All Stories

  1. Insights into the toxic effects of micro-nano-plastics on the human brain and their relationship with the onset of neurological diseases: A narrative review
  2. Biomarkers in Heart Failure: A Review and a Wish
  3. Is It the Time to Revolutionize the Heart Failure Management with Emerging Biomarkers and Innovative Targeted Treatments? From Re-Search Evidence to Clinic
  4. Rituximab in stiff-person syndrome with glutamic acid decarboxylase 65 autoantibody: a systematic review
  5. Shed Syndecans (1–3), ELA-32, BDNF, NLR, and hs-CRP in Parkinson’s Disease: Appropriate Diagnostic and Prognostic Biomarkers When Combined in a Unique Panel
  6. TREM 2 in Parkinson’s Disease: A Promising Candidate Gene for Disease Susceptibility and Progression
  7. A Narrative Review: Syndecans in Aortic Aneurysm Pathogenesis and Course—Biomarkers and Targets?
  8. Towards personalized management of myasthenia gravis phenotypes: From the role of multi-omics to the emerging biomarkers and therapeutic targets
  9. In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targets for personalized treatments
  10. Correction: Inflammation scores based on C‑reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis
  11. Syndecans in Aortic Aneurysm Pathogenesis and Course: A Narrative Review. Biomarkers and Targets?
  12. Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis
  13. Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]
  14. Syndecans in Alzheimer’s disease: pathogenetic mechanisms and potential therapeutic targets
  15. Dietary Exposure to Pesticide and Veterinary Drug Residues and Their Effects on Human Fertility and Embryo Development: A Global Overview
  16. Dietary Exposure to Pesticide and Veterinary Drugs Residues and Their Effects on Human Fertility and Embryo Development: A Global Overview
  17. CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?
  18. Focus of endothelial glycocalyx dysfunction in ischemic stroke and Alzheimer’s disease: Possible intervention strategies
  19. miRNA-Driven Regulation of Endothelial-to-Mesenchymal Transition Differs among Thoracic Aortic Aneurysms
  20. Is the Myasthenia Gravis (MG) the Result of Age and Sex/Gender? A Narrative Review for Identifying Genetic and Epigenetic Biomarkers for a Differential MG Management in Old and Young Women
  21. Is the Myasthenia Gravis (MG) the Result of Age and Sex/Gender? A Narrative Review for Identifying Genetic and Epigenetic Biomarkers for a Differential MG Management in Old and Young Women
  22. Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children
  23. Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children
  24. miRNA Regulation of Cell Phenotype and Parietal Remodeling in Atherosclerotic and Non-Atherosclerotic Aortic Aneurysms: Differences and Similarities
  25. The key role of miRNA in syndromic and sporadic forms of ascending aortic aneurysms as biomarkers and targets of novel therapeutic strategies
  26. Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?
  27. Could the Combination of eGFR and mGPS Facilitate the Differential Diagnosis of Age-Related Renal Decline from Diseases? A Large Study on the Population of Western Sicily
  28. Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?
  29. A promising therapeutic peptide and preventive/diagnostic biomarker for age-related diseases: The Elabela/Apela/Toddler peptide
  30. Could the Combination of eGFR and mGPS Facilitate the Differential Diagnosis of Age-Related Renal Decline from Diseases? A Large Study on the Population of Western Sicily
  31. New frontiers in ageing and longevity: Sex and gender medicine
  32. Prenatal exposure to CB2 receptors agonist differentially impacts male and female germ cells via histone modification
  33. Impact of age and gender on glioblastoma onset, progression, and management
  34. Sex differences in neuromuscular disorders
  35. The Role of Human Microbiota in Myasthenia Gravis: A Narrative Review
  36. A Particular Focus on the Prevalence of α- and β-Thalassemia in Western Sicilian Population from Trapani Province in the COVID-19 Era
  37. Circulating Levels of Ferritin, RDW, PTLs as Predictive Biomarkers of Postoperative Atrial Fibrillation Risk after Cardiac Surgery in Extracorporeal Circulation
  38. Circulating Levels of Ferritin, RDW, PTLs as Predictive Biomarkers of Postoperative Atrial Fibrillation Risk after Cardiac Surgery in Extracorporeal Circulation
  39. Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis
  40. The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A Preliminary Study
  41. Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis
  42. Biomarkers of Oxidative Stress in Acute and Chronic Diseases
  43. The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A Preliminary Study
  44. A Brief Overview on BDNF-Trk Pathway in the Nervous System: A Potential Biomarker or Possible Target in Treatment of Multiple Sclerosis?
  45. Promising Strategies for Preserving Adult Endothelium Health and Reversing Its Dysfunction: From Liquid Biopsy to New Omics Technologies and Noninvasive Circulating Biomarkers
  46. Promising Strategies for Preserving Adult Endothelium Health and Reversing Its Dysfunction: From the Liquid Biopsy to New Omics Technologies and Non-invasive Circulating Biomarkers
  47. Sodium-glucose cotransporter type 2 inhibitors prevent ponatinib-induced endothelial senescence and disfunction: A potential rescue strategy
  48. The close link between brain vascular pathological conditions and neurodegenerative diseases: Focus on some examples and potential treatments
  49. MIF rs755622 and IL6 rs1800795 Are Implied in Genetic Susceptibility to End-Stage Renal Disease (ESRD)
  50. Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms
  51. Direct RNA Nanopore Sequencing of SARS-CoV-2 Extracted from Critical Material from Swabs
  52. Risk of aortic dissection in patients with ascending aorta aneurysm: a new biological, morphological, and biomechanical network behind the aortic diameter
  53. Oxidative Stress Inside the Pathogenesis of Ascending Aorta Aneurysms: A Clearer Vision for Identifying Promising Biomarkers and Therapeutic Targets
  54. Genetic and Epigenetic Factors of Takotsubo Syndrome: A Systematic Review
  55. Genetic and Epigenetic Factors of Takotsubo Syndrome: a Systematic Review
  56. Polymorphisms of Pro-Inflammatory IL-6 and IL-1β Cytokines in Ascending Aortic Aneurysms as Genetic Modifiers and Predictive and Prognostic Biomarkers
  57. Constitutive PSGL-1 Correlates with CD30 and TCR Pathways and Represents a Potential Target for Immunotherapy in Anaplastic Large T-Cell Lymphoma
  58. To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm
  59. Vascular ageing and the related complications in the brain: New insights on related mechanisms and their translational applications
  60. SARS CoV2 infection _The longevity study perspectives
  61. The close link between the fetal programming imprinting and neurodegeneration in adulthood: The key role of “hemogenic endothelium” programming
  62. Role of Cachexia and Fragility in the Patient Candidate for Cardiac Surgery
  63. Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing?
  64. Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes
  65. Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease
  66. Genotyping strategy of SMAD-3 rs3825977 gene variant for a differential management of ascending aorta aneurysm in women people: Gender oriented diagnostic tools
  67. Fetal programming as the cause of all the evils in adult humans: atherosclerosis and coronary heart disease included
  68. To the research of treatments for the typical calcific disease of old aortic valve in the omics era: Is the miR-195 a therapeutic signature via targetable p38-MAPK/VWF axis in bicuspid aortic valve?
  69. Biomechanical properties and histomorphometric features of aortic tissue in patients with or without bicuspid aortic valve
  70. Stem cell therapy: old challenges and new solutions
  71. New Directions for Use of Systemic Drug Delivery in Anti-aging Medicine
  72. Stem cells and new intervention measures as emerging therapy in cardiac surgery
  73. Anti-ageing gene therapy: Not so far away?
  74. Biomarkers for vascular ageing in aorta tissues and blood samples
  75. On the Road to Accurate Biomarkers for Cardiometabolic Diseases by Integrating Precision and Gender Medicine Approaches
  76. Red Blood Cell Distribution Width, Vascular Aging Biomarkers, and Endothelial Progenitor Cells for Predicting Vascular Aging and Diagnosing/Prognosing Age-Related Degenerative Arterial Diseases
  77. Developmental programming of adult haematopoiesis system
  78. Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms
  79. Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity
  80. Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome
  81. An overview of the molecular mechanisms underlying development and progression of bicuspid aortic valve disease
  82. Diagnostic and Prognostic Relevance of Red Blood Cell Distribution Width for Vascular Aging and Cardiovascular Diseases
  83. Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy
  84. Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease
  85. Stem Cell Therapy
  86. The endoclamp device as a useful strategy during redo surgery on the aortic root and arch
  87. Fetal programming and its effects on vascular pulmonary circulation
  88. Deregulation of Notch1 pathway and circulating endothelial progenitor cell (EPC) number in patients with bicuspid aortic valve with and without ascending aorta aneurysm
  89. Diabetic macroangiopathy: Pathogenetic insights and novel therapeutic approaches with focus on high glucose-mediated vascular damage
  90. Early structural degeneration of Mitroflow aortic valve: another issue in addition to the mismatch?
  91. Stem Cells and Other Emerging Agents as Innovative “Drugs” in Neurodegenerative Diseases: Benefits and Limitations
  92. Cellular Senescence and Inflammaging in Age-Related Diseases
  93. A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?
  94. Anti-Inflamm-Ageing and/or Anti-Age-Related Disease Emerging Treatments: A Historical Alchemy or Revolutionary Effective Procedures?
  95. Role of TLR Polymorphisms in Aging and Age-Related Diseases
  96. Toll-like receptor-4 signaling pathway in aorta aging and diseases: “its double nature”
  97. Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches
  98. Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease
  99. Endothelial Progenitor Cells
  100. Endothelial Progenitor Cells and Their Clinical Applications as Potential Disease Biomarkers and Therapeutic Agents: Evidence and Controversies Regarding Their Effectiveness
  101. Endothelial Progenitor Cells: A Real Hope or an Unrealizable Dream? Which Measures or Strategies Are Necessary for making EPCs a clinical reality? Focus on a Potential Roadmap
  102. From Regenerative Medicine to Endothelial Progenitor Cells as Potential Candidates
  103. Abstracts of the 3rd Joint Meeting of Pathology and Laboratory Medicine
  104. Cellular and molecular basis of the imbalance between vascular damage and repair in ageing and age-related diseases: As biomarkers and targets for new treatments
  105. Endothelial progenitor cells in ageing
  106. Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?
  107. Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases
  108. Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative mitral valve diseases: a 4.8-year prospective cohort study
  109. The emerging role of Notch pathway in ageing: Focus on the related mechanisms in age-related diseases
  110. Penn classification in acute aortic dissection patients
  111. Genetic contribution in sporadic thoracic aortic aneurysm? Emerging evidence of genetic variants related to TLR-4-mediated signaling pathway as risk determinants
  112. Aging and Anti-Aging Strategies
  113. Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives
  114. Double negative (CD19+IgG+IgD−CD27−) B lymphocytes: A new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients
  115. Polymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and Aggressive Prostate Cancer Risk: A Systematic Review and Meta-Analysis
  116. 185 * RED BLOOD CELL DISTRIBUTION WIDTH PREDICTS MORBIDITY AND MORTALITY AFTER AORTIC VALVE REPLACEMENT
  117. Are the leukocyte telomere length attrition and telomerase activity alteration potential predictor biomarkers for sporadic TAA in aged individuals?
  118. SHIP2: A “NEW” Insulin Pathway Target for Aging Research
  119. Identification of Three Particular Morphological Phenotypes in Sporadic Thoracic Aortic Aneurysm: Phenotype III As Sporadic Thoracic Aortic Aneurysm Biomarker in Aged Individuals
  120. CRT-723 Is the Sporadic Thoracic Aortic Aneurysm the Result of an Inflammatory Process?
  121. CRT-724 Can the Aortic Wall Communicate with Us?
  122. Valves in the Heart of the Big Apple VIII: Evaluation and Management of Valvular Heart Diseases 2014. Fifth Annual Joint Scientific Session of the Heart Valve Society of America and Society of Heart Valve Diseases, New York City, N.Y., May 8-10, 2014: ...
  123. Can the TLR-4-Mediated Signaling Pathway Be “A Key Inflammatory Promoter for Sporadic TAA”?
  124. Evidences of +896 A/G TLR4 Polymorphism as an Indicative of Prevalence of Complications in T2DM Patients
  125. Prostate cancer: from the pathophysiologic implications of some genetic risk factors to translation in personalized cancer treatments
  126. Role of TGF-βPathway Polymorphisms in Sporadic Thoracic Aortic Aneurysm: rs900 TGF-β2 Is a Marker of Differential Gender Susceptibility
  127. Biomarkers and Inflammatory Network in Aging
  128. A model for studying longevity
  129. Diet and Immunosenescence
  130. Pathological Implications of Th1/Th2 Cytokine Genetic Variants in Behçet’s Disease: Data from a Pilot Study in a Sicilian Population
  131. NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
  132. Pro-Inflammatory Genetic Markers of Atherosclerosis
  133. Probiotics and Prebiotics
  134. The Role of Inflammation in Type a Aortic Dissection: A Pilot Study
  135. Focus on the unique mechanisms involved in thoracic aortic aneurysm formation in bicuspid aortic valve versus tricuspid aortic valve patients: clinical implications of a pilot study
  136. Abstracts of the 1st Joint Meeting of Pathology and Laboratory Diagnostics
  137. A particular phenotype of ascending aorta aneurysms as precursor of type A aortic dissection
  138. Genetics of longevity. Data from the studies on Sicilian centenarians
  139. Is the Mean Blood Leukocyte Telomere Length a Predictor for Sporadic Thoracic Aortic Aneurysm? Data from a Preliminary Study
  140. Histological and genetic studies in patients with bicuspid aortic valve and ascending aorta complications
  141. The Role of Macrophage Colony-Stimulating Factor in Patients With Acute Myocardial Infarction
  142. Genotyping of Sex Hormone-Related Pathways in Benign and Malignant Human Prostate Tissues: Data of a Preliminary Study
  143. LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: Biological effects of +896A/G TLR4 polymorphism in a Sicilian population of healthy subjects
  144. Prognostic value of PCR, IL-6 and IL-10 serum levels in determining postoperative complications after geriatric surgery in diabetic patients
  145. Changes of Inflammatory Mediators in Obese Patients After Laparoscopic Cholecystectomy
  146. Gender-Related Immune-Inflammatory Factors, Age-Related Diseases, and Longevity
  147. A Pilot Study on Prostate Cancer Risk and Pro-Inflammatory Genotypes: Pathophysiology and Therapeutic Implications
  148. Role of genetic polymorphisms in myocardial infarction at young age
  149. The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases
  150. Chronic Kidney Disease and Inflammation: Role of +896A/G Pro-Inflammatory Polymorphism of TLR4 Gene and Δ32 Deletion of CCR5 Gene
  151. TLR4 Polymorphisms and Ageing: Implications for the Pathophysiology of Age-Related Diseases
  152. Prognostic value of IL-6 and IL-10 serum levels and immunonutritional assessment in determining postoperative complications after geriatric surgery
  153. Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach
  154. CCR5 Proinflammatory Allele in Prostate Cancer Risk
  155. Pro-inflammatory genetic background and zinc status in old atherosclerotic subjects
  156. Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimers Disease
  157. Pro-Inflammatory Gene Variants in Myocardial Infarction and Longevity: Implications for Pharmacogenomics
  158. Inflammation, genes and zinc in Alzheimer's disease
  159. Immunosenescence and Anti-Immunosenescence Therapies: The Case of Probiotics
  160. TLR2 and Age-Related Diseases: Potential Effects of Arg753Gln and Arg677Trp Polymorphisms in Acute Myocardial Infarction
  161. Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity
  162. Impact of Different Texture of Polypropylene Mesh on the Inflammatory Response
  163. Pharmacogenomics: A Tool to Prevent and Cure Coronary Heart Disease
  164. Role of TLR4 Polymorphisms in Inflammatory Responses
  165. CCR5 Receptor
  166. Connexin37 1019 gene polymorphism in myocardial infarction patients and centenarians
  167. Genetics of Inflammation in Age‐Related Atherosclerosis
  168. PECAM‐1/CD31 in Infarction and Longevity
  169. Inflammatory networks in ageing, age-related diseases and longevity
  170. Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk: A pharmacogenomic approach
  171. Age‐Related Inflammatory Diseases
  172. Association between the Polymorphism of CCR5 and Alzheimer's Disease
  173. Genetic Control of Immune Response in Carriers of Ancestral Haplotype 8.1
  174. Immunogenetics, Gender, and Longevity
  175. Role of Proinflammatory Alleles in Longevity and Atherosclerosis
  176. Association between +1059G/C CRP Polymorphism and Acute Myocardial Infarction in a Cohort of Patients from Sicily
  177. Inflammation, Longevity, and Cardiovascular Diseases
  178. Opposite Role of Pro‐Inflammatory Alleles in Acute Myocardial Infarction and Longevity
  179. Systemic inflammatory response in erderly patients following hernioplastical operation
  180. ACUTE PHASE RESPONSE IN OLDEST‐OLD INDIVIDUALS AFTER SURGICAL STRESS
  181. Association Between the HLA-A2 Allele and Alzheimer Disease
  182. Biology of Longevity: Role of the Innate Immune System
  183. The nACHR4 594C/T Polymorphism in Alzheimer Disease
  184. Role of TLR4 Receptor Polymorphisms in Boutonneuse Fever
  185. Role of Toll-like Receptor 4 in Acute Myocardial Infarction and Longevity
  186. Major histocompatibility complex and sporadic Alzheimer's disease: a critical reappraisal
  187. Association between HFE mutations and acute myocardial infarction: a study in patients from Northern and Southern Italy
  188. Association between the HFE mutations and longevity: a study in Sardinian population
  189. Association between the HFE mutations and unsuccessful ageing: a study in Alzheimer's disease patients from Northern Italy
  190. Frequency of the HFE Gene Mutations in Five Italian Populations
  191. Prescribing behavior for the elderly in the United Arab Emirates: psychotropic medication use remains low despite rising overall appropriate and inappropriate medication use
  192. Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population
  193. Analysis of hemochromatosis gene mutations in the sicilian population: implications for survival and longevity
  194. Effects of in vitro treatment with fluticasone propionate on natural killer and lymphokine‐induced killer activity in asthmatic and healthy individuals
  195. In Vitro Treatment with Interleukin-2 Normalizes Type-1 Cytokine Production by Lymphocytes from Elderly
  196. Granulocyte and natural killer activity in the elderly
  197. Interleukin-5 production by mononuclear cells from aged individuals: implication for autoimmunity
  198. Apoptosis and ageing