All Stories

  1. Insulin receptorT1160 phosphorylation mediates renal cortical insulin resistance but not excess gluconeogenesis from glycerol

    Article • Nature Communications, May 2026, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  2. Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD

    Article • Journal of Hepatology, February 2026, Elsevier

    Sami Qadri, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  3. High-fat diet ablates an insulin-responsive pool of GLUT4 glucose transporters in skeletal muscle

    Article • July 2025, openRxiv

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  4. Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis

    Article • Proceedings of the National Academy of Sciences, May 2025, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  5. Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals

    Article • Science Advances, January 2025, American Association for the Advancement of Science

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  6. Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease

    Article • Cell Metabolism, November 2024, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  7. Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway

    Article • Cell Reports, October 2024, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  8. Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition

    Article • Proceedings of the National Academy of Sciences, December 2023, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  9. Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis

    Article • Proceedings of the National Academy of Sciences, January 2023, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  10. Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo

    Article • Cell Metabolism, January 2023, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  11. Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice

    Article • Proceedings of the National Academy of Sciences, November 2022, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  12. Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance

    Article • Journal of Clinical Investigation, May 2022, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  13. Ethnic and sex differences in hepatic lipid content and related cardiometabolic parameters in lean individuals

    Article • JCI Insight, April 2022, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  14. Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis

    Article • Proceedings of the National Academy of Sciences, March 2022, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  15. Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice

    Article • Aging Cell, January 2022, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  16. MMAB promotes negative feedback control of cholesterol homeostasis

    Article • Nature Communications, November 2021, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  17. Point: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes

    Article • AJP Endocrinology and Metabolism, May 2021, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  18. Reply to Carter et al.: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes

    Article • AJP Endocrinology and Metabolism, May 2021, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  19. Mechanisms and disease consequences of nonalcoholic fatty liver disease

    Article • Cell, May 2021, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  20. An update on brown adipose tissue biology: a discussion of recent findings

    Article • AJP Endocrinology and Metabolism, March 2021, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  21. Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr1160 phosphorylation

    Article • JCI Insight, February 2021, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  22. A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

    Article • Genes & Development, December 2020, Cold Spring Harbor Laboratory Press

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  23. Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance

    Article • Journal of Experimental Medicine, December 2020, Rockefeller University Press

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  24. Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice

    Article • Proceedings of the National Academy of Sciences, December 2020, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  25. Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks

    Article • Journal of Biological Chemistry, October 2020, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  26. Cellular and Molecular Mechanisms of Metformin Action

    Article • Endocrine Reviews, September 2020, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  27. The omentum of obese girls harbors small adipocytes and browning transcripts

    Article • JCI Insight, March 2020, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  28. Leptin mediates postprandial increases in body temperature through hypothalamus–adrenal medulla–adipose tissue crosstalk

    Article • Journal of Clinical Investigation, March 2020, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  29. Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications

    Article • Endocrinology, February 2020, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  30. Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans

    Article • Journal of Clinical Investigation, September 2019, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  31. GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)

    Article • Expert Opinion on Investigational Drugs, September 2019, Taylor & Francis

    Professor Eric J Lawitz, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  32. Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

    Article • The FASEB Journal, July 2019, Federation of American Societies For Experimental Biology (FASEB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Daniel Vatner

  33. TFAM Enhances Fat Oxidation and Attenuates High Fat Diet Induced Insulin Resistance in Skeletal Muscle

    Article • Diabetes, May 2019, American Diabetes Association

    K Sreekumaran Nair, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  34. Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function

    Article • Journal of Biological Chemistry, May 2019, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  35. Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls

    Article • Diabetes, April 2019, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  36. Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats

    Article • Nature Communications, February 2019, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  37. Mechanisms of Insulin Action and Insulin Resistance

    Article • Physiological Reviews, October 2018, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  38. PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling

    Article • Proceedings of the National Academy of Sciences, September 2018, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  39. The circulating metabolome of human starvation

    Article • JCI Insight, August 2018, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  40. Lacteal junction zippering protects against diet-induced obesity

    Article • Science, August 2018, American Association for the Advancement of Science

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  41. Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

    Article • Nature Medicine, July 2018, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  42. Deciphering the Role of Lipid Droplets in Cardiovascular Disease

    Article • Circulation, July 2018, Wolters Kluwer Health

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  43. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity

    Article • Cell Reports, July 2018, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  44. Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer

    Article • Cell Reports, July 2018, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  45. Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents

    Article • Hepatology, May 2018, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  46. Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia

    Article • JCI Insight, May 2018, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  47. The link between insulin and fatty liver

    Article • Endocrine Abstracts, May 2018, Bioscientifica

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  48. Effect of a Controlled-Release Mitochondrial Protonophore (CRMP) on Healthspan and Lifespan in Mice

    Article • Diabetes, May 2018, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  49. Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

    Article • JCI Insight, March 2018, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  50. The Role of Leptin in Maintaining Plasma Glucose During Starvation

    Article • Postdoc Journal, March 2018, Postdoc Journal

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  51. Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents

    Article • Diabetologia, March 2018, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  52. In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia

    Article • Biochemical Journal, February 2018, Portland Press Ltd.

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  53. Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

    Article • Nature Communications, January 2018, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  54. Skeletal Muscle–Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance

    Article • Diabetes, January 2018, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  55. Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation

    Article • Cell, January 2018, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  56. Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes

    Article • Cell Metabolism, January 2018, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  57. Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

    Article • Cell Metabolism, January 2018, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  58. Mechanism by which arylamine N -acetyltransferase 1 ablation causes insulin resistance in mice

    Article • Proceedings of the National Academy of Sciences, December 2017, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  59. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling

    Article • Diabetes, December 2017, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Ethan Weiss

  60. Retinol saturase modulates lipid metabolism and the production of reactive oxygen species

    Article • Archives of Biochemistry and Biophysics, November 2017, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  61. Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms

    Article • Proceedings of the National Academy of Sciences, October 2017, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  62. Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

    Article • Nature Communications, October 2017, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  63. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport

    Article • Cell Reports, October 2017, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  64. Regulation of hepatic glucose metabolism in health and disease

    Article • Nature Reviews Endocrinology, July 2017, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  65. Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

    Article • Trends in Pharmacological Sciences, July 2017, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  66. The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism

    Article • Hepatology, June 2017, Wiley

    Christoph Harms, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  67. Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

    Article • Cell Reports, June 2017, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  68. Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver

    Article • Diabetes, May 2017, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  69. Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

    Article • Diabetes, May 2017, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  70. A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice

    Article • The FASEB Journal, March 2017, Federation of American Societies For Experimental Biology (FASEB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Patricia Aspichueta, Rachel Perry

  71. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes

    Article • Cell, March 2017, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  72. A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo

    Article • Cell Metabolism, March 2017, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  73. Adipocyte JAK2 mediates growth hormone–induced hepatic insulin resistance

    Article • JCI Insight, February 2017, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  74. Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis

    Article • Journal of Clinical Investigation, January 2017, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  75. Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

    Article • Proceedings of the National Academy of Sciences, January 2017, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  76. Insulin Resistance in Type 2 Diabetes

    Article • December 2016, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  77. Hepatic inositol 1,4,5 trisphosphate receptor type 1 mediates fatty liver

    Article • Hepatology Communications, November 2016, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  78. Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism

    Article • Pediatric Transplantation, October 2016, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  79. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

    Article • Journal of Clinical Investigation, October 2016, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  80. CD301b + Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha

    Article • Immunity, September 2016, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  81. MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels

    Article • Nature Communications, August 2016, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  82. Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents

    Article • AJP Endocrinology and Metabolism, August 2016, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  83. Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice

    Article • AJP Endocrinology and Metabolism, July 2016, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  84. Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by 13 C Magnetic Resonance Spectroscopy

    Article • Cell Metabolism, July 2016, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  85. Hypophosphatemia promotes lower rates of muscle ATP synthesis

    Article • The FASEB Journal, June 2016, Federation of American Societies For Experimental Biology (FASEB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  86. XBP1s Is an Anti-lipogenic Protein

    Article • Journal of Biological Chemistry, June 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  87. Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

    Article • Nature, June 2016, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  88. Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism

    Article • Proceedings of the National Academy of Sciences, May 2016, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  89. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance

    Article • Diabetes, March 2016, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  90. Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism

    Article • Journal of Biological Chemistry, March 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  91. Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis

    Article • Diabetologia, March 2016, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  92. Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

    Article • Proceedings of the National Academy of Sciences, February 2016, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  93. AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia

    Article • Journal of Molecular and Cellular Cardiology, February 2016, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  94. 17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

    Article • The Journals of Gerontology Series A, January 2016, Oxford University Press (OUP)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  95. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

    Article • Journal of Clinical Investigation, January 2016, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  96. Metabolic Syndrome

    Article • January 2016, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  97. A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

    Article • Diabetes, December 2015, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  98. Second-generation antisense oligonucleotides against  -catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

    Article • The FASEB Journal, December 2015, Federation of American Societies For Experimental Biology (FASEB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  99. Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

    Article • Aging, December 2015, Impact Journals, LLC

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  100. Macrophage-specificde NovoSynthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity

    Article • Journal of Biological Chemistry, October 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  101. Correction for Petersen et al., Effect of aging on muscle mitochondrial substrate utilization in humans

    Article • Proceedings of the National Academy of Sciences, October 2015, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  102. Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults

    Article • Diabetes, August 2015, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  103. Effect of aging on muscle mitochondrial substrate utilization in humans

    Article • Proceedings of the National Academy of Sciences, August 2015, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  104. Type 2 diabetes mellitus

    Article • Nature Reviews Disease Primers, July 2015, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  105. Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice

    Article • The Journal of Nutritional Biochemistry, July 2015, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  106. FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

    Article • Nature Communications, April 2015, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  107. Pathogenesis of type 2 diabetes mellitus

    Article • March 2015, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  108. Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

    Article • Science, February 2015, American Association for the Advancement of Science

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  109. Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

    Article • Cell, February 2015, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  110. Response to Burgess

    Article • Nature Medicine, February 2015, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  111. Reply to Constantin-Teodosiu et al.: Mice with genetic PDH activation are not protected from high-fat diet–induced muscle insulin resistance

    Article • Proceedings of the National Academy of Sciences, January 2015, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  112. Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation

    Article • Proceedings of the National Academy of Sciences, January 2015, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  113. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids

    Article • Proceedings of the National Academy of Sciences, January 2015, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  114. Acetylation of TUG Protein Promotes the Accumulation of GLUT4 Glucose Transporters in an Insulin-responsive Intracellular Compartment

    Article • Journal of Biological Chemistry, January 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  115. ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content

    Article • Journal of Lipid Research, December 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  116. Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, December 2014, New England Journal of Medicine (NEJM/MMS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  117. Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, December 2014, New England Journal of Medicine (NEJM/MMS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  118. Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II

    Article • AJP Endocrinology and Metabolism, December 2014, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  119. An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

    Article • Nature, November 2014, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  120. The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells

    Article • Nucleic Acids Research, November 2014, Oxford University Press (OUP)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  121. Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance

    Article • Proceedings of the National Academy of Sciences, November 2014, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  122. Hepatic Mitogen-Activated Protein Kinase Phosphatase 1 Selectively Regulates Glucose Metabolism and Energy Homeostasis

    Article • Molecular and Cellular Biology, October 2014, ASM Journals

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  123. Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

    Article • Nature Medicine, October 2014, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  124. Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, September 2014, New England Journal of Medicine (NEJM/MMS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  125. Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release

    Article • Diabetes, July 2014, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  126. PKCλ Haploinsufficiency Prevents Diabetes by a Mechanism Involving Alterations in Hepatic Enzymes

    Article • Molecular Endocrinology, July 2014, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  127. Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

    Article • Proceedings of the National Academy of Sciences, June 2014, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  128. Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

    Article • Nature Medicine, June 2014, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  129. Tissue-Specific Differences in the Development of Insulin Resistance in a Mouse Model for Type 1 Diabetes

    Article • Diabetes, June 2014, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  130. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

    Article • Nature, June 2014, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  131. Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression

    Article • Nature, May 2014, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  132. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

    Article • Nature, May 2014, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  133. Ceramide-Activated Phosphatase Mediates Fatty Acid–Induced Endothelial VEGF Resistance and Impaired Angiogenesis

    Article • American Journal Of Pathology, May 2014, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  134. Muscle-specific activation of Ca2+/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice

    Article • Diabetologia, April 2014, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  135. Early Life Exposure to Maternal Insulin Resistance Has Persistent Effects on Hepatic NAFLD in Juvenile Nonhuman Primates

    Article • Diabetes, April 2014, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  136. Ostα−/− mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity

    Article • AJP Gastrointestinal and Liver Physiology, March 2014, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  137. A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis

    Article • Journal of Biological Chemistry, February 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  138. Nonalcoholic Fatty Liver Disease, Hepatic Insulin Resistance, and Type 2 Diabetes

    Article • Hepatology, February 2014, Wolters Kluwer Health

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  139. Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD

    Article • Cell Metabolism, February 2014, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  140. Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

    Article • Cell, January 2014, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  141. Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy

    Article • Nature Medicine, December 2013, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  142. Treating fatty liver and insulin resistance

    Article • Aging, November 2013, Impact Journals, LLC

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  143. The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes

    Article • Diabetes, November 2013, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  144. Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

    Article • Cell Metabolism, November 2013, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  145. PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

    Article • Aging, October 2013, Impact Journals, LLC

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  146. A β-Peptide Agonist of the GLP-1 Receptor, a Class B GPCR

    Article • Organic Letters, October 2013, American Chemical Society (ACS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  147. Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis

    Article • Adipocyte, September 2013, Taylor & Francis

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  148. Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

    Article • Endocrinology, September 2013, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  149. Lipid-induced hepatic insulin resistance

    Article • Aging, August 2013, Impact Journals, LLC

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  150. Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

    Article • Proceedings of the National Academy of Sciences, July 2013, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  151. Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways

    Article • AJP Endocrinology and Metabolism, July 2013, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  152. Enhanced Fasting Glucose Turnover in Mice with Disrupted Action of TUG Protein in Skeletal Muscle

    Article • Journal of Biological Chemistry, June 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  153. Increased Brain Lactate Concentrations Without Increased Lactate Oxidation During Hypoglycemia in Type 1 Diabetic Individuals

    Article • Diabetes, May 2013, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  154. cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 2 (CRTC2) Promotes Glucagon Clearance and Hepatic Amino Acid Catabolism to Regulate Glucose Homeostasis

    Article • Journal of Biological Chemistry, April 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  155. Fish Oil Selectively Improves Heart Function in a Mouse Model of Lipid-induced Cardiomyopathy

    Article • Journal of Cardiovascular Pharmacology, April 2013, Wolters Kluwer Health

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  156. Role of caspase-1 in regulation of triglyceride metabolism

    Article • Proceedings of the National Academy of Sciences, March 2013, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  157. Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice From High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance

    Article • Endocrinology, March 2013, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  158. Mechanisms Underlying the Onset of Oral Lipid-Induced Skeletal Muscle Insulin Resistance in Humans

    Article • Diabetes, March 2013, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  159. Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

    Article • Diabetes, February 2013, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  160. Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

    Article • Hepatology, January 2013, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  161. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

    Article • Proceedings of the National Academy of Sciences, January 2013, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  162. The Role of the Carbohydrate Response Element-Binding Protein in Male Fructose-Fed Rats

    Article • Endocrinology, January 2013, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  163. Decreased Transcription of ChREBP- /  Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia

    Article • Diabetes, December 2012, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  164. The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

    Article • Molecular Cell, December 2012, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  165. 31P-Magnetization Transfer Magnetic Resonance Spectroscopy Measurements of In Vivo Metabolism

    Article • Diabetes, October 2012, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  166. Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism

    Article • Proceedings of the National Academy of Sciences, August 2012, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  167. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism

    Article • Proceedings of the National Academy of Sciences, June 2012, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  168. Development of insulin resistance in mice lacking PGC-1α in adipose tissues

    Article • Proceedings of the National Academy of Sciences, May 2012, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  169. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

    Article • Nature Medicine, May 2012, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  170. Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

    Article • Cell Metabolism, May 2012, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  171. Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

    Article • Proceedings of the National Academy of Sciences, April 2012, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  172. Mechanisms for Insulin Resistance: Common Threads and Missing Links

    Article • Cell, March 2012, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  173. Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes

    Article • Diabetes, February 2012, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  174. Thyroid Hormone Receptor-α Gene Knockout Mice Are Protected from Diet-Induced Hepatic Insulin Resistance

    Article • Endocrinology, February 2012, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  175. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

    Article • Nature, February 2012, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  176. Low Density Lipoprotein (LDL) Receptor-related Protein 6 (LRP6) Regulates Body Fat and Glucose Homeostasis by Modulating Nutrient Sensing Pathways and Mitochondrial Energy Expenditure

    Article • Journal of Biological Chemistry, January 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  177. A guide to analysis of mouse energy metabolism

    Article • Nature Chemical Biology, December 2011, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  178. Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats

    Article • AJP Endocrinology and Metabolism, December 2011, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  179. Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice

    Article • Journal of Biological Chemistry, November 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  180. SirT1 Regulates Adipose Tissue Inflammation

    Article • Diabetes, November 2011, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  181. Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice

    Article • Cell Metabolism, November 2011, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  182. Impact of CD1d Deficiency on Metabolism

    Article • PLOS One, September 2011, PLOS

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  183. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

    Article • Proceedings of the National Academy of Sciences, September 2011, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  184. Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

    Article • Nature, September 2011, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  185. Indy knockdown in mice mimics elements of dietary restriction

    Article • Aging, August 2011, Impact Journals, LLC

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  186. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

    Article • Hepatology, August 2011, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  187. Influence of the Hepatic Eukaryotic Initiation Factor 2α (eIF2α) Endoplasmic Reticulum (ER) Stress Response Pathway on Insulin-mediated ER Stress and Hepatic and Peripheral Glucose Metabolism

    Article • Journal of Biological Chemistry, August 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  188. Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

    Article • Cell Metabolism, August 2011, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  189. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals

    Article • Proceedings of the National Academy of Sciences, August 2011, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  190. Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

    Article • Nature Medicine, July 2011, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  191. GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function

    Article • Neurobiology of Disease, July 2011, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  192. Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

    Article • Cell Metabolism, June 2011, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  193. Magnetic Resonance Spectroscopy Studies of Human Metabolism

    Article • Diabetes, April 2011, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  194. Lysophosphatidic Acid Activates Peroxisome Proliferator Activated Receptor-γ in CHO Cells That Over-Express Glycerol 3-Phosphate Acyltransferase-1

    Article • PLOS One, April 2011, PLOS

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  195. FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

    Article • Science, March 2011, American Association for the Advancement of Science

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  196. Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

    Article • Proceedings of the National Academy of Sciences, March 2011, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  197. Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance

    Article • Hepatology, March 2011, Wiley

    Dr Roberto Codella, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  198. Characterization of the Hyperphagic Response to Dietary Fat in the MC4R Knockout Mouse

    Article • Endocrinology, March 2011, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  199. SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function

    Article • Diabetes, February 2011, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  200. Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance

    Article • Diabetes, February 2011, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Chen Xie

  201. Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues

    Article • Diabetes, January 2011, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  202. Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy

    Article • Molecular and Cellular Biology, January 2011, ASM Journals

    Dr. Monte S. Willis, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  203. Regulation of Hepatic Glucose Uptake

    Article • January 2011, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  204. Sirtuin-1 regulation of mammalian metabolism

    Article • Trends in Molecular Medicine, January 2011, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  205. Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance

    Article • Diabetologia, December 2010, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  206. Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

    Article • Cell Metabolism, December 2010, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  207. A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

    Article • AJP Endocrinology and Metabolism, November 2010, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  208. The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy

    Article • Journal of Neuroscience, October 2010, Society for Neuroscience

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  209. PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation

    Article • Journal of Clinical Investigation, October 2010, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  210. Downregulation ofADIPOQandPPARγ2Gene Expression in Subcutaneous Adipose Tissue of Obese Adolescents With Hepatic Steatosis

    Article • Obesity, October 2010, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  211. Chylomicron- and VLDL-derived Lipids Enter the Heart through Different Pathways

    Article • Journal of Biological Chemistry, September 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  212. Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis

    Article • Diabetes, August 2010, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  213. A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

    Article • Hepatology, August 2010, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  214. CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

    Article • Journal of Lipid Research, August 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  215. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

    Article • Disease Models & Mechanisms, August 2010, The Company of Biologists

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  216. The Role of Muscle Insulin Resistance in the Pathogenesis of Atherogenic Dyslipidemia and Nonalcoholic Fatty Liver Disease Associated with the Metabolic Syndrome

    Article • Annual Review of Nutrition, July 2010, Annual Reviews

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  217. Regulation of mitochondrial biogenesis

    Article • Essays in Biochemistry, June 2010, Portland Press Ltd.

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  218. Lipid-induced insulin resistance: unravelling the mechanism

    Article • The Lancet, June 2010, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  219. Uncoupling Protein-2 Decreases the Lipogenic Actions of Ghrelin

    Article • Endocrinology, May 2010, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  220. Resistance to High-Fat Diet-Induced Obesity and Insulin Resistance in Mice with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency

    Article • Cell Metabolism, May 2010, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  221. Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia

    Article • Journal of Clinical Investigation, April 2010, American Society for Clinical Investigation

    Nadia Schoenmakers, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  222. Effects of Pioglitazone on Intramyocellular Fat Metabolism in Patients with Type 2 Diabetes Mellitus

    Article • The Journal of Clinical Endocrinology & Metabolism, April 2010, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  223. Diacylglycerol-mediated insulin resistance

    Article • Nature Medicine, April 2010, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  224. Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, March 2010, New England Journal of Medicine (NEJM/MMS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  225. Deletion of the  -Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

    Article • Diabetes, March 2010, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  226. Glycerol-3-Phosphate Acyltransferase 1 Deficiency in ob/ob Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity

    Article • Diabetes, March 2010, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  227. PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor of Pharmacology Jorge Lira Ruas

  228. Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein

    Article • Cell Metabolism, December 2009, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  229. MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice

    Article • Journal of Clinical Investigation, December 2009, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  230. Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

    Article • Cell Metabolism, November 2009, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  231. Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy

    Article • Journal of Cerebral Blood Flow & Metabolism, September 2009, SAGE Publications

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  232. Paradoxical Coupling of Triglyceride Synthesis and Fatty Acid Oxidation in Skeletal Muscle Overexpressing DGAT1

    Article • Diabetes, August 2009, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  233. Liver-specific Loss of Long Chain Acyl-CoA Synthetase-1 Decreases Triacylglycerol Synthesis and β-Oxidation and Alters Phospholipid Fatty Acid Composition

    Article • Journal of Biological Chemistry, August 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  234. Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion

    Article • Journal of Biological Chemistry, July 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  235. Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

    Article • Proceedings of the National Academy of Sciences, July 2009, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  236. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

    Article • Proceedings of the National Academy of Sciences, July 2009, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  237. Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans

    Article • AJP Endocrinology and Metabolism, July 2009, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  238. Mitochondrial Dysfunction Contributes to Impaired Insulin Secretion in INS-1 Cells with Dominant-negative Mutations of HNF-1α and in HNF-1α-deficient Islets

    Article • Journal of Biological Chemistry, April 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  239. Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator-Activated Receptor-  Coactivator-1  Expression

    Article • Diabetes, April 2009, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  240. STAT3 inhibition of gluconeogenesis is downregulated by SirT1

    Article • Nature Cell Biology, March 2009, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  241. The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance

    Article • Cell Metabolism, March 2009, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  242. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

    Article • Nature Medicine, January 2009, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  243. Adipose Overexpression of Desnutrin Promotes Fatty Acid Use and Attenuates Diet-Induced Obesity

    Article • Diabetes, January 2009, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  244. Increased Energy Expenditure and Insulin Sensitivity in the High Bone Mass ΔFosB Transgenic Mice

    Article • Endocrinology, January 2009, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  245. METABOLISM

    Article • January 2009, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  246. Chapter 21 Assessment of In Vivo Mitochondrial Metabolism by Magnetic Resonance Spectroscopy

    Article • January 2009, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  247. Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

    Article • Proceedings of the National Academy of Sciences, December 2008, Proceedings of the National Academy of Sciences

    Dr Roberto Codella, Professor Christoph Handschin, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  248. N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake

    Article • Cell, November 2008, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  249. Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals

    Article • Proceedings of the National Academy of Sciences, October 2008, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  250. Resistance to High-Fat Diet-Induced Obesity but Exacerbated Insulin Resistance in Mice Overexpressing Preadipocyte Factor-1 (Pref-1): A New Model of Partial Lipodystrophy

    Article • Diabetes, October 2008, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Dr Josep A Villena

  251. UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

    Article • Nature, July 2008, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  252. Muscle-Specific IRS-1 Ser->Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle

    Article • Diabetes, July 2008, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  253. Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice

    Article • AJP Heart and Circulatory Physiology, July 2008, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  254. Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight

    Article • Journal of Neurochemistry, May 2008, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  255. Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL

    Article • Magnetic Resonance in Medicine, March 2008, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  256. A Prevalent Variant in PPP1R3A Impairs Glycogen Synthesis and Reduces Muscle Glycogen Content in Humans and Mice

    Article • PLoS Medicine, January 2008, PLOS

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  257. Dual role of proapoptotic BAD in insulin secretion and beta cell survival

    Article • Nature Medicine, January 2008, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  258. Regulation of hypothalamic malonyl-CoA by central glucose and leptin

    Article • Proceedings of the National Academy of Sciences, December 2007, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  259. Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

    Article • Journal of Clinical Investigation, November 2007, American Society for Clinical Investigation

    Professor Christoph Handschin, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  260. Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

    Article • Proceedings of the National Academy of Sciences, October 2007, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  261. Continuous fat oxidation in acetyl–CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

    Article • Proceedings of the National Academy of Sciences, October 2007, Proceedings of the National Academy of Sciences

    Dr Roberto Codella, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  262. Obesity-associated improvements in metabolic profile through expansion of adipose tissue

    Article • Journal of Clinical Investigation, September 2007, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  263. Muscle-specific knockout of PKC-λ impairs glucose transport and induces metabolic and diabetic syndromes

    Article • Journal of Clinical Investigation, August 2007, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  264. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

    Article • Proceedings of the National Academy of Sciences, July 2007, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  265. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

    Article • Journal of Clinical Investigation, July 2007, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  266. Interethnic Differences in Muscle, Liver and Abdominal Fat Partitioning in Obese Adolescents

    Article • PLOS One, June 2007, PLOS

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  267. Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but NotDGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance

    Article • Journal of Biological Chemistry, May 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  268. Synaptic Glutamate Release by Ventromedial Hypothalamic Neurons Is Part of the Neurocircuitry that Prevents Hypoglycemia

    Article • Cell Metabolism, May 2007, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  269. Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance

    Article • Physiological Reviews, April 2007, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  270. Mitochondrial GTP Regulates Glucose-Stimulated Insulin Secretion

    Article • Cell Metabolism, April 2007, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  271. Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance

    Article • Journal of Biological Chemistry, March 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  272. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo

    Article • Proceedings of the National Academy of Sciences, March 2007, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  273. Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

    Article • Journal of Clinical Investigation, March 2007, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  274. Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients

    Article • Diabetes, February 2007, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  275. Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis

    Article • Cell Metabolism, February 2007, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  276. n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator-Activated Receptor- -Dependent Manner

    Article • Diabetes, January 2007, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  277. Measurements of the anaplerotic rate in the human cerebral cortex using13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose

    Article • Journal of Neurochemistry, January 2007, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  278. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

    Article • Nature Medicine, December 2006, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  279. Hypomorphic mutation of PGC-1β causes mitochondrial dysfunction and liver insulin resistance

    Article • Cell Metabolism, December 2006, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  280. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men

    Article • Proceedings of the National Academy of Sciences, November 2006, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  281. Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction

    Article • Diabetes, November 2006, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  282. Cytosolic and Mitochondrial Malic Enzyme Isoforms Differentially Control Insulin Secretion

    Article • Journal of Biological Chemistry, November 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  283. Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle

    Article • Proceedings of the National Academy of Sciences, October 2006, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  284. Immunoneutralization of Endogenous Glucagon Reduces Hepatic Glucose Output and Improves Long-Term Glycemic Control in Diabetic ob/ob Mice

    Article • Diabetes, September 2006, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  285. Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1

    Article • AJP Endocrinology and Metabolism, September 2006, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  286. Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity

    Article • Cell Metabolism, July 2006, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  287. Regulation of Metabolic Responses by Adipocyte/ Macrophage Fatty Acid-Binding Proteins in Leptin-Deficient Mice

    Article • Diabetes, June 2006, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  288. Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

    Article • Diabetes, June 2006, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  289. The role of AMP-activated protein kinase in mitochondrial biogenesis

    Article • The Journal of Physiology, June 2006, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  290. Introduction

    Article • The American Journal of Medicine, May 2006, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  291. Etiology of Insulin Resistance

    Article • The American Journal of Medicine, May 2006, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  292. Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice

    Article • AJP Endocrinology and Metabolism, May 2006, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  293. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis

    Article • Nature Medicine, April 2006, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  294. Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

    Article • AJP Endocrinology and Metabolism, April 2006, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  295. Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator-Activated Receptor- -Dependent Mechanism in Mice

    Article • Diabetes, March 2006, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  296. Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes

    Article • Diabetes, March 2006, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  297. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

    Article • Journal of Clinical Investigation, March 2006, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  298. New Insights into the Pathogenesis of Insulin Resistance in Humans Using Magnetic Resonance Spectroscopy

    Article • Obesity, February 2006, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  299. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents

    Article • Journal of Clinical Investigation, December 2005, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  300. Effect of a Sustained Reduction in Plasma Free Fatty Acid Concentration on Intramuscular Long-Chain Fatty Acyl-CoAs and Insulin Action in Type 2 Diabetic Patients

    Article • Diabetes, October 2005, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  301. The Role of Intramyocellular Lipids during Hypoglycemia in Patients with Intensively Treated Type 1 Diabetes

    Article • The Journal of Clinical Endocrinology & Metabolism, October 2005, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  302. MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes

    Article • August 2005, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  303. Decreased Insulin-Stimulated ATP Synthesis and Phosphate Transport in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Parents

    Article • PLoS Medicine, August 2005, PLOS

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  304. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

    Article • Cell Metabolism, July 2005, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  305. Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart

    Article • AJP Endocrinology and Metabolism, July 2005, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  306. The “Obese Insulin-Sensitive” Adolescent: Importance of Adiponectin and Lipid Partitioning

    Article • The Journal of Clinical Endocrinology & Metabolism, June 2005, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  307. Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance

    Article • Diabetes, May 2005, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  308. Mitochondrial Glycerol-3-phosphate Acyltransferase-1 Is Essential in Liver for the Metabolism of Excess Acyl-CoAs

    Article • Journal of Biological Chemistry, May 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  309. Mechanisms of Insulin Resistance in Humans and Possible Links With Inflammation

    Article • Hypertension, April 2005, Wolters Kluwer Health

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  310. Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

    Article • Diabetes, February 2005, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  311. Mitochondrial Dysfunction and Type 2 Diabetes

    Article • Science, January 2005, American Association for the Advancement of Science

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  312. Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes

    Article • Diabetes, November 2004, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  313. A Cluster of Metabolic Defects Caused by Mutation in a Mitochondrial tRNA

    Article • Science, November 2004, American Association for the Advancement of Science

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  314. Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

    Article • Cell, October 2004, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  315. PKC-θ knockout mice are protected from fat-induced insulin resistance

    Article • Journal of Clinical Investigation, September 2004, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  316. 13C NMR Isotopomer Analysis of Anaplerotic Pathways in INS-1 Cells

    Article • Journal of Biological Chemistry, August 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  317. 40th EASD Annual Meeting of the European Association for the Study of Diabetes

    Article • Diabetologia, August 2004, Springer Science + Business Media

    Dr. Mykola D. Khalangot, Professor Alexandra Kautzky-Willer, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor marija B Vavlukis

  318. Unraveling the Cellular Mechanism of Insulin Resistance in Humans: New Insights from Magnetic Resonance Spectroscopy

    Article • Physiology, August 2004, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  319. Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease

    Article • Journal of Biological Chemistry, May 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  320. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

    Article • Proceedings of the National Academy of Sciences, March 2004, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  321. Transgenic Overexpression of Protein-tyrosine Phosphatase 1B in Muscle Causes Insulin Resistance, but Overexpression with Leukocyte Antigen-related Phosphatase Does Not Additively Impair Insulin Action

    Article • Journal of Biological Chemistry, March 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  322. Effects of Rexinoids on Glucose Transport and Insulin-mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice

    Article • Journal of Biological Chemistry, March 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  323. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

    Article • Journal of Clinical Investigation, March 2004, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  324. Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, February 2004, New England Journal of Medicine (NEJM/MMS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  325. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

    Article • Nature Medicine, February 2004, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  326. Liver fatty acid-binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPAR-  in fasting mice

    Article • The FASEB Journal, December 2003, Federation of American Societies For Experimental Biology (FASEB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  327. Effects of depletion exercise and light training on muscle glycogen supercompensation in men

    Article • AJP Endocrinology and Metabolism, December 2003, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  328. Cellular mechanism of insulin resistance: potential links with inflammation

    Article • International Journal of Obesity, November 2003, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  329. Genetic Modulation of PPARγ Phosphorylation Regulates Insulin Sensitivity

    Article • Developmental Cell, October 2003, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  330. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning

    Article • The Lancet, September 2003, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  331. Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise

    Article • AJP Endocrinology and Metabolism, September 2003, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  332. Insulin Resistance in Tetracycline-Repressible Munc18c Transgenic Mice

    Article • Diabetes, July 2003, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  333. Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry

    Article • Nature Biotechnology, June 2003, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  334. Differential Effects of Rosiglitazone on Skeletal Muscle and Liver Insulin Resistance in A-ZIP/F-1 Fatless Mice

    Article • Diabetes, June 2003, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  335. Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

    Article • Science, May 2003, American Association for the Advancement of Science

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  336. Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke

    Article • Neurology, May 2003, Wolters Kluwer Health

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  337. Low Adiponectin Levels in Adolescent Obesity: A Marker of Increased Intramyocellular Lipid Accumulation

    Article • The Journal of Clinical Endocrinology & Metabolism, May 2003, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  338. Pioglitazone Improves Insulin Sensitivity Among Nondiabetic Patients With a Recent Transient Ischemic Attack or Ischemic Stroke

    Article • Stroke, May 2003, Wolters Kluwer Health

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  339. Defective Activation of Skeletal Muscle and Adipose Tissue Lipolysis in Type 1 Diabetes Mellitus during Hypoglycemia

    Article • The Journal of Clinical Endocrinology & Metabolism, April 2003, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  340. Skeletal muscle lipid metabolism with obesity

    Article • AJP Endocrinology and Metabolism, April 2003, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  341. Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation

    Article • Diabetes, March 2003, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  342. A comparison of 13C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-13C]glucose

    Article • Brain Research Protocols, February 2003, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  343. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

    Article • Proceedings of the National Academy of Sciences, November 2002, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  344. Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

    Article • Journal of Biological Chemistry, November 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  345. AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat

    Article • AJP Endocrinology and Metabolism, November 2002, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  346. Effect of Weight Loss on Insulin Sensitivity and Intramuscular Long-Chain Fatty Acyl-CoAs in Morbidly Obese Subjects

    Article • Diabetes, October 2002, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  347. Effects of a Novel Glycogen Synthase Kinase-3 Inhibitor on Insulin-Stimulated Glucose Metabolism in Zucker Diabetic Fatty (fa/fa) Rats

    Article • Diabetes, October 2002, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  348. Nonalcoholic Fatty Liver Disease

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, September 2002, New England Journal of Medicine (NEJM/MMS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  349. Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

    Article • The American Journal of Cardiology, September 2002, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  350. Fatty Acid Infusion Selectively Impairs Insulin Action on Akt1 and Protein Kinase C lambda /zeta but Not on Glycogen Synthase Kinase-3

    Article • Journal of Biological Chemistry, July 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  351. Adrenalectomy Improves Diabetes in A-ZIP/F-1 Lipoatrophic Mice by Increasing Both Liver and Muscle Insulin Sensitivity

    Article • Diabetes, July 2002, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  352. [2,4-13C2]-β-Hydroxybutyrate Metabolism in Human Brain

    Article • Journal of Cerebral Blood Flow & Metabolism, July 2002, SAGE Publications

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  353. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction

    Article • European Journal of Clinical Investigation, June 2002, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  354. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

    Article • Journal of Clinical Investigation, May 2002, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  355. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

    Article • Journal of Clinical Investigation, May 2002, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  356. Assessment of Skeletal Muscle Triglyceride Content by 1H Nuclear Magnetic Resonance Spectroscopy in Lean and Obese Adolescents: Relationships to Insulin Sensitivity, Total Body Fat, and Central Adiposity

    Article • Diabetes, April 2002, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  357. Astroglial Contribution to Brain Energy Metabolism in Humans Revealed by13C Nuclear Magnetic Resonance Spectroscopy: Elucidation of the Dominant Pathway for Neurotransmitter Glutamate Repletion and Measurement of Astrocytic Oxidative Metabolism

    Article • Journal of Neuroscience, March 2002, Society for Neuroscience

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  358. The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

    Article • Diabetes, March 2002, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  359. Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content

    Article • AJP Endocrinology and Metabolism, February 2002, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  360. Inclusion of Low Amounts of Fructose With an Intraduodenal Glucose Load Markedly Reduces Postprandial Hyperglycemia and Hyperinsulinemia in the Conscious Dog

    Article • Diabetes, February 2002, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  361. Hepatic Glycogen Metabolism in Type 1 Diabetes After Long-Term Near Normoglycemia

    Article • Diabetes, January 2002, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  362. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis

    Article • AJP Endocrinology and Metabolism, December 2001, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  363. Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

    Article • Journal of Clinical Investigation, September 2001, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  364. Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

    Article • Genes & Development, August 2001, Cold Spring Harbor Laboratory Press

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  365. Prevention of fat-induced insulin resistance by salicylate

    Article • Journal of Clinical Investigation, August 2001, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  366. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

    Article • Journal of Clinical Investigation, July 2001, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  367. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

    Article • Proceedings of the National Academy of Sciences, June 2001, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  368. Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBbeta )

    Article • Science, June 2001, American Association for the Advancement of Science

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  369. Stimulating Effects of Low-Dose Fructose on Insulin-Stimulated Hepatic Glycogen Synthesis in Humans

    Article • Diabetes, June 2001, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  370. Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes

    Article • Cell, June 2001, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  371. Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance

    Article • Journal of Clinical Investigation, May 2001, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  372. Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans

    Article • Metabolism, May 2001, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  373. Effect of 5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and Obese Zucker Rats

    Article • Diabetes, May 2001, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  374. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance

    Article • Proceedings of the National Academy of Sciences, April 2001, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  375. In VivoEffects of Uncoupling Protein-3 Gene Disruption on Mitochondrial Energy Metabolism

    Article • Journal of Biological Chemistry, March 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  376. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

    Article • Nature, February 2001, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  377. Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

    Article • Journal of Clinical Investigation, January 2001, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  378. Lipid-dependent control of hepatic glycogen stores in healthy humans

    Article • Diabetologia, January 2001, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  379. Nuclear Magnetic Resonance Studies of Hepatic Glucose Metabolism in Humans

    Article • Recent Progress in Hormone Research, January 2001, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  380. Mechanism by which metformin reduces glucose production in type 2 diabetes

    Article • Diabetes, December 2000, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  381. 13C/31P NMR Assessment of Mitochondrial Energy Coupling in Skeletal Muscle of Awake Fed and Fasted Rats

    Article • Journal of Biological Chemistry, September 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  382. Contrasting Effects of IRS-1VersusIRS-2 Gene Disruption on Carbohydrate and Lipid Metabolismin Vivo

    Article • Journal of Biological Chemistry, September 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  383. Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

    Article • Molecular and Cellular Biology, August 2000, ASM Journals

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  384. Cellular mechanisms of insulin resistance

    Article • Journal of Clinical Investigation, July 2000, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  385. Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

    Article • Molecular Cell, July 2000, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  386. Regulation of myocardial [13C]glucose metabolism in conscious rats

    Article • AJP Heart and Circulatory Physiology, July 2000, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  387. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

    Article • Journal of Clinical Investigation, June 2000, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  388. Effects of Caffeine on Muscle Glycogen Utilization and the Neuroendocrine Axis during Exercise

    Article • The Journal of Clinical Endocrinology & Metabolism, June 2000, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  389. Assessment of mitochondrial energy coupling in vivo by 13 C/ 31 P NMR

    Article • Proceedings of the National Academy of Sciences, May 2000, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  390. Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans

    Article • Diabetes, May 2000, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  391. Mechanism of troglitazone action in type 2 diabetes

    Article • Diabetes, May 2000, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  392. Mechanism of muscle glycogen autoregulation in humans

    Article • AJP Endocrinology and Metabolism, April 2000, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  393. Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after exercise

    Article • AJP Endocrinology and Metabolism, April 2000, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  394. Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

    Article • Journal of Biological Chemistry, March 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  395. Persistent Changes in Myocardial Glucose Metabolism In Vivo During Reperfusion of a Limited-Duration Coronary Occlusion

    Article • Circulation, February 2000, Wolters Kluwer Health

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  396. Glycogen loading alters muscle glycogen resynthesis after exercise

    Article • Journal of Applied Physiology, February 2000, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  397. Intramuscular Glycogen and Intramyocellular Lipid Utilization during Prolonged Exercise and Recovery in Man: A 13C and 1H Nuclear Magnetic Resonance Spectroscopy Study

    Article • The Journal of Clinical Endocrinology & Metabolism, February 2000, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  398. Spectroscopic imaging of glutamate C4 turnover in human brain

    Article • Magnetic Resonance in Medicine, January 2000, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  399. Intense exercise stimulates albumin synthesis in the upright posture

    Article • Journal of Applied Physiology, January 2000, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  400. Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, July 1999, New England Journal of Medicine (NEJM/MMS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  401. Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13 C NMR

    Article • Proceedings of the National Academy of Sciences, July 1999, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  402. Cellular mechanisms of insulin resistance in humans

    Article • The American Journal of Cardiology, July 1999, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  403. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

    Article • Diabetes, June 1999, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  404. Regulation of myocardial glucose uptake and transport during ischemia and energetic stress

    Article • The American Journal of Cardiology, June 1999, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  405. Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats

    Article • Diabetes, March 1999, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  406. APPLICATIONS OF NMR SPECTROSCOPY TO STUDY MUSCLE GLYCOGEN METABOLISM IN MAN

    Article • Annual Review of Medicine, February 1999, Annual Reviews

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  407. Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

    Article • Journal of Clinical Investigation, January 1999, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  408. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

    Article • Diabetologia, January 1999, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  409. NMR Studies on the Mechanism of Insulin Resistance

    Article • January 1999, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  410. Differential effects of safflower oil versus fish oil feeding on insulin-stimulated glycogen synthesis, glycolysis, and pyruvate dehydrogenase flux in skeletal muscle: a 13C nuclear magnetic resonance study

    Article • Diabetes, January 1999, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  411. Additive Effects of Hyperinsulinemia and Ischemia on Myocardial GLUT1 and GLUT4 Translocation In Vivo

    Article • Circulation, November 1998, Wolters Kluwer Health

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  412. Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, March 1998, New England Journal of Medicine (NEJM/MMS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  413. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans.

    Article • Journal of Clinical Investigation, March 1998, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  414. 13C/31P NMR studies on the mechanism of insulin resistance in obesity

    Article • Diabetes, March 1998, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  415. Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis

    Article • Diabetes, March 1998, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  416. Disruption of IRS-2 causes type 2 diabetes in mice

    Article • Nature, February 1998, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  417. Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus

    Article • Annals of Internal Medicine, February 1998, American College of Physicians

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  418. Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart. A three tracer study of glycolysis, glycogen metabolism, and glucose oxidation.

    Article • Journal of Clinical Investigation, December 1997, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  419. In vivo NMR investigation of intramuscular glucose metabolism in conscious rats

    Article • AJP Endocrinology and Metabolism, July 1997, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  420. Metabolic Defects in Lean Nondiabetic Offspring of NIDDM Parents: A Cross-Sectional Study

    Article • Diabetes, June 1997, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  421. Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus.

    Article • Journal of Clinical Investigation, May 1997, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  422. 13C and31P NMR Studies on the Effects of Increased Plasma Free Fatty Acids on Intramuscular Glucose Metabolism in the Awake Rat

    Article • Journal of Biological Chemistry, April 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  423. Low-Flow Ischemia Leads to Translocation of Canine Heart GLUT-4 and GLUT-1 Glucose Transporters to the Sarcolemma In Vivo

    Article • Circulation, January 1997, Wolters Kluwer Health

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  424. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

    Article • Journal of Clinical Investigation, January 1997, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  425. The Effect of Leptin Is Enhanced by Microinjection Into the Ventromedial Hypothalamus

    Article • Diabetes, January 1997, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  426. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria.

    Article • Journal of Clinical Investigation, November 1996, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  427. Time course of the defective α-cell response to hypoglycemia in diabetic BB rats

    Article • Metabolism, November 1996, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  428. Increased Glucose Transport–Phosphorylation and Muscle Glycogen Synthesis after Exercise Training in Insulin-Resistant Subjects

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, October 1996, New England Journal of Medicine (NEJM/MMS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  429. Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.

    Article • Journal of Clinical Investigation, October 1996, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  430. Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia.

    Article • Journal of Clinical Investigation, July 1996, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  431. Noninvasive assessment of hepatic triglyceride content in humans with13C nuclear magnetic resonance spectroscopy

    Article • Hepatology, July 1996, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  432. Mechanism of free fatty acid-induced insulin resistance in humans.

    Article • Journal of Clinical Investigation, June 1996, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  433. NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise.

    Article • Proceedings of the National Academy of Sciences, May 1996, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  434. The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans.

    Article • Journal of Clinical Investigation, February 1996, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  435. Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period

    Article • AJP Endocrinology and Metabolism, January 1996, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  436. Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.

    Article • Journal of Clinical Investigation, January 1996, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  437. Mass and Positional Isotopomer Analysis of Glucose Metabolism in Periportal and Pericentral Hepatocytes

    Article • Journal of Biological Chemistry, November 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  438. Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver

    Article • Metabolism, November 1995, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  439. Central adiposity and its metabolic correlates in obese adolescent girls

    Article • AJP Endocrinology and Metabolism, July 1995, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  440. Islet Phosphoinositide Hydrolysis and Insulin Secretory Responses from Prediabetic fA/fA ZDF Rats

    Article • Biochemical and Biophysical Research Communications, April 1995, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  441. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.

    Article • Proceedings of the National Academy of Sciences, February 1995, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  442. Contribution of Hepatic Glycogenolysis to Glucose Production in Humans in Response to a Physiological Increase in Plasma Glucagon Concentration

    Article • Diabetes, February 1995, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  443. Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study.

    Article • Journal of Clinical Investigation, February 1995, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  444. Local Ventromedial Hypothalamus Glucopenia Triggers Counterregulatory Hormone Release

    Article • Diabetes, February 1995, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  445. Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice.

    Article • Journal of Clinical Investigation, January 1995, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  446. 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus.

    Article • Journal of Clinical Investigation, December 1994, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  447. Substrate cycling between pyruvate and oxaloacetate in awake normal and 3,3'-5-triiodo-L-thyronine-treated rats

    Article • AJP Endocrinology and Metabolism, August 1994, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  448. Effects of puberty and diabetes on metabolism of insulin-sensitive fuels

    Article • AJP Endocrinology and Metabolism, June 1994, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  449. Validation of13C NMR measurements of liver glycogenin vivo

    Article • Magnetic Resonance in Medicine, June 1994, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  450. Liver glycogen turnover in fed and fasted humans

    Article • AJP Endocrinology and Metabolism, May 1994, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  451. Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

    Article • Journal of Clinical Investigation, April 1994, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  452. Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases

    Article • Journal of Applied Physiology, January 1994, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  453. In vivo regulation of rat muscle glycogen resynthesis after intense exercise

    Article • AJP Endocrinology and Metabolism, January 1994, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  454. Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. Reversibility and stimulus specificity of the deficits.

    Article • Journal of Clinical Investigation, December 1993, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  455. Temporal changes in insulin resistance and secretion in 24-h-fasted conscious pregnant rats

    Article • AJP Endocrinology and Metabolism, December 1993, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  456. Inhibitory Effect of Pregnancy on Counterregulatory Hormone Responses to Hypoglycemia in Awake Rat

    Article • Diabetes, October 1993, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  457. Effect of hepatic nerves on disposition of an intraduodenal glucose load

    Article • AJP Endocrinology and Metabolism, September 1993, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  458. Direct measurement of change in muscle glycogen concentration after a mixed meal in normal subjects

    Article • AJP Endocrinology and Metabolism, August 1993, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  459. Comparative Effects of Monomethylsuccinate and Glucose on Insulin Secretion from Perifused Rat Islets

    Article • Diabetes, June 1993, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  460. Enhancement of the gluconeogenic flux of hepatic glycogen repletion by a phenacyl imidazolium compound in vivo

    Article • Acta Diabetologica, June 1993, Springer Science + Business Media

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  461. Cerebral Lactate Turnover after Electroshock: In vivo Measurements by 1H/13C Magnetic Resonance Spectroscopy

    Article • Journal of Cerebral Blood Flow & Metabolism, November 1992, SAGE Publications

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  462. Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion

    Article • Journal of Cell Biology, October 1992, Rockefeller University Press

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  463. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

    Article • Journal of Clinical Investigation, October 1992, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  464. Pathways of glycogen repletion

    Article • Physiological Reviews, October 1992, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  465. Detection and assignment of the glucose signal in1h nmr difference spectra of the human brain

    Article • Magnetic Resonance in Medicine, September 1992, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  466. Validation of13c nmr measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples

    Article • Magnetic Resonance in Medicine, September 1992, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  467. Simultaneous Insulinlike Growth Factor I and Insulin Resistance in Obese Zucker Rats

    Article • Diabetes, June 1992, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  468. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.

    Article • Journal of Clinical Investigation, April 1992, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  469. Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy.

    Article • Proceedings of the National Academy of Sciences, February 1992, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  470. Hypopituitarism associated with a hypothalamic CMV infection in a patient with AIDS

    Article • The American Journal of Medicine, February 1992, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  471. N.m.r. studies of muscle glycogen synthesis in normal and non-insulin-dependent diabetic subjects

    Article • Biochemical Society Transactions, November 1991, Portland Press Ltd.

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  472. Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR

    Article • Science, October 1991, American Association for the Advancement of Science

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  473. Localized proton NMR observation of [3-13C] lactate in stroke after [1-13C] glucose infusion

    Article • Magnetic Resonance in Medicine, October 1991, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  474. The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats

    Article • Metabolism, October 1991, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  475. Sources of carbon for hepatic glycogen synthesis in the conscious dog.

    Article • Journal of Clinical Investigation, August 1991, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  476. Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion

    Article • AJP Endocrinology and Metabolism, May 1991, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  477. Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats

    Article • AJP Endocrinology and Metabolism, February 1991, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  478. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.

    Article • Journal of Clinical Investigation, February 1991, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  479. Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans.

    Article • AJP Endocrinology and Metabolism, September 1990, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  480. Effect of metformin treatment on insulin action in diabetic rats: In vivo and in vitro correlations

    Article • Metabolism, April 1990, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  481. Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by13C Nuclear Magnetic Resonance Spectroscopy

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, January 1990, New England Journal of Medicine (NEJM/MMS)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  482. Chronicin VivoHyperglycemia Impairs Phosphoinositide Hydrolysis and Insulin Release in Isolated Perifused Rat Islets*

    Article • Endocrinology, January 1990, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  483. Influence of the route of glucose administration on hepatic glycogen repletion

    Article • AJP Endocrinology and Metabolism, November 1989, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  484. Effect of dietary protein on in vivo insulin action and liver glycogen repletion

    Article • AJP Endocrinology and Metabolism, August 1989, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  485. Direct observation of glycogen synthesis in human muscle with 13C NMR.

    Article • Proceedings of the National Academy of Sciences, June 1989, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  486. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

    Article • Journal of Clinical Investigation, October 1987, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  487. Physiological Role of Cholecystokinin in Meal-Induced Insulin Secretion in Conscious Rats: Studies With L 364718, A Specific Inhibitor of CCK-Receptor Binding

    Article • Diabetes, October 1987, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  488. Quantitative analysis of glycogen repletion by nuclear magnetic resonance spectroscopy in the conscious rat.

    Article • Journal of Clinical Investigation, August 1987, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  489. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.

    Article • Journal of Clinical Investigation, May 1987, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  490. Plasma Level of 13,14-Dihydro-15-keto-PGE2 in Patients With Diabetic Ketoacidosis and in Normal Fasting Subjects

    Article • Diabetes, September 1986, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  491. Metabolic Response to Three Years of Continuous, Basal Rate Intravenous Insulin Infusion in Type II Diabetic Patients*

    Article • The Journal of Clinical Endocrinology & Metabolism, October 1985, Endocrine Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  492. Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy.

    Article • Journal of Clinical Investigation, September 1985, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  493. A 1H NMR technique for observing metabolite signals in the spectrum of perfused liver.

    Article • Proceedings of the National Academy of Sciences, August 1985, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  494. Substrate cycling between gluconeogenesis and glycolysis in euthyroid, hypothyroid, and hyperthyroid man.

    Article • Journal of Clinical Investigation, August 1985, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  495. 23Na and 39K NMR studies of ion transport in human erythrocytes.

    Article • Proceedings of the National Academy of Sciences, February 1985, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  496. Nuclear magnetic resonance spectroscopy in diagnostic and investigative medicine.

    Article • Journal of Clinical Investigation, October 1984, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  497. Implantable Insulin Infusion Devices

    Article • JAMA, November 1982, American Medical Association (AMA)

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  498. Differential Time Course of Glucagon's Effect on Glycogenolysis and Gluconeogenesis in the Conscious Dog

    Article • Diabetes, March 1981, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  499. Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog

    Article • Metabolism, April 1980, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  500. Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog.

    Article • Journal of Clinical Investigation, February 1980, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  501. Glucose Disposal during Insulinopenia in Somatostatin-Treated Dogs

    Article • Journal of Clinical Investigation, August 1978, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  502. Insulin Resistance

    Article • Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman