All Stories

  1. Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone
  2. PatternExtract: A facile, scalable pipeline for point pattern generation from spatial imaging data
  3. A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements
  4. Unsupervised representation learning of chromatin images identifies changes in cell state and tissue organization in DCIS
  5. Iron capture through CD71 drives perinatal and tumor-associated Treg expansion
  6. ANGPTL3 Downregulation Increases Intracellular Lipids by Reducing Energy Utilization
  7. Combined therapy targeting AR and EZH2 curbs castration-resistant prostate cancer enhancing anti-tumor T-cell response
  8. Bendamustine and rituximab as first-line treatment for symptomatic splenic marginal zone lymphoma: long-term outcome and impact of early unmeasurable minimal residual disease attainment from the BRISMA/IELSG36 phase II study
  9. Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma
  10. Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer
  11. Neutrophils Mediate Protection Against Colitis and Carcinogenesis by Controlling Bacterial Invasion and IL22 Production by γδ T Cells
  12. ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion
  13. Unveiling the mechanistic link between extracellular amyloid fibrils, mechano-signaling and YAP activation in cancer
  14. EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening
  15. Impaired activation of plasmacytoid dendritic cells via toll-like receptor 7/9 and STING is mediated by melanoma-derived immunosuppressive cytokines and metabolic drift
  16. Resampling approaches for the quantitative analysis of spatially distributed cells
  17. Author Correction: Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth
  18. Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth
  19. Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects
  20. Pseudotemporal ordering of spatial lymphoid tissue microenvironment profiles trails Unclassified DLBCL at the periphery of the follicle
  21. No Clear Clustering Dysbiosis from Salivary Microbiota Analysis by Long Sequencing Reads in Patients Affected by Oral Squamous Cell Carcinoma: A Single Center Study
  22. A three-gene signature marks the time to locoregional recurrence in luminal-like breast cancer
  23. hMENA isoforms regulate cancer intrinsic type I IFN signaling and extrinsic mechanisms of resistance to immune checkpoint blockade in NSCLC
  24. Rewiring innate and adaptive immunity with TLR9 agonist to treat osteosarcoma
  25. Inhibition of FGF23 is a therapeutic strategy to target hematopoietic stem cell niche defects in β-thalassemia
  26. Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease
  27. Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma
  28. Pseudotemporal ordering of spatial lymphoid tissue microenvironment profiles trails Unclassified DLBCL at the periphery of the follicle
  29. Counteracting gemcitabine+nab-paclitaxel induced dysbiosis in KRAS wild type and KRASG12D mutated pancreatic cancer in vivo model
  30. Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells
  31. Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells
  32. Supplementary Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells
  33. Supplementary Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells
  34. Supplementary Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells
  35. Supplementary Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells
  36. SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
  37. Author Correction: Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer
  38. A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia
  39. CK2β-regulated signaling controls B cell differentiation and function
  40. Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
  41. Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer
  42. Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling
  43. Salivary Microbiota Composition in Patients with Oral Squamous Cell Carcinoma: A Systematic Review
  44. MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells
  45. Identification of an effective chemotherapy and DNA damage response inhibitor combination for diffuse large b cell lymphoma
  46. Publisher Correction: Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma
  47. Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects
  48. Stromal and Immune Cell Dynamics in Tumor Associated Tertiary Lymphoid Structures and Anti-Tumor Immune Responses
  49. Butyrate, a postbiotic of intestinal bacteria, affects pancreatic cancer and gemcitabine response in in vitro and in vivo models
  50. YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING
  51. Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88 / CD79B mutants‐enriched diffuse large B‐cell lymphomas
  52. Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation
  53. Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells
  54. Histological and immunohistochemical findings in a fatal case of thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination
  55. A murine model of cerebral cavernous malformations with acute hemorrhage
  56. Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS
  57. Direct RNA Nanopore Sequencing of SARS-CoV-2 Extracted from Critical Material from Swabs
  58. DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging
  59. Tuning gut microbiota through a probiotic blend in gemcitabine‐treated pancreatic cancer xenografted mice
  60. PD‐1‐induced T cell exhaustion is controlled by a Drp1‐dependent mechanism
  61. A novel CXCR4 antagonist counteracts paradoxical generation of cisplatin-induced pro-metastatic niches in lung cancer
  62. A tribute to Juan Rosai
  63. HER2 Signaling and Breast Cancer Stem Cells: The Bridge behind HER2-Positive Breast Cancer Aggressiveness and Therapy Refractoriness
  64. Newly-Discovered Neural Features Expand the Pathobiological Knowledge of Blastic Plasmacytoid Dendritic Cell Neoplasm
  65. Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
  66. The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
  67. Papulo‐purpuric dermatitis of childhood: a distinct PLEVA‐like eruption associated to SARS‐CoV‐2 infection. Clinical, histopathological and immunohistochemical study of 10 cases
  68. Burkitt lymphoma with a granulomatous reaction: an M1/Th1‐polarised microenvironment is associated with controlled growth and spontaneous regression
  69. Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer
  70. DIGITAL SPATIAL PROFILING OF DIFFUSE LARGE B‐CELL LYMPHOMAS REVEALS STING AS AN IMMUNE‐RELATED DETERMINANT OF SURVIVAL AFTER R‐CHOP THERAPY
  71. Conceptual design of the main Ancillary Systems of the ITER Water Cooled Lithium Lead Test Blanket System
  72. SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis
  73. COVID-19 Vaccine and Death: Causality Algorithm According to the WHO Eligibility Diagnosis
  74. Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation
  75. Post-mortem findings in vaccine-induced thrombotic thombocytopenia
  76. CD40 Activity on Mesenchymal Cells Negatively Regulates OX40L to Maintain Bone Marrow Immune Homeostasis Under Stress Conditions
  77. Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
  78. Myeloid and T-Cell Microenvironment Immune Features Identify Two Prognostic Sub-Groups in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms
  79. Myeloid cell heterogeneity in lung cancer: implication for immunotherapy
  80. Predictive and Prognostic Molecular Factors in Diffuse Large B-Cell Lymphomas
  81. Repurposing of the Antiepileptic Drug Levetiracetam to Restrain Neuroendocrine Prostate Cancer and Inhibit Mast Cell Support to Adenocarcinoma
  82. Definition of model-based control strategies for the Molten Salt Fast Reactor nuclear power plant
  83. MYD88 L265P mutation and interleukin‐10 detection in cerebrospinal fluid are highly specific discriminating markers in patients with primary central nervous system lymphoma: results from a prospective study
  84. Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia
  85. Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
  86. T-Cell Lymphoma Clonality by Copy Number Variation Analysis of T-Cell Receptor Genes
  87. Breast Cancer Organoids Model Patient-Specific Response to Drug Treatment
  88. Intra-tumour heterogeneity of diffuse large B-cell lymphoma involves the induction of diversified stroma-tumour interfaces
  89. Mast cells crosstalk with B cells in the gut and sustain IgA response in the inflamed intestine
  90. A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell Lymphomas
  91. SARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of Placenta
  92. Abstract 1106: Cisplatin-induced activation of SDF-1/CXCR4 axis sustains lung cancer metastasis by promoting co-recruitment of metastasis initiating cells and inflammatory monocytes
  93. SPARC regulation of PMN clearance protects from pristane induced lupus and rheumatoid arthritis
  94. Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
  95. Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche
  96. IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
  97. Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs
  98. Infiltrating Mast Cell–Mediated Stimulation of Estrogen Receptor Activity in Breast Cancer Cells Promotes the Luminal Phenotype
  99. ATR expands embryonic stem cell fate potential in response to replication stress
  100. Heterogeneity Fair: Commentary to Menter and Tzankov “Lymphomas and Their Microenvironment: A Multifaceted Relationship”
  101. Dissection of DLBCL microenvironment provides a gene expression-based predictor of survival applicable to formalin-fixed paraffin-embedded tissue
  102. Transcriptional profiles and stromal changes reveal bone marrow adaptation to early breast cancer in association with deregulated circulating microRNAs
  103. Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
  104. Hematopoietic Stem Cell Function in β-Thalassemia Is Impaired and Is Rescued By Targeting the Bone Marrow Niche
  105. Correction to: A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit
  106. MA13.09 Cisplatin Sustains Lung Cancer Metastasis Through the Systemic Activation of SDF-1/CXCR4 Axis
  107. OA14.06 Hyperprogressive Disease in Advanced Non–Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors
  108. Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis
  109. Neoadjuvant eribulin mesylate following anthracycline and taxane in triple negative breast cancer: Results from the HOPE study
  110. A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit
  111. Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma
  112. Abstract 4959: The gut microbiota contributes to the effectiveness of HER2-targeted therapy
  113. SPARC Is a New Myeloid-Derived Suppressor Cell Marker Licensing Suppressive Activities
  114. Follicular dendritic cells display microvesicle-associated LMP1 in reactive germinal centers of EBV+ classic Hodgkin lymphoma
  115. IL‐10‐producing B cells are characterized by a specific methylation signature
  116. The B‐cell receptor in control of tumor B‐cell fitness: Biology and clinical relevance
  117. Frontline Science: Mast cells regulate neutrophil homeostasis by influencing macrophage clearance activity
  118. Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells
  119. Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade
  120. WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer
  121. Circulating mir‐320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk
  122. Development of a control-oriented power plant simulator for the molten salt fast reactor
  123. Time for a “Plan B” in Peritoneal Metastatic Disease
  124. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming
  125. Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting
  126. Dissection of DLBCL microenvironment provides a gene expression-based predictor of survival applicable to formalin-fixed paraffin-embedded tissue
  127. Targeting a Specific Glycosylated Epitope of CD43 with a New Humanized Monoclonal Antibody for the Treatment of Pediatric and Adult T-Cell Acute Lymphoblastic Leukemia (T-ALL)
  128. Efficacy of bendamustine and rituximab in splenic marginal zone lymphoma: results from the phase II BRISMA/IELSG36 study
  129. Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target
  130. MA04.06 PD-1 Blockade Promotes Hyperprogressive Disease in NSCLC Through Macrophages Activation via Antibody-Fc/FcR Interaction
  131. Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer
  132. Wnt3a Neutralization Enhances T-cell Responses through Indirect Mechanisms and Restrains Tumor Growth
  133. Abstract 4981: Circulating mir-320 promotes immunosuppressive macrophages M2 phenotype associated with lung cancer progression
  134. Abstract 2141: Stromal SPARC deficiency skews prostate cancer toward neuroendocrine differentiation
  135. Abstract A24: Bone marrow hematopoietic adaptation as a sensor of early, pre-invasive, epithelial malignancy
  136. Cross-Talk between Myeloid-Derived Suppressor Cells and Mast Cells Mediates Tumor-Specific Immunosuppression in Prostate Cancer
  137. Microenvironmental regulation of the IL-23R/IL-23 axis overrides chronic lymphocytic leukemia indolence
  138. Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8
  139. Real-time detection of BRAF V600E mutation from archival hairy cell leukemia FFPE tissue by nanopore sequencing
  140. Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells
  141. IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis
  142. Complement Protein C1q Binds to Hyaluronic Acid in the Malignant Pleural Mesothelioma Microenvironment and Promotes Tumor Growth
  143. Rheostatic Functions of Mast Cells in the Control of Innate and Adaptive Immune Responses
  144. Distribution and function of the complement protein C1q in malignant pleural mesothelioma microenvironment
  145. Neoadjuvant eribulin following anthracycline and taxane in triple negative breast cancer (HOPE): A multicenter, two stage, phase II trial
  146. Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities
  147. The good and bad of targeting cancer-associated extracellular matrix
  148. Microenvironment modulation and enhancement of antilymphoma therapy by the heparanase inhibitor roneparstat
  149. Abstract 5437: miR-302b as adjuvant therapeutic tool to improve chemotherapy efficacy in human triple-negative breast cancer
  150. Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer
  151. Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors
  152. Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling
  153. IFI16 reduced expression is correlated with unfavorable outcome in chronic lymphocytic leukemia
  154. Common extracellular matrix regulation of myeloid cell activity in the bone marrow and tumor microenvironments
  155. Mast cells contribute to autoimmune diabetes by releasing interleukin-6 and failing to acquire a tolerogenic IL-10 + phenotype
  156. Mast cells are associated with the onset and progression of celiac disease
  157. Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas
  158. P2.01-017 Circulating miRNAs in Lung Cancer Are Associated to Pro-Tumorigenic and Immunosuppressive Microenvironment
  159. Imatinib Spares cKit-Expressing Prostate Neuroendocrine Tumors, whereas Kills Seminal Vesicle Epithelial–Stromal Tumors by Targeting PDGFR-β
  160. Arginase 1 Is a Marker of Myeloid-Mediated Immunosuppression with Prognostic Meaning in Classic Hodgkin Lymphoma
  161. The combined role of biomarkers and interim PET scan in prediction of treatment outcome in classical Hodgkin's lymphoma: a retrospective, European, multicentre cohort study
  162. The prognostic value of the myeloid-mediated immunosuppression marker Arginase-1 in classic Hodgkin lymphoma
  163. Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell Activity
  164. Abstract 3289: Microenvironment modulation and enhancement of cytotoxic therapy by the heparanase inhibitor Roneparstat against human B-non Hodgkin lymphomas
  165. miR-9 and miR-200 Regulate PDGFRβ-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer
  166. FRI0030 Anti-TNF-α Antibody Targeted To Inflamed Synovial Tissue for The Treatment of Rheumatoid Arthritis
  167. Abstract A18: miR-9 and miR-200 regulate PDGFRβ-mediated endothelial differentiation of neoplastic cells in triple-negative breast cancer
  168. MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease
  169. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation
  170. Abstract B157: OX40 expression in tumor-associated Tregs as a potential prognostic biomarker and immunotherapeutic target in ovarian cancer
  171. MEF2C and SOCS2 in stemness regulation
  172. Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers
  173. A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles
  174. Alteration of HSC Functions in Thalassemia
  175. Microenvironment Regulation of IL23R/IL-23 Axis Drives Chronic Lymphocytic Leukemia (CLL) Progression
  176. A ceRNA approach may unveil unexpected contributors to deletion syndromes, the model of 5q- syndrome
  177. AP2α controls the dynamic balance between miR-126&126* and miR-221&222 during melanoma progression
  178. Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment
  179. Interleukin-17A promotes the growth of human germinal center derived non-Hodgkin B cell lymphoma
  180. RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis
  181. Abstract 4054: Mast cells contribute to T cell tolerance against prostate cancer- associated antigens favoring tumor growth
  182. Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
  183. Mast Cells Infiltrating Inflamed or Transformed Gut Alternatively Sustain Mucosal Healing or Tumor Growth
  184. Rituximab with cyclophosphamide, vincristine, non-pegylated liposomal doxorubicin and prednisone as first-line treatment for splenic marginal zone lymphoma: a Fondazione Italiana Linfomi phase II study
  185. Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies
  186. OX40 expression in tumor-associated Tregs as a potential prognostic biomarker and immunotherapeutic target in ovarian cancer.
  187. “Cancer Bio-Immunotherapy in Siena”: Twelfth Meeting of the Network Italiano per la Bioterapia dei Tumori (NIBIT), Siena, Italy, October 9–11, 2014
  188. SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B
  189. SOCS2 Controls Proliferation and Stemness of Hematopoietic Cells under Stress Conditions and Its Deregulation Marks Unfavorable Acute Leukemias
  190. HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma
  191. The ins and outs of osteopontin
  192. IFI16Expression Is Related to Selected Transcription Factors during B-Cell Differentiation
  193. The Hepatic Expression of Vitamin D Receptor Is Inversely Associated With the Severity of Liver Damage in Genotype 1 Chronic Hepatitis C Patients
  194. Molecular signature of Epstein Barr virus-positive Burkitt lymphoma and post-transplant lymphoproliferative disorder suggest different roles for Epstein Barr virus
  195. Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus–infected liver tissue
  196. Pathogenetic and diagnostic significance of microRNA deregulation in peripheral T-cell lymphoma not otherwise specified
  197. Mast Cells Boost Myeloid-Derived Suppressor Cell Activity and Contribute to the Development of Tumor-Favoring Microenvironment
  198. Abstract A42: miR34a: A valuable indicator of differential outcome of Ewing sarcoma patients with complex functions
  199. The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma
  200. Abstract 2362: Identification and characterization of pathogenetic pathways and potential therapeutic targets in tumors derived from histiocytes and follicular dendritic cells
  201. Mast Cells Control the Expansion and Differentiation of IL-10–Competent B Cells
  202. Dynamics of complement activation in aHUS and how to monitor eculizumab therapy
  203. Osteopontin Shapes Immunosuppression in the Metastatic Niche
  204. Prognostic significance of miR-34a in Ewing sarcoma is associated with cyclin D1 and ki-67 expression
  205. Bispecific antibodies targeting tumor-associated antigens and neutralizing complement regulators increase the efficacy of antibody-based immunotherapy in mice
  206. Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies
  207. P816 MERTK rs4374383 AA GENOTYPE IS ASSOCIATED WITH A LOWER PREVALENCE OF SEVERE HEPATIC STEATOSIS IN NON-ALCOHOLIC FATTY LIVER DISEASE
  208. PDGFRβ and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells
  209. Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma
  210. C1q as a unique player in angiogenesis with therapeutic implication in wound healing
  211. Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages
  212. Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition
  213. MERTK rs4374383 AA genotype is associated with a lower prevalence of severe hepatic steatosis in non-alcoholic fatty liver disease
  214. Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway
  215. The Role of Inflammation in Lymphoma
  216. RNA recognition by human TLR8 can lead to autoimmune inflammation
  217. Reproducibility of the WHO histological criteria for the diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms
  218. Defective Stromal Remodeling and Neutrophil Extracellular Traps in Lymphoid Tissues Favor the Transition from Autoimmunity to Lymphoma
  219. Ultrasound-guided intra-tumor injection of combined immunotherapy cures mice from orthotopic prostate cancer
  220. New Potential Therapeutic Approach for the Treatment of B-Cell Malignancies Using Chlorambucil/Hydroxychloroquine-Loaded Anti-CD20 Nanoparticles
  221. Two Patients With History of STEC-HUS, Posttransplant Recurrence and Complement Gene Mutations
  222. Response to Villanacci et al.
  223. The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR‐221&222‐c‐FOS pathway
  224. The monocytic population in chronic lymphocytic leukemia shows altered composition and deregulation of genes involved in phagocytosis and inflammation
  225. Class IIa HDACs repressive activities on MEF2-depedent transcription are associated with poor prognosis of ER+ breast tumors
  226. New Therapeutic Approach for the Treatment of B-Cell Disorders Using Chlorambucil/Hydroxychloroquine-Loaded AntiCD20 Nanoparticles
  227. C1q secreted in the tumour microenvironment promotes tumour growth in the absence of complement activation
  228. Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion
  229. Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity
  230. A complex case of fatal calciphylaxis in a female patient with hyperparathyroidism secondary to end stage renal disease of graft and coexistence of haemolytic uremic syndrome
  231. Sistemic calciphylaxis and thrombotic microangiopathy in a kidney transplant patient: Two mixing fatal syndromes?
  232. 243 Triple Negative Breast Carcinoma Cells Directly Contribute to Tumor Vasculature by Endothelial Differentiation Capability
  233. The Aryl Hydrocarbon Receptor Modulates Acute and Late Mast Cell Responses
  234. Abstract 2997: Peripheral T-cell lymphomas not otherwise specified correspond to distinct mature T-cell populations basing on the global gene expression profile
  235. Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas
  236. The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia
  237. CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death
  238. SPARC Oppositely Regulates Inflammation and Fibrosis in Bleomycin-Induced Lung Damage
  239. The matricellular protein SPARC supports follicular dendritic cell networking toward Th17 responses
  240. CD73-Generated Extracellular Adenosine Creates Microenvironmental Conditions Favoring Growth and Survival of Chronic Lymphocytic Leukemia Cells
  241. SNPs Array Karyotyping Reveals a Novel Recurrent 20p13 Amplification in Primary Myelofibrosis
  242. Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target
  243. MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases
  244. Mast Cell Targeting Hampers Prostate Adenocarcinoma Development but Promotes the Occurrence of Highly Malignant Neuroendocrine Cancers
  245. Peripheral T-cell lymphoma classification: the matter of cellular derivation
  246. C1q induces in vivo angiogenesis and promotes wound healing
  247. Preeclampsia is associated with defective production of C1q by invasive trophoblast
  248. New treatment of multiple mieloma and anaplastic T cell lymphoma using C-fixing anti-CD162 antibodies
  249. Technical Advance: Soluble OX40 molecule mimics regulatory T cell modulatory activity on FcɛRI-dependent mast cell degranulation
  250. A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment
  251. High liver RBP4 protein content is associated with histological features in patients with genotype 1 chronic hepatitis C and with nonalcoholic steatohepatitis
  252. Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes
  253. The bone marrow stroma in hematological neoplasms—a guilty bystander
  254. How I diagnose and treat splenic lymphomas
  255. 480 FOLLICULAR HELPER T-CELLS POPULATE THE INTRAHEPATIC INFILTRATES OF HCV GENOTYPE-1 CHRONICALLY INFECTED PATIENTS AND PREDICT THE ACHIEVEMENT OF VIROLOGICAL RESPONSE FOLLOWING IFN-BASED TREATMENT
  256. Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient KitW-sh/W-sh mice
  257. T-18 Liver follicular helper T-cells in chronic hepatitis C
  258. Liver follicular helper T-cells predict the achievement of virological response following interferon-based treatment in HCV-infected patients
  259. Pathobiology of Hodgkin Lymphoma
  260. Posters of XXXVIII Annual ESAO & IV Biennial IFAO Congress, 9-12 October 2011, Porto, Portugal
  261. A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome
  262. Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome
  263. Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
  264. Gene Expression Analysis Uncovers Similarity and Differences Among Burkitt Lymphoma Subtypes
  265. Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors
  266. Exploratory Study on the Effects of Biodegradable Nanoparticles with Drugs on Malignant B Cells and on a Human/Mouse Model of Burkitt Lymphoma
  267. Oncogene-Driven Intrinsic Inflammation Induces Leukocyte Production of Tumor Necrosis Factor That Critically Contributes to Mammary Carcinogenesis
  268. Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts
  269. An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development
  270. Mast Cells and Th17 Cells Contribute to the Lymphoma-Associated Pro-Inflammatory Microenvironment of Angioimmunoblastic T-Cell Lymphoma
  271. Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia
  272. A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2
  273. Human Bone Marrow Mesenchymal Stem Cells Display Anti-Cancer Activity in SCID Mice Bearing Disseminated Non-Hodgkin's Lymphoma Xenografts
  274. Mast cells enhance proliferation of B lymphocytes and drive their differentiation toward IgA-secreting plasma cells
  275. Humoral immunotherapy of multiple myeloma: perspectives and perplexities
  276. Monocytes/macrophages but not T lymphocytes are the major targets of the CCL3/CCL4 chemokines produced by CD38+CD49d+chronic lymphocytic leukaemia cells
  277. Exploring a regulatory role for mast cells: ‘MCregs’?
  278. F.N.32 LIVER EXPRESSION OF RBP4 CORRELATES WITH LIVER DAMAGE IN CHRONIC HEPATITIS C AND IN NONALCOHOLIC FATTY LIVER DISEASE
  279. T Cell Large Granular Lymphocytic Leukemia in Association with Sjögren’s Syndrome
  280. Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C
  281. Gamma-delta T-cell lymphomas
  282. Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation
  283. Phenotype characterization of the anti-inflammatory behavior of decidual endothelial cells
  284. P-Selectin Glycoprotein Ligand-1 as a Potential Target for Humoral Immunotherapy of Multiple Myeloma (Supplementry Material)
  285. Serum BLyS/BAFF predicts the outcome of acute hepatitis C virus infection
  286. CD38/CD31, the CCL3 and CCL4 Chemokines, and CD49d/Vascular Cell Adhesion Molecule-1 Are Interchained by Sequential Events Sustaining Chronic Lymphocytic Leukemia Cell Survival
  287. C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function
  288. Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis
  289. Response-Guided ABVD Chemotherapy plus Involved-Field Radiation Therapy for Intermediate-Stage Hodgkin Lymphoma in the Pre–Positron Emission Tomography Era: A Gruppo Italiano Studio Linfomi (GISL) Prospective Trial
  290. Different immunophenotypical apoptotic profiles characterise megakaryocytes of essential thrombocythaemia and primary myelofibrosis
  291. CD146+ bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis
  292. Progressive visceral leishmaniasis misdiagnosed as cirrhosis of the liver: a case report
  293. Selection and Characterization of a Novel Agonistic Human Recombinant Anti-Trail-R2 Minibody with Antileukemic Activity
  294. An automated image analysis methodology for classifying megakaryocytes in chronic myeloproliferative disorders
  295. Angioimmunoblastic T-cell lymphoma
  296. CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction
  297. In Vivo Biodistribution and Lifetime Analysis of Cy5.5-Conjugated Rituximab in Mice Bearing Lymphoid Tumor Xenograft Using Time-Domain Near-Infrared Optical Imaging
  298. The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial cells: implications in rheumatoid arthritis
  299. Carbamazepine Transbuccal Delivery: The Histo-Morphological Features of Reconstituted Human Oral Epithelium and Buccal Porcine Mucosae in the Transmucosal Permeation
  300. Development of a human-SCID lymphoma as a model to evaluate the therapeutic effect of Rituximab
  301. Is local complement activation involved in renal damage in patients with atypical haemolytic uraemic syndrome?
  302. An Update on the Xenograft and Mouse Models Suitable for Investigating New Therapeutic Compounds for the Treatment of B-Cell Malignancies
  303. Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium
  304. Serum BLyS/BAFF levels in acute hepatitis C predict clinical outcome
  305. Histological Features and ki-67 Index in Cervical Atypical Lesions
  306. In vivo Targeting of Human Neutralizing Antibodies against CD55 and CD59 to Lymphoma Cells Increases the Antitumor Activity of Rituximab
  307. Predictive role of histological features and Ki67 pattern on high-risk HPV presence in atypical cervical lesions
  308. Use of intrapleural bortezomib in myelomatous pleural effusion
  309. Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4
  310. Release of naltrexone on buccal mucosa: Permeation studies, histological aspects and matrix system design
  311. C1q is involved in human trophoblast invasion
  312. C1q Production by Bone Marrow Stromal Cells
  313. Associations between Notch-2, Akt-1 and HER2/neu Expression in Invasive Human Breast Cancer: A Tissue Microarray Immunophenotypic Analysis on 98 Patients
  314. Neutralizing human antibodies against CD55 and CD59 targeted to lymphoma cells in vivo potentiate the therapeutic effect of Rituximab
  315. Constant Detection of Cyclooxygenase 2 in Terminal Stages of Myeloid Maturation
  316. Thyroid Sarcoidosis as a Unique Localization
  317. Reply to Pich et al.: intrasinusoidal bone marrow infiltration and splenic marginal zone lymphoma: a quantitative study
  318. Small Bowel Angiodysplasia Associated with von Willebrand's Disease: Report of a Case
  319. Splenic marginal zone lymphoma: a prognostic model for clinical use
  320. Assessment of the frequency of additional cancers in patients with splenic marginal zone lymphoma
  321. Immunophenotypic profile and role of adhesion molecules in splenic marginal zone lymphoma with bone marrow involvement
  322. Deoxycoformycin (pentostatin) in the treatment of splenic marginal zone lymphoma (SMZL) with or without villous lymphocytes
  323. Identification of CD162 in plasma-cell dyscrasia
  324. 16. Clinical-Pathological Correlations
  325. Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: Possible role in tumor promotion and angiogenesis
  326. Splenic marginal zone lymphoma with or without villous lymphocytes
  327. Re: ?Splenic marginal zone B-cell lymphoma associated with primary Sj�gren?s syndrome?
  328. Bone marrow biopsy in Hodgkin's lymphoma
  329. Long-lasting remission of primary hepatic lymphoma and hepatitis C virus infection achieved by the alpha-interferon treatment
  330. Primary T-cell rich B-cell lymphoma of the penis: a first case