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  1. Behind the scenes: how the EMILIN /Multimerin family shapes the cancer landscape

    Article • European Journal of Biochemistry, November 2025, Wiley

    PhD Paola Spessotto

  2. Gastrointestinal cancers: Therapeutic progress, diagnostic challenges, and the imperative of prevention

    Article • Digestive and Liver Disease, November 2025, Elsevier

    PhD Paola Spessotto

  3. Disrupted mucosal vascular barrier in eosinophilic esophagitis

    Article • Scientific Reports, July 2025, Springer Science + Business Media

    PhD Paola Spessotto

  4. The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway

    Article • Frontiers in Immunology, June 2025, Frontiers

    PhD Paola Spessotto

  5. “Unraveling EMILIN-1: A Multifunctional ECM Protein with Tumor-Suppressive Roles” Mechanistic Insights into Cancer Protection Through Signaling Modulation and Lymphangiogenesis Control

    Article • Cells, June 2025, MDPI AG

    PhD Paola Spessotto

  6. "Unraveling EMILIN-1: A Multifunctional ECM Protein with Tumor-Suppressive Roles" Mechanistic Insights Into Cancer Protection Through Signaling Modulation and Lymphangiogenesis Control

    Article • June 2025, MDPI AG

    PhD Paola Spessotto

  7. Probe-based confocal laser endomicroscopy intra-operative evaluation in ovarian cancer: definition of in vivo architectural patterns to determine resection strategies

    Article • International Journal of Gynecological Cancer, February 2025, Elsevier

    PhD Paola Spessotto

  8. The extracellular matrix protein EMILIN-1 impacts on the microenvironment by hampering gastric cancer development and progression

    Article • Gastric Cancer, June 2024, Springer Science + Business Media

    PhD Paola Spessotto

  9. Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer

    Article • EMBO Molecular Medicine, April 2024, Springer Science + Business Media

    PhD Paola Spessotto

  10. Loss of the extracellular matrix glycoprotein EMILIN1 accelerates Δ16HER2-driven breast cancer initiation in mice

    Article • npj Breast Cancer, January 2024, Springer Science + Business Media

    PhD Paola Spessotto

  11. Emilin2 fosters vascular stability by promoting pericyte recruitment

    Article • Matrix Biology, September 2023, Elsevier

    PhD Paola Spessotto

  12. EMILIN-1 deficiency promotes chronic inflammatory disease through TGFβ signaling alteration and impairment of the gC1q/α4β1 integrin interaction

    Article • Matrix Biology, August 2022, Elsevier

    PhD Paola Spessotto

  13. pCLE detects mucosal neoplastic vascular pattern in gastric linitis plastica

    Article • Clinical and Experimental Medicine, June 2022, Springer Science + Business Media

    PhD Paola Spessotto

  14. Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway

    Article • Journal of Experimental & Clinical Cancer Research, February 2022, Springer Science + Business Media

    Dr Marco Scarpa, PhD Paola Spessotto

  15. Nucleofection of Adipose Mesenchymal Stem/Stromal Cells: Improved Transfection Efficiency for GMP Grade Applications

    Article • Cells, December 2021, MDPI AG

    PhD Paola Spessotto

  16. Elastin MIcrofibriL INterfacer1 (EMILIN‐1) is an alternative prosurvival VLA‐4 ligand in chronic lymphocytic leukemia

    Article • Hematological Oncology, November 2021, Wiley

    PhD Paola Spessotto

  17. pCLE highlights distinctive vascular patterns in early gastric cancer and in gastric diseases with high risk of malignant complications

    Article • Scientific Reports, October 2021, Springer Science + Business Media

    PhD Paola Spessotto

  18. Multimerin-2 orchestrates the cross-talk between endothelial cells and pericytes: A mechanism to maintain vascular stability

    Article • Matrix Biology Plus, August 2021, Elsevier

    PhD Paola Spessotto

  19. Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis

    Article • International Journal of Molecular Sciences, July 2021, MDPI AG

    PhD Paola Spessotto

  20. Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells

    Article • Oncogene, August 2020, Springer Science + Business Media

    PhD Paola Spessotto

  21. The Autophagy Machinery Contributes to E-cadherin Turnover in Breast Cancer

    Article • Frontiers in Cell and Developmental Biology, June 2020, Frontiers

    PhD Paola Spessotto

  22. Role of Extracellular Matrix in Gastrointestinal Cancer-Associated Angiogenesis

    Article • International Journal of Molecular Sciences, May 2020, MDPI AG

    PhD Paola Spessotto

  23. Deregulated expression of Elastin Microfibril Interfacer 2 (EMILIN2) in gastric cancer affects tumor growth and angiogenesis

    Article • Matrix Biology Plus, May 2020, Elsevier

    PhD Paola Spessotto

  24. Distal motor neuropathy associated with novel EMILIN1 mutation

    Article • Neurobiology of Disease, April 2020, Elsevier

    PhD Paola Spessotto

  25. Multispectral imaging technology: Visualize, analyze, phenotyping, and quantify immune cells in situ

    Article • The International Journal of Biological Markers, February 2020, SAGE Publications

    PhD Paola Spessotto

  26. The role of molecular and imaging biomarkers in the evaluation of inflammation in oncology

    Article • The International Journal of Biological Markers, February 2020, SAGE Publications

    PhD Paola Spessotto

  27. Multiplex staining depicts the immune infiltrate in colitis-induced colon cancer model

    Article • Scientific Reports, September 2019, Springer Science + Business Media

    PhD Paola Spessotto

  28. Abrogation of EMILIN1-β1 integrin interaction promotes experimental colitis and colon carcinogenesis

    Article • Matrix Biology, August 2019, Elsevier

    PhD Paola Spessotto

  29. Evaluation of neoangiogenesis in locally advanced gastric cancer before and after neoadjuvant radiochemotherapy by probe confocal laser endomicroscopy (PCLE)

    Article • Annals of Oncology, July 2019, Elsevier

    PhD Paola Spessotto

  30. The Probe Based Confocal Laser Endomicroscopy (pCLE) in Locally Advanced Gastric Cancer: A Powerful Technique for Real–Time Analysis of Vasculature

    Article • Frontiers in Oncology, June 2019, Frontiers

    PhD Paola Spessotto

  31. Endomicroscopy for HGNEC diagnosis

    Article • OncoTargets and Therapy, June 2019, Dove Medical Press

    Renato Cannizzaro, PhD Paola Spessotto, Giovanni Guarnieri

  32. OC.04.4 EMILIN1 DEFICIENCY AFFECTS EXPERIMENTAL COLITIS AND COLON CARCINOGENESIS ENHANCING LYMPHATIC DYSFUNCTION

    Article • Digestive and Liver Disease, March 2019, Elsevier

    PhD Paola Spessotto

  33. P.05.34 EVALUATION OF NEOANGIOGENESIS IN LOCALLY ADVANCED GASTRIC CANCER BEFORE AND AFTER NEOADJUVANT RADIOCHEMOTHERAPY BY PROBE CONFOCAL LASER ENDOMICROSCOPY (PCLE)

    Article • Digestive and Liver Disease, March 2019, Elsevier

    PhD Paola Spessotto

  34. Diagnosis and Surveillance: Endoscopic Hallmarks

    Article • January 2019, Springer Science + Business Media

    PhD Paola Spessotto

  35. Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis

    Article • International Journal of Molecular Sciences, December 2018, MDPI AG

    PhD Paola Spessotto

  36. Integrin binding site within the gC1q domain orchestrates EMILIN-1-induced lymphangiogenesis

    Article • Matrix Biology, October 2018, Elsevier

    PhD Paola Spessotto

  37. The α4β1/EMILIN1 interaction discloses a novel and unique integrin-ligand type of engagement

    Article • Matrix Biology, March 2018, Elsevier

    PhD Paola Spessotto

  38. The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis

    Article • Matrix Biology, December 2017, Elsevier

    PhD Paola Spessotto

  39. Probe-based confocal laser endomicroscopy for in vivo evaluation of the tumor vasculature in gastric and rectal carcinomas

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    PhD Paola Spessotto

  40. Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    PhD Paola Spessotto

  41. The extracellular matrix protein EMILIN1 silences the RAS-ERK pathway via α4β1 integrin and decreases tumor cell growth

    Article • Oncotarget, February 2017, Impact Journals, LLC

    PhD Paola Spessotto

  42. Neutrophil elastase cleavage of the gC1q domain impairs the EMILIN1-α4β1 integrin interaction, cell adhesion and anti-proliferative activity

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    PhD Paola Spessotto

  43. Angiogenesis evaluation in locally advanced colo-rectal and gastric cancers by probe-based Confocal Laser Endomicroscopy (pCLE)

    Article • Annals of Oncology, September 2016, Elsevier

    PhD Paola Spessotto

  44. Tumor microenvironment in diffuse large B-cell lymphoma: Matrixmetalloproteinases activation is mediated by osteopontin overexpression

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, March 2016, Elsevier

    Professor Claudio Guarneri, PhD Paola Spessotto

  45. Local inhibition of elastase reduces EMILIN1 cleavage reactivating lymphatic vessel function in a mouse lymphoedema model

    Article • Clinical Science, February 2016, Portland Press Ltd.

    PhD Paola Spessotto

  46. Diagnostic Exome Sequencing Identifies a Novel Gene, EMILIN1 , Associated with Autosomal‐Dominant Hereditary Connective Tissue Disease

    Article • Human Mutation, November 2015, Wiley

    Ms Kelly D Farwell Hagman, PhD Paola Spessotto

  47. Functional osteoclastogenesis: the baseline variability in blood donor precursors is not associated with age and gender

    Article • Oncotarget, September 2015, Impact Journals, LLC

    PhD Paola Spessotto

  48. Su1708 Probe-Based Confocal LASER Endomicroscopy (pCLE) for Angiogenesis Evaluation in Locally Advanced Rectal and Gastric Cancers

    Article • Gastrointestinal Endoscopy, May 2015, Elsevier

    PhD Paola Spessotto

  49. Probe-confocal laser endomicroscopy: implications for nursing care

    Article • Gastrointestinal Nursing, June 2014, Mark Allen Group

    PhD Paola Spessotto

  50. P.01.10 DIFFERENTIAL PROTEOMICS OF COLORECTAL CANCER: SEARCHING FOR SENTINEL CANCER AND ANGIOGENIC PROTEINS

    Article • Digestive and Liver Disease, March 2014, Elsevier

    PhD Paola Spessotto

  51. Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1

    Article • Matrix Biology, February 2014, Elsevier

    PhD Paola Spessotto

  52. EMILIN1/α9β1 Integrin Interaction Is Crucial in Lymphatic Valve Formation and Maintenance

    Article • Molecular and Cellular Biology, September 2013, ASM Journals

    PhD Paola Spessotto

  53. The Elastin Microfibril Interfacer-1 (EMILIN-1) Is a Ligand for CD49d in Chronic Lymphocytic Leukemia Cells

    Article • Blood, November 2012, American Society of Hematology

    PhD Paola Spessotto

  54. An EMILIN1-Negative Microenvironment Promotes Tumor Cell Proliferation and Lymph Node Invasion

    Article • Cancer Prevention Research, July 2012, American Association for Cancer Research (AACR)

    PhD Paola Spessotto

  55. EMILIN1–α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation

    Article • Journal of Cell Biology, January 2012, Rockefeller University Press

    PhD Paola Spessotto

  56. Endomicroscopy and Cancer: A New Approach to the Visualization of Neoangiogenesis

    Article • Gastroenterology Research and Practice, January 2012, Hindawi Publishing Corporation

    PhD Paola Spessotto

  57. The EMILIN/Multimerin Family

    Article • Frontiers in Immunology, January 2012, Frontiers

    PhD Paola Spessotto

  58. MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases

    Article • October 2011, Springer Science + Business Media

    PhD Paola Spessotto, Claudio Tripodo

  59. EMILIN1–α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation

    Article • Journal of Cell Biology, September 2011, Rockefeller University Press

    PhD Paola Spessotto

  60. Cancer Stem Cells and the Microenvironment

    Article • September 2011, Springer Science + Business Media

    PhD Paola Spessotto

  61. Preeclampsia is associated with defective production of C1q by invasive trophoblast

    Article • Molecular Immunology, August 2011, Elsevier

    Claudio Tripodo, PhD Paola Spessotto

  62. Blood-derived human osteoclast resorption activity is impaired by Hyaluronan-CD44 engagement via a p38-dependent mechanism

    Article • Journal of Cellular Physiology, December 2010, Wiley

    PhD Paola Spessotto

  63. An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development

    Article • The Journal of Immunology, September 2010, The American Association of Immunologists

    PhD Paola Spessotto, Claudio Tripodo

  64. Effect of intensive insulin therapy on glutathione synthesis rate in cancer patients with stress hyperglycemia after major surgery.

    Article • Journal of Clinical Oncology, May 2010, American Society of Clinical Oncology (ASCO)

    PhD Paola Spessotto

  65. Abstract 3013: Differential approach to define microRNA expression patterns in osteosarcomas

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    PhD Paola Spessotto

  66. MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment

    Article • Molecular Cancer, January 2010, Springer Science + Business Media

    PhD Paola Spessotto

  67. Role of E2F1-Cyclin E1-Cyclin E2 Circuit in Human Coronary Smooth Muscle Cell Proliferation and Therapeutic Potential of Its Downregulation by siRNAs

    Article • World Journal of Surgery, June 2009, Springer Science + Business Media

    PhD Paola Spessotto

  68. A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction

    Article • Glycobiology, June 2009, Oxford University Press (OUP)

    PhD Paola Spessotto

  69. Fluorescence-Based Assays for In Vitro Analysis of Cell Adhesion and Migration

    Article • January 2009, Springer Science + Business Media

    PhD Paola Spessotto

  70. The Solution Structure of EMILIN1 Globular C1q Domain Reveals a Disordered Insertion Necessary for Interaction with the α4β1 Integrin

    Article • Journal of Biological Chemistry, May 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Paola Spessotto

  71. Emilin1 Deficiency Causes Structural and Functional Defects of Lymphatic Vasculature

    Article • Molecular and Cellular Biology, April 2008, ASM Journals

    PhD Paola Spessotto

  72. Expression profiles in malignant fibrous histiocytomas: Clues for differentiating ‘spindle cell’ and ‘pleomorphic’ subtypes

    Article • European Journal of Cancer, January 2008, Elsevier

    PhD Paola Spessotto

  73. Laminin-332 (Laminin-5) is the major motility ligand for B cell chronic lymphocytic leukemia

    Article • Matrix Biology, July 2007, Elsevier

    PhD Paola Spessotto

  74. EMILIN1 represents a major stromal element determining human trophoblast invasion of the uterine wall

    Article • Journal of Cell Science, November 2006, The Company of Biologists

    PhD Paola Spessotto

  75. Inhibition of B16 Melanoma Metastases with the Ruthenium Complex Imidazolium trans-Imidazoledimethylsulfoxide-tetrachlororuthenate and Down-Regulation of Tumor Cell Invasion

    Article • Journal of Pharmacology and Experimental Therapeutics, December 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    PhD Paola Spessotto

  76. p27Kip1-stathmin interaction influences sarcoma cell migration and invasion

    Article • Cancer Cell, January 2005, Elsevier

    PhD Paola Spessotto

  77. VE-cadherin is a critical molecule for trophoblast?endothelial cell interaction in decidual spiral arteries

    Article • Experimental Cell Research, October 2004, Elsevier

    PhD Paola Spessotto

  78. Actin-dependent tumour cell adhesion after short-term exposure to the antimetastasis ruthenium complex NAMI-A

    Article • European Journal of Cancer, June 2004, Elsevier

    PhD Paola Spessotto

  79. Role of α8 integrin in mesangial cell adhesion, migration, and proliferation

    Article • Kidney International, July 2003, Elsevier

    PhD Paola Spessotto

  80. Preferential locomotion of leukemic cells towards laminin isoforms 8 and 10

    Article • Matrix Biology, June 2003, Elsevier

    PhD Paola Spessotto

  81. Vascular PG-M/versican variants promote platelet adhesion at low shear rates and cooperate with collagens to induce aggregation

    Article • The FASEB Journal, December 2002, Federation of American Societies For Experimental Biology (FASEB)

    PhD Paola Spessotto

  82. β1Integrin-dependent Cell Adhesion to EMILIN-1 Is Mediated by the gC1q Domain

    Article • Journal of Biological Chemistry, November 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Paola Spessotto

  83. H2O2 induces translocation of APE/Ref-1 to mitochondria in the Raji B-cell line

    Article • Journal of Cellular Physiology, October 2002, Wiley

    PhD Paola Spessotto

  84. Hyaluronan–CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9

    Article • Journal of Cell Biology, September 2002, Rockefeller University Press

    PhD Paola Spessotto

  85. Distribution of PG-M/Versican Variants in Human Tissues andde NovoExpression of Isoform V3 upon Endothelial Cell Activation, Migration, and Neoangiogenesisin Vitro

    Article • Journal of Biological Chemistry, September 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Paola Spessotto

  86. Antigene Effect in K562 Cells of a PEG-Conjugated Triplex-Forming Oligonucleotide Targeted to thebcr/ablOncogene†

    Article • Biochemistry, January 2002, American Chemical Society (ACS)

    PhD Paola Spessotto

  87. Differential Expression of IRS-1 and IRS-2 in Uterine Leiomyosarcomas with Distinct Oncogenic Phenotypes: Lack of Correlation with Downstream Signaling Events

    Article • Sarcoma, January 2002, Hindawi Publishing Corporation

    PhD Paola Spessotto

  88. Improving Fluorescence-Based Assays for the In Vitro Analysis of Cell Adhesion and Migration

    Article • Molecular Biotechnology, January 2002, Springer Science + Business Media

    PhD Paola Spessotto

  89. The EMILIN protein family

    Article • Matrix Biology, August 2000, Elsevier

    PhD Paola Spessotto

  90. Bidirectional induction of the cognate receptor-ligand α4/VCAM-1 pair defines a novel mechanism of tumor intravasation

    Article • Blood, April 2000, American Society of Hematology

    PhD Paola Spessotto

  91. An environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation

    Article • Nucleic Acids Research, March 2000, Oxford University Press (OUP)

    PhD Paola Spessotto

  92. Article • Inflammation, January 2000, Springer Science + Business Media

    PhD Paola Spessotto

  93. Paracrine effects of IL- 4 transfection on TS/A adenocarcinoma cells mediate reducedin Vivo growth

    Article • Pathology & Oncology Research, June 1999, Springer Science + Business Media

    PhD Paola Spessotto

  94. Identification of Domains Responsible for von Willebrand Factor Type VI Collagen Interaction Mediating Platelet Adhesion under High Flow

    Article • Journal of Biological Chemistry, January 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Paola Spessotto

  95. Human eosinophil peroxidase enhances tumor necrosis factor and hydrogen peroxide release by human monocyte-derived macrophages

    Article • European Journal of Immunology, May 1995, Wiley

    PhD Paola Spessotto

  96. Identification of elastase in human eosinophils: Immunolocalization, isolation, and partial characterization

    Article • Archives of Biochemistry and Biophysics, January 1992, Elsevier

    PhD Paola Spessotto