All Stories

  1. A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell Lymphomas
  2. SPARC regulation of PMN clearance protects from pristane induced lupus and rheumatoid arthritis
  3. Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche
  4. Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs
  5. Infiltrating Mast Cell–Mediated Stimulation of Estrogen Receptor Activity in Breast Cancer Cells Promotes the Luminal Phenotype
  6. ATR expands embryonic stem cell fate potential in response to replication stress
  7. Transcriptional profiles and stromal changes reveal bone marrow adaptation to early breast cancer in association with deregulated circulating microRNAs
  8. Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
  9. Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis
  10. Neoadjuvant eribulin mesylate following anthracycline and taxane in triple negative breast cancer: Results from the HOPE study
  11. SPARC Is a New Myeloid-Derived Suppressor Cell Marker Licensing Suppressive Activities
  12. Follicular dendritic cells display microvesicle-associated LMP1 in reactive germinal centers of EBV+ classic Hodgkin lymphoma
  13. IL‐10‐producing B cells are characterized by a specific methylation signature
  14. The B‐cell receptor in control of tumor B‐cell fitness: Biology and clinical relevance
  15. Frontline Science: Mast cells regulate neutrophil homeostasis by influencing macrophage clearance activity
  16. Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells
  17. Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade
  18. WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer
  19. Circulating mir‐320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk
  20. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming
  21. Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting
  22. Efficacy of bendamustine and rituximab in splenic marginal zone lymphoma: results from the phase II BRISMA/IELSG36 study
  23. Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target
  24. Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer
  25. Wnt3a Neutralization Enhances T-cell Responses through Indirect Mechanisms and Restrains Tumor Growth
  26. Cross-Talk between Myeloid-Derived Suppressor Cells and Mast Cells Mediates Tumor-Specific Immunosuppression in Prostate Cancer
  27. Microenvironmental regulation of the IL-23R/IL-23 axis overrides chronic lymphocytic leukemia indolence
  28. Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8
  29. Real-time detection of BRAF V600E mutation from archival hairy cell leukemia FFPE tissue by nanopore sequencing
  30. Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells
  31. IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis
  32. Complement Protein C1q Binds to Hyaluronic Acid in the Malignant Pleural Mesothelioma Microenvironment and Promotes Tumor Growth
  33. Rheostatic Functions of Mast Cells in the Control of Innate and Adaptive Immune Responses
  34. Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities
  35. The good and bad of targeting cancer-associated extracellular matrix
  36. Microenvironment modulation and enhancement of antilymphoma therapy by the heparanase inhibitor roneparstat
  37. Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer
  38. Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors
  39. Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling
  40. IFI16 reduced expression is correlated with unfavorable outcome in chronic lymphocytic leukemia
  41. Common extracellular matrix regulation of myeloid cell activity in the bone marrow and tumor microenvironments
  42. Mast cells contribute to autoimmune diabetes by releasing interleukin-6 and failing to acquire a tolerogenic IL-10 + phenotype
  43. Mast cells are associated with the onset and progression of celiac disease
  44. Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas
  45. Imatinib Spares cKit-Expressing Prostate Neuroendocrine Tumors, whereas Kills Seminal Vesicle Epithelial–Stromal Tumors by Targeting PDGFR-β
  46. The combined role of biomarkers and interim PET scan in prediction of treatment outcome in classical Hodgkin's lymphoma: a retrospective, European, multicentre cohort study
  47. The prognostic value of the myeloid-mediated immunosuppression marker Arginase-1 in classic Hodgkin lymphoma
  48. Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell Activity
  49. miR-9 and miR-200 Regulate PDGFRβ-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer
  50. MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease
  51. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation
  52. MEF2C and SOCS2 in stemness regulation
  53. Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers
  54. A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles
  55. A ceRNA approach may unveil unexpected contributors to deletion syndromes, the model of 5q- syndrome
  56. AP2α controls the dynamic balance between miR-126&126* and miR-221&222 during melanoma progression
  57. Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment
  58. Interleukin-17A promotes the growth of human germinal center derived non-Hodgkin B cell lymphoma
  59. RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis
  60. Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
  61. Mast Cells Infiltrating Inflamed or Transformed Gut Alternatively Sustain Mucosal Healing or Tumor Growth
  62. Rituximab with cyclophosphamide, vincristine, non-pegylated liposomal doxorubicin and prednisone as first-line treatment for splenic marginal zone lymphoma: a Fondazione Italiana Linfomi phase II study
  63. Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies
  64. “Cancer Bio-Immunotherapy in Siena”: Twelfth Meeting of the Network Italiano per la Bioterapia dei Tumori (NIBIT), Siena, Italy, October 9–11, 2014
  65. SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B
  66. SOCS2 Controls Proliferation and Stemness of Hematopoietic Cells under Stress Conditions and Its Deregulation Marks Unfavorable Acute Leukemias
  67. HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma
  68. The ins and outs of osteopontin
  69. IFI16Expression Is Related to Selected Transcription Factors during B-Cell Differentiation
  70. The Hepatic Expression of Vitamin D Receptor Is Inversely Associated With the Severity of Liver Damage in Genotype 1 Chronic Hepatitis C Patients
  71. Molecular signature of Epstein Barr virus-positive Burkitt lymphoma and post-transplant lymphoproliferative disorder suggest different roles for Epstein Barr virus
  72. Pathogenetic and diagnostic significance of microRNA deregulation in peripheral T-cell lymphoma not otherwise specified
  73. Mast Cells Boost Myeloid-Derived Suppressor Cell Activity and Contribute to the Development of Tumor-Favoring Microenvironment
  74. The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma
  75. Mast Cells Control the Expansion and Differentiation of IL-10–Competent B Cells
  76. Dynamics of complement activation in aHUS and how to monitor eculizumab therapy
  77. Osteopontin Shapes Immunosuppression in the Metastatic Niche
  78. Prognostic significance of miR-34a in Ewing sarcoma is associated with cyclin D1 and ki-67 expression
  79. Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus-infected liver tissue
  80. Bispecific antibodies targeting tumor-associated antigens and neutralizing complement regulators increase the efficacy of antibody-based immunotherapy in mice
  81. Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies
  82. PDGFRβ and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells
  83. Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma
  84. C1q as a unique player in angiogenesis with therapeutic implication in wound healing
  85. Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages
  86. Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition
  87. Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway
  88. The Role of Inflammation in Lymphoma
  89. RNA recognition by human TLR8 can lead to autoimmune inflammation
  90. Reproducibility of the WHO histological criteria for the diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms
  91. Defective Stromal Remodeling and Neutrophil Extracellular Traps in Lymphoid Tissues Favor the Transition from Autoimmunity to Lymphoma
  92. Ultrasound-guided intra-tumor injection of combined immunotherapy cures mice from orthotopic prostate cancer
  93. New Potential Therapeutic Approach for the Treatment of B-Cell Malignancies Using Chlorambucil/Hydroxychloroquine-Loaded Anti-CD20 Nanoparticles
  94. Two Patients With History of STEC-HUS, Posttransplant Recurrence and Complement Gene Mutations
  95. Response to Villanacci et al.
  96. The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR‐221&222‐c‐FOS pathway
  97. The monocytic population in chronic lymphocytic leukemia shows altered composition and deregulation of genes involved in phagocytosis and inflammation
  98. Class IIa HDACs repressive activities on MEF2-depedent transcription are associated with poor prognosis of ER+ breast tumors
  99. Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion
  100. Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity
  101. A complex case of fatal calciphylaxis in a female patient with hyperparathyroidism secondary to end stage renal disease of graft and coexistence of haemolytic uremic syndrome
  102. Sistemic calciphylaxis and thrombotic microangiopathy in a kidney transplant patient: Two mixing fatal syndromes?
  103. The Aryl Hydrocarbon Receptor Modulates Acute and Late Mast Cell Responses
  104. Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas
  105. The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia
  106. CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death
  107. SPARC Oppositely Regulates Inflammation and Fibrosis in Bleomycin-Induced Lung Damage
  108. The matricellular protein SPARC supports follicular dendritic cell networking toward Th17 responses
  109. SNPs Array Karyotyping Reveals a Novel Recurrent 20p13 Amplification in Primary Myelofibrosis
  110. Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target
  111. MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases
  112. Mast Cell Targeting Hampers Prostate Adenocarcinoma Development but Promotes the Occurrence of Highly Malignant Neuroendocrine Cancers
  113. Peripheral T-cell lymphoma classification: the matter of cellular derivation
  114. C1q induces in vivo angiogenesis and promotes wound healing
  115. Preeclampsia is associated with defective production of C1q by invasive trophoblast
  116. Technical Advance: Soluble OX40 molecule mimics regulatory T cell modulatory activity on FcɛRI-dependent mast cell degranulation
  117. A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment
  118. High liver RBP4 protein content is associated with histological features in patients with genotype 1 chronic hepatitis C and with nonalcoholic steatohepatitis
  119. Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes
  120. The bone marrow stroma in hematological neoplasms—a guilty bystander
  121. How I diagnose and treat splenic lymphomas
  122. Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient KitW-sh/W-sh mice
  123. Liver follicular helper T-cells predict the achievement of virological response following interferon-based treatment in HCV-infected patients
  124. Pathobiology of Hodgkin Lymphoma
  125. A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome
  126. Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome
  127. Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
  128. Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors
  129. Exploratory Study on the Effects of Biodegradable Nanoparticles with Drugs on Malignant B Cells and on a Human/Mouse Model of Burkitt Lymphoma
  130. Oncogene-Driven Intrinsic Inflammation Induces Leukocyte Production of Tumor Necrosis Factor That Critically Contributes to Mammary Carcinogenesis
  131. Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts
  132. An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development
  133. Mast Cells and Th17 Cells Contribute to the Lymphoma-Associated Pro-Inflammatory Microenvironment of Angioimmunoblastic T-Cell Lymphoma
  134. Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia
  135. A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2
  136. Human Bone Marrow Mesenchymal Stem Cells Display Anti-Cancer Activity in SCID Mice Bearing Disseminated Non-Hodgkin's Lymphoma Xenografts
  137. Mast cells enhance proliferation of B lymphocytes and drive their differentiation toward IgA-secreting plasma cells
  138. Humoral immunotherapy of multiple myeloma: perspectives and perplexities
  139. Monocytes/macrophages but not T lymphocytes are the major targets of the CCL3/CCL4 chemokines produced by CD38+CD49d+chronic lymphocytic leukaemia cells
  140. Exploring a regulatory role for mast cells: ‘MCregs’?
  141. T Cell Large Granular Lymphocytic Leukemia in Association with Sjögren’s Syndrome
  142. Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C
  143. Gamma-delta T-cell lymphomas
  144. Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation
  145. P-Selectin Glycoprotein Ligand-1 as a Potential Target for Humoral Immunotherapy of Multiple Myeloma (Supplementry Material)
  146. Serum BLyS/BAFF predicts the outcome of acute hepatitis C virus infection
  147. CD38/CD31, the CCL3 and CCL4 Chemokines, and CD49d/Vascular Cell Adhesion Molecule-1 Are Interchained by Sequential Events Sustaining Chronic Lymphocytic Leukemia Cell Survival
  148. C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function
  149. Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis
  150. Response-Guided ABVD Chemotherapy plus Involved-Field Radiation Therapy for Intermediate-Stage Hodgkin Lymphoma in the Pre–Positron Emission Tomography Era: A Gruppo Italiano Studio Linfomi (GISL) Prospective Trial
  151. Different immunophenotypical apoptotic profiles characterise megakaryocytes of essential thrombocythaemia and primary myelofibrosis
  152. CD146+ bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis
  153. Progressive visceral leishmaniasis misdiagnosed as cirrhosis of the liver: a case report
  154. Selection and Characterization of a Novel Agonistic Human Recombinant Anti-Trail-R2 Minibody with Antileukemic Activity
  155. An automated image analysis methodology for classifying megakaryocytes in chronic myeloproliferative disorders
  156. Angioimmunoblastic T-cell lymphoma
  157. CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction
  158. In Vivo Biodistribution and Lifetime Analysis of Cy5.5-Conjugated Rituximab in Mice Bearing Lymphoid Tumor Xenograft Using Time-Domain Near-Infrared Optical Imaging
  159. The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial cells: implications in rheumatoid arthritis
  160. Carbamazepine Transbuccal Delivery: The Histo-Morphological Features of Reconstituted Human Oral Epithelium and Buccal Porcine Mucosae in the Transmucosal Permeation
  161. An Update on the Xenograft and Mouse Models Suitable for Investigating New Therapeutic Compounds for the Treatment of B-Cell Malignancies
  162. Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium
  163. In vivo Targeting of Human Neutralizing Antibodies against CD55 and CD59 to Lymphoma Cells Increases the Antitumor Activity of Rituximab
  164. Predictive role of histological features and Ki67 pattern on high-risk HPV presence in atypical cervical lesions
  165. Use of intrapleural bortezomib in myelomatous pleural effusion
  166. Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4
  167. Release of naltrexone on buccal mucosa: Permeation studies, histological aspects and matrix system design
  168. C1q Production by Bone Marrow Stromal Cells
  169. Associations between Notch-2, Akt-1 and HER2/neu Expression in Invasive Human Breast Cancer: A Tissue Microarray Immunophenotypic Analysis on 98 Patients
  170. Constant Detection of Cyclooxygenase 2 in Terminal Stages of Myeloid Maturation
  171. Thyroid Sarcoidosis as a Unique Localization
  172. Reply to Pich et al.: intrasinusoidal bone marrow infiltration and splenic marginal zone lymphoma: a quantitative study
  173. Small Bowel Angiodysplasia Associated with von Willebrand's Disease: Report of a Case
  174. Splenic marginal zone lymphoma: a prognostic model for clinical use
  175. Assessment of the frequency of additional cancers in patients with splenic marginal zone lymphoma
  176. Immunophenotypic profile and role of adhesion molecules in splenic marginal zone lymphoma with bone marrow involvement
  177. Deoxycoformycin (pentostatin) in the treatment of splenic marginal zone lymphoma (SMZL) with or without villous lymphocytes
  178. Identification of CD162 in plasma-cell dyscrasia
  179. 16. Clinical-Pathological Correlations
  180. Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: Possible role in tumor promotion and angiogenesis
  181. Splenic marginal zone lymphoma with or without villous lymphocytes
  182. Re: ?Splenic marginal zone B-cell lymphoma associated with primary Sj�gren?s syndrome?
  183. Bone marrow biopsy in Hodgkin's lymphoma
  184. Long-lasting remission of primary hepatic lymphoma and hepatitis C virus infection achieved by the alpha-interferon treatment
  185. Primary T-cell rich B-cell lymphoma of the penis: a first case