All Stories

  1. ABO blood groups and ageing-related outcomes: Insights from a narrative review
  2. Individuals with ABO Groups Show Significant Differences in Levels of Circulating Biomarkers Related to Inflammation, Apoptosis, Endothelial Dysfunction, Tissue Remodeling and Neurodegeneration: A Pilot Study
  3. The Efficacy of Antihypertensive Drugs and miR-632 Inhibition on Parietal Remodeling in a Model of Marfan Thoracic Aortic Aneurysm
  4. Artificial Intelligence in Aorta Aneurysm Management: Translational Applications and Limits
  5. <span class="word">Efficacy <span class="word">of <span class="word"><span class="changedDisabled">Antihypertensive <span class="word"><span class="changedDisabled">Drugs <span class="word">and <span class="...
  6. Cytokine Gene Polymorphisms Modulate Isohemagglutinin Titers and Classes: Another Aspect Towards the Link Between ABO Groups and Human Pathologies?
  7. Promising biomarkers for mild cognitive impairment and Alzheimer’s disease: Levels of soluble endothelial glycocalyx products
  8. The Promising Role of Artificial Intelligence in Aorta Aneurysms: An Aid not a Surrogate in Clinical Management
  9. Insights into the toxic effects of micro-nano-plastics on the human brain and their relationship with the onset of neurological diseases: A narrative review
  10. Biomarkers in Heart Failure: A Review and a Wish
  11. Is It the Time to Revolutionize the Heart Failure Management with Emerging Biomarkers and Innovative Targeted Treatments? From Re-Search Evidence to Clinic
  12. Rituximab in stiff-person syndrome with glutamic acid decarboxylase 65 autoantibody: a systematic review
  13. Shed Syndecans (1–3), ELA-32, BDNF, NLR, and hs-CRP in Parkinson’s Disease: Appropriate Diagnostic and Prognostic Biomarkers When Combined in a Unique Panel
  14. TREM 2 in Parkinson’s Disease: A Promising Candidate Gene for Disease Susceptibility and Progression
  15. A Narrative Review: Syndecans in Aortic Aneurysm Pathogenesis and Course—Biomarkers and Targets?
  16. Towards personalized management of myasthenia gravis phenotypes: From the role of multi-omics to the emerging biomarkers and therapeutic targets
  17. In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targets for personalized treatments
  18. Correction: Inflammation scores based on C‑reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis
  19. Syndecans in Aortic Aneurysm Pathogenesis and Course: A Narrative Review. Biomarkers and Targets?
  20. Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis
  21. Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]
  22. Syndecans in Alzheimer’s disease: pathogenetic mechanisms and potential therapeutic targets
  23. Dietary Exposure to Pesticide and Veterinary Drug Residues and Their Effects on Human Fertility and Embryo Development: A Global Overview
  24. Dietary Exposure to Pesticide and Veterinary Drugs Residues and Their Effects on Human Fertility and Embryo Development: A Global Overview
  25. CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?
  26. Focus of endothelial glycocalyx dysfunction in ischemic stroke and Alzheimer’s disease: Possible intervention strategies
  27. miRNA-Driven Regulation of Endothelial-to-Mesenchymal Transition Differs among Thoracic Aortic Aneurysms
  28. Is the Myasthenia Gravis (MG) the Result of Age and Sex/Gender? A Narrative Review for Identifying Genetic and Epigenetic Biomarkers for a Differential MG Management in Old and Young Women
  29. Is the Myasthenia Gravis (MG) the Result of Age and Sex/Gender? A Narrative Review for Identifying Genetic and Epigenetic Biomarkers for a Differential MG Management in Old and Young Women
  30. Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children
  31. Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children
  32. miRNA Regulation of Cell Phenotype and Parietal Remodeling in Atherosclerotic and Non-Atherosclerotic Aortic Aneurysms: Differences and Similarities
  33. The key role of miRNA in syndromic and sporadic forms of ascending aortic aneurysms as biomarkers and targets of novel therapeutic strategies
  34. Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?
  35. Could the Combination of eGFR and mGPS Facilitate the Differential Diagnosis of Age-Related Renal Decline from Diseases? A Large Study on the Population of Western Sicily
  36. Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?
  37. A promising therapeutic peptide and preventive/diagnostic biomarker for age-related diseases: The Elabela/Apela/Toddler peptide
  38. Could the Combination of eGFR and mGPS Facilitate the Differential Diagnosis of Age-Related Renal Decline from Diseases? A Large Study on the Population of Western Sicily
  39. New frontiers in ageing and longevity: Sex and gender medicine
  40. Prenatal exposure to CB2 receptors agonist differentially impacts male and female germ cells via histone modification
  41. Impact of age and gender on glioblastoma onset, progression, and management
  42. Sex differences in neuromuscular disorders
  43. The Role of Human Microbiota in Myasthenia Gravis: A Narrative Review
  44. A Particular Focus on the Prevalence of α- and β-Thalassemia in Western Sicilian Population from Trapani Province in the COVID-19 Era
  45. Circulating Levels of Ferritin, RDW, PTLs as Predictive Biomarkers of Postoperative Atrial Fibrillation Risk after Cardiac Surgery in Extracorporeal Circulation
  46. Circulating Levels of Ferritin, RDW, PTLs as Predictive Biomarkers of Postoperative Atrial Fibrillation Risk after Cardiac Surgery in Extracorporeal Circulation
  47. Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis
  48. The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A Preliminary Study
  49. Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis
  50. Biomarkers of Oxidative Stress in Acute and Chronic Diseases
  51. The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A Preliminary Study
  52. A Brief Overview on BDNF-Trk Pathway in the Nervous System: A Potential Biomarker or Possible Target in Treatment of Multiple Sclerosis?
  53. Promising Strategies for Preserving Adult Endothelium Health and Reversing Its Dysfunction: From Liquid Biopsy to New Omics Technologies and Noninvasive Circulating Biomarkers
  54. Promising Strategies for Preserving Adult Endothelium Health and Reversing Its Dysfunction: From the Liquid Biopsy to New Omics Technologies and Non-invasive Circulating Biomarkers
  55. Sodium-glucose cotransporter type 2 inhibitors prevent ponatinib-induced endothelial senescence and disfunction: A potential rescue strategy
  56. The close link between brain vascular pathological conditions and neurodegenerative diseases: Focus on some examples and potential treatments
  57. MIF rs755622 and IL6 rs1800795 Are Implied in Genetic Susceptibility to End-Stage Renal Disease (ESRD)
  58. Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms
  59. Direct RNA Nanopore Sequencing of SARS-CoV-2 Extracted from Critical Material from Swabs
  60. Risk of aortic dissection in patients with ascending aorta aneurysm: a new biological, morphological, and biomechanical network behind the aortic diameter
  61. Oxidative Stress Inside the Pathogenesis of Ascending Aorta Aneurysms: A Clearer Vision for Identifying Promising Biomarkers and Therapeutic Targets
  62. Genetic and Epigenetic Factors of Takotsubo Syndrome: A Systematic Review
  63. Genetic and Epigenetic Factors of Takotsubo Syndrome: a Systematic Review
  64. Polymorphisms of Pro-Inflammatory IL-6 and IL-1β Cytokines in Ascending Aortic Aneurysms as Genetic Modifiers and Predictive and Prognostic Biomarkers
  65. Constitutive PSGL-1 Correlates with CD30 and TCR Pathways and Represents a Potential Target for Immunotherapy in Anaplastic Large T-Cell Lymphoma
  66. To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm
  67. Vascular ageing and the related complications in the brain: New insights on related mechanisms and their translational applications
  68. SARS CoV2 infection _The longevity study perspectives
  69. The close link between the fetal programming imprinting and neurodegeneration in adulthood: The key role of “hemogenic endothelium” programming
  70. Role of Cachexia and Fragility in the Patient Candidate for Cardiac Surgery
  71. Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing?
  72. Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes
  73. Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease
  74. Genotyping strategy of SMAD-3 rs3825977 gene variant for a differential management of ascending aorta aneurysm in women people: Gender oriented diagnostic tools
  75. Fetal programming as the cause of all the evils in adult humans: atherosclerosis and coronary heart disease included
  76. To the research of treatments for the typical calcific disease of old aortic valve in the omics era: Is the miR-195 a therapeutic signature via targetable p38-MAPK/VWF axis in bicuspid aortic valve?
  77. Biomechanical properties and histomorphometric features of aortic tissue in patients with or without bicuspid aortic valve
  78. Stem cell therapy: old challenges and new solutions
  79. New Directions for Use of Systemic Drug Delivery in Anti-aging Medicine
  80. Stem cells and new intervention measures as emerging therapy in cardiac surgery
  81. Anti-ageing gene therapy: Not so far away?
  82. Biomarkers for vascular ageing in aorta tissues and blood samples
  83. On the Road to Accurate Biomarkers for Cardiometabolic Diseases by Integrating Precision and Gender Medicine Approaches
  84. Red Blood Cell Distribution Width, Vascular Aging Biomarkers, and Endothelial Progenitor Cells for Predicting Vascular Aging and Diagnosing/Prognosing Age-Related Degenerative Arterial Diseases
  85. Developmental programming of adult haematopoiesis system
  86. Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms
  87. Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity
  88. Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome
  89. An overview of the molecular mechanisms underlying development and progression of bicuspid aortic valve disease
  90. Diagnostic and Prognostic Relevance of Red Blood Cell Distribution Width for Vascular Aging and Cardiovascular Diseases
  91. Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy
  92. Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease
  93. Stem Cell Therapy
  94. The endoclamp device as a useful strategy during redo surgery on the aortic root and arch
  95. Fetal programming and its effects on vascular pulmonary circulation
  96. Deregulation of Notch1 pathway and circulating endothelial progenitor cell (EPC) number in patients with bicuspid aortic valve with and without ascending aorta aneurysm
  97. Diabetic macroangiopathy: Pathogenetic insights and novel therapeutic approaches with focus on high glucose-mediated vascular damage
  98. Early structural degeneration of Mitroflow aortic valve: another issue in addition to the mismatch?
  99. Stem Cells and Other Emerging Agents as Innovative “Drugs” in Neurodegenerative Diseases: Benefits and Limitations
  100. Cellular Senescence and Inflammaging in Age-Related Diseases
  101. A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?
  102. Anti-Inflamm-Ageing and/or Anti-Age-Related Disease Emerging Treatments: A Historical Alchemy or Revolutionary Effective Procedures?
  103. Role of TLR Polymorphisms in Aging and Age-Related Diseases
  104. Toll-like receptor-4 signaling pathway in aorta aging and diseases: “its double nature”
  105. Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches
  106. Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease
  107. Endothelial Progenitor Cells
  108. Endothelial Progenitor Cells and Their Clinical Applications as Potential Disease Biomarkers and Therapeutic Agents: Evidence and Controversies Regarding Their Effectiveness
  109. Endothelial Progenitor Cells: A Real Hope or an Unrealizable Dream? Which Measures or Strategies Are Necessary for making EPCs a clinical reality? Focus on a Potential Roadmap
  110. From Regenerative Medicine to Endothelial Progenitor Cells as Potential Candidates
  111. Abstracts of the 3rd Joint Meeting of Pathology and Laboratory Medicine
  112. Cellular and molecular basis of the imbalance between vascular damage and repair in ageing and age-related diseases: As biomarkers and targets for new treatments
  113. Endothelial progenitor cells in ageing
  114. Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?
  115. Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases
  116. Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative mitral valve diseases: a 4.8-year prospective cohort study
  117. The emerging role of Notch pathway in ageing: Focus on the related mechanisms in age-related diseases
  118. Penn classification in acute aortic dissection patients
  119. Genetic contribution in sporadic thoracic aortic aneurysm? Emerging evidence of genetic variants related to TLR-4-mediated signaling pathway as risk determinants
  120. Aging and Anti-Aging Strategies
  121. Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives
  122. Double negative (CD19+IgG+IgD−CD27−) B lymphocytes: A new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients
  123. Polymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and Aggressive Prostate Cancer Risk: A Systematic Review and Meta-Analysis
  124. 185 * RED BLOOD CELL DISTRIBUTION WIDTH PREDICTS MORBIDITY AND MORTALITY AFTER AORTIC VALVE REPLACEMENT
  125. Are the leukocyte telomere length attrition and telomerase activity alteration potential predictor biomarkers for sporadic TAA in aged individuals?
  126. SHIP2: A “NEW” Insulin Pathway Target for Aging Research
  127. Identification of Three Particular Morphological Phenotypes in Sporadic Thoracic Aortic Aneurysm: Phenotype III As Sporadic Thoracic Aortic Aneurysm Biomarker in Aged Individuals
  128. CRT-723 Is the Sporadic Thoracic Aortic Aneurysm the Result of an Inflammatory Process?
  129. CRT-724 Can the Aortic Wall Communicate with Us?
  130. Valves in the Heart of the Big Apple VIII: Evaluation and Management of Valvular Heart Diseases 2014. Fifth Annual Joint Scientific Session of the Heart Valve Society of America and Society of Heart Valve Diseases, New York City, N.Y., May 8-10, 2014: ...
  131. Can the TLR-4-Mediated Signaling Pathway Be “A Key Inflammatory Promoter for Sporadic TAA”?
  132. Evidences of +896 A/G TLR4 Polymorphism as an Indicative of Prevalence of Complications in T2DM Patients
  133. Prostate cancer: from the pathophysiologic implications of some genetic risk factors to translation in personalized cancer treatments
  134. Role of TGF-βPathway Polymorphisms in Sporadic Thoracic Aortic Aneurysm: rs900 TGF-β2 Is a Marker of Differential Gender Susceptibility
  135. Biomarkers and Inflammatory Network in Aging
  136. A model for studying longevity
  137. Diet and Immunosenescence
  138. Pathological Implications of Th1/Th2 Cytokine Genetic Variants in Behçet’s Disease: Data from a Pilot Study in a Sicilian Population
  139. NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
  140. Pro-Inflammatory Genetic Markers of Atherosclerosis
  141. Probiotics and Prebiotics
  142. The Role of Inflammation in Type a Aortic Dissection: A Pilot Study
  143. Focus on the unique mechanisms involved in thoracic aortic aneurysm formation in bicuspid aortic valve versus tricuspid aortic valve patients: clinical implications of a pilot study
  144. Abstracts of the 1st Joint Meeting of Pathology and Laboratory Diagnostics
  145. A particular phenotype of ascending aorta aneurysms as precursor of type A aortic dissection
  146. Genetics of longevity. Data from the studies on Sicilian centenarians
  147. Is the Mean Blood Leukocyte Telomere Length a Predictor for Sporadic Thoracic Aortic Aneurysm? Data from a Preliminary Study
  148. Histological and genetic studies in patients with bicuspid aortic valve and ascending aorta complications
  149. The Role of Macrophage Colony-Stimulating Factor in Patients With Acute Myocardial Infarction
  150. Genotyping of Sex Hormone-Related Pathways in Benign and Malignant Human Prostate Tissues: Data of a Preliminary Study
  151. LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: Biological effects of +896A/G TLR4 polymorphism in a Sicilian population of healthy subjects
  152. Prognostic value of PCR, IL-6 and IL-10 serum levels in determining postoperative complications after geriatric surgery in diabetic patients
  153. Changes of Inflammatory Mediators in Obese Patients After Laparoscopic Cholecystectomy
  154. Gender-Related Immune-Inflammatory Factors, Age-Related Diseases, and Longevity
  155. A Pilot Study on Prostate Cancer Risk and Pro-Inflammatory Genotypes: Pathophysiology and Therapeutic Implications
  156. Role of genetic polymorphisms in myocardial infarction at young age
  157. The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases
  158. Chronic Kidney Disease and Inflammation: Role of +896A/G Pro-Inflammatory Polymorphism of TLR4 Gene and Δ32 Deletion of CCR5 Gene
  159. TLR4 Polymorphisms and Ageing: Implications for the Pathophysiology of Age-Related Diseases
  160. Prognostic value of IL-6 and IL-10 serum levels and immunonutritional assessment in determining postoperative complications after geriatric surgery
  161. Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach
  162. CCR5 Proinflammatory Allele in Prostate Cancer Risk
  163. Pro-inflammatory genetic background and zinc status in old atherosclerotic subjects
  164. Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimers Disease
  165. Pro-Inflammatory Gene Variants in Myocardial Infarction and Longevity: Implications for Pharmacogenomics
  166. Inflammation, genes and zinc in Alzheimer's disease
  167. Immunosenescence and Anti-Immunosenescence Therapies: The Case of Probiotics
  168. TLR2 and Age-Related Diseases: Potential Effects of Arg753Gln and Arg677Trp Polymorphisms in Acute Myocardial Infarction
  169. Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity
  170. Impact of Different Texture of Polypropylene Mesh on the Inflammatory Response
  171. Pharmacogenomics: A Tool to Prevent and Cure Coronary Heart Disease
  172. Role of TLR4 Polymorphisms in Inflammatory Responses
  173. CCR5 Receptor
  174. Connexin37 1019 gene polymorphism in myocardial infarction patients and centenarians
  175. Genetics of Inflammation in Age‐Related Atherosclerosis
  176. PECAM‐1/CD31 in Infarction and Longevity
  177. Inflammatory networks in ageing, age-related diseases and longevity
  178. Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk: A pharmacogenomic approach
  179. Age‐Related Inflammatory Diseases
  180. Association between the Polymorphism of CCR5 and Alzheimer's Disease
  181. Genetic Control of Immune Response in Carriers of Ancestral Haplotype 8.1
  182. Immunogenetics, Gender, and Longevity
  183. Role of Proinflammatory Alleles in Longevity and Atherosclerosis
  184. Association between +1059G/C CRP Polymorphism and Acute Myocardial Infarction in a Cohort of Patients from Sicily
  185. Inflammation, Longevity, and Cardiovascular Diseases
  186. Opposite Role of Pro‐Inflammatory Alleles in Acute Myocardial Infarction and Longevity
  187. Systemic inflammatory response in erderly patients following hernioplastical operation
  188. ACUTE PHASE RESPONSE IN OLDEST‐OLD INDIVIDUALS AFTER SURGICAL STRESS
  189. Association Between the HLA-A2 Allele and Alzheimer Disease
  190. Biology of Longevity: Role of the Innate Immune System
  191. The nACHR4 594C/T Polymorphism in Alzheimer Disease
  192. Role of TLR4 Receptor Polymorphisms in Boutonneuse Fever
  193. Role of Toll-like Receptor 4 in Acute Myocardial Infarction and Longevity
  194. Major histocompatibility complex and sporadic Alzheimer's disease: a critical reappraisal
  195. Association between HFE mutations and acute myocardial infarction: a study in patients from Northern and Southern Italy
  196. Association between the HFE mutations and longevity: a study in Sardinian population
  197. Association between the HFE mutations and unsuccessful ageing: a study in Alzheimer's disease patients from Northern Italy
  198. Frequency of the HFE Gene Mutations in Five Italian Populations
  199. Prescribing behavior for the elderly in the United Arab Emirates: psychotropic medication use remains low despite rising overall appropriate and inappropriate medication use
  200. Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population
  201. Analysis of hemochromatosis gene mutations in the sicilian population: implications for survival and longevity
  202. Effects of in vitro treatment with fluticasone propionate on natural killer and lymphokine‐induced killer activity in asthmatic and healthy individuals
  203. In Vitro Treatment with Interleukin-2 Normalizes Type-1 Cytokine Production by Lymphocytes from Elderly
  204. Granulocyte and natural killer activity in the elderly
  205. Interleukin-5 production by mononuclear cells from aged individuals: implication for autoimmunity
  206. Apoptosis and ageing