All Stories

  1. Cardiomyocyte-specific ACSL1 Deficiency Prevents Cardiac Lipotoxicity and Alleviates Heart Dysfunction in the ob/ob Model of Obesity
  2. Walk the Line: The Role of Ubiquitin in Regulating Transcription in Myocytes
  3. Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosa Model of Sepsis Using Nontargeted Metabolomics Analysis
  4. Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice
  5. Doxorubicin Exposure Causes Subacute Cardiac Atrophy Dependent on the Striated Muscle–Specific Ubiquitin Ligase MuRF1
  6. F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria
  7. Image-Based Methods for Phase Estimation, Gating, and Temporal Superresolution of Cardiac Ultrasound
  8. The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability
  9. Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice
  10. Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16
  11. Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP
  12. Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo
  13. Tumor necrosis factor receptor-associated factor 6 as a nuclear factor kappa B-modulating therapeutic target in cardiovascular diseases: at the heart of it all
  14. Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations
  15. Modeling the Transition From Decompensated to Pathological Hypertrophy
  16. Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations
  17. Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study
  18. The role of heat shock proteins and co-chaperones in heart failure
  19. Untargeted metabolomics analysis of ischemia–reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats
  20. Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease
  21. Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis
  22. Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association
  23. Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Rece...
  24. Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes
  25. MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C
  26. Exercise-Induced Alterations in Skeletal Muscle, Heart, Liver, and Serum Metabolome Identified by Non-Targeted Metabolomics Analysis
  27. Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo
  28. Loss of CHIP Expression Perturbs Glucose Homeostasis and Leads to Type II Diabetes through Defects in Microtubule Polymerization and Glucose Transporter Localization
  29. Erratum to ‘Cessation of biomechanical stretch model of C2C12 cells modelsmyocyte atrophy and anaplerotic changes in metabolism usingnon-targeted metabolomics analysisAmro’ [Int. J. Biochem. Cell Biol. (2016) 80–92]
  30. Non-Targeted Metabolomics Analysis of the Effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Heart, Muscle, Liver and Serum Metabolism In Vivo
  31. Ubiquitin Ligases and Posttranslational Regulation of Energy in the Heart: The Hand that Feeds
  32. BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility
  33. A purified MAA-based ELISA is a useful tool for determining anti-MAA antibody titer with high sensitivity
  34. The Head and the Heart
  35. Cessation of biomechanical stretch model of C2C12 cells models myocyte atrophy and anaplerotic changes in metabolism using non-targeted metabolomics analysis
  36. The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo
  37. Proteolysis in the Interstitial Space
  38. Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling
  39. Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism
  40. Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential
  41. Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice
  42. BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo
  43. Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo
  44. Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures
  45. Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1
  46. Heart-specific regulation of thyroid hormone activity.
  47. Nebulized Delivery of the MAPKAP Kinase 2 Peptide Inhibitor MMI-0100 Protects Against Ischemia-Induced Systolic Dysfunction
  48. Influence of Ischemia-Reperfusion Injury on Cardiac Metabolism
  49. Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study
  50. The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination
  51. MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet
  52. Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet
  53. Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart Failure
  54. Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions
  55. Cancer cachexia update in head and neck cancer: Pathophysiology and treatment
  56. Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis
  57. Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis
  58. Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin
  59. Delayed Contrast Enhancement Imaging of a Murine Model for Ischemia Reperfusion with Carbon Nanotube Micro-CT
  60. Platelet Endothelial Cell Adhesion Molecule‐1 Mediates Endothelial‐Cardiomyocyte Communication and Regulates Cardiac Function
  61. Erratum to: MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
  62. MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition
  63. Genetics and Heart Failure: A Concise Guide for the Clinician
  64. Corrigendum to “Protein quality control, the ubiquitin proteasome system, and autophagy: When worlds collide” [J Mol Cell Cardiol 71 (2014) 1–2]
  65. Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans
  66. Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes
  67. The Hypermetabolic Giant: 18F-FDG avid Giant Cell Tumor identified on PET-CT
  68. The role of ubiquitin ligases in cardiac disease
  69. Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin
  70. Protein Quality Control, The Ubiquitin Proteosome System, and Authophagy: When Worlds Collide
  71. Muscle RING Finger-1 Promotes a Maladaptive Phenotype in Chronic Hypoxia-Induced Right Ventricular Remodeling
  72. MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
  73. Cancer cachexia update in head and neck cancer: Definitions and diagnostic features
  74. Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans
  75. SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease
  76. Regulation of Large Conductance Ca2+-activated K+(BK) Channel β1 Subunit Expression by Muscle RING Finger Protein 1 in Diabetic Vessels
  77. Precision-cut liver slices from diet-induced obese rats exposed to ethanol are susceptible to oxidative stress and increased fatty acid synthesis
  78. Muscle RING finger-1 attenuates IGF-I-dependent cardiomyocyte hypertrophy by inhibiting JNK signaling
  79. Dedication
  80. The Pathophysiology of Cardiac Hypertrophy and Heart Failure
  81. Cellular and Molecular Pathobiology of Cardiovascular Disease
  82. Reducing Laboratory Billing Defects Using Six Sigma Principles
  83. Targeting Angiogenesis and the Tumor Microenvironment
  84. Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease
  85. The Maladaptive Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir) on the Rat Heart
  86. Ephrin–Eph signaling as a potential therapeutic target for the treatment of myocardial infarction
  87. Proteotoxicity and Cardiac Dysfunction
  88. BMPER regulates cardiomyocyte size and vessel density in vivo
  89. Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise
  90. Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expressionin vivo
  91. Rib Fractures and Death from Deletion of Osteoblast βcatenin in Adult Mice Is Rescued by Corticosteroids
  92. Evaluation of digital images for identification and characterization of monoclonal immunoglobulins by immunofixation
  93. Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?
  94. Metabolic derangements in the gastrocnemius and the effect of Compound A therapy in a murine model of cancer cachexia
  95. Cancer cachexia’s metabolic signature in a murine model confirms a distinct entity
  96. Myosin Light Chain Phosphorylation Is Critical for Adaptation to Cardiac Stress
  97. Bedbugs in the 21st Century: The Reemergence of an Old Foe
  98. Bmper Inhibits Endothelial Expression of Inflammatory Adhesion Molecules and Protects Against Atherosclerosis
  99. Functional Redundancy of SWI/SNF Catalytic Subunits in Maintaining Vascular Endothelial Cells in the Adult Heart
  100. A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury–associated Skeletal Muscle Wasting
  101. Back to your heart: Ubiquitin proteasome system-regulated signal transduction
  102. Multiple Positive Sweat Chloride Tests in an Infant Asymptomatic for Cystic Fibrosis
  103. Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart
  104. Translational Cardiology
  105. Molecular and Translational Vascular Medicine
  106. Ubiquitylation - Dependent Signaling in Heart Disease
  107. Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair
  108. Albert Szent-Györgyi, MD, PhD
  109. The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation
  110. Kids in America: Newborn Screening for Cystic Fibrosis
  111. Dietary Salt Exacerbates Isoproterenol-Induced Cardiomyopathy in Rats
  112. Regulation of the calpain and ubiquitin-proteasome systems in a canine model of muscular dystrophy
  113. Tear Me Down: Role of Calpain in the Development of Cardiac Ventricular Hypertrophy
  114. Oral Resveratrol Therapy Inhibits Cancer-Induced Skeletal Muscle and Cardiac Atrophy In Vivo
  115. Testicular Mass in a 40-Year-Old Man
  116. Konrad Bloch, PhD
  117. Imaging of myocardial infarction using carbon nanotube micro-computed tomography and delayed contrast enhancement
  118. NF-κB Inhibition Protects against Tumor-Induced Cardiac Atrophy in Vivo
  119. The Ubiquitin Ligase MuRF1 Protects Against Cardiac Ischemia/Reperfusion Injury by Its Proteasome-Dependent Degradation of Phospho-c-Jun
  120. Self-Discovered Breast Mass in a 38-Year-Old Woman
  121. Merits of Non-Invasive Rat Models of Left Ventricular Heart Failure
  122. Tearin' Up My Heart: Proteolysis in the Cardiac Sarcomere
  123. Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy
  124. All the Little Pieces
  125. Unexpected Death in a Heart Transplant Recipient
  126. Regulation of AMPK by the Ubiquitin Proteasome System
  127. Selective Inhibition of NF-kappa-B with NBD Peptide Reduces Tumor- Induced Wasting in a Murine Model of Cancer Cachexia In vivo
  128. Edge of the world: practical considerations and a clinical perspective of next-generation sequencing for hereditary cardiac disease
  129. The therapeutic potential of heat shock proteins in cardiomyopathies due to mutations in cardiac structural proteins
  130. Episodic Fever and Neutropenia in a 22-Year-Old Male
  131. Atherosclerosis: Pathogenesis, Genetics and Experimental Models
  132. Percy Lavon Julian
  133. Unexpected Cause of Anemia in a 45-Year-Old Patient With Acute Lymphoblastic Leukemia
  134. Hold Me Tight: Role of the Heat Shock Protein Family of Chaperones in Cardiac Disease
  135. Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy
  136. Interference of Monoclonal Antibody Therapies with Serum Protein Electrophoresis Tests
  137. Autoimmune Hepatitis Induced by Syngeneic Liver Cytosolic Proteins Biotransformed by Alcohol Metabolites
  138. Urine Crystals in a 1-Year-Old Male
  139. Minireview: Won’t Get Fooled Again: The Nonmetabolic Roles of Peroxisome Proliferator-Activated Receptors (PPARs) in the Heart
  140. Sir Hans Adolf Krebs: Architect of Metabolic Cycles
  141. The Challenges and Complexities of Thyroid Hormone Replacement
  142. Evolving molecular diagnostics for familial cardiomyopathies: at the heart of it all
  143. Sent to Destroy: The Ubiquitin Proteasome System Regulates Cell Signaling and Protein Quality Control in Cardiovascular Development and Disease
  144. Ivar Asbjörn Følling
  145. Karl Landsteiner, MD
  146. Cardiac Muscle Ring Finger-1—Friend or Foe?
  147. Robert Guthrie, MD, PhD
  148. Seek and destroy: The ubiquitin-proteasome system in cardiac disease
  149. Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms
  150. Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers†
  151. Arne Tiselius
  152. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
  153. The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy
  154. Cardiac Muscle Ring Finger-1 Increases Susceptibility to Heart Failure In Vivo
  155. Familial hypertrophic cardiomyopathy: Basic concepts and future molecular diagnostics
  156. Recent Advances in the Detection of Prostate Cancer Using Epigenetic Markers in Commonly Collected Laboratory Samples
  157. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling
  158. Muscle ring finger 1 mediates cardiac atrophy in vivo
  159. The ubiquitin–proteasome system in cardiac dysfunction
  160. Inhibitory kappa B kinase-β is a target for specific nuclear factor kappa B-mediated delayed cardioprotection
  161. Build it up-Tear it down: protein quality control in the cardiac sarcomere
  162. Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde
  163. Metabolomic analysis of cancer cachexia reveals distinct lipid and glucose alterations
  164. Performance Comparison of Capillary and Agarose Gel Electrophoresis for the Identification and Characterization of Monoclonal Immunoglobulins
  165. You spin me round: MafBx/Atrogin-1 feeds forward on FOXO transcription factors (like a record)
  166. Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease
  167. Hypercalcemia in a 56-Year-Old Female
  168. Proteasome inhibition promotes regression of left ventricular hypertrophy
  169. Persistent Low Concentration of Human Chorionic Gonadotropin in a Nonpregnant Woman
  170. Blood bank management of sickle cell patients at comprehensive sickle cell centers
  171. Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
  172. The E3 Ligase MuRF1 Degrades Myosin Heavy Chain Protein in Dexamethasone-Treated Skeletal Muscle
  173. Characterization of a Model to Independently Study Regression of Ventricular Hypertrophy
  174. Chest Pain, Dyspnea, and Fatigue in a 57-Year-Old Man
  175. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury
  176. Proteasome Inhibition Attenuates Infarct Size and Preserves Cardiac Function in a Murine Model of Myocardial Ischemia-Reperfusion Injury
  177. Biclonal M-Spike in a 7-Year-Old Child
  178. The Bitter End: The Ubiquitin-Proteasome System and Cardiac Dysfunction
  179. Muscle Ring Finger 1, but not Muscle Ring Finger 2, Regulates Cardiac Hypertrophy In Vivo
  180. Bovine Cardiac Troponin T is Not Accurately Quantified with a Common Human Clinical Immunoassay
  181. Hepatosplenomegaly in an 8-Month-Old Child
  182. Endotoxin-Induced Cardiomyopathy and Systemic Inflammation in Mice Is Prevented by Aldose Reductase Inhibition
  183. Recurrent Nephrolithiasis in a 9-Year-Old Child
  184. Recurrent Nephrolithiasis in a 9-Year-Old Child
  185. Into the heart: The emerging role of the ubiquitin–proteasome system
  186. Immunofixation reveals an apparent α heavy chain caused by precipitation of fibrinogen with IgA antiserum
  187. Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol
  188. Scavenger Receptors on Sinusoidal Liver Endothelial Cells Are Involved in the Uptake of Aldehyde-Modified Proteins
  189. Effect of anemia on plasma concentrations of NT-proBNP
  190. Low Blast Count Myeloid Disorders With Auer Rods
  191. Neck Pain and Rash in an 18-Year-Old Student
  192. Aortic Valve Insufficiency in a 45-Year-Old Male
  193. Aortic Valve Insufficiency in a 45-Year-Old Male
  194. Gliosarcoma Cell Death After Radiosurgery in a Rat Model
  195. Tumor necrosis factor-α-induced caspase activation mediates endotoxin-related cardiac dysfunction*
  196. Obesity, macrophage migration inhibitory factor and weight loss
  197. Relapse of Thrombotic Thrombocytopenic Purpura: Is It a Continuum of Disease?
  198. Zinc-Induced Copper Deficiency
  199. Lipopolysaccharide Is a Cofactor for Malondialdehyde-Acetaldehyde Adduct???Mediated Cytokine/Chemokine Release by Rat Sinusoidal Liver Endothelial and Kupffer Cells
  200. Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock
  201. Macrophage migration inhibitory factor mediates late cardiac dysfunction after burn injury
  202. Refeeding Syndrome in a Severely Malnourished Child
  203. Refeeding Syndrome in a Severely Malnourished Child
  204. Malondialdehyde–acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage
  205. Periumbilical Rash in an Immunosuppressed Patient
  206. Macrophage Migration Inhibitory Factor (MIF) & Weight Loss
  207. Macrophage Migration Inhibitory Factor (MIF) & Weight Loss
  208. Nasal Discharge in a 50-Year-Old Woman
  209. Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity
  210. Proximal Extremity Weakness and Altered Mental Status
  211. Proximal Extremity Weakness and Altered Mental Status
  212. T cell proliferative responses to malondialdehyde–acetaldehyde haptenated protein are scavenger receptor mediated
  213. case study [hematology | microbiology]: Fever and Neutropenia in an Adolescent with Leukemia
  214. Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells
  215. Failure to Thrive in a 14-Month-Old Child
  216. Confounding Issues in the Diagnosis of Multiple Sclerosis: Lyme Disease Testing
  217. The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances
  218. case study [chemistry | histology]: Chronic Cough in an Older Female
  219. Autoimmune Hepatitis Type 2
  220. Chronic Myelogenous Leukemia
  221. Malondialdehyde–acetaldehyde-haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells
  222. In Vitro Exposure to Malondialdehyde-Acetaldehyde Adducted Protein Inhibits Cell Proliferation and Viability
  223. Adduction of Soluble Proteins with Malondialdehyde-Acetaldehyde (MAA) Induces Antibody Production and Enhances T-Cell Proliferation