cell interaction: an update
  99. Native Thrombocidin-1 and Unfolded Thrombocidin-1 Exert Antimicrobial Activity via Distinct Structural Elements
  100. Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response
  101. Does constructive neutral evolution play an important role in the origin of cellular complexity?
  102. The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation
  103. Oxygen radicals shaping evolution: Why fatty acid catabolism leads to peroxisomes while neurons do without it
  104. Proteome-wide Alterations inEscherichia coliTranslation Rates upon Anaerobiosis
  105. How honey kills bacteria
  106. Constructive neutral evolution cannot explain current kinetoplastid panediting patterns
  107. Identification of a novel anti-σE factor in Neisseria meningitidis
  108. Specific Human Astrocyte Subtype Revealed by Affinity Purified GFAP+1 Antibody; Unpurified Serum Cross-Reacts with Neurofilament-L in Alzheimer
  109. Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4+ T-lymphocytes
  110. Defining numbers in terms of their divisors
  111. Gaucher disease: a model disorder for biomarker discovery
  112. Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium
  113. Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium
  114. Molecular characterization and identification of proteins regulated by Hfq in Neisseria meningitidis
  115. P07-10. Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells
  116. Potential artefacts in proteome analysis of plasma of Gaucher patients due to protease abnormalities
  117. Differences in matrix composition between calvaria and long bone in mice suggest differences in biomechanical properties and resorption
  118. Intragenomic Variation in the Internal Transcribed Spacer 1 Region of Dientamoeba fragilis as a Molecular Epidemiological Marker
  119. Identification by UV Cross-Linking of Oligo(U)-Binding Proteins in Mitochondria of the Insect Trypanosomatid Crithidia fasciculata
  120. Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease
  121. Proteomic Studies Reveal Coordinated Changes in T-Cell Expression Patterns upon Infection with Human Immunodeficiency Virus Type 1
  122. Making Sense of Scrambled Genomes
  123. Evolutionary Aspects of RNA Editing
  124. Bile-salt stimulated lipase in human milk binds DC-SIGN and inhibits HIV-1 transmission
  125. TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase
  126. Evolution of Mammalian Chitinase(-Like) Members of Family 18 Glycosyl Hydrolases
  127. The mixed xylem sap proteome of Fusarium oxysporum-infected tomato plants
  128. 1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics
  129. Bile Salt-Stimulated Lipase from Human Milk Binds DC-SIGN and Inhibits Human Immunodeficiency Virus Type 1 Transfer to CD4+ T Cells
  130. Is kinetoplastid pan-editing the result of an evolutionary balancing act?
  131. Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity
  132. Proteomic analysis of high-density lipoprotein
  133. Carbohydrate Moieties of Microsporidian Polar Tube Proteins Are Targeted by Immunoglobulin G in Immunocompetent Individuals
  134. The N5-Glutamine S-Adenosyl-l-Methionine-Dependent Methyltransferase PrmC/HemK in Chlamydia trachomatis Methylates Class 1 Release Factors
  135. Major Histocompatibility Complex Class I Peptide Presentation after Salmonella enterica Serovar Typhimurium Infection Assessed via Stable Isotope Tagging of the B27-Presented Peptide Repertoire
  136. Role of the  -Glucanase Agn1p in Fission-Yeast Cell Separation
  137. Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry
  138. The ocular humoral immune response in health and disease
  139. Igm recognition of recombinant Toxoplasma gondii antigens by sera of acutely or latently infected humans
  140. Recombinant Enzyme Therapy for Fabry Disease: Absence of Editing of Human α-Galactosidase A mRNA
  141. Conserved regions of protein disulfide isomerase are targeted by natural IgA antibodies in humans
  142. Mass Spectrometric Identification of Isoforms of PR Proteins in Xylem Sap of Fungus-Infected Tomato
  143. Protein disulfide isomerase ofToxoplasma gondiiis targeted by mucosal IgA antibodies in humans
  144. Nano-Porn™: Assiduous Assessment of Proteins
  145. Cloning and characterization of two guide RNA-binding proteins from mitochondria of Crithidia fasciculata: gBP27, a novel protein, and gBP29, the orthologue of Trypanosoma brucei gBP21
  146. In VivoFunctional Analysis of the Human Mitochondrial DNA Polymerase POLG Expressed in Cultured Human Cells
  147. Chloramphenicol-sensitive mitochondrial translation in Trypanosoma brucei
  148. Trypanosoma brucei TBRGG1, a Mitochondrial Oligo(U)-binding Protein That Co-localizes with an in VitroRNA Editing Activity
  149. Assembly of cytochrome-c oxidase in cultured human cells
  150. Characterization of the respiratory chain from cultured Crithidia fasciculata
  151. Further Evidence for the Presence of Mitochondrially Encoded Subunits in Cytochrome c Oxidase of the Trypanosomatid Crithidia fasciculata
  152. Purification and characterization of cytochrome c oxidase from the insect trypanosomatid Crithidia fasciculata
  153. A homologue of the cysteine proteinase gene (ACP or Eh-CPp) of pathogenic Entamoeba histolytica is present in non-pathogenic E. dispar strains
  154. The sequence of a small subunit of cytochrome c oxidase from Crithidia fasciculata which is homologous to mammalian subunit IV
  155. Identification by UV Cross-Linking of Oligo(U)-Binding Proteins in Mitochondria of the Insect Trypanosomatid Crithidia fasciculata
  156. Implications of novel guide RNA features for the mechanism of RNA editing in Crithidia fasciculata.
  157. RNA editing in transcripts of the mitochondrial genes of the insect trypanosome Crithidia fasciculata.