All Stories

  1. The hallmarks of skeletal muscle health

    Article • Nature Metabolism, August 2026, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  2. The E3 ligase HECTD1 controls skeletal muscle sarcomere and mitochondrial integrity

    Article • March 2026, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  3. Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity

    Article • Cell Reports, December 2025, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  4. Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers

    Article • Skeletal Muscle, March 2025, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  5. Constitutive loss of kynurenine-3-monooxygenase changes circulating kynurenine metabolites without affecting systemic energy metabolism

    Article • AJP Endocrinology and Metabolism, February 2025, American Physiological Society

    Professor of Pharmacology Jorge Lira Ruas

  6. The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

    Article • Nature Communications, November 2024, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  7. Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Professor of Pharmacology Jorge Lira Ruas

  8. A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

    Article • eLife, September 2024, eLife

    Professor of Pharmacology Jorge Lira Ruas

  9. Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling

    Article • Proceedings of the National Academy of Sciences, August 2024, Proceedings of the National Academy of Sciences

    Professor of Pharmacology Jorge Lira Ruas

  10. Senescence detection using reflected light

    Article • Aging Cell, August 2024, Wiley

    Professor of Pharmacology Jorge Lira Ruas

  11. Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition

    Article • Molecular Metabolism, April 2024, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  12. Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration

    Article • European Journal of Cell Biology, March 2024, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  13. NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, February 2024, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  14. Multivalent insulin receptor activation using insulin–DNA origami nanostructures

    Article • Nature Physics, October 2023, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  15. Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration

    Article • June 2023, Cold Spring Harbor Laboratory Press

    Professor of Pharmacology Jorge Lira Ruas

  16. Improving human mesenchymal stem cell-derived hepatic cell energy metabolism by manipulating glucose homeostasis and glucocorticoid signaling

    Article • Frontiers in Endocrinology, January 2023, Frontiers

    Professor of Pharmacology Jorge Lira Ruas

  17. Epiblast-like stem cells established by Wnt/β-catenin signaling manifest distinct features of formative pluripotency and germline competence

    Article • Cell Reports, January 2023, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  18. PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes

    Article • Cells, September 2022, MDPI AG

    Professor of Pharmacology Jorge Lira Ruas

  19. Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias

    Article • Journal of Biological Chemistry, September 2022, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  20. Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

    Article • BMC Biology, July 2022, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  21. Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome

    Article • Nature Metabolism, June 2022, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  22. SnapShot: Regulation and biology of PGC-1α

    Article • Cell, April 2022, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  23. HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes

    Article • Science Translational Medicine, March 2022, American Association for the Advancement of Science

    Professor of Pharmacology Jorge Lira Ruas

  24. Changes in plasma concentration of kynurenine following intake of branched-chain amino acids are not caused by alterations in muscle kynurenine metabolism

    Article • AJP Cell Physiology, January 2022, American Physiological Society

    Professor of Pharmacology Jorge Lira Ruas

  25. Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force

    Article • The FASEB Journal, November 2021, Wiley

    Professor of Pharmacology Jorge Lira Ruas

  26. Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

    Article • Cell Metabolism, November 2021, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  27. Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

    Article • Nature Communications, October 2021, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  28. The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?

    Article • Trends in Molecular Medicine, October 2021, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  29. Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans

    Article • Metabolites, August 2021, MDPI AG

    Professor of Pharmacology Jorge Lira Ruas

  30. PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice

    Article • Cardiovascular Research, June 2021, Oxford University Press (OUP)

    Professor of Pharmacology Jorge Lira Ruas

  31. Effects of topological constraints on the alignment and maturation of multinucleated myotubes

    Article • Biotechnology and Bioengineering, April 2021, Wiley

    Professor of Pharmacology Jorge Lira Ruas

  32. Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

    Article • BMC Biology, March 2021, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  33. High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles

    Article • Scientific Reports, March 2021, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  34. Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

    Article • Nature Communications, February 2021, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  35. Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats

    Article • Frontiers in Endocrinology, October 2020, Frontiers

    Professor of Pharmacology Jorge Lira Ruas

  36. Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes

    Article • Communications Biology, September 2020, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  37. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN

    Article • Molecular Metabolism, September 2020, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  38. A qualitative study—Patient experience of tactile massage after stroke

    Article • Nursing Open, May 2020, Wiley

    Professor of Pharmacology Jorge Lira Ruas

  39. The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain

    Article • AJP Cell Physiology, May 2020, American Physiological Society

    Professor of Pharmacology Jorge Lira Ruas

  40. Exercised cytokines promote endurance

    Article • Science, May 2020, American Association for the Advancement of Science

    Professor of Pharmacology Jorge Lira Ruas

  41. PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

    Article • Molecular Metabolism, April 2020, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  42. Modeling the transport of nuclear proteins along single skeletal muscle cells

    Article • Proceedings of the National Academy of Sciences, January 2020, Proceedings of the National Academy of Sciences

    Professor of Pharmacology Jorge Lira Ruas

  43. Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status

    Article • Redox Biology, January 2020, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  44. LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force

    Article • Skeletal Muscle, October 2019, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  45. Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

    Article • Nature Communications, June 2019, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  46. Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice

    Article • Physiological Genomics, December 2018, American Physiological Society

    Professor of Pharmacology Jorge Lira Ruas

  47. The weight of nutrients: kynurenine metabolites in obesity and exercise

    Article • Journal of Internal Medicine, September 2018, Wiley

    Professor of Pharmacology Jorge Lira Ruas

  48. Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors

    Article • EMBO Molecular Medicine, July 2018, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  49. Heart specific PGC-1α deletion identifies metabolome of cardiac restricted metabolic heart failure

    Article • Cardiovascular Research, June 2018, Oxford University Press (OUP)

    Professor of Pharmacology Jorge Lira Ruas

  50. Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration

    Article • Molecular Metabolism, March 2018, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  51. Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

    Article • Cell Metabolism, February 2018, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  52. Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation

    Article • Molecular Metabolism, January 2018, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  53. Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

    Article • Science, July 2017, American Association for the Advancement of Science

    Professor of Pharmacology Jorge Lira Ruas

  54. Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

    Article • Cell Reports, January 2017, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  55. Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling

    Article • The Journal of Physiology, December 2016, Wiley

    Dr Seppo Yla-Herttuala, Professor of Pharmacology Jorge Lira Ruas

  56. The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells

    Article • Archives of Toxicology, December 2016, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  57. Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk

    Article • Scientific Reports, August 2016, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  58. The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

    Article • Science Translational Medicine, August 2016, American Association for the Advancement of Science

    Professor Lars Larsson, Professor of Pharmacology Jorge Lira Ruas

  59. Targeting mitochondrial mRNA translation to tackle obesity-induced insulin resistance: thumbs up for exercise

    Article • Acta Physiologica, July 2016, Wiley

    Professor of Pharmacology Jorge Lira Ruas

  60. Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes

    Article • Journal of Biological Chemistry, July 2016, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  61. Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans

    Article • AJP Cell Physiology, May 2016, American Physiological Society

    Professor of Pharmacology Jorge Lira Ruas

  62. Mechano-signalling pathways in an experimental intensive critical illness myopathy model

    Article • The Journal of Physiology, April 2016, Wiley

    Professor Lars Larsson, Professor of Pharmacology Jorge Lira Ruas

  63. Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle

    Article • Acta Neuropsychiatrica, February 2016, Cambridge University Press

    Professor of Pharmacology Jorge Lira Ruas

  64. Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

    Article • Molecular Metabolism, December 2015, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  65. Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca 2+ leak after one session of high-intensity interval exercise

    Article • Proceedings of the National Academy of Sciences, November 2015, Proceedings of the National Academy of Sciences

    Professor of Pharmacology Jorge Lira Ruas

  66. The hitchhiker’s guide to PGC-1α isoform structure and biological functions

    Article • Diabetologia, June 2015, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  67. Intercellular: local and systemic actions of skeletal muscle PGC-1s

    Article • Trends in Endocrinology and Metabolism, June 2015, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  68. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

    Article • Proceedings of the National Academy of Sciences, October 2014, Proceedings of the National Academy of Sciences

    Professor of Pharmacology Jorge Lira Ruas

  69. Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

    Article • Cell, September 2014, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  70. Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

    Article • Cell, June 2014, Elsevier

    John Hawley, Professor of Pharmacology Jorge Lira Ruas

  71. Loss ofPgc-1αexpression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

    Article • AJP Endocrinology and Metabolism, January 2014, American Physiological Society

    Professor of Pharmacology Jorge Lira Ruas

  72. Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways

    Article • Molecular Cancer, January 2014, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  73. A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

    Article • Cell, December 2012, Elsevier

    Dr Jennifer L Estall, Professor of Pharmacology Jorge Lira Ruas

  74. Image Processing Assisted Algorithms for Optical Projection Tomography

    Article • IEEE Transactions on Medical Imaging, January 2012, Institute of Electrical & Electronics Engineers (IEEE)

    Professor of Pharmacology Jorge Lira Ruas

  75. Separation of the gluconeogenic and mitochondrial functions of PGC-1α through S6 kinase

    Article • Genes & Development, June 2011, Cold Spring Harbor Laboratory Press

    Professor of Pharmacology Jorge Lira Ruas

  76. The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

    Article • Cell Metabolism, February 2011, Elsevier

    Dr Jennifer L Estall, Professor of Pharmacology Jorge Lira Ruas

  77. PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types

    Article • Proceedings of the National Academy of Sciences, November 2010, Proceedings of the National Academy of Sciences

    Professor of Pharmacology Jorge Lira Ruas

  78. Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons

    Article • Development, October 2010, The Company of Biologists

    Professor of Pharmacology Jorge Lira Ruas

  79. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

    Article • Nature, July 2010, Nature

    Dr Jennifer L Estall, Professor of Pharmacology Jorge Lira Ruas

  80. Complex Regulation of the Transactivation Function of Hypoxia-inducible Factor-1α by Direct Interaction with Two Distinct Domains of the CREB-binding Protein/p300

    Article • Journal of Biological Chemistry, January 2010, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  81. PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Professor of Pharmacology Jorge Lira Ruas

  82. The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Professor of Pharmacology Jorge Lira Ruas

  83. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

    Article • Genes & Development, May 2008, Cold Spring Harbor Laboratory Press

    Professor of Pharmacology Jorge Lira Ruas

  84. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

    Article • Proceedings of the National Academy of Sciences, March 2008, Proceedings of the National Academy of Sciences

    Professor of Pharmacology Jorge Lira Ruas

  85. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

    Article • Nature, February 2008, Springer Science + Business Media

    Professor of Pharmacology Jorge Lira Ruas

  86. Modulation of vascular gene expression by hypoxia

    Article • Current Opinion in Lipidology, October 2007, Wolters Kluwer Health

    Professor of Pharmacology Jorge Lira Ruas

  87. Hypoxia inducible factor regulates the cardiac expression and secretion of apelin

    Article • The FASEB Journal, March 2007, Wiley

    Professor of Pharmacology Jorge Lira Ruas

  88. Cell-Type-Specific Regulation of Degradation of Hypoxia-Inducible Factor 1α: Role of Subcellular Compartmentalization

    Article • Molecular and Cellular Biology, June 2006, ASM Journals

    Professor of Pharmacology Jorge Lira Ruas

  89. Hypoxia Requires Notch Signaling to Maintain the Undifferentiated Cell State

    Article • Developmental Cell, November 2005, Elsevier

    Maria Bondesson, Professor of Pharmacology Jorge Lira Ruas

  90. Hypoxia-dependent activation of HIF into a transcriptional regulator

    Article • Seminars in Cell and Developmental Biology, August 2005, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  91. Identification of Residues Critical for Regulation of Protein Stability and the Transactivation Function of the Hypoxia-inducible Factor-1α by the von Hippel-Lindau Tumor Suppressor Gene Product

    Article • Journal of Biological Chemistry, February 2003, Elsevier

    Professor of Pharmacology Jorge Lira Ruas

  92. Functional Analysis of Hypoxia-inducible Factor-1α-mediated Transactivation

    Article • Journal of Biological Chemistry, October 2002, Elsevier

    Professor of Pharmacology Jorge Lira Ruas