All Stories

  1. Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19

    Article • Viruses, April 2023, MDPI AG

    PhD. Guillermo Lopez-Lluch

  2. Coenzyme Q10 Metabolism: A Review of Unresolved Issues

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    PhD. Guillermo Lopez-Lluch

  3. Coenzyme Q10 Levels Associated With Cognitive Functioning and Executive Function in Older Adults

    Article • The Journals of Gerontology Series A, July 2022, Oxford University Press (OUP)

    PhD. Guillermo Lopez-Lluch

  4. Levels of Plasma Coenzyme Q10 Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly

    Article • Antioxidants, January 2022, MDPI AG

    PhD. Guillermo Lopez-Lluch

  5. Coenzyme Q at the Hinge of Health and Metabolic Diseases

    Article • Antioxidants, November 2021, MDPI AG

    PhD. Guillermo Lopez-Lluch

  6. Cellular Models for Primary CoQ Deficiency Pathogenesis Study

    Article • International Journal of Molecular Sciences, September 2021, MDPI AG

    Dr Carlos Santos Ocaña, PhD. Guillermo Lopez-Lluch

  7. Coenzyme Q homeostasis in aging: Response to non-genetic interventions

    Article • Free Radical Biology and Medicine, February 2021, Elsevier

    PhD. Guillermo Lopez-Lluch

  8. Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

    Article • Experimental Gerontology, December 2020, Elsevier

    PhD. Guillermo Lopez-Lluch

  9. Physiopathology of Lifestyle Interventions in Non-Alcoholic Fatty Liver Disease (NAFLD)

    Article • Nutrients, November 2020, MDPI AG

    PhD. Guillermo Lopez-Lluch

  10. Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species

    Article • Redox Biology, October 2020, Elsevier

    PhD. Guillermo Lopez-Lluch

  11. High coenzyme Q10 plasma levels improve stress and damage markers in professional soccer players during competition

    Article • International Journal for Vitamin and Nutrition Research, July 2020, Hogrefe Publishing Group

    PhD. Guillermo Lopez-Lluch

  12. Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet

    Article • Antioxidants, May 2020, MDPI AG

    PhD. Guillermo Lopez-Lluch

  13. The Important Role of CoQ10 in Aging

    Article • Antioxidants, November 2019, MDPI AG

    PhD. Guillermo Lopez-Lluch

  14. ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency

    Article • Journal of Clinical Medicine, September 2019, MDPI AG

    PhD. Guillermo Lopez-Lluch

  15. Calorie Restriction

    Article • January 2019, Elsevier

    PhD. Guillermo Lopez-Lluch

  16. PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome

    Article • Proceedings of the National Academy of Sciences, December 2018, Proceedings of the National Academy of Sciences

    PhD. Guillermo Lopez-Lluch

  17. Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?

    Article • Biogerontology, August 2018, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  18. The Impact of Aging, Calorie Restriction and Dietary Fat on Autophagy Markers and Mitochondrial Ultrastructure and Dynamics in Mouse Skeletal Muscle

    Article • The Journals of Gerontology Series A, July 2018, Oxford University Press (OUP)

    PhD. Guillermo Lopez-Lluch

  19. High-Intensity Interval Training Combined With Vibration and Dietary Restriction Improves Body Composition and Blood Lipids in Obese Adults: A Randomized Trial

    Article • Dose-Response, July 2018, SAGE Publications

    PhD. Guillermo Lopez-Lluch

  20. Bioavailability of coenzyme Q 10 supplements depends on carrier lipids and solubilization

    Article • Nutrition, June 2018, Elsevier

    PhD. Guillermo Lopez-Lluch

  21. SOX2 expression diminishes with ageing in several tissues in mice and humans

    Article • Mechanisms of Ageing and Development, March 2018, Elsevier

    PhD. Guillermo Lopez-Lluch

  22. Coenzyme Q10 Supplementation in Aging and Disease

    Article • Frontiers in Physiology, February 2018, Frontiers

    PhD. Guillermo Lopez-Lluch

  23. La expresión del complejo de síntesis de coenzima Q es regulada durante el envejecimiento

    Article • Revista Española de Geriatría y Gerontología, November 2017, Elsevier

    PhD. Guillermo Lopez-Lluch

  24. Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity

    Article • Mechanisms of Ageing and Development, March 2017, Elsevier

    PhD. Guillermo Lopez-Lluch

  25. Resveratrol primes the effects of physical activity in old mice

    Article • British Journal Of Nutrition, August 2016, Cambridge University Press

    PhD. Guillermo Lopez-Lluch

  26. mitochondria in muscle physiology

    Article • Acta Physiologica, July 2016, Wiley

    PhD. Guillermo Lopez-Lluch

  27. Omega-3 fatty acids partially revert the metabolic gene expression profile induced by long-term calorie restriction

    Article • Experimental Gerontology, May 2016, Elsevier

    PhD. Guillermo Lopez-Lluch

  28. Vacuolar H+-Pyrophosphatase AVP1 is Involved in Amine Fungicide Tolerance in Arabidopsis thaliana and Provides Tridemorph Resistance in Yeast

    Article • Frontiers in Plant Science, February 2016, Frontiers

    PhD. Guillermo Lopez-Lluch

  29. Agin, calorie restriction and kidney

    Article • Aging Cell, February 2016, Wiley

    Dr José A González-Reyes, PhD. Guillermo Lopez-Lluch

  30. Calorie restriction as an intervention in ageing

    Article • The Journal of Physiology, January 2016, Wiley

    PhD. Guillermo Lopez-Lluch

  31. Análisis de la edad morfológica en nadadores y triatletas adolescentes

    Article • Nutrición Hospitalaria, January 2016, Sociedad Espanola de Nutricion Parenteral y Enteral (SENPE)

    PhD. Guillermo Lopez-Lluch

  32. RNA-binding proteins regulate cell respiration and coenzyme Q biosynthesis by post-transcriptional regulation ofCOQ7

    Article • RNA Biology, December 2015, Taylor & Francis

    PhD. Guillermo Lopez-Lluch

  33. Facing challenges in an ageing world

    Article • Biogerontology, August 2015, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  34. Mitochondrial responsibility in ageing process: innocent, suspect or guilty

    Article • Biogerontology, June 2015, Springer Science + Business Media

    Dr Carlos Santos Ocaña, PhD. Guillermo Lopez-Lluch

  35. Organ and tissue-dependent effect of resveratrol and exercise on antioxidant defenses of old mice

    Article • Aging Clinical and Experimental Research, May 2015, Springer Science + Business Media

    Dr Bui Thanh Tung, PhD. Guillermo Lopez-Lluch, Dr Huong Le-Thi-Thu

  36. The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice

    Article • Biogerontology, April 2015, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  37. Anti-inflammatory effect of resveratrol in old mice liver

    Article • Experimental Gerontology, April 2015, Elsevier

    Dr Bui Thanh Tung, PhD. Guillermo Lopez-Lluch

  38. Membrane-Bound CYB5R3 Is a Common Effector of Nutritional and Oxidative Stress Response Through FOXO3a and Nrf2

    Article • Antioxidants & Redox Signaling, October 2014, Mary Ann Liebert Inc

    PhD. Guillermo Lopez-Lluch

  39. The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice

    Article • The Journals of Gerontology Series A, October 2014, Oxford University Press (OUP)

    PhD. Guillermo Lopez-Lluch

  40. Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats

    Article • Experimental Gerontology, August 2014, Elsevier

    PhD. Guillermo Lopez-Lluch

  41. Relationship between functional capacity and body mass index with plasma coenzyme Q10 and oxidative damage in community-dwelling elderly-people

    Article • Experimental Gerontology, April 2014, Elsevier

    PhD. Guillermo Lopez-Lluch

  42. Dietary Fat and Aging Modulate Apoptotic Signaling in Liver of Calorie-Restricted Mice

    Article • The Journals of Gerontology Series A, April 2014, Oxford University Press (OUP)

    PhD. Guillermo Lopez-Lluch

  43. Age-Dependent Effect of Every-Other-Day Feeding and Aerobic Exercise in Ubiquinone Levels and Related Antioxidant Activities in Mice Muscle

    Article • The Journals of Gerontology Series A, February 2014, Oxford University Press (OUP)

    PhD. Guillermo Lopez-Lluch

  44. Physical activity affects plasma coenzyme Q10 levels differently in young and old humans

    Article • Biogerontology, January 2014, Springer Science + Business Media

    Dr Bui Thanh Tung, PhD. Guillermo Lopez-Lluch

  45. Modulation of Endogenous Antioxidant Activity by Resveratrol and Exercise in Mouse Liver is Age Dependent

    Article • The Journals of Gerontology Series A, July 2013, Oxford University Press (OUP)

    Dr Bui Thanh Tung, PhD. Guillermo Lopez-Lluch

  46. Influencia de la capacidad funcional sobre el perfil lipídico, daño muscular y perfil bioquímico en personas mayores no institucionalizadas

    Article • Revista Andaluza de Medicina del Deporte, June 2013, Elsevier

    PhD. Guillermo Lopez-Lluch

  47. Inorganic Pyrophosphatase Defects Lead to Cell Cycle Arrest and Autophagic Cell Death through NAD+ Depletion in Fermenting Yeast

    Article • Journal of Biological Chemistry, March 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD. Guillermo Lopez-Lluch

  48. Alterations of Ultrastructural and Fission/Fusion Markers in Hepatocyte Mitochondria From Mice Following Calorie Restriction With Different Dietary Fats

    Article • The Journals of Gerontology Series A, February 2013, Oxford University Press (OUP)

    PhD. Guillermo Lopez-Lluch

  49. The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction

    Article • Bioscience Reports, December 2012, Portland Press Ltd.

    PhD. Guillermo Lopez-Lluch

  50. Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice

    Article • AGE, November 2012, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  51. The Influence of Dietary Lipid Composition on Skeletal Muscle Mitochondria From Mice Following 1 Month of Calorie Restriction

    Article • The Journals of Gerontology Series A, April 2012, Oxford University Press (OUP)

    PhD. Guillermo Lopez-Lluch

  52. Resveratrol in Cancer: Cellular and Mitochondrial Consequences of Proton Transport Inhibition

    Article • Current Pharmaceutical Design, April 2012, Bentham Science Publishers

    PhD. Guillermo Lopez-Lluch

  53. Sirtuin-Dependent Metabolic Control and Its Role in the Aging Process

    Article • March 2012, IntechOpen

    PhD. Guillermo Lopez-Lluch

  54. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues

    Article • Free Radical Biology and Medicine, June 2011, Elsevier

    PhD. Guillermo Lopez-Lluch

  55. Caloric restriction reduces IgA levels and modifies cytokine mRNA expression in mouse small intestine

    Article • The Journal of Nutritional Biochemistry, June 2011, Elsevier

    PhD. Guillermo Lopez-Lluch

  56. Muscle Physiology Changes Induced by Every Other Day Feeding and Endurance Exercise in Mice: Effects on Physical Performance

    Article • PLoS ONE, November 2010, PLOS

    PhD. Guillermo Lopez-Lluch

  57. Complex I-Associated Hydrogen Peroxide Production Is Decreased and Electron Transport Chain Enzyme Activities Are Altered in n-3 Enriched fat-1 Mice

    Article • PLoS ONE, September 2010, PLOS

    PhD. Guillermo Lopez-Lluch

  58. Is coenzyme Q a key factor in aging?

    Article • Mechanisms of Ageing and Development, April 2010, Elsevier

    Dr Carlos Santos Ocaña, PhD. Guillermo Lopez-Lluch

  59. N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes

    Article • Chemico-Biological Interactions, September 2009, Elsevier

    PhD. Guillermo Lopez-Lluch

  60. NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast

    Article • Aging Cell, April 2009, Wiley

    Dr Carlos Santos Ocaña, PhD. Guillermo Lopez-Lluch

  61. HDAC and Hsp90 inhibitors down-regulatePTTG1/securin but do not induce aneuploidy

    Article • Genes Chromosomes and Cancer, February 2009, Wiley

    PhD. Guillermo Lopez-Lluch

  62. Protein Kinase C as an Effector of Lipid-Derived Second Messengers

    Article • September 2008, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  63. Enhanced induction of apoptosis in a radio-resistant bladder tumor cell line by combined treatments with X-rays and wortmannin

    Article • Radiation and Environmental Biophysics, September 2008, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  64. Mitochondrial biogenesis and healthy aging

    Article • Experimental Gerontology, September 2008, Elsevier

    PhD. Guillermo Lopez-Lluch

  65. Molecular Bases of Caloric Restriction Regulation of Neuronal Synaptic Plasticity

    Article • Molecular Neurobiology, August 2008, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  66. Dicoumarol down-regulates human PTTG1/Securin mRNA expression through inhibition of Hsp90

    Article • Molecular Cancer Therapeutics, March 2008, American Association for Cancer Research (AACR)

    PhD. Guillermo Lopez-Lluch

  67. Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA Receptor

    Article • Journal of Neuroscience, September 2007, Society for Neuroscience

    PhD. Guillermo Lopez-Lluch

  68. Resveratrol improves health and survival of mice on a high-calorie diet

    Article • Nature, November 2006, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  69. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

    Article • Proceedings of the National Academy of Sciences, January 2006, Proceedings of the National Academy of Sciences

    PhD. Guillermo Lopez-Lluch

  70. Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 2005, Elsevier

    PhD. Guillermo Lopez-Lluch

  71. Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction

    Article • AGE, June 2005, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  72. Dicoumarol relieves serum withdrawal-induced G0/1 blockade in HL-60 cells through a superoxide-dependent mechanism

    Article • Biochemical Pharmacology, June 2005, Elsevier

    PhD. Guillermo Lopez-Lluch

  73. Inhibition of COX activity by NSAIDs or ascorbate increases cAMP levels and enhances differentiation in 1α,25-dihydroxyvitamin D3-induced HL-60 cells

    Article • Archives of Biochemistry and Biophysics, April 2005, Elsevier

    PhD. Guillermo Lopez-Lluch

  74. Coenzyme Q and the regulation of intracellular steady-state levels of superoxide in HL-60 cells

    Article • BioFactors, January 2005, Wiley

    PhD. Guillermo Lopez-Lluch

  75. Specificity of coenzyme Q10 for a balanced function of respiratory chain and endogenous ubiquinone biosynthesis in human cells

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, January 2005, Elsevier

    PhD. Guillermo Lopez-Lluch

  76. Demethoxy-Q, An Intermediate of Coenzyme Q Biosynthesis, Fails to Support Respiration in Saccharomyces cerevisiae and Lacks Antioxidant Activity

    Article • Journal of Biological Chemistry, April 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Carlos Santos Ocaña, PhD. Guillermo Lopez-Lluch

  77. Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver

    Article • Experimental Gerontology, March 2004, Elsevier

    PhD. Guillermo Lopez-Lluch

  78. Effects of microinjected small GTPases on the actin cytoskeleton of human neutrophils

    Article • Journal of Anatomy, October 2003, Wiley

    PhD. Guillermo Lopez-Lluch

  79. Antioxidant response induced by serum withdrawal protects HL-60 cells against inhibition of NAD(P)H:quinone oxidoreductase 1

    Article • BioFactors, January 2003, Wiley

    PhD. Guillermo Lopez-Lluch

  80. Article • Journal of Bioenergetics and Biomembranes, January 2003, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  81. Involvement of protein kinase D in Fcγ-receptor activation of the NADPH oxidase in neutrophils

    Article • Biochemical Journal, April 2002, Portland Press Ltd.

    PhD. Guillermo Lopez-Lluch

  82. Involvement of protein kinase D in Fcγ-receptor activation of the NADPH oxidase in neutrophils

    Article • Biochemical Journal, April 2002, Portland Press Ltd.

    PhD. Guillermo Lopez-Lluch

  83. Ceramide-dependent Caspase 3 Activation is Prevented by Coenzyme Q from Plasma Membrane in Serum-deprived Cells

    Article • Free Radical Research, January 2002, Taylor & Francis

    PhD. Guillermo Lopez-Lluch

  84. Protein kinase C-δ C2-like domain is a binding site for actin and enables actin redistribution in neutrophils

    Article • Biochemical Journal, July 2001, Portland Press Ltd.

    PhD. Guillermo Lopez-Lluch

  85. Protein kinase C-δ C2-like domain is a binding site for actin and enables actin redistribution in neutrophils

    Article • Biochemical Journal, July 2001, Portland Press Ltd.

    PhD. Guillermo Lopez-Lluch

  86. Cellular redox state and activating protein-1 are involved in ascorbate effect on calcitriol-induced differentiation

    Article • PROTOPLASMA, March 2001, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  87. Extramitochondrial Functions of Coenzyme Q

    Article • August 2000, Taylor & Francis

    Dr Carlos Santos Ocaña, PhD. Guillermo Lopez-Lluch

  88. Coenzyme Q Protects Cells Against Serum Withdrawal-Induced Apoptosis by Inhibition of Ceramide Release and Caspase-3 Activation

    Article • Antioxidants & Redox Signaling, June 2000, Mary Ann Liebert Inc

    PhD. Guillermo Lopez-Lluch

  89. Plasma membrane redox system protects cells against oxidative stress

    Article • Redox Report, April 2000, Taylor & Francis

    PhD. Guillermo Lopez-Lluch

  90. Redox regulation of cAMP levels by ascorbate in 1,25-dihydroxy- vitamin D3-induced differentiation of HL-60 cells

    Article • Biochemical Journal, April 1998, Portland Press Ltd.

    PhD. Guillermo Lopez-Lluch

  91. Ascorbate and α-Tocopherol Prevent Apoptosis Induced by Serum Removal Independent of Bcl-2

    Article • Archives of Biochemistry and Biophysics, July 1997, Elsevier

    PhD. Guillermo Lopez-Lluch

  92. Article • Journal of Bioenergetics and Biomembranes, January 1997, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  93. Ascorbate Increases the 1,25 Dihydroxyvitamin D 3 -Induced Monocytic Differentiation of HL-60 Cells

    Article • Calcified Tissue International, October 1996, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch

  94. Plasma membrane redox system during HL-60 induced differentiation

    Article • PROTOPLASMA, March 1995, Springer Science + Business Media

    PhD. Guillermo Lopez-Lluch