All Stories

  1. Transcriptional control of cardiac energy metabolism in health and disease: Lessons from animal models

    Article • Biochemical Pharmacology, June 2024, Elsevier

    Dr Josep A Villena

  2. Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis

    Article • Autophagy, August 2022, Taylor & Francis

    Dr Josep A Villena

  3. Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat

    Article • Disease Models & Mechanisms, April 2022, The Company of Biologists

    Dr Josep A Villena

  4. Angiocrine polyamine production regulates adiposity

    Article • Nature Metabolism, March 2022, Springer Science + Business Media

    PhD Pablo M. Garcia-Roves, Dr Josep A Villena

  5. Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality

    Article • International Journal of Molecular Sciences, July 2021, MDPI AG

    Dr Josep A Villena

  6. Nicotinamide Protects Against Diet‐Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging

    Article • Molecular Nutrition & Food Research, May 2021, Wiley

    Dr Josep A Villena

  7. Calorie Restriction and SIRT1 Overexpression Induce Different Gene Expression Profiles in White Adipose Tissue in Association with Metabolic Improvement

    Article • Molecular Nutrition & Food Research, March 2021, Wiley

    Dr Josep A Villena

  8. Sex hormone-binding globulin overexpression protects against high-fat diet-induced obesity in transgenic male mice

    Article • The Journal of Nutritional Biochemistry, November 2020, Elsevier

    Dr Josep A Villena

  9. Enhancing Glycolysis Protects against Ischemia-Reperfusion Injury by Reducing ROS Production

    Article • Metabolites, March 2020, MDPI AG

    Dr Josep A Villena

  10. Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy

    Article • International Journal of Molecular Sciences, June 2019, MDPI AG

    Dr Josep A Villena

  11. Adipocyte MTERF4 regulates non-shivering adaptive thermogenesis and sympathetic-dependent glucose homeostasis

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, June 2019, Elsevier

    Dr Josep A Villena

  12. Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program

    Article • iScience, May 2019, Elsevier

    PhD Pablo M. Garcia-Roves, Dr Josep A Villena

  13. Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue

    Article • The FASEB Journal, February 2019, Federation of American Societies For Experimental Biology (FASEB)

    Dr Josep A Villena, PhD Pablo M. Garcia-Roves, Luis Cervela

  14. Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis

    Article • International Journal of Molecular Sciences, September 2018, MDPI AG

    Dr Josep A Villena

  15. Kidney Androgen-Regulated Protein (KAP) Transgenic Mice Are Protected Against High-Fat Diet Induced Metabolic Syndrome

    Article • Scientific Reports, November 2017, Springer Science + Business Media

    Dr Josep A Villena

  16. EndoG Knockout Mice Show Increased Brown Adipocyte Recruitment in White Adipose Tissue and Improved Glucose Homeostasis

    Article • Endocrinology, October 2016, Endocrine Society

    Dr Josep A Villena

  17. Gene expression profiling in hearts of diabetic mice uncovers a potential role of estrogen-related receptor γ in diabetic cardiomyopathy

    Article • Molecular and Cellular Endocrinology, July 2016, Elsevier

    Dr Josep A Villena

  18. Pharmacological induction of mitochondrial biogenesis as a therapeutic strategy for the treatment of type 2 diabetes

    Article • Biochemical Pharmacology, November 2015, Elsevier

    Dr Josep A Villena

  19. HMGA1 overexpression in adipose tissue impairs adipogenesis and prevents diet-induced obesity and insulin resistance

    Article • Scientific Reports, September 2015, Springer Science + Business Media

    Dr Josep A Villena

  20. New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

    Article • FEBS Journal, January 2015, Wiley

    Dr Josep A Villena

  21. Targeting Mitochondrial Biogenesis to Treat Insulin Resistance

    Article • Current Pharmaceutical Design, September 2014, Bentham Science Publishers

    Dr Josep A Villena

  22. Expression of Adenine Nucleotide Translocase (ANT) Isoform Genes Is Controlled by PGC-1α Through Different Transcription Factors

    Article • Journal of Cellular Physiology, August 2014, Wiley

    Dr Josep A Villena

  23. Correction: The db/db Mouse: A Useful Model for the Study of Diabetic Retinal Neurodegeneration

    Article • PLOS One, August 2014, PLOS

    Dr Josep A Villena

  24. The db/db Mouse: A Useful Model for the Study of Diabetic Retinal Neurodegeneration

    Article • PLOS One, May 2014, PLOS

    Dr Josep A Villena

  25. Mice lacking PGC-1β in adipose tissues reveal a dissociation between mitochondrial dysfunction and insulin resistance

    Article • Molecular Metabolism, August 2013, Elsevier

    Dr Josep A Villena

  26. Pref-1 in brown adipose tissue: specific involvement in brown adipocyte differentiation and regulatory role of C/EBPδ

    Article • Biochemical Journal, April 2012, Portland Press Ltd.

    Dr Josep A Villena

  27. Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α

    Article • PLOS One, November 2011, PLOS

    Dr Josep A Villena

  28. Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of the Sirt3 Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype

    Article • Journal of Biological Chemistry, May 2011, Elsevier

    Dr Josep A Villena

  29. Resistance to High-Fat Diet-Induced Obesity but Exacerbated Insulin Resistance in Mice Overexpressing Preadipocyte Factor-1 (Pref-1): A New Model of Partial Lipodystrophy

    Article • Diabetes, October 2008, American Diabetes Association

    George R. Cowgill Professor of Medicine and Physiology Gerald I Shulman, Dr Josep A Villena

  30. ERRα: a metabolic function for the oldest orphan

    Article • Trends in Endocrinology and Metabolism, October 2008, Elsevier

    Anastasia Kralli, Dr Josep A Villena

  31. Orphan nuclear receptor estrogen-related receptor α is essential for adaptive thermogenesis

    Article • Proceedings of the National Academy of Sciences, January 2007, Proceedings of the National Academy of Sciences

    Dr Josep A Villena

  32. Estrogen-related Receptor α Is a Repressor of Phosphoenolpyruvate Carboxykinase Gene Transcription

    Article • Journal of Biological Chemistry, November 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Anastasia Kralli, Dr Josep A Villena

  33. Desnutrin, an Adipocyte Gene Encoding a Novel Patatin Domain-containing Protein, Is Induced by Fasting and Glucocorticoids

    Article • Journal of Biological Chemistry, November 2004, Elsevier

    Dr Josep A Villena

  34. Induced Adiposity and Adipocyte Hypertrophy in Mice Lacking the AMP-Activated Protein Kinase-α2 Subunit

    Article • Diabetes, September 2004, American Diabetes Association

    Dr Josep A Villena

  35. Human adipose cells as candidates in defense and tissue remodeling phenomena

    Article • Biochemical and Biophysical Research Communications, September 2003, Elsevier

    Dr Josep A Villena

  36. Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor–1 (Pref-1)

    Article • Journal of Clinical Investigation, February 2003, American Society for Clinical Investigation

    Dr Josep A Villena

  37. Mitochondrial biogenesis in brown adipose tissue is associated with differential expression of transcription regulatory factors

    Article • Cellular and Molecular Life Sciences, November 2002, Springer Science + Business Media

    Dr Josep A Villena

  38. Pref-1 and ADSF/Resistin: Two Secreted Factors Inhibiting Adipose Tissue Development

    Article • Hormone and Metabolic Research, November 2002, Thieme Publishing Group

    Dr Josep A Villena

  39. Mice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth Retardation and Accelerated Adiposity

    Article • Molecular and Cellular Biology, August 2002, ASM Journals

    Dr Josep A Villena

  40. Adipose tissues display differential phagocytic and microbicidal activities depending on their localization

    Article • International Journal of Obesity, September 2001, Springer Science + Business Media

    Dr Josep A Villena

  41. Influence of thyroid hormones on the human ATP synthase β-subunit gene promoter

    Article • Molecular and Cellular Biochemistry, September 1996, Springer Science + Business Media

    Dr Josep A Villena