All Stories

  1. Acute experimental infection of bats and ferrets with Hendra virus: Insights into the early host response of the reservoir host and susceptible model species

    Article • PLoS Pathogens, March 2020, PLOS

    Professor Anthony W Purcell

  2. Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response

    Article • Nature Communications, August 2018, Springer Science + Business Media

    Professor Anthony W Purcell

  3. Employing proteomics in the study of antigen presentation: an update

    Article • Expert Review of Proteomics, August 2018, Taylor & Francis

    Professor Anthony W Purcell

  4. Immunopeptidomics Special Issue

    Article • PROTEOMICS, June 2018, Wiley

    Professor Anthony W Purcell

  5. Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses

    Article • The Journal of Immunology, May 2018, The American Association of Immunologists

    Professor Anthony W Purcell

  6. Reply to Roudieret al.: HLA-DRB1 polymorphism, anti-citrullinated protein antibodies, and rheumatoid arthritis

    Article • Journal of Biological Chemistry, May 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  7. Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics

    Article • PROTEOMICS, April 2018, Wiley

    Professor Anthony W Purcell

  8. In Immunopeptidomics We Need a Sniper Instead of a Shotgun

    Article • PROTEOMICS, March 2018, Wiley

    Professor Anthony W Purcell

  9. Structural and regulatory diversity shape HLA-C protein expression levels

    Article • Nature Communications, June 2017, Nature

    Professor Anthony W Purcell

  10. Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

    Article • Nature, May 2017, Nature

    Professor Anthony W Purcell, Professor A. Richard Kitching

  11. Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis

    Article • Cell Reports, May 2017, Elsevier

    Professor Anthony W Purcell

  12. Hormone-like peptides in the venoms of marine cone snails

    Article • General and Comparative Endocrinology, April 2017, Elsevier

    Professor Anthony W Purcell

  13. HIVed, a knowledgebase for differentially expressed human genes and proteins during HIV infection, replication and latency

    Article • Scientific Reports, March 2017, Nature

    Professor Anthony W Purcell

  14. MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

    Article • Nature Structural & Molecular Biology, February 2017, Nature

    Professor Anthony W Purcell

  15. Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells

    Article • Nature Immunology, February 2017, Nature

    Dr Jeffrey Mak, Professor Anthony W Purcell

  16. The primary immune response to Vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T-cell phenotype

    Article • Vaccine, October 2016, Elsevier

    Professor Anthony W Purcell

  17. CD1a on Langerhans cells controls inflammatory skin disease

    Article • Nature Immunology, August 2016, Nature

    Professor Anthony W Purcell

  18. Immunology by numbers: quantitation of antigen presentation completes the quantitative milieu of systems immunology!

    Article • Current Opinion in Immunology, June 2016, Elsevier

    Professor Anthony W Purcell

  19. A prominent role of PDIA6 in processing of misfolded proinsulin

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, June 2016, Elsevier

    Professor Anthony W Purcell

  20. Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family

    Article • Genome Biology and Evolution, May 2016, Oxford University Press (OUP)

    Professor Trevor Lithgow, Professor Anthony W Purcell

  21. Characterization of the Antigen Processing Machinery and Endogenous Peptide Presentation of a Bat MHC Class I Molecule

    Article • The Journal of Immunology, April 2016, The American Association of Immunologists

    Professor Anthony W Purcell

  22. Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

    Article • Proceedings of the National Academy of Sciences, March 2016, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell, Lars Ellgaard

  23. Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

    Article • Scientific Reports, February 2016, Nature

    Professor Anthony W Purcell

  24. Human Leukocyte Antigen (HLA) B27 Allotype-Specific Binding and Candidate Arthritogenic Peptides Revealed through Heuristic Clustering of Data-independent Acquisition Mass Spectrometry (DIA-MS) Data

    Article • Molecular & Cellular Proteomics, February 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  25. Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma

    Article • Journal for ImmunoTherapy of Cancer, February 2016, Springer Science + Business Media

    Professor Anthony W Purcell

  26. A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold

    Article • Structure, February 2016, Elsevier

    Professor Anthony W Purcell

  27. A Systems Approach to Understand Antigen Presentation and the Immune Response

    Article • December 2015, Springer Science + Business Media

    Professor Anthony W Purcell

  28. Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

    Article • The Journal of Antibiotics, December 2015, Nature

    Professor Anthony W Purcell

  29. Quantifying epitope presentation using mass spectrometry

    Article • Molecular Immunology, December 2015, Elsevier

    Professor Anthony W Purcell

  30. Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells

    Article • European Journal of Immunology, November 2015, Wiley

    Professor Anthony W Purcell

  31. T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

    Article • Nature Immunology, October 2015, Nature

    Professor Anthony W Purcell

  32. An open-source computational and data resource to analyze digital maps of immunopeptidomes

    Article • eLife, July 2015, eLife

    Professor Anthony W Purcell

  33. Assembly of the secretion pores GspD, Wza and CsgG into bacterial outer membranes does not require the Omp85 proteins BamA or TamA

    Article • Molecular Microbiology, June 2015, Wiley

    Professor Anthony W Purcell, Professor Trevor Lithgow

  34. Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients

    Article • Science Translational Medicine, June 2015, American Association for the Advancement of Science

    Professor Anthony W Purcell

  35. A comprehensive analysis of peptides presented by HLA-A1

    Article • Tissue Antigens, April 2015, Wiley

    Professor Anthony W Purcell

  36. T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ Cells

    Article • The Journal of Immunology, April 2015, The American Association of Immunologists

    Professor Anthony W Purcell

  37. Simultaneous Quantification of Viral Antigen Expression Kinetics Using Data-Independent (DIA) Mass Spectrometry

    Article • Molecular & Cellular Proteomics, March 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  38. Revisiting the Arthritogenic Peptide Theory: Quantitative Not Qualitative Changes in the Peptide Repertoire of HLA-B27 Allotypes

    Article • Arthritis & Rheumatology, February 2015, Wiley

    Professor Anthony W Purcell

  39. Pancreatic Beta Cells Are Highly Susceptible to Oxidative and ER Stresses during the Development of Diabetes

    Article • Journal of Proteome Research, February 2015, American Chemical Society (ACS)

    Professor Anthony W Purcell

  40. Specialized insulin is used for chemical warfare by fish-hunting cone snails

    Article • Proceedings of the National Academy of Sciences, January 2015, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell, Lars Ellgaard

  41. C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.

    Article • Journal of Biological Chemistry, January 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Heung-Chin Cheng, Professor Anthony W Purcell

  42. Ingestion of oats and barley in patients with celiac disease mobilizes cross-reactive T cells activated by avenin peptides and immuno-dominant hordein peptides

    Article • Journal of Autoimmunity, January 2015, Elsevier

    Professor Anthony W Purcell

  43. Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom

    Article • Journal of Proteomics, January 2015, Elsevier

    Professor Anthony W Purcell

  44. An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant

    Article • The Journal of Immunology, October 2014, The American Association of Immunologists

    Professor Anthony W Purcell

  45. Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+T Cells Infiltrate Islets in Type 1 Diabetes

    Article • Diabetes, August 2014, American Diabetes Association

    Professor Anthony W Purcell

  46. The Cellular Redox Environment Alters Antigen Presentation

    Article • Journal of Biological Chemistry, August 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  47. Using mass spectrometry to monitor drug induced changes in antigen presentation by the human leukocyte antigen

    Article • Clinical and Translational Allergy, July 2014, Springer Science + Business Media

    Professor Anthony W Purcell

  48. A mortise–tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes

    Article • Nature Communications, June 2014, Springer Science + Business Media

    Professor Anthony W Purcell, Dr Travis Beddoe, Professor Trevor Lithgow

  49. Structural and Functional Correlates of Enhanced Antiviral Immunity Generated by Heteroclitic CD8 T Cell Epitopes

    Article • The Journal of Immunology, May 2014, The American Association of Immunologists

    Professor Anthony W Purcell

  50. A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism

    Article • Journal of Biological Chemistry, April 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  51. Serum phosphorylated neurofilament-heavy chain levels in multiple sclerosis patients

    Article • Journal of Neurology Neurosurgery & Psychiatry, March 2014, BMJ

    Professor Anthony W Purcell, Mr axel petzold

  52. Diversity of Conotoxin Gene Superfamilies in the Venomous Snail, Conus victoriae

    Article • PLoS ONE, February 2014, PLOS

    Professor Anthony W Purcell

  53. Combined Proteomic and Transcriptomic Interrogation of the Venom Gland of Conus geographus Uncovers Novel Components and Functional Compartmentalization

    Article • Molecular & Cellular Proteomics, January 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  54. A comprehensive analysis of constitutive naturally processed and presentedHLA-C*04:01(Cw4) - specific peptides

    Article • Tissue Antigens, January 2014, Wiley

    Professor Anthony W Purcell

  55. Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain

    Article • PROTEOMICS, January 2014, Wiley

    Professor Anthony W Purcell

  56. The Beta Cell Immunopeptidome

    Article • January 2014, Elsevier

    Professor Anthony W Purcell

  57. Discovery of Novel Disease-specific and Membrane-associated Candidate Markers in a Mouse Model of Multiple Sclerosis

    Article • Molecular & Cellular Proteomics, December 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  58. A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

    Article • The Journal of Experimental Medicine, November 2013, Rockefeller University Press

    Professor Anthony W Purcell

  59. High molecular weight components of the injected venom of fish-hunting cone snails target the vascular system

    Article • Journal of Proteomics, October 2013, Elsevier

    Professor Anthony W Purcell

  60. HLA Peptide Length Preferences Control CD8+ T Cell Responses

    Article • The Journal of Immunology, June 2013, The American Association of Immunologists

    Professor Anthony W Purcell

  61. Highly Divergent T-cell Receptor Binding Modes Underlie Specific Recognition of a Bulged Viral Peptide bound to a Human Leukocyte Antigen Class I Molecule

    Article • Journal of Biological Chemistry, April 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  62. Preemptive priming readily overcomes structure-based mechanisms of virus escape

    Article • Proceedings of the National Academy of Sciences, March 2013, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  63. Human leukocyte antigen-associated drug hypersensitivity

    Article • Current Opinion in Immunology, February 2013, Elsevier

    Professor Anthony W Purcell

  64. Kinetics of Antigen Expression and Epitope Presentation during Virus Infection

    Article • PLoS Pathogens, January 2013, PLOS

    Professor Anthony W Purcell

  65. Membrane proteomics by high performance liquid chromatography-tandem mass spectrometry: Analytical approaches and challenges

    Article • PROTEOMICS, January 2013, Wiley

    Professor Anthony W Purcell, Associate Professor Dajana Vuckovic

  66. Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS

    Article • PLoS Pathogens, January 2013, PLOS

    Professor Anthony W Purcell, Professor Trevor Lithgow

  67. Novel Tumor Derived Peptides in Vaccines

    Article • January 2013, Elsevier

    Professor Anthony W Purcell

  68. Application of quantitative proteomics technologies to the biomarker discovery pipeline for multiple sclerosis

    Article • PROTEOMICS - CLINICAL APPLICATIONS, January 2013, Wiley

    Professor Anthony W Purcell

  69. The Use of Proteomics to Dissect the Molecular Specificities of T Cells in Type 1 Diabetes

    Article • Journal of Diabetes & Metabolism, January 2013, OMICS Publishing Group

    Professor Anthony W Purcell

  70. MR1 presents microbial vitamin B metabolites to MAIT cells

    Article • Nature, October 2012, Springer Science + Business Media

    Professor Anthony W Purcell

  71. Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease

    Article • Immunity, October 2012, Elsevier

    Professor Anthony W Purcell, Dr Travis Beddoe

  72. Modulation of Conotoxin Structure and Function Is Achieved through a Multienzyme Complex in the Venom Glands of Cone Snails

    Article • Journal of Biological Chemistry, August 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  73. Constitutive and Inflammatory Immunopeptidome of Pancreatic  -Cells

    Article • Diabetes, August 2012, American Diabetes Association

    Professor Anthony W Purcell

  74. Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?

    Article • Diabetes, July 2012, American Diabetes Association

    Professor Anthony W Purcell

  75. Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02:01 ligands

    Article • Molecular Immunology, June 2012, Elsevier

    Professor Anthony W Purcell

  76. Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

    Article • Nature, May 2012, Springer Science + Business Media

    Professor Anthony W Purcell

  77. Immune self-reactivity triggered by drug-modified human leukocyte antigen-peptide presentation

    Article • Molecular Immunology, May 2012, Elsevier

    Professor Anthony W Purcell

  78. Discovery of an archetypal protein transport system in bacterial outer membranes

    Article • Nature Structural & Molecular Biology, April 2012, Springer Science + Business Media

    Professor Mark A Schembri, Professor Anthony W Purcell, Professor Trevor Lithgow

  79. Tracking protein aggregation and mislocalization in cells with flow cytometry

    Article • Nature Methods, March 2012, Springer Science + Business Media

    Professor Anthony W Purcell

  80. The Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I Molecule

    Article • Journal of Biological Chemistry, February 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  81. Drug Hypersensitivity and Human Leukocyte Antigens of the Major Histocompatibility Complex

    Article • The Annual Review of Pharmacology and Toxicology, February 2012, Annual Reviews

    Professor Anthony W Purcell

  82. T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles

    Article • Arthritis Research & Therapy, January 2012, Springer Science + Business Media

    Professor Anthony W Purcell

  83. A Structural Basis for Varied    TCR Usage against an Immunodominant EBV Antigen Restricted to a HLA-B8 Molecule

    Article • The Journal of Immunology, December 2011, The American Association of Immunologists

    Professor Anthony W Purcell

  84. CD4+ T-Cell Deficiency in HIV Patients Responding to Antiretroviral Therapy Is Associated With Increased Expression of Interferon-Stimulated Genes in CD4+ T Cells

    Article • The Journal of Infectious Diseases, October 2011, Oxford University Press (OUP)

    Professor Anthony W Purcell

  85. Specialisation of the Venom Gland Proteome in Predatory Cone Snails Reveals Functional Diversification of the Conotoxin Biosynthetic Pathway

    Article • Journal of Proteome Research, September 2011, American Chemical Society (ACS)

    Professor Anthony W Purcell

  86. Defining the Substrate Specificity Determinants Recognized by the Active Site of C-Terminal Src Kinase-Homologous Kinase (CHK) and Identification of β-Synuclein as a Potential CHK Physiological Substrate

    Article • Biochemistry, August 2011, American Chemical Society (ACS)

    Dr Heung-Chin Cheng, Professor Anthony W Purcell

  87. Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8 + T-cell responses

    Article • Proceedings of the National Academy of Sciences, May 2011, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  88. Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring

    Article • PROTEOMICS, May 2011, Wiley

    Professor Anthony W Purcell

  89.  2-Glycoprotein I and Protection from Anti-SSA/Ro60-Associated Cardiac Manifestations of Neonatal Lupus

    Article • The Journal of Immunology, May 2011, The American Association of Immunologists

    Professor Anthony W Purcell

  90. Embryonic Toxin Expression in the Cone Snail Conus victoriae: PRIMED TO KILL OR DIVERGENT FUNCTION?

    Article • Journal of Biological Chemistry, April 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell, Distinguished Professor David J. Adams

  91. Linear ubiquitination prevents inflammation and regulates immune signalling

    Article • Nature, March 2011, Springer Science + Business Media

    Professor Anthony W Purcell

  92. Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis

    Article • Journal of Neuroimmunology, March 2011, Elsevier

    Professor Anthony W Purcell

  93. Peptidomimetics: modifying peptides in the pursuit of better vaccines

    Article • Expert Review of Vaccines, February 2011, Taylor & Francis

    Professor Anthony W Purcell

  94. Stable isotope shifted matrices enable the use of low mass ion precursor scanning for targeted metabolite identification

    Article • Proteome Science, January 2011, Springer Science + Business Media

    Professor Anthony W Purcell

  95. A novel strategy for the targeted analysis of protein and peptide metabolites

    Article • PROTEOMICS, December 2010, Wiley

    Professor Anthony W Purcell

  96. Proteomic Interrogation of Venom Delivery in Marine Cone Snails: Novel Insights into the Role of the Venom Bulb

    Article • Journal of Proteome Research, November 2010, American Chemical Society (ACS)

    Professor Anthony W Purcell

  97. The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

    Article • Nature, October 2010, Springer Science + Business Media

    Professor Anthony W Purcell, Dr Travis Beddoe

  98. Epitope Discovery and Their Use in Peptide Based Vaccines

    Article • Current Pharmaceutical Design, September 2010, Bentham Science Publishers

    Professor Anthony W Purcell

  99. Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

    Article • PLoS Pathogens, August 2010, PLOS

    Professor Anthony W Purcell

  100. Allelic polymorphism in the T cell receptor and its impact on immune responses

    Article • The Journal of Experimental Medicine, June 2010, Rockefeller University Press

    Professor Anthony W Purcell

  101. Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

    Article • Proceedings of the National Academy of Sciences, May 2010, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  102. Constraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognition

    Article • Proceedings of the National Academy of Sciences, March 2010, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  103. Identification of Conus Peptidylprolyl Cis-Trans Isomerases (PPIases) and Assessment of Their Role in the Oxidative Folding of Conotoxins

    Article • Journal of Biological Chemistry, February 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  104. Enhancing tumor vaccines: catalyzing MHC class II peptide exchange

    Article • Expert Review of Vaccines, February 2010, Taylor & Francis

    Professor Anthony W Purcell

  105. Reactivity with dichotomous determinants of Ro 60 stratifies autoantibody responses in lupus and primary Sjögren's syndrome

    Article • Arthritis & Rheumatism, January 2010, Wiley

    Professor Anthony W Purcell

  106. A Modular BAM Complex in the Outer Membrane of the α-Proteobacterium Caulobacter crescentus

    Article • PLoS ONE, January 2010, PLOS

    Professor Anthony W Purcell, Professor Trevor Lithgow

  107. Rapid microscale in-gel processing and digestion of proteins using surface acoustic waves

    Article • Lab on a Chip, January 2010, Royal Society of Chemistry

    Professor Anthony W Purcell

  108. Molecular Markers of Preterm Labor in the Choriodecidua

    Article • Reproductive Sciences, December 2009, SAGE Publications

    Professor Anthony W Purcell

  109. T Cell Allorecognition via Molecular Mimicry

    Article • Immunity, December 2009, Elsevier

    Professor Anthony W Purcell

  110. Post-translationally modified T cell epitopes: immune recognition and immunotherapy

    Article • Journal of Molecular Medicine, September 2009, Springer Science + Business Media

    Professor Anthony W Purcell

  111. The Protein Import Channel in the Outer Mitosomal Membrane of Giardia intestinalis

    Article • Molecular Biology and Evolution, June 2009, Oxford University Press (OUP)

    Professor Anthony W Purcell, Professor Trevor Lithgow

  112. Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor

    Article • Immunity, June 2009, Elsevier

    Professor Anthony W Purcell, Dr Travis Beddoe

  113. Correction: Article on Vaccination Reveals a Long Dominant CTL Epitope

    Article • Cancer Research, May 2009, American Association for Cancer Research (AACR)

    Professor Anthony W Purcell

  114. The A-chain of insulin is a hot-spot for CD4+T cell epitopes in human type 1 diabetes

    Article • Clinical & Experimental Immunology, May 2009, Wiley

    Professor Anthony W Purcell

  115. Mass Spectral Identification of Vc1.1 and Differential Distribution of Conopeptides in the Venom Duct of Conus victoriae. Effect of Post-Translational Modifications and Disulfide Isomerisation on Bioactivity

    Article • International Journal of Peptide Research and Therapeutics, March 2009, Springer Science + Business Media

    Professor Anthony W Purcell

  116. Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes

    Article • Proceedings of the National Academy of Sciences, February 2009, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  117. The Shaping of T Cell Receptor Recognition by Self-Tolerance

    Article • Immunity, February 2009, Elsevier

    Professor Anthony W Purcell

  118. A Long, Naturally Presented Immunodominant Epitope from NY-ESO-1 Tumor Antigen: Implications for Cancer Vaccine Design

    Article • Cancer Research, January 2009, American Association for Cancer Research (AACR)

    Professor Anthony W Purcell

  119. Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

    Article • The Journal of Experimental Medicine, January 2009, Rockefeller University Press

    Professor Anthony W Purcell, Dr Travis Beddoe

  120. Complete modification of TCR specificity and repertoire selection does not perturb a CD8 + T cell immunodominance hierarchy

    Article • Proceedings of the National Academy of Sciences, December 2008, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  121. Can α- and β-Alanine Containing Peptides Be Distinguished Based on the CID Spectra of Their Protonated Ions?

    Article • Journal of the American Society for Mass Spectrometry, December 2008, Springer Science + Business Media

    Professor Anthony W Purcell

  122. Protein secretion and outer membrane assembly in Alphaproteobacteria

    Article • FEMS Microbiology Reviews, November 2008, Oxford University Press (OUP)

    Professor Anthony W Purcell, Professor Trevor Lithgow

  123. Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell Determinant

    Article • PLoS Pathogens, October 2008, PLOS

    Professor Anthony W Purcell

  124. T-cells behaving badly: structural insights into alloreactivity and autoimmunity

    Article • Current Opinion in Immunology, October 2008, Elsevier

    Professor Anthony W Purcell

  125. Refinement in the production and purification of recombinant HCMV IE1–pp65 protein for the generation of epitope-specific T cell immunity

    Article • Protein Expression and Purification, September 2008, Elsevier

    Professor Anthony W Purcell

  126. The Enantioselective Total Synthesis and Unambiguous Proof of the Absolute Stereochemistry of Pervilleine C

    Article • Synlett, August 2008, Thieme Publishing Group

    Professor Anthony W Purcell

  127. Impact of glycans on T‐cell tolerance to glycosylated self‐antigens

    Article • Immunology and Cell Biology, July 2008, Wiley

    Professor Anthony W Purcell

  128. Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity

    Article • Immunity, July 2008, Elsevier

    Professor Anthony W Purcell

  129. Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity

    Article • Immunity, June 2008, Elsevier

    Professor Anthony W Purcell

  130. Structural and Biological Basis of CTL Escape in Coronavirus-Infected Mice

    Article • The Journal of Immunology, March 2008, The American Association of Immunologists

    Professor Anthony W Purcell

  131. Epitope-specific TCRβ repertoire diversity imparts no functional advantage on the CD8+T cell response to cognate viral peptides

    Article • Proceedings of the National Academy of Sciences, February 2008, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  132. Molecular machinations of the MHC-I peptide loading complex

    Article • Current Opinion in Immunology, February 2008, Elsevier

    Professor Anthony W Purcell

  133. Immunodominance Hierarchies and Gender Bias in Direct TCD8-Cell Alloreactivity

    Article • American Journal of Transplantation, December 2007, Wiley

    Professor Anthony W Purcell

  134. β-Amino Acid-Containing Hybrid Peptides — New Opportunities in Peptidomimetics.

    Article • ChemInform, December 2007, Wiley

    Professor Anthony W Purcell

  135. The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK)

    Article • Toxicon, December 2007, Elsevier

    Professor Anthony W Purcell

  136. Expression and purification of the minor histocompatibility antigen, HA-1H generated in Escherichia coli

    Article • Protein Expression and Purification, July 2007, Elsevier

    Professor Anthony W Purcell

  137. A Structural and Immunological Basis for the Role of Human Leukocyte Antigen DQ8 in Celiac Disease

    Article • Immunity, July 2007, Elsevier

    Professor Anthony W Purcell

  138. Immune responses to abacavir in antigen-presenting cells from hypersensitive patients

    Article • AIDS, June 2007, Wolters Kluwer Health

    Professor Anthony W Purcell

  139. More than one reason to rethink the use of peptides in vaccine design

    Article • Nature Reviews Drug Discovery, May 2007, Springer Science + Business Media

    Professor Anthony W Purcell

  140. Mass Spectrometric Applications in Immunoproteomics

    Article • March 2007, Taylor & Francis

    Professor Anthony W Purcell

  141. Conserved Motifs Reveal Details of Ancestry and Structure in the Small TIM Chaperones of the Mitochondrial Intermembrane Space

    Article • Molecular Biology and Evolution, February 2007, Oxford University Press (OUP)

    Professor Anthony W Purcell, Professor Trevor Lithgow

  142. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

    Article • Nature Immunology, January 2007, Springer Science + Business Media

    Professor Anthony W Purcell, Dr Travis Beddoe

  143. β-Amino acid-containing hybrid peptides—new opportunities in peptidomimetics

    Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

    Professor Anthony W Purcell

  144. Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

    Article • Journal of Clinical Investigation, December 2006, American Society for Clinical Investigation

    Professor Anthony W Purcell

  145. Tumors reveal their secrets to cytotoxic T cells

    Article • Proceedings of the National Academy of Sciences, October 2006, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  146. C-terminal Src Kinase-homologous Kinase (CHK), a Unique Inhibitor Inactivating Multiple Active Conformations of Src Family Tyrosine Kinases

    Article • Journal of Biological Chemistry, September 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Heung-Chin Cheng, Professor Anthony W Purcell

  147. Disparate thermodynamics governing T cell receptor–MHC-I interactions implicate extrinsic factors in guiding MHC restriction

    Article • Proceedings of the National Academy of Sciences, April 2006, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  148. Su.31. An Enigmatic Human Cd4+ T-Cell Epitope in the C-Peptide of Proinsulin

    Article • Clinical Immunology, January 2006, Elsevier

    Professor Anthony W Purcell

  149. The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

    Article • The Journal of Experimental Medicine, November 2005, Rockefeller University Press

    Professor Anthony W Purcell

  150. The insulin A-chain epitope recognized by human T cells is posttranslationally modified

    Article • The Journal of Experimental Medicine, October 2005, Rockefeller University Press

    Professor Anthony W Purcell

  151. T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I–bound peptide

    Article • Nature Immunology, September 2005, Springer Science + Business Media

    Professor Anthony W Purcell, Dr Travis Beddoe

  152. T Cell Determinants Incorporating  -Amino Acid Residues Are Protease Resistant and Remain Immunogenic In Vivo

    Article • The Journal of Immunology, September 2005, The American Association of Immunologists

    Professor Anthony W Purcell

  153. CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection

    Article • The Journal of Immunology, September 2005, The American Association of Immunologists

    Professor Anthony W Purcell

  154. Qualitative and Quantitative Differences in Peptides Bound to HLA-B27 in the Presence of Mouse versus Human Tapasin Define a Role for Tapasin as a Size-Dependent Peptide Editor

    Article • The Journal of Immunology, June 2005, The American Association of Immunologists

    Professor Anthony W Purcell

  155. Use of proteomics to define targets of T-cell immunity

    Article • Expert Review of Proteomics, June 2005, Taylor & Francis

    Professor Anthony W Purcell

  156. An emerging role for comprehensive proteome analysis in human pregnancy research

    Article • Reproduction, May 2005, Bioscientifica

    Professor Anthony W Purcell

  157. High Resolution Structures of Highly Bulged Viral Epitopes Bound to Major Histocompatibility Complex Class I

    Article • Journal of Biological Chemistry, April 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell, Dr Travis Beddoe

  158. Antagonism of Antiviral and Allogeneic Activity of a Human Public CTL Clonotype by a Single Altered Peptide Ligand: Implications for Allograft Rejection

    Article • The Journal of Immunology, April 2005, The American Association of Immunologists

    Professor Anthony W Purcell

  159. Lack of prominent peptide–major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

    Article • Nature Immunology, February 2005, Springer Science + Business Media

    Professor Anthony W Purcell

  160. The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

    Article • Nature Immunology, January 2005, Springer Science + Business Media

    Professor Anthony W Purcell, Dr Travis Beddoe

  161. A Charged Amino Acid Residue in the Transmembrane/Cytoplasmic Region of Tapasin Influences MHC Class I Assembly and Maturation

    Article • The Journal of Immunology, January 2005, The American Association of Immunologists

    Professor Anthony W Purcell

  162. TAP genes and immunity

    Article • Current Opinion in Immunology, October 2004, Elsevier

    Professor Anthony W Purcell

  163. The production and purification of the human T-cell receptors, the CD3∊γ and CD3∊δ heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

    Article • Acta Crystallographica Section D Biological Crystallography, July 2004, International Union of Crystallography

    Professor Anthony W Purcell

  164. Natural HLA Class I Polymorphism Controls the Pathway of Antigen Presentation and Susceptibility to Viral Evasion

    Article • The Journal of Experimental Medicine, June 2004, Rockefeller University Press

    Professor Anthony W Purcell, Dr Travis Beddoe

  165. The Structure of H-2Kb and Kbm8 Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance

    Article • The Journal of Immunology, June 2004, The American Association of Immunologists

    Professor Anthony W Purcell

  166. Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAb OKT3

    Article • Proceedings of the National Academy of Sciences, May 2004, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  167. Predisposition to abacavir hypersensitivity conferred byHLA-B*5701and a haplotypicHsp70-Homvariant

    Article • Proceedings of the National Academy of Sciences, March 2004, Proceedings of the National Academy of Sciences

    Professor Anthony W Purcell

  168. Functional and Structural Characteristics of NY-ESO-1-related HLA A2-restricted Epitopes and the Design of a Novel Immunogenic Analogue

    Article • Journal of Biological Chemistry, March 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  169. Immunoproteomics: Mass Spectrometry-based Methods to Study the Targets of the Immune Response

    Article • Molecular & Cellular Proteomics, January 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Anthony W Purcell

  170. A sensitive method for detecting proliferation of rare autoantigen-specific human T cells

    Article • Journal of Immunological Methods, December 2003, Elsevier

    Professor Anthony W Purcell

  171. Optimisation of peptide-based cytotoxic T-cell determinants using

    Article • Letters in Peptide Science, November 2003, Springer Science + Business Media

    Professor Anthony W Purcell

  172. Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin

    Article • Tissue Antigens, October 2003, Wiley

    Professor Anthony W Purcell

  173. Human T-cells recognise N-terminally Fmoc-modified peptide

    Article • Vaccine, September 2003, Elsevier

    Professor Anthony W Purcell

  174. Preface: Peptides —From discovery to therapeutics

    Article • September 2003, Springer Science + Business Media

    Professor Anthony W Purcell

  175. Optimisation of peptide-based cytotoxic T-cell determinants using non-natural amino acids

    Article • September 2003, Springer Science + Business Media

    Professor Anthony W Purcell

  176. A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition

    Article • The Journal of Experimental Medicine, August 2003, Rockefeller University Press

    Professor Anthony W Purcell

  177. Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?

    Article • Clinical & Experimental Immunology, April 2003, Wiley

    Professor Anthony W Purcell

  178. A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity

    Article • Immunity, January 2003, Elsevier

    Professor Anthony W Purcell

  179. Dissecting the role of peptides in the immune response: theory, practice and the application to vaccine design

    Article • Journal of Peptide Science, January 2003, Wiley

    Professor Anthony W Purcell

  180. Identification of an I-Adrestricted peptide on the 65-kilodalton heat shock protein ofMycobacterium avium

    Article • Immunology and Cell Biology, December 2002, Wiley

    Professor Anthony W Purcell

  181. The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state

    Article • Acta Crystallographica Section D Biological Crystallography, November 2002, International Union of Crystallography

    Professor Anthony W Purcell

  182. The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance

    Article • Structure, November 2002, Elsevier

    Professor Anthony W Purcell

  183. The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I Dimerization

    Article • The Journal of Immunology, November 2002, The American Association of Immunologists

    Professor Anthony W Purcell

  184. Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex

    Article • FEBS Letters, August 2002, Wiley

    Professor Anthony W Purcell

  185. Restricted Specificity of Intermolecular Spreading to Endogenous La (SS-B) and 60 kDa Ro (SS-A) in Experimental Autoimmunity

    Article • Scandinavian Journal of Immunology, July 2002, Wiley

    Professor Anthony W Purcell

  186. Optimization of the MHC Class I Peptide Cargo Is Dependent on Tapasin

    Article • Immunity, April 2002, Elsevier

    Professor Anthony W Purcell

  187. The Central Role Played by Peptides in the Immune Response and the Design of Peptide-Based Vaccines Against Infectious Diseases and Cancer

    Article • Current Drug Targets, April 2002, Bentham Science Publishers

    Professor Anthony W Purcell

  188. The use of post-source decay in matrix-assisted laser desorption/ionisation mass spectrometry to delineate T cell determinants

    Article • Journal of Immunological Methods, March 2001, Elsevier

    Professor Anthony W Purcell

  189. Quantitative and Qualitative Influences of Tapasin on the Class I Peptide Repertoire

    Article • The Journal of Immunology, January 2001, The American Association of Immunologists

    Professor Anthony W Purcell

  190. Tapasin-Mediated Retention and Optimization of Peptide Ligands During the Assembly of Class I Molecules

    Article • The Journal of Immunology, July 2000, The American Association of Immunologists

    Professor Anthony W Purcell

  191. The peptide-loading complex and ligand selection during the assembly of HLA class I molecules

    Article • Molecular Immunology, June 2000, Elsevier

    Professor Anthony W Purcell

  192. Endogenous and exogenous factors contributing to the surface expression of HLA B27 on mutant APC

    Article • Human Immunology, February 2000, Elsevier

    Professor Anthony W Purcell

  193. The Biology of Major Histocompatibility Complex Molecules—II: Antigen Processing and Presentation

    Article • January 2000, Elsevier

    Professor Anthony W Purcell

  194. Comparison between the isocratic and gradient retention behaviour of polypeptides in reversed-phase liquid chromatographic environments

    Article • Journal of Chromatography A, August 1999, Elsevier

    Professor Anthony W Purcell

  195. Probing the Binding Behavior and Conformational States of Globular Proteins in Reversed-Phase High-Performance Liquid Chromatography

    Article • Analytical Chemistry, July 1999, American Chemical Society (ACS)

    Professor Anthony W Purcell

  196. Molecular chaperones are targets of autoimmunity in Ro(SS-A) immune mice

    Article • Clinical & Experimental Immunology, February 1999, Wiley

    Professor Anthony W Purcell

  197. RP-HPLC Binding Domains of Proteins

    Article • Analytical Chemistry, December 1998, American Chemical Society (ACS)

    Professor Anthony W Purcell

  198. Determinant spreading: lessons from animal models and human disease

    Article • Immunological Reviews, August 1998, Wiley

    Professor Anthony W Purcell

  199. Spreading of the immune response from 52 kDaRo and 60 kDaRo to calreticulin in experimental autoimmunity

    Article • Lupus, January 1998, SAGE Publications

    Professor Anthony W Purcell

  200. Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice

    Article • The Journal of Experimental Medicine, November 1996, Rockefeller University Press

    Professor Anthony W Purcell

  201. The Accessibility of the Prosthetic Group Biotin during Monomeric Avidin Affinity Chromatography

    Article • Analytical Biochemistry, July 1996, Elsevier

    Professor Anthony W Purcell

  202. Nonprecipitating Anti-La(SS-B) Autoantibodies in Primary Sjögren's Syndrome

    Article • Clinical Immunology and Immunopathology, June 1996, Elsevier

    Professor Anthony W Purcell

  203. Conformational effects in reversed-phase high-performance liquid chromatography of polypeptides II. The role of insulin A and B chains in the chromatographic behaviour of insulin

    Article • Journal of Chromatography A, September 1995, Elsevier

    Professor Anthony W Purcell

  204. Conformational effects in reversed-phase high-performance liquid chromatography of polypeptides I. Resolution of insulin variants

    Article • Journal of Chromatography A, September 1995, Elsevier

    Professor Anthony W Purcell

  205. High-performance liquid chromatography of amino acids, peptides, and proteins. 123. Dynamics of peptides in reversed-phase high-performance liquid chromatography

    Article • Analytical Chemistry, November 1993, American Chemical Society (ACS)

    Professor Anthony W Purcell

  206. High-performance liquid chromatography of amino acids, peptides and proteins CXV. Thermodynamic behaviour of peptides in reversed-phase chromatography

    Article • Journal of Chromatography A, February 1992, Elsevier

    Professor Anthony W Purcell

  207. High-performance liquid chromatography of amino acids, peptides and proteins

    Article • Journal of Chromatography A, January 1989, Elsevier

    Professor Anthony W Purcell

  208. High-performance liquid chromatography of amino acids, peptides and proteins

    Article • Journal of Chromatography A, January 1989, Elsevier

    Professor Anthony W Purcell

  209. Isolation and Characterization of Naturally Processed MHC-Bound Peptides From the Surface of Antigen-Presenting Cells

    Article • Springer Science + Business Media

    Professor Anthony W Purcell