All Stories

  1. Selected cryptic exons accumulate in hippocampal cell nuclei in Alzheimer’s disease with and without associated TDP-43 proteinopathy

    Article • Brain, February 2020, Oxford University Press (OUP)

    Manuel Portero-Otin

  2. Poultry diets containing (keto)carotenoid-enriched maize improve egg yolk color and maintain quality

    Article • Animal Feed Science and Technology, February 2020, Elsevier

    Manuel Portero-Otin

  3. Lipidomic profiling identifies signatures of metabolic risk

    Article • EBioMedicine, January 2020, Elsevier

    Manuel Portero-Otin

  4. Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential

    Article • Redox Biology, January 2020, Elsevier

    Manuel Portero-Otin

  5. Adipose Tissue Mitochondrial Factors Profile after Dietary Bioactive Compound Weight Reduction Treatments in a Mice Obesity Model

    Article • International Journal of Molecular Sciences, November 2019, MDPI AG

    Manuel Portero-Otin

  6. Gender-Specific Beneficial Effects of Docosahexaenoic Acid Dietary Supplementation in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

    Article • Neurotherapeutics, November 2019, Springer Science + Business Media

    Manuel Portero-Otin

  7. Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project

    Article • Cardiovascular Diabetology, November 2019, Springer Science + Business Media

    Manuel Portero-Otin

  8. Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project

    Article • Journal of Atherosclerosis and Thrombosis, October 2019, Japan Atherosclerosis Society

    Manuel Portero-Otin

  9. Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness

    Article • Journal of Translational Medicine, September 2019, Springer Science + Business Media

    Manuel Portero-Otin

  10. Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients

    Article • Frontiers in Neuroscience, September 2019, Frontiers

    Manuel Portero-Otin

  11. A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma

    Article • Scandinavian Journal of Trauma Resuscitation and Emergency Medicine, May 2019, Springer Science + Business Media

    Manuel Portero-Otin

  12. Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential

    Article • Obesity, May 2019, Wiley

    Manuel Portero-Otin

  13. Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study

    Article • Neurotherapeutics, May 2019, Springer Science + Business Media

    Manuel Portero-Otin

  14. Lung function measurements in the prediabetes stage: data from the ILERVAS Project

    Article • Acta Diabetologica, April 2019, Springer Science + Business Media

    Manuel Portero-Otin

  15. Altered Dynein Axonemal Assembly Factor 1 Expression in C-Boutons in Bulbar and Spinal Cord Motor-Neurons in Sporadic Amyotrophic Lateral Sclerosis

    Article • Journal of Neuropathology & Experimental Neurology, April 2019, Oxford University Press (OUP)

    Manuel Portero-Otin

  16. Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Manuel Portero-Otin

  17. Location-dependent effects of trauma on oxidative stress in humans

    Article • PLoS ONE, October 2018, PLOS

    Manuel Portero-Otin

  18. Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study

    Article • Journal of the European Academy of Dermatology and Venereology, July 2018, Wiley

    Manuel Portero-Otin

  19. Aberrant regulation of the GSK‐3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy

    Article • EMBO Molecular Medicine, July 2018, EMBO

    Manuel Portero-Otin

  20. Manipulation of gut intestinal fungy for the treatment of cardiovascular diseases

    Article • Beneficial Microbes, February 2018, Wageningen Academic Publishers

    Jose Fernandez-Real, Manuel Portero-Otin, Dr Josep Puig, Gerard Blasco, MATILDE RODRIGUEZ CHACON, Wifredo Ricart

  21. Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence

    Article • Cellular Physiology and Biochemistry, January 2018, Karger Publishers

    Jose Fernandez-Real, Manuel Portero-Otin

  22. Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance

    Article • Aging Cell, October 2017, Wiley

    Manuel Portero-Otin, Isidro Ferrer

  23. Pulque for your health?

    Article • September 2017, Cold Spring Harbor Laboratory Press

    Manuel Portero-Otin

  24. Characterization of the post-prandial insulinemic response and low glycaemic index of a soy beverage

    Article • PLoS ONE, August 2017, PLOS

    Manuel Portero-Otin

  25. Differential metabolic profiles associated to movement behaviour of stream-resident brown trout (Salmo trutta)

    Article • PLoS ONE, July 2017, PLOS

    Manuel Portero-Otin

  26. Adipose tissue: a new pituitary gland?

    Article • The FASEB Journal, June 2017, Federation of American Societies For Experimental Biology (FASEB)

    Manuel Portero-Otin, Jose Fernandez-Real, Wifredo Ricart

  27. The Gut Metagenome Changes in Parallel to Waist Circumference, Brain Iron Deposition, and Cognitive Function

    Article • The Journal of Clinical Endocrinology & Metabolism, June 2017, Endocrine Society

    Dr Josep Puig, Dr Josep Garre-Olmo, Gerard Blasco, Manuel Portero-Otin, Jose Fernandez-Real, Wifredo Ricart, Fernando Fernandez-Aranda

  28. High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition

    Article • Phytochemistry Reviews, June 2017, Springer Science + Business Media

    Manuel Portero-Otin

  29. Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, May 2017, Elsevier

    Manuel Portero-Otin

  30. Biofortification of crops with nutrients: factors affecting utilization and storage

    Article • Current Opinion in Biotechnology, April 2017, Elsevier

    Manuel Portero-Otin

  31. Sixty years old is the breakpoint of human frontal cortex aging

    Article • Free Radical Biology and Medicine, February 2017, Elsevier

    Manuel Portero-Otin

  32. Adipocyte lipopolysaccharide binding protein (LBP) is linked to a specific lipidomic signature

    Article • Obesity, December 2016, Wiley

    Manuel Portero-Otin, Jose Fernandez-Real

  33. Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex

    Article • Frontiers in Molecular Neuroscience, December 2016, Frontiers

    Manuel Portero-Otin

  34. Metabolomics Predicts Neuroimaging Characteristics of Transient Ischemic Attack Patients

    Article • EBioMedicine, December 2016, Elsevier

    Manuel Portero-Otin

  35. The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage

    Article • Scientific Reports, October 2016, Springer Science + Business Media

    Manuel Portero-Otin

  36. Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism

    Article • Oncotarget, July 2016, Impact Journals, LLC

    Manuel Portero-Otin

  37. Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

    Article • Neurobiology of Disease, April 2016, Elsevier

    Manuel Portero-Otin

  38. Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, April 2016, Elsevier

    Manuel Portero-Otin

  39. A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans

    Article • The Journals of Gerontology Series A, March 2016, Oxford University Press (OUP)

    Manuel Portero-Otin

  40. Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury

    Article • Glia, February 2016, Wiley

    Manuel Portero-Otin

  41. Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity

    Article • Diabetologia, February 2016, Springer Science + Business Media

    Manuel Portero-Otin, Jose Fernandez-Real

  42. Erratum: Obesity changes the human gut mycobiome

    Article • Scientific Reports, February 2016, Springer Science + Business Media

    Manuel Portero-Otin, Jose Fernandez-Real

  43. Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS

    Article • Acta Neuropathologica Communications, January 2016, Springer Science + Business Media

    Manuel Portero-Otin

  44. Gut Microbiota Interacts With Brain Microstructure and Function

    Article • The Journal of Clinical Endocrinology & Metabolism, December 2015, Endocrine Society

    Manuel Portero-Otin, Fernando Fernandez-Aranda, Jose Fernandez-Real

  45. Obesity changes the human gut mycobiome

    Article • Scientific Reports, October 2015, Springer Science + Business Media

    Manuel Portero-Otin, Jose Fernandez-Real

  46. Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy

    Article • Human Molecular Genetics, September 2015, Oxford University Press (OUP)

    Manuel Portero-Otin

  47. Dietary Advanced Glycation End Products and Their Role in Health and Disease

    Article • Advances in Nutrition, July 2015, Oxford University Press (OUP)

    Jaime Uribarri, Manuel Portero-Otin

  48. Human Aging Is a Metabolome-related Matter of Gender

    Article • The Journals of Gerontology Series A, May 2015, Oxford University Press (OUP)

    Manuel Portero-Otin

  49. Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice

    Article • Journal of Neuropathology & Experimental Neurology, April 2015, Oxford University Press (OUP)

    Manuel Portero-Otin

  50. Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy

    Article • Cell Death and Differentiation, March 2015, Springer Science + Business Media

    Manuel Portero-Otin

  51. Nutridynamics: mechanism(s) of action of bioactive compounds and their effects

    Article • International Journal of Food Sciences and Nutrition, January 2015, Taylor & Francis

    Manuel Portero-Otin

  52. Deregulation of purine metabolism in Alzheimer's disease

    Article • Neurobiology of Aging, January 2015, Elsevier

    Manuel Portero-Otin

  53. Lipidomics of Human Brain Aging and Alzheimer's Disease Pathology

    Article • January 2015, Elsevier

    Manuel Portero-Otin

  54. The Antioxidant Effect of LMN Diet, Rich in Polyphenols and Polyunsaturated Fatty Acids, in Alzheimer’s Disease

    Article • January 2015, Elsevier

    Manuel Portero-Otin

  55. Muscle metabolic reprogramming by mitochondrial stress

    Article • The FASEB Journal, December 2014, Federation of American Societies For Experimental Biology (FASEB)

    Professor Susanne Klaus, Manuel Portero-Otin

  56. Metabolomics predicts stroke recurrence after transient ischemic attack

    Article • Neurology, December 2014, Wolters Kluwer Health

    Manuel Portero-Otin

  57. Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype

    Article • The FASEB Journal, August 2014, Federation of American Societies For Experimental Biology (FASEB)

    Manuel Portero-Otin

  58. Brain Iron Overload, Insulin Resistance, and Cognitive Performance in Obese Subjects: A Preliminary MRI Case-Control Study

    Article • Diabetes Care, August 2014, American Diabetes Association

    Manuel Portero-Otin, Fernando Fernandez-Aranda, Jose Fernandez-Real

  59. Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

    Article • Aging Cell, July 2014, Wiley

    Manuel Portero-Otin

  60. Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model

    Article • Molecular and Cellular Neuroscience, July 2014, Elsevier

    Manuel Portero-Otin

  61. Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner

    Article • NeuroMolecular Medicine, July 2014, Springer Science + Business Media

    Manuel Portero-Otin

  62. Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer

    Article • Biochemical Pharmacology, July 2014, Elsevier

    Manuel Portero-Otin

  63. Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases

    Article • Journal of Neuropathology & Experimental Neurology, July 2014, Oxford University Press (OUP)

    Manuel Portero-Otin

  64. Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

    Article • Aging Cell, February 2014, Wiley

    Manuel Portero-Otin

  65. Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

    Article • Human Molecular Genetics, February 2014, Oxford University Press (OUP)

    Manuel Portero-Otin

  66. Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice

    Article • Neurotherapeutics, January 2014, Springer Science + Business Media

    Manuel Portero-Otin

  67. Plasma antioxidant capacity in critical polytraumatized patients?: methods, severity, and anatomic location

    Article • Critical Care, January 2014, Springer Science + Business Media

    Manuel Portero-Otin

  68. Plasma long-chain free fatty acids predict mammalian longevity

    Article • Scientific Reports, November 2013, Springer Science + Business Media

    Manuel Portero-Otin

  69. Human omental and subcutaneous adipose tissue exhibit specific lipidomic signatures

    Article • The FASEB Journal, November 2013, Federation of American Societies For Experimental Biology (FASEB)

    Manuel Portero-Otin, Jose Fernandez-Real

  70. Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile

    Article • Genes & Nutrition, September 2013, Springer Science + Business Media

    Manuel Portero-Otin

  71. Estudio de la vulnerabilidad neuronal selectiva en el sistema nervioso central humano

    Article • Revista Española de Geriatría y Gerontología, September 2013, Elsevier

    Manuel Portero-Otin

  72. Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy

    Article • Brain, June 2013, Oxford University Press (OUP)

    Manuel Portero-Otin

  73. Specific Lipidome Signatures in Central Nervous System from Methionine-Restricted Mice

    Article • Journal of Proteome Research, April 2013, American Chemical Society (ACS)

    Manuel Portero-Otin

  74. Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

    Article • Human Molecular Genetics, April 2013, Oxford University Press (OUP)

    Manuel Portero-Otin

  75. Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system

    Article • AJP Endocrinology and Metabolism, March 2013, American Physiological Society

    Manuel Portero-Otin

  76. Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats

    Article • Transgenic Research, February 2013, Springer Science + Business Media

    Manuel Portero-Otin

  77. Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions

    Article • International Journal of Molecular Sciences, February 2013, MDPI AG

    Manuel Portero-Otin

  78. Atherosclerosis prevention by nutritional factors: A meta-analysis in small animal models

    Article • Nutrition Metabolism and Cardiovascular Diseases, February 2013, Elsevier

    Manuel Portero-Otin

  79. Membrane lipid unsaturation as physiological adaptation to animal longevity

    Article • Frontiers in Physiology, January 2013, Frontiers

    Manuel Portero-Otin

  80. Dietary intake of green tea polyphenols regulates insulin sensitivity with an increase in AMP-activated protein kinase α content and changes in mitochondrial respiratory complexes

    Article • Molecular Nutrition & Food Research, December 2012, Wiley

    Manuel Portero-Otin

  81. Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters

    Article • Cardiovascular Research, December 2012, European Society of Cardiology

    Manuel Portero-Otin

  82. Fish oil and 3-thia fatty acid have additive effects on lipid metabolism but antagonistic effects on oxidative damage when fed to rats for 50 weeks

    Article • The Journal of Nutritional Biochemistry, November 2012, Elsevier

    Manuel Portero-Otin

  83. Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism

    Article • Journal of Neurochemistry, September 2012, Wiley

    Manuel Portero-Otin

  84. Region Specific Vulnerability to Lipid Peroxidation in the Human Central Nervous System

    Article • August 2012, IntechOpen

    Manuel Portero-Otin

  85. Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction

    Article • Amino Acids, June 2012, Springer Science + Business Media

    Manuel Portero-Otin

  86. Amyloid Generation and Dysfunctional Immunoproteasome Activation with Disease Progression in Animal Model of Familial Alzheimer's Disease

    Article • Brain Pathology, January 2012, Wiley

    Manuel Portero-Otin

  87. Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

    Article • Experimental Diabetes Research, January 2012, Hindawi Publishing Corporation

    Manuel Portero-Otin

  88. Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats

    Article • Scandinavian Journal of Gastroenterology, November 2011, Taylor & Francis

    Manuel Portero-Otin

  89. Type-Dependent Oxidative Damage in Frontotemporal Lobar Degeneration: Cortical Astrocytes Are Targets of Oxidative Damage

    Article • Journal of Neuropathology & Experimental Neurology, December 2008, Oxford University Press (OUP)

    Manuel Portero-Otin

  90. Fluorescent Products from Aminophospholipids and Glucose

    Article • January 2005, Elsevier

    Manuel Portero-Otin

  91. Mitochondrial Aminophospholipid Modification by Advanced Maillard Reaction is Related to the Longevity of Mammalian Species

    Article • January 2005, Elsevier

    Manuel Portero-Otin

  92. Presence of Pyrraline in Human Urine and its Relationship with Glycaemic Control

    Article • January 2005, Elsevier

    Manuel Portero-Otin