All Stories

  1. Cardiomyocyte microRNA-150 confers cardiac protection and directly represses proapoptotic small proline–rich protein 1A
  2. ACVR2B antagonism as a countermeasure to multi‐organ perturbations in metastatic colorectal cancer cachexia
  3. The Unraveling
  4. Cardiomyocyte-specific ACSL1 Deficiency Prevents Cardiac Lipotoxicity and Alleviates Heart Dysfunction in the ob/ob Model of Obesity
  5. Walk the Line: The Role of Ubiquitin in Regulating Transcription in Myocytes
  6. Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosa Model of Sepsis Using Nontargeted Metabolomics Analysis
  7. Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice
  8. Doxorubicin Exposure Causes Subacute Cardiac Atrophy Dependent on the Striated Muscle–Specific Ubiquitin Ligase MuRF1
  9. F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria
  10. Image-Based Methods for Phase Estimation, Gating, and Temporal Superresolution of Cardiac Ultrasound
  11. The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability
  12. Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice
  13. Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16
  14. Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP
  15. Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo
  16. Tumor necrosis factor receptor-associated factor 6 as a nuclear factor kappa B-modulating therapeutic target in cardiovascular diseases: at the heart of it all
  17. Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations
  18. Modeling the Transition From Decompensated to Pathological Hypertrophy
  19. Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations
  20. Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study
  21. The role of heat shock proteins and co-chaperones in heart failure
  22. Untargeted metabolomics analysis of ischemia–reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats
  23. Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease
  24. Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis
  25. Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association
  26. Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Rece...
  27. Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes
  28. MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C
  29. Exercise-Induced Alterations in Skeletal Muscle, Heart, Liver, and Serum Metabolome Identified by Non-Targeted Metabolomics Analysis
  30. Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo
  31. Loss of CHIP Expression Perturbs Glucose Homeostasis and Leads to Type II Diabetes through Defects in Microtubule Polymerization and Glucose Transporter Localization
  32. Erratum to ‘Cessation of biomechanical stretch model of C2C12 cells modelsmyocyte atrophy and anaplerotic changes in metabolism usingnon-targeted metabolomics analysisAmro’ [Int. J. Biochem. Cell Biol. (2016) 80–92]
  33. Non-Targeted Metabolomics Analysis of the Effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Heart, Muscle, Liver and Serum Metabolism In Vivo
  34. Ubiquitin Ligases and Posttranslational Regulation of Energy in the Heart: The Hand that Feeds
  35. BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility
  36. A purified MAA-based ELISA is a useful tool for determining anti-MAA antibody titer with high sensitivity
  37. The Head and the Heart
  38. Cessation of biomechanical stretch model of C2C12 cells models myocyte atrophy and anaplerotic changes in metabolism using non-targeted metabolomics analysis
  39. The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo
  40. Proteolysis in the Interstitial Space
  41. Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling
  42. Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism
  43. Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential
  44. Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice
  45. BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo
  46. Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo
  47. Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures
  48. Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1
  49. Heart-specific regulation of thyroid hormone activity.
  50. Nebulized Delivery of the MAPKAP Kinase 2 Peptide Inhibitor MMI-0100 Protects Against Ischemia-Induced Systolic Dysfunction
  51. Influence of Ischemia-Reperfusion Injury on Cardiac Metabolism
  52. Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study
  53. The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination
  54. MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet
  55. Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet
  56. Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart Failure
  57. Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions
  58. Cancer cachexia update in head and neck cancer: Pathophysiology and treatment
  59. Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis
  60. Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis
  61. Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin
  62. Delayed Contrast Enhancement Imaging of a Murine Model for Ischemia Reperfusion with Carbon Nanotube Micro-CT
  63. Platelet Endothelial Cell Adhesion Molecule‐1 Mediates Endothelial‐Cardiomyocyte Communication and Regulates Cardiac Function
  64. Erratum to: MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
  65. MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition
  66. Genetics and Heart Failure: A Concise Guide for the Clinician
  67. Corrigendum to “Protein quality control, the ubiquitin proteasome system, and autophagy: When worlds collide” [J Mol Cell Cardiol 71 (2014) 1–2]
  68. Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans
  69. Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes
  70. The Hypermetabolic Giant: 18F-FDG avid Giant Cell Tumor identified on PET-CT
  71. The role of ubiquitin ligases in cardiac disease
  72. Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin
  73. Protein Quality Control, The Ubiquitin Proteosome System, and Authophagy: When Worlds Collide
  74. Muscle RING Finger-1 Promotes a Maladaptive Phenotype in Chronic Hypoxia-Induced Right Ventricular Remodeling
  75. MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
  76. Cancer cachexia update in head and neck cancer: Definitions and diagnostic features
  77. Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans
  78. SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease
  79. Regulation of Large Conductance Ca2+-activated K+(BK) Channel β1 Subunit Expression by Muscle RING Finger Protein 1 in Diabetic Vessels
  80. Precision-cut liver slices from diet-induced obese rats exposed to ethanol are susceptible to oxidative stress and increased fatty acid synthesis
  81. Muscle RING finger-1 attenuates IGF-I-dependent cardiomyocyte hypertrophy by inhibiting JNK signaling
  82. Dedication
  83. The Pathophysiology of Cardiac Hypertrophy and Heart Failure
  84. Cellular and Molecular Pathobiology of Cardiovascular Disease
  85. Reducing Laboratory Billing Defects Using Six Sigma Principles
  86. Targeting Angiogenesis and the Tumor Microenvironment
  87. Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease
  88. The Maladaptive Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir) on the Rat Heart
  89. Ephrin–Eph signaling as a potential therapeutic target for the treatment of myocardial infarction
  90. Proteotoxicity and Cardiac Dysfunction
  91. BMPER regulates cardiomyocyte size and vessel density in vivo
  92. Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise
  93. Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expressionin vivo
  94. Rib Fractures and Death from Deletion of Osteoblast βcatenin in Adult Mice Is Rescued by Corticosteroids
  95. Evaluation of digital images for identification and characterization of monoclonal immunoglobulins by immunofixation
  96. Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?
  97. Metabolic derangements in the gastrocnemius and the effect of Compound A therapy in a murine model of cancer cachexia
  98. Cancer cachexia’s metabolic signature in a murine model confirms a distinct entity
  99. Myosin Light Chain Phosphorylation Is Critical for Adaptation to Cardiac Stress
  100. Bedbugs in the 21st Century: The Reemergence of an Old Foe
  101. Bmper Inhibits Endothelial Expression of Inflammatory Adhesion Molecules and Protects Against Atherosclerosis
  102. Functional Redundancy of SWI/SNF Catalytic Subunits in Maintaining Vascular Endothelial Cells in the Adult Heart
  103. A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury–associated Skeletal Muscle Wasting
  104. Back to your heart: Ubiquitin proteasome system-regulated signal transduction
  105. Multiple Positive Sweat Chloride Tests in an Infant Asymptomatic for Cystic Fibrosis
  106. Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart
  107. Translational Cardiology
  108. Molecular and Translational Vascular Medicine
  109. Ubiquitylation - Dependent Signaling in Heart Disease
  110. Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair
  111. Albert Szent-Györgyi, MD, PhD
  112. The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation
  113. Kids in America: Newborn Screening for Cystic Fibrosis
  114. Dietary Salt Exacerbates Isoproterenol-Induced Cardiomyopathy in Rats
  115. Regulation of the calpain and ubiquitin-proteasome systems in a canine model of muscular dystrophy
  116. Tear Me Down: Role of Calpain in the Development of Cardiac Ventricular Hypertrophy
  117. Oral Resveratrol Therapy Inhibits Cancer-Induced Skeletal Muscle and Cardiac Atrophy In Vivo
  118. Testicular Mass in a 40-Year-Old Man
  119. Konrad Bloch, PhD
  120. Imaging of myocardial infarction using carbon nanotube micro-computed tomography and delayed contrast enhancement
  121. NF-κB Inhibition Protects against Tumor-Induced Cardiac Atrophy in Vivo
  122. The Ubiquitin Ligase MuRF1 Protects Against Cardiac Ischemia/Reperfusion Injury by Its Proteasome-Dependent Degradation of Phospho-c-Jun
  123. Self-Discovered Breast Mass in a 38-Year-Old Woman
  124. Merits of Non-Invasive Rat Models of Left Ventricular Heart Failure
  125. Tearin' Up My Heart: Proteolysis in the Cardiac Sarcomere
  126. Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy
  127. All the Little Pieces
  128. Unexpected Death in a Heart Transplant Recipient
  129. Regulation of AMPK by the Ubiquitin Proteasome System
  130. Selective Inhibition of NF-kappa-B with NBD Peptide Reduces Tumor- Induced Wasting in a Murine Model of Cancer Cachexia In vivo
  131. Edge of the world: practical considerations and a clinical perspective of next-generation sequencing for hereditary cardiac disease
  132. The therapeutic potential of heat shock proteins in cardiomyopathies due to mutations in cardiac structural proteins
  133. Episodic Fever and Neutropenia in a 22-Year-Old Male
  134. Atherosclerosis: Pathogenesis, Genetics and Experimental Models
  135. Percy Lavon Julian
  136. Unexpected Cause of Anemia in a 45-Year-Old Patient With Acute Lymphoblastic Leukemia
  137. Hold Me Tight: Role of the Heat Shock Protein Family of Chaperones in Cardiac Disease
  138. Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy
  139. Interference of Monoclonal Antibody Therapies with Serum Protein Electrophoresis Tests
  140. Autoimmune Hepatitis Induced by Syngeneic Liver Cytosolic Proteins Biotransformed by Alcohol Metabolites
  141. Urine Crystals in a 1-Year-Old Male
  142. Minireview: Won’t Get Fooled Again: The Nonmetabolic Roles of Peroxisome Proliferator-Activated Receptors (PPARs) in the Heart
  143. Sir Hans Adolf Krebs: Architect of Metabolic Cycles
  144. The Challenges and Complexities of Thyroid Hormone Replacement
  145. Evolving molecular diagnostics for familial cardiomyopathies: at the heart of it all
  146. Sent to Destroy: The Ubiquitin Proteasome System Regulates Cell Signaling and Protein Quality Control in Cardiovascular Development and Disease
  147. Ivar Asbjörn Følling
  148. Karl Landsteiner, MD
  149. Cardiac Muscle Ring Finger-1—Friend or Foe?
  150. Robert Guthrie, MD, PhD
  151. Seek and destroy: The ubiquitin-proteasome system in cardiac disease
  152. Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms
  153. Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers†
  154. Arne Tiselius
  155. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
  156. The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy
  157. Cardiac Muscle Ring Finger-1 Increases Susceptibility to Heart Failure In Vivo
  158. Familial hypertrophic cardiomyopathy: Basic concepts and future molecular diagnostics
  159. Recent Advances in the Detection of Prostate Cancer Using Epigenetic Markers in Commonly Collected Laboratory Samples
  160. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling
  161. Muscle ring finger 1 mediates cardiac atrophy in vivo
  162. The ubiquitin–proteasome system in cardiac dysfunction
  163. Inhibitory kappa B kinase-β is a target for specific nuclear factor kappa B-mediated delayed cardioprotection
  164. Build it up-Tear it down: protein quality control in the cardiac sarcomere
  165. Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde
  166. Metabolomic analysis of cancer cachexia reveals distinct lipid and glucose alterations
  167. Performance Comparison of Capillary and Agarose Gel Electrophoresis for the Identification and Characterization of Monoclonal Immunoglobulins
  168. You spin me round: MafBx/Atrogin-1 feeds forward on FOXO transcription factors (like a record)
  169. Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease
  170. Hypercalcemia in a 56-Year-Old Female
  171. Proteasome inhibition promotes regression of left ventricular hypertrophy
  172. Persistent Low Concentration of Human Chorionic Gonadotropin in a Nonpregnant Woman
  173. Blood bank management of sickle cell patients at comprehensive sickle cell centers
  174. Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
  175. The E3 Ligase MuRF1 Degrades Myosin Heavy Chain Protein in Dexamethasone-Treated Skeletal Muscle
  176. Characterization of a Model to Independently Study Regression of Ventricular Hypertrophy
  177. Chest Pain, Dyspnea, and Fatigue in a 57-Year-Old Man
  178. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury
  179. Proteasome Inhibition Attenuates Infarct Size and Preserves Cardiac Function in a Murine Model of Myocardial Ischemia-Reperfusion Injury
  180. Biclonal M-Spike in a 7-Year-Old Child
  181. The Bitter End: The Ubiquitin-Proteasome System and Cardiac Dysfunction
  182. Muscle Ring Finger 1, but not Muscle Ring Finger 2, Regulates Cardiac Hypertrophy In Vivo
  183. Bovine Cardiac Troponin T is Not Accurately Quantified with a Common Human Clinical Immunoassay
  184. Hepatosplenomegaly in an 8-Month-Old Child
  185. Endotoxin-Induced Cardiomyopathy and Systemic Inflammation in Mice Is Prevented by Aldose Reductase Inhibition
  186. Recurrent Nephrolithiasis in a 9-Year-Old Child
  187. Recurrent Nephrolithiasis in a 9-Year-Old Child
  188. Into the heart: The emerging role of the ubiquitin–proteasome system
  189. Immunofixation reveals an apparent α heavy chain caused by precipitation of fibrinogen with IgA antiserum
  190. Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol
  191. Scavenger Receptors on Sinusoidal Liver Endothelial Cells Are Involved in the Uptake of Aldehyde-Modified Proteins
  192. Effect of anemia on plasma concentrations of NT-proBNP
  193. Low Blast Count Myeloid Disorders With Auer Rods
  194. Neck Pain and Rash in an 18-Year-Old Student
  195. Aortic Valve Insufficiency in a 45-Year-Old Male
  196. Aortic Valve Insufficiency in a 45-Year-Old Male
  197. Gliosarcoma Cell Death After Radiosurgery in a Rat Model
  198. Tumor necrosis factor-α-induced caspase activation mediates endotoxin-related cardiac dysfunction*
  199. Obesity, macrophage migration inhibitory factor and weight loss
  200. Relapse of Thrombotic Thrombocytopenic Purpura: Is It a Continuum of Disease?
  201. Zinc-Induced Copper Deficiency
  202. Lipopolysaccharide Is a Cofactor for Malondialdehyde-Acetaldehyde Adduct???Mediated Cytokine/Chemokine Release by Rat Sinusoidal Liver Endothelial and Kupffer Cells
  203. Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock
  204. Macrophage migration inhibitory factor mediates late cardiac dysfunction after burn injury
  205. Refeeding Syndrome in a Severely Malnourished Child
  206. Refeeding Syndrome in a Severely Malnourished Child
  207. Malondialdehyde–acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage
  208. Periumbilical Rash in an Immunosuppressed Patient
  209. Macrophage Migration Inhibitory Factor (MIF) & Weight Loss
  210. Macrophage Migration Inhibitory Factor (MIF) & Weight Loss
  211. Nasal Discharge in a 50-Year-Old Woman
  212. Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity
  213. Proximal Extremity Weakness and Altered Mental Status
  214. Proximal Extremity Weakness and Altered Mental Status
  215. T cell proliferative responses to malondialdehyde–acetaldehyde haptenated protein are scavenger receptor mediated
  216. case study [hematology | microbiology]: Fever and Neutropenia in an Adolescent with Leukemia
  217. Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells
  218. Failure to Thrive in a 14-Month-Old Child
  219. Confounding Issues in the Diagnosis of Multiple Sclerosis: Lyme Disease Testing
  220. The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances
  221. case study [chemistry | histology]: Chronic Cough in an Older Female
  222. Autoimmune Hepatitis Type 2
  223. Chronic Myelogenous Leukemia
  224. Malondialdehyde–acetaldehyde-haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells
  225. In Vitro Exposure to Malondialdehyde-Acetaldehyde Adducted Protein Inhibits Cell Proliferation and Viability
  226. Adduction of Soluble Proteins with Malondialdehyde-Acetaldehyde (MAA) Induces Antibody Production and Enhances T-Cell Proliferation