All Stories

  1. Teaching an old dog new tricks: A new tool for protein tyrosine phosphatase substrate discovery

    Article • Journal of Biological Chemistry, May 2023, Elsevier

    Professor Anton M Bennett

  2. SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts

    Article • Diagnostics, March 2023, MDPI AG

    Professor Anton M Bennett

  3. Hepatocyte-specific miR-33 deletion attenuates NAFLD-NASH-HCC progression

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Professor Anton M Bennett

  4. Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?

    Article • The Annual Review of Pharmacology and Toxicology, January 2023, Annual Reviews

    Professor Anton M Bennett

  5. Abstract 2374: MAP Kinase Phosphatases as Nodal Signal Regulators in Health and Disease

    Article • Journal of Biological Chemistry, January 2023, Elsevier

    Professor Anton M Bennett

  6. Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors

    Article • European Journal of Medicinal Chemistry, December 2022, Elsevier

    Professor Anton M Bennett

  7. Abstract 225: Lack Of Map Kinase Phosphatase-5 In Macrophages Protects Ldlr-null Mice Against Atherogenesis

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2022, Wolters Kluwer Health

    Professor Anton M Bennett

  8. The seventh international RASopathies symposium: Pathways to a cure—expanding knowledge, enhancing research, and therapeutic discovery

    Article • American Journal of Medical Genetics Part A, March 2022, Wiley

    Professor Anton M Bennett

  9. An Assessment of the Therapeutic Landscape for the Treatment of Heart Disease in the RASopathies

    Article • Cardiovascular Drugs and Therapy, February 2022, Springer Science + Business Media

    Professor Anton M Bennett

  10. MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis

    Article • Frontiers in Immunology, December 2021, Frontiers

    Professor Anton M Bennett

  11. Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines

    Article • Cardiovascular Drugs and Therapy, March 2021, Springer Science + Business Media

    Professor Anton M Bennett

  12. An allosteric site on MKP5 reveals a strategy for small-molecule inhibition

    Article • Science Signaling, August 2020, American Association for the Advancement of Science

    Professor Anton M Bennett

  13. Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines

    Article • JCI Insight, August 2020, American Society for Clinical Investigation

    Professor Anton M Bennett

  14. The sixth international RASopathies symposium: Precision medicine—From promise to practice

    Article • American Journal of Medical Genetics Part A, December 2019, Wiley

    Professor Anton M Bennett

  15. O-GlcNAc transferase suppresses necroptosis and liver fibrosis

    Article • JCI Insight, November 2019, American Society for Clinical Investigation

    Professor Anton M Bennett

  16. Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis

    Article • AJP Lung Cellular and Molecular Physiology, November 2019, American Physiological Society

    Professor Anton M Bennett

  17. SH2 domain-containing Phosphatase-(SHP)-2 blunts fibrotic responses through regulation of fibroblast mitochondrial metabolism and autophagy

    Article • September 2019, European Respiratory Society (ERS)

    Professor Anton M Bennett

  18. O-GlcNAc transferase suppresses necroptosis and liver fibrosis

    Article • January 2019, Cold Spring Harbor Laboratory Press

    Professor Anton M Bennett

  19. Role of Mitogen activated-kinase (MAPK)-phosphatase (MKP)-5 in pulmonary fibrosis

    Article • September 2018, European Respiratory Society (ERS)

    Professor Anton M Bennett

  20. MKP-5 inhibition blunts fibrotic responses in-vitro and in-vivo through negative regulation of TGFB1-induced smad3-signalling

    Article • September 2018, European Respiratory Society (ERS)

    Professor Anton M Bennett

  21. Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function

    Article • Cell Reports, August 2018, Elsevier

    Professor Anton M Bennett

  22. DUSPs, twists and turns in the Journey to Vascular Inflammation

    Article • FEBS Journal, April 2018, Wiley

    Professor Anton M Bennett

  23. Skeletal Muscle–Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance

    Article • Diabetes, January 2018, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  24. Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism

    Article • Trends in Endocrinology and Metabolism, December 2017, Elsevier

    Professor Anton M Bennett

  25. Loss of MKP-5 promotes myofiber survival by activating STAT3/Bcl-2 signaling during regenerative myogenesis

    Article • Skeletal Muscle, October 2017, Springer Science + Business Media

    Professor Anton M Bennett

  26. Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation

    Article • Genes & Development, August 2017, Cold Spring Harbor Laboratory Press

    Professor Anton M Bennett

  27. MKP-5 Establishes Skeletal Muscle Metabolic Quiescence by Negatively Regulating MAPK-dependent Mitochondrial Function

    Article • Medicine & Science in Sports & Exercise, May 2017, Wolters Kluwer Health

    Professor Anton M Bennett

  28. A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis

    Article • Journal of Biological Chemistry, March 2017, Elsevier

    Professor Anton M Bennett

  29. SH2 Domain–Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis

    Article • American Review of Respiratory Disease, February 2017, American Thoracic Society

    Prof Naftali Kaminski, Professor Anton M Bennett

  30. Low-dose dasatinib rescues cardiac function in Noonan syndrome

    Article • JCI Insight, December 2016, American Society for Clinical Investigation

    Professor Anton M Bennett

  31. Hepatic inositol 1,4,5 trisphosphate receptor type 1 mediates fatty liver

    Article • Hepatology Communications, November 2016, Wiley

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  32. SH2 domain-containing phosphatase-SHP-2 is a novel anti-fibrotic regulator in pulmonary fibrosis

    Article • September 2016, European Respiratory Society (ERS)

    Professor Anton M Bennett

  33. Mining the function of protein tyrosine phosphatases in health and disease

    Article • Seminars in Cell and Developmental Biology, January 2015, Elsevier

    Professor Anton M Bennett

  34. Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II

    Article • AJP Endocrinology and Metabolism, December 2014, American Physiological Society

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  35. Hepatic Mitogen-Activated Protein Kinase Phosphatase 1 Selectively Regulates Glucose Metabolism and Energy Homeostasis

    Article • Molecular and Cellular Biology, October 2014, ASM Journals

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  36. Identification of Receptor Protein Tyrosine Phosphatases (RPTPs) as Regulators of Receptor Tyrosine Kinases (RTKs) Using an RPTP siRNA-RTK Substrate Screen

    Article • October 2014, Springer Science + Business Media

    Professor Anton M Bennett

  37. PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice

    Article • Molecular and Cellular Biology, May 2014, ASM Journals

    Professor Anton M Bennett

  38. The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs

    Article • Molecular Cell, October 2013, Elsevier

    Professor Anton M Bennett

  39. Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5

    Article • Journal of Clinical Investigation, April 2013, American Society for Clinical Investigation

    Professor Anton M Bennett

  40. Receptor Protein Tyrosine Phosphatase-Receptor Tyrosine Kinase Substrate Screen Identifies EphA2 as a Target for LAR in Cell Migration

    Article • Molecular and Cellular Biology, January 2013, ASM Journals

    Professor Anton M Bennett

  41. Novel Role for SHP-2 in Nutrient-Responsive Control of S6 Kinase 1 Signaling

    Article • Molecular and Cellular Biology, November 2012, ASM Journals

    Professor Anton M Bennett

  42. The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation

    Article • Molecular Biology of the Cell, November 2012, American Society for Cell Biology (ASCB)

    Professor Anton M Bennett

  43. O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability

    Article • Cell Metabolism, August 2012, Elsevier

    Professor Anton M Bennett

  44. Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions

    Article • Cellular and Molecular Life Sciences, June 2012, Springer Science + Business Media

    Professor Anton M Bennett

  45. Erratum: Corrigendum: Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

    Article • Nature Medicine, October 2011, Springer Science + Business Media

    Professor Anton M Bennett

  46. Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

    Article • Nature Medicine, August 2011, Springer Science + Business Media

    Professor Anton M Bennett

  47. Loss of Mitogen-activated Protein Kinase Phosphatase-1 Protects from Hepatic Steatosis by Repression of Cell Death-inducing DNA Fragmentation Factor A (DFFA)-like Effector C (CIDEC)/Fat-specific Protein 27

    Article • Journal of Biological Chemistry, June 2011, Elsevier

    Professor Anton M Bennett

  48. Mitogen-activated protein kinase phosphatase-1 – a potential therapeutic target in metabolic disease

    Article • Expert Opinion on Therapeutic Targets, November 2010, Informa Healthcare

    Professor Anton M Bennett

  49. The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching

    Article • Nature Neuroscience, October 2010, Springer Science + Business Media

    Professor Anton M Bennett

  50. Analysis of Protein Tyrosine Phosphatases and Substrates

    Article • Current Protocols in Molecular Biology, July 2010, Wiley

    Professor Anton M Bennett

  51. MAP kinase phosphatase‐1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy

    Article • The FASEB Journal, April 2010, Wiley

    Professor Anton M Bennett

  52. MAP kinase phosphatase-1 - a new player at the nexus between sarcopenia and metabolic disease

    Article • Aging, April 2010, Impact Journals, LLC

    Professor Anton M Bennett

  53. MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice

    Article • Journal of Clinical Investigation, December 2009, American Society for Clinical Investigation

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  54. Physiological Signaling Specificity by Protein Tyrosine Phosphatases

    Article • Physiology, October 2009, American Physiological Society

    Professor Anton M Bennett

  55. Role of MKP-1 in Osteoclasts and Bone Homeostasis

    Article • American Journal Of Pathology, October 2009, Elsevier

    Professor Anton M Bennett

  56. JAK2 and SHP2 Reciprocally Regulate Tyrosine Phosphorylation and Stability of Proapoptotic Protein ASK1

    Article • Journal of Biological Chemistry, May 2009, Elsevier

    Professor Anton M Bennett

  57. Noonan Syndrome-associated SHP-2/Ptpn11 Mutants Enhance SIRPα and PZR Tyrosyl Phosphorylation and Promote Adhesion-mediated ERK Activation

    Article • Journal of Biological Chemistry, May 2008, Elsevier

    Professor Anton M Bennett

  58. A Novel Role of Vascular Endothelial Cadherin in Modulating c-Src Activation and Downstream Signaling of Vascular Endothelial Growth Factor

    Article • Journal of Biological Chemistry, March 2008, Elsevier

    Professor Anton M Bennett

  59. c-Met Must Translocate to the Nucleus to Initiate Calcium Signals

    Article • Journal of Biological Chemistry, February 2008, Elsevier

    Professor Anton M Bennett

  60. Nucleoplasmic Calcium Is Required for Cell Proliferation

    Article • Journal of Biological Chemistry, June 2007, Elsevier

    Professor Anton M Bennett

  61. SHP-2 Regulates Cell Growth by Controlling the mTOR/S6 Kinase 1 Pathway

    Article • Journal of Biological Chemistry, March 2007, Elsevier

    Professor Anton M Bennett

  62. Protein tyrosine phosphatase function: the substrate perspective

    Article • Biochemical Journal, January 2007, Portland Press Ltd.

    Professor Anton M Bennett

  63. Mitogen-activated protein kinase phosphatase-1 (MKP-1): a critical regulator of innate immune responses

    Article • Journal of Organ Dysfunction, January 2007, Taylor & Francis

    Professor Anton M Bennett

  64. SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth

    Article • The Journal of Cell Biology, October 2006, Rockefeller University Press

    Professor Anton M Bennett

  65. Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity

    Article • Cell Metabolism, July 2006, Elsevier

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor Anton M Bennett

  66. Calcium signaling in the nucleusThis paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell.

    Article • Canadian Journal of Physiology and Pharmacology, March 2006, Canadian Science Publishing

    Professor Anton M Bennett

  67. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

    Article • Proceedings of the National Academy of Sciences, February 2006, Proceedings of the National Academy of Sciences

    Professor Anton M Bennett

  68. Gain-of-function/Noonan syndrome SHP-2/ Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling

    Article • Proceedings of the National Academy of Sciences, February 2006, Proceedings of the National Academy of Sciences

    Professor Anton M Bennett

  69. Insulin Resistance in Heart and Liver Due to PPARα Overexpression

    Article • Diabetes, September 2005, American Diabetes Association

    Professor Anton M Bennett

  70. The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase Phosphatase 1 Directs Nuclear Targeting and Serum Response Element Transcriptional Regulation

    Article • Molecular and Cellular Biology, June 2005, ASM Journals

    Professor Anton M Bennett

  71. Essential Role for Mitogen-activated Protein (MAP) Kinase Phosphatase-1 in Stress-responsive MAP Kinase and Cell Survival Signaling

    Article • Journal of Biological Chemistry, April 2005, Elsevier

    Professor Anton M Bennett

  72. Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

    Article • Journal of Clinical Investigation, March 2005, American Society for Clinical Investigation

    Professor Anton M Bennett

  73. Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

    Article • Journal of Clinical Investigation, November 2004, American Society for Clinical Investigation

    Professor Anton M Bennett

  74. SHP-2 Positively Regulates Myogenesis by Coupling to the Rho GTPase Signaling Pathway

    Article • Molecular and Cellular Biology, June 2004, ASM Journals

    Professor Anton M Bennett

  75. The Major Vault Protein Is a Novel Substrate for the Tyrosine Phosphatase SHP-2 and Scaffold Protein in Epidermal Growth Factor Signaling

    Article • Journal of Biological Chemistry, May 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Erik A.C. Wiemer, Professor Anton M Bennett

  76. SHP-2 regulates the phosphatidylinositide 3?-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis

    Article • Journal of Cellular Physiology, January 2004, Wiley

    Professor Anton M Bennett

  77. Nuclear and cytosolic calcium are regulated independently

    Article • Proceedings of the National Academy of Sciences, February 2003, Proceedings of the National Academy of Sciences

    Professor Anton M Bennett

  78. Epidermal Growth Factor-mediated Activation of the ETS Domain Transcription Factor Elk-1 Requires Nuclear Calcium

    Article • Journal of Biological Chemistry, July 2002, Elsevier

    Professor Anton M Bennett

  79. Role of SHP-2 in Fibroblast Growth Factor Receptor-Mediated Suppression of Myogenesis in C2C12 Myoblasts

    Article • Molecular and Cellular Biology, June 2002, ASM Journals

    Professor Anton M Bennett

  80. Differential Role of β1Cand β1AIntegrin Cytoplasmic Variants in Modulating Focal Adhesion Kinase, Protein Kinase B/AKT, and Ras/Mitogen-activated Protein Kinase Pathways

    Article • Molecular Biology of the Cell, July 2000, American Society for Cell Biology (ASCB)

    Professor Anton M Bennett

  81. Epidermal Growth Factor Receptor and the Adaptor Protein p52Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase

    Article • Molecular and Cellular Biology, March 1998, ASM Journals

    Professor Anton M Bennett

  82. Regulation of Distinct Stages of Skeletal Muscle Differentiation by Mitogen-Activated Protein Kinases

    Article • Science, November 1997, American Association for the Advancement of Science

    Professor Anton M Bennett

  83. Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression.

    Article • Molecular and Cellular Biology, March 1996, ASM Journals

    Professor Anton M Bennett

  84. Different Signaling Roles of SHPTP2 in Insulin-induced GLUT1 Expression and GLUT4 Translocation

    Article • Journal of Biological Chemistry, June 1995, Elsevier

    Professor Anton M Bennett

  85. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

    Article • Proceedings of the National Academy of Sciences, July 1994, Proceedings of the National Academy of Sciences

    Professor Anton M Bennett

  86. Calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate

    Article • Biochemical Pharmacology, December 1993, Elsevier

    Professor Anton M Bennett

  87. Alteration of rat liver endoplasmic reticulum Ca2+-ATPase thiol integrity by ciprofibrate, a peroxisome proliferator

    Article • Biochemical Pharmacology, April 1993, Elsevier

    Professor Anton M Bennett

  88. Reduction of rat liver endoplasmic reticulum Ca2+-ATPase activity and mobilization of hepatic intracellular calcium by ciprofibrate, a peroxisome proliferator

    Article • Biochemical Pharmacology, February 1992, Elsevier

    Professor Anton M Bennett