All Stories

  1. Impaired age-associated mitochondrial translation is mitigated by exercise and PGC-1α

    Article • Proceedings of the National Academy of Sciences, August 2023, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  2. Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice

    Article • Nitric Oxide, July 2018, Elsevier

    Professor Christoph Handschin

  3. Pathologies caused by aging of the heart can be reduced by the protein PGC-1alpha

    Article • Frontiers in Physiology, March 2018, Frontiers

    Professor Christoph Handschin

  4. Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance

    Article • Scientific Reports, January 2018, Nature

    Professor Christoph Handschin

  5. Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma

    Article • Stem Cells International, January 2018, Hindawi Publishing Corporation

    Professor Christoph Handschin, Professor Simon M Ametamey

  6. Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls

    Article • Biochemical Pharmacology, January 2018, Elsevier

    Professor Christoph Handschin

  7. Faculty of 1000 evaluation for Cellular and molecular anatomy of the human neuromuscular junction.

    Article • December 2017, Faculty of 1000, Ltd.

    Professor Christoph Handschin

  8. Faculty of 1000 evaluation for Proprotein convertase furin regulates osteocalcin and bone endocrine function.

    Article • November 2017, Faculty of 1000, Ltd.

    Professor Christoph Handschin

  9. Faculty of 1000 evaluation for MyD88 promotes myoblast fusion in a cell-autonomous manner.

    Article • November 2017, Faculty of 1000, Ltd.

    Professor Christoph Handschin

  10. Faculty of 1000 evaluation for Multigenerational silencing dynamics control cell aging.

    Article • November 2017, Faculty of 1000, Ltd.

    Professor Christoph Handschin

  11. Faculty of 1000 evaluation for Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.

    Article • November 2017, Faculty of 1000, Ltd.

    Professor Christoph Handschin

  12. PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice

    Article • Aging Cell, October 2017, Wiley

    Professor Christoph Handschin

  13. Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Early Skeletal Muscle Tissue Formation

    Article • Cell Transplantation, June 2017, SAGE Publications

    Professor Christoph Handschin

  14. Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice

    Article • AJP Endocrinology and Metabolism, May 2017, American Physiological Society

    Professor Christoph Handschin

  15. Coregulator-mediated control of skeletal muscle plasticity – A mini-review

    Article • Biochimie, May 2017, Elsevier

    Professor Christoph Handschin

  16. Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations

    Article • Cold Spring Harbor Perspectives in Medicine, February 2017, Cold Spring Harbor Laboratory Press

    Professor Christoph Handschin

  17. Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP

    Article • Scientific Reports, January 2017, Nature

    Professor Christoph Handschin

  18. Plasticity of the Muscle Stem Cell Microenvironment

    Article • January 2017, Springer Science + Business Media

    Professor Christoph Handschin

  19. Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle

    Article • January 2017, Springer Science + Business Media

    Professor Christoph Handschin

  20. Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres

    Article • Journal of Cellular Physiology, December 2016, Wiley

    Professor Christoph Handschin

  21. Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche

    Article • Skeletal Muscle, December 2016, Springer Science + Business Media

    Professor Christoph Handschin

  22. PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle

    Article • Skeletal Muscle, November 2016, Springer Science + Business Media

    Professor Christoph Handschin

  23. Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice

    Article • PLoS ONE, July 2016, PLOS

    Professor Christoph Handschin

  24. PGC-1α expression in murine AgRP neurons regulates food intake and energy balance

    Article • Molecular Metabolism, July 2016, Elsevier

    Professor Christoph Handschin

  25. The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells

    Article • Molecular Endocrinology, July 2016, Endocrine Society

    Professor Christoph Handschin

  26. Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering

    Article • Journal of Nuclear Medicine, May 2016, Society of Nuclear Medicine

    Professor Christoph Handschin

  27. Magnetic stimulation supports muscle and nerve regeneration after trauma in mice

    Article • Muscle & Nerve, March 2016, Wiley

    Professor Christoph Handschin

  28. Skeletal muscle PGC-1  modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice

    Article • The FASEB Journal, February 2016, Federation of American Societies For Experimental Biology (FASEB)

    Professor Christoph Handschin

  29. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

    Article • EMBO Molecular Medicine, January 2016, EMBO

    Professor Christoph Handschin

  30. Caloric restriction and exercise “mimetics’’: Ready for prime time?

    Article • Pharmacological Research, January 2016, Elsevier

    Professor Christoph Handschin

  31. Körperliche Aktivität und PGC-1alpha bei Entzündung und chronischen Krankheiten

    Article • Deutsche Zeitschrift für Sportmedizin/German Journal of Sports Medicine, December 2015, Deutsche Zeitschrift Fur Sportmedizin

    Professor Christoph Handschin

  32. Complex Coordination of Cell Plasticity by a PGC-1α-controlled Transcriptional Network in Skeletal Muscle

    Article • Frontiers in Physiology, November 2015, Frontiers

    Professor Christoph Handschin

  33. Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

    Article • Bone, November 2015, Elsevier

    Professor Christoph Handschin

  34. The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo

    Article • Biochemical and Biophysical Research Communications, August 2015, Elsevier

    Professor Christoph Handschin

  35. Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α)

    Article • Journal of Biological Chemistry, May 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christoph Handschin

  36. External physical and biochemical stimulation to enhance skeletal muscle bioengineering

    Article • Advanced Drug Delivery Reviews, March 2015, Elsevier

    Professor Christoph Handschin

  37. PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects

    Article • Experimental Biology and Medicine, November 2014, SAGE Publications

    Professor Christoph Handschin

  38. The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet

    Article • Diabetologia, August 2014, Springer Science + Business Media

    Professor Christoph Handschin

  39. Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases

    Article • Drug Discovery Today, July 2014, Elsevier

    Professor Christoph Handschin

  40. Transcriptional Network Analysis in Muscle Reveals AP-1 as a Partner of PGC-1α in the Regulation of the Hypoxic Gene Program

    Article • Molecular and Cellular Biology, June 2014, ASM Journals

    Professor Christoph Handschin, Daan de Groot

  41. MicroRNAs Emerge as Modulators of NAD+-Dependent Energy Metabolism in Skeletal Muscle

    Article • Diabetes, April 2014, American Diabetes Association

    Professor Christoph Handschin

  42. Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α

    Article • Nature Communications, April 2014, Nature

    Professor Christoph Handschin

  43. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice

    Article • Zeitschrift für Ernährungswissenschaft, December 2013, Springer Science + Business Media

    Professor Christoph Handschin

  44. The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling

    Article • Proceedings of the National Academy of Sciences, November 2013, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  45. Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology

    Article • Seminars in Immunopathology, November 2013, Springer Science + Business Media

    Professor Christoph Handschin

  46. New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases

    Article • Drug Discovery Today Disease Models, June 2013, Elsevier

    Professor Christoph Handschin

  47. Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A

    Article • Proceedings of the National Academy of Sciences, May 2013, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  48. Myoblasts Inhibit Prostate Cancer Growth by Paracrine Secretion of Tumor Necrosis Factor-α

    Article • The Journal of Urology, May 2013, Elsevier

    Professor Christoph Handschin

  49. The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells.

    Article • Journal of Biological Chemistry, March 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christoph Handschin

  50. Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy

    Article • Skeletal Muscle, January 2013, Springer Science + Business Media

    Professor Christoph Handschin

  51. The Peroxisome Proliferator-activated Receptor γ Coactivator 1α/β (PGC-1) Coactivators Repress the Transcriptional Activity of NF-κB in Skeletal Muscle Cells

    Article • Journal of Biological Chemistry, December 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christoph Handschin

  52. PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner

    Article • Diabetes, October 2012, American Diabetes Association

    Professor Christoph Handschin

  53. The Corepressor NCoR1 Antagonizes PGC-1  and Estrogen-Related Receptor   in the Regulation of Skeletal Muscle Function and Oxidative Metabolism

    Article • Molecular and Cellular Biology, October 2012, ASM Journals

    Professor Christoph Handschin

  54. Warum reagiert mein Patient anders auf dieses Medikament?

    Article • Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, May 2012, EMH Swiss Medical Publishers, Ltd.

    Professor Christoph Handschin

  55. Pourquoi mon patient réagit-il différemment à ce médicament?

    Article • Forum Médical Suisse ‒ Swiss Medical Forum, May 2012, EMH Swiss Medical Publishers, Ltd.

    Professor Christoph Handschin

  56. A Functional Motor Unit in the Culture Dish: Co-culture of Spinal Cord Explants and Muscle Cells

    Article • Journal of Visualized Experiments, April 2012, MyJove Corporation

    Professor Christoph Handschin

  57. PGC-1α Determines Light Damage Susceptibility of the Murine Retina

    Article • PLoS ONE, February 2012, PLOS

    Professor Christoph Handschin

  58. PGC-1α and exercise in the control of body weight

    Article • International Journal of Obesity, January 2012, Nature

    Professor Christoph Handschin

  59. Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type

    Article • AJP Cell Physiology, January 2012, American Physiological Society

    Professor Christoph Handschin

  60. Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

    Article • Proceedings of the National Academy of Sciences, December 2011, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  61. Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) improves skeletal muscle mitochondrial function and insulin sensitivity

    Article • Diabetologia, April 2011, Springer Science + Business Media

    Professor Christoph Handschin

  62. Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity

    Article • Biochemical and Biophysical Research Communications, April 2011, Elsevier

    Professor Christoph Handschin

  63. PGC-1 Coactivators and the Regulation of Skeletal Muscle Fiber-Type Determination

    Article • Cell Metabolism, April 2011, Elsevier

    Professor Christoph Handschin

  64. PGC-1α and Myokines in the Aging Muscle – A Mini-Review

    Article • Gerontology, January 2011, Karger Publishers

    Professor Christoph Handschin

  65. ApoE−/− PGC-1α−/− Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis

    Article • PLoS ONE, October 2010, PLOS

    Professor Christoph Handschin

  66. Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Promotes Skeletal Muscle Lipid Refuelingin Vivoby Activatingde NovoLipogenesis and the Pentose Phosphate Pathway

    Article • Journal of Biological Chemistry, August 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christoph Handschin

  67. Electric Pulse Stimulation of Cultured Murine Muscle Cells Reproduces Gene Expression Changes of Trained Mouse Muscle

    Article • PLoS ONE, June 2010, PLOS

    Professor Christoph Handschin

  68. Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor γ coactivator 1α

    Article • Journal of Receptors and Signal Transduction, February 2010, Taylor & Francis

    Professor Christoph Handschin

  69. Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation

    Article • Clinical and Experimental Pharmacology and Physiology, December 2009, Wiley

    Professor Christoph Handschin

  70. The biology of PGC-1α and its therapeutic potential

    Article • Trends in Pharmacological Sciences, June 2009, Elsevier

    Professor Christoph Handschin

  71. Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

    Article • Proceedings of the National Academy of Sciences, December 2008, Proceedings of the National Academy of Sciences

    Dr Roberto Codella, Professor Christoph Handschin, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  72. A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells

    Article • Blood, October 2008, American Society of Hematology

    Professor Christoph Handschin

  73. The role of exercise and PGC1α in inflammation and chronic disease

    Article • Nature, July 2008, Nature

    Professor Christoph Handschin

  74. Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

    Article • Journal of Clinical Investigation, November 2007, American Society for Clinical Investigation

    Professor Christoph Handschin, George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman

  75. Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals

    Article • Journal of Biological Chemistry, August 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christoph Handschin

  76. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

    Article • Proceedings of the National Academy of Sciences, July 2007, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  77. A fundamental system of cellular energy homeostasis regulated by PGC-1α

    Article • Proceedings of the National Academy of Sciences, May 2007, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  78. PGC-1  regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy

    Article • Genes & Development, April 2007, Cold Spring Harbor Laboratory Press

    Professor Christoph Handschin

  79. RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted), Inflammation, Obesity, and the Metabolic Syndrome

    Article • Circulation, February 2007, Wolters Kluwer Health

    Professor Christoph Handschin

  80. Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism

    Article • Endocrine Reviews, December 2006, Endocrine Society

    Professor Christoph Handschin

  81. PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

    Article • Proceedings of the National Academy of Sciences, October 2006, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  82. Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

    Article • Cell, October 2006, Elsevier

    Professor Christoph Handschin

  83. Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells

    Article • Proceedings of the National Academy of Sciences, September 2006, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  84. Partnership of PGC-1α and HNF4α in the Regulation of Lipoprotein Metabolism

    Article • Journal of Biological Chemistry, March 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christoph Handschin

  85. Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α

    Article • Cell, August 2005, Elsevier

    Professor Christoph Handschin

  86. Correction

    Article • Proceedings of the National Academy of Sciences, July 2005, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  87. LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver

    Article • Journal of Lipid Research, June 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christoph Handschin

  88. Metabolic control through the PGC-1 family of transcription coactivators

    Article • Cell Metabolism, June 2005, Elsevier

    Professor Christoph Handschin

  89. Estrogen-related receptor α (ERRα): A novel target in type 2 diabetes

    Article • Drug Discovery Today Therapeutic Strategies, June 2005, Elsevier

    Professor Christoph Handschin

  90. Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

    Article • Cell Metabolism, April 2005, Elsevier

    Professor Christoph Handschin

  91. Species-specific mechanisms for cholesterol 7α-hydroxylase (CYP7A1) regulation by drugs and bile acids

    Article • Archives of Biochemistry and Biophysics, February 2005, Elsevier

    Professor Christoph Handschin

  92. Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP

    Article • Cell, January 2005, Elsevier

    Professor Christoph Handschin

  93. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR

    Article • Archives of Biochemistry and Biophysics, January 2005, Elsevier

    Professor Christoph Handschin

  94. Identification of the xenosensors regulating human 5-aminolevulinate synthase

    Article • Proceedings of the National Academy of Sciences, June 2004, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  95. Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

    Article • Proceedings of the National Academy of Sciences, April 2004, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  96. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1 : modulation by p38 MAPK

    Article • Genes & Development, February 2004, Cold Spring Harbor Laboratory Press

    Professor Christoph Handschin

  97. Article • Nuclear Receptor, January 2004, Springer Science + Business Media

    Professor Christoph Handschin

  98. Induction of Drug Metabolism: The Role of Nuclear Receptors

    Article • Pharmacological Reviews, December 2003, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Christoph Handschin

  99. Molecular cloning and characterization of chicken orphan nuclear receptor cTR21

    Article • General and Comparative Endocrinology, July 2003, Elsevier

    Professor Christoph Handschin

  100. An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle

    Article • Proceedings of the National Academy of Sciences, May 2003, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  101. Cholesterol and Bile Acids Regulate Xenosensor Signaling in Drug-mediated Induction of Cytochromes P450

    Article • Journal of Biological Chemistry, June 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christoph Handschin

  102. NUBIScan, an in Silico Approach for Prediction of Nuclear Receptor Response Elements

    Article • Molecular Endocrinology, June 2002, Endocrine Society

    Professor Christoph Handschin

  103. NUBIScan, anin SilicoApproach for Prediction of Nuclear Receptor Response Elements

    Article • Molecular Endocrinology, June 2002, Endocrine Society

    Professor Christoph Handschin

  104. A Link between Cholesterol Levels and Phenobarbital Induction of Cytochromes P450

    Article • Biochemical and Biophysical Research Communications, February 2002, Elsevier

    Professor Christoph Handschin

  105. Conservation of Signaling Pathways of Xenobiotic-Sensing Orphan Nuclear Receptors, Chicken Xenobiotic Receptor, Constitutive Androstane Receptor, and Pregnane X Receptor, from Birds to Humans

    Article • Molecular Endocrinology, September 2001, Endocrine Society

    Professor Christoph Handschin

  106. CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

    Article • Proceedings of the National Academy of Sciences, September 2000, Proceedings of the National Academy of Sciences

    Professor Christoph Handschin

  107. A Conserved Nuclear Receptor Consensus Sequence (DR-4) Mediates Transcriptional Activation of the ChickenCYP2H1Gene by Phenobarbital in a Hepatoma Cell Line

    Article • Journal of Biological Chemistry, April 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christoph Handschin

  108. Induction of Drug Metabolism: Role for Nuclear Receptors

    Article • Wiley

    Professor Christoph Handschin