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  1. Mitochondrial Fragmentation Induced by the CFTR Modulators Lumacaftor and Ivacaftor in Immortalized Cystic Fibrosis Cell Lines

    Article • Cells, October 2025, MDPI AG

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  2. Vitamin D and retinoic acid stimulates GPRC5A expression.

    Article • Biomolecules, May 2025, MDPI AG

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  3. Vitamin D and Retinoic Acid Induce Reactive Oxygen Species (ROS) and PKC Signaling as Opposed Signals Upregulating PEIG-1/GPRC5A Expression in Caco-2 and T84 Colon Carcinoma Cells

    Article • January 2024, Elsevier

    Dr Tomás A. Santa Coloma

  4. GPRC5A is a phorbol ester and retinoic acid induced gene associated to different diseases.

    Article • Biochemistry and Cell Biology, December 2023, Canadian Science Publishing

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  5. The use of synthetic peptides to map binding regions and how to predict their binding affinity

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 2022, Elsevier

    Dr Tomás A. Santa Coloma

  6. Epidermal growth factor receptor activity upregulates lactate dehydrogenase A expression, lactate dehydrogenase activity, and lactate secretion in cultured IB3-1 cystic fibrosis lung epithelial cells

    Article • Biochemistry and Cell Biology, August 2021, Canadian Science Publishing

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  7. CFTR chloride channel activity modulates the mitochondrial morphology in cultured epithelial cells

    Article • The International Journal of Biochemistry & Cell Biology, June 2021, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  8. NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl – concentration

    Article • Immunology, May 2021, Wiley

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  9. PEIG1/GPRC5A as a phorbol ester induced gene

    Article • Archives of Biochemistry and Biophysics, July 2020, Elsevier

    PhD Angel Gabriel Valdivieso, Dr Tomás A. Santa Coloma

  10. The Airborne and Gastrointestinal Coronavirus SARS-COV-2 Pathways

    Article • April 2020, MDPI AG

    Dr Tomás A. Santa Coloma

  11. Cl- as a signaling effector

    Article • Biological Reviews, June 2019, Wiley

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  12. IL-1β, IL-2 and IL-4 concentration during porcine gestation

    Article • Theriogenology, April 2019, Elsevier

    Dr Tomás A. Santa Coloma

  13. Increased intracellular chloride upregulates LDH expression/activity and lactic acid secretion

    Article • Cellular and Molecular Life Sciences, January 2019, Springer Science + Business Media

    Dr Tomás A. Santa Coloma, Dr. Cristian Jorge Alejandro Asensio , PhD Angel Gabriel Valdivieso

  14. Cigarette smoke extract causes increased cellular and mitochondrial ROS and inflammation

    Article • August 2018, Science Trends

    PhD Angel Gabriel Valdivieso, Dr Tomás A. Santa Coloma

  15. Extracellular pH and lung infections

    Article • European Journal of Cell Biology, August 2018, Elsevier

    Dr Tomás A. Santa Coloma

  16. NAC blocks oxidative burst in lung epithelial cells exposed to cigarette smoke

    Article • Redox Biology, June 2018, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  17. CFTR failure produces a Cl- accumulation that induces epiregulin upregulation through an IL1B loop

    Article • Journal of Cellular Biochemistry, November 2017, Wiley

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  18. Cl- as a second messenger for CFTR

    Article • Archives of Biochemistry and Biophysics, November 2017, Elsevier

    PhD Angel Gabriel Valdivieso, Dr Tomás A. Santa Coloma

  19. Cl- acts as a second messenger and pro-inflammatory signal

    Article • Journal of Cellular Biochemistry, April 2017, Wiley

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  20. CFTR failure stimulates IL-1b secretion and autocrine signaling through c-Src

    Article • Archives of Biochemistry and Biophysics, February 2017, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  21. c-Src and its role en Cystic Fibrosis

    Article • European Journal of Cell Biology, October 2016, Elsevier

    Dr Tomás A. Santa Coloma

  22. Cl- modulates the expression of specific genes

    Article • Cellular Physiology and Biochemistry, January 2016, Karger Publishers

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  23. Blocking Interleukin-1β signaling rescues mitochondrial Complex I Activity and improves ROS Levels

    Article • PLOS One, June 2014, PLOS

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  24. CFTR modulates ROS levels and mitochondrial function - Review

    Article • Redox Biology, January 2013, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  25. Mitochondrial Complex I-III Activity Is Reduced in Cells with Impaired CFTR Function

    Article • PLOS One, November 2012, PLOS

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  26. Measurement of CFTR activity using fluorescence spectrophotometry with SPQ

    Article • Analytical Biochemistry, November 2011, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  27. CISD1 codifies a mitochondrial protein upregulated by the CFTR channel

    Article • Biochemical and Biophysical Research Communications, January 2008, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  28. The expression of the mitochondrial gene MT-ND4 is downregulated in cystic fibrosis

    Article • Biochemical and Biophysical Research Communications, May 2007, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  29. Anp32e (Cpd1) and related protein phosphatase 2 inhibitors

    Article • The Cerebellum, December 2003, Springer Science + Business Media

    Dr Tomás A. Santa Coloma

  30. c-Src Constitutes a Bridge between the CFTR Failure and MUC1 Overexpression in Cystic Fibrosis

    Article • Journal of Biological Chemistry, May 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Tomás A. Santa Coloma

  31. Article • Neurochemical Research, January 2002, Springer Science + Business Media

    Dr Tomás A. Santa Coloma

  32. Differential expression of genes during postnatal development

    Article • Brain Research, July 2001, Elsevier

    Dr Tomás A. Santa Coloma

  33. APC Senses Cell–Cell Contacts and Moves to the Nucleus upon Their Disruption

    Article • Biochemical and Biophysical Research Communications, June 2001, Elsevier

    Dr Tomás A. Santa Coloma

  34. Specific oligobodies against ERK-2 that recognize both the native and the denatured state of the protein

    Article • Journal of Immunological Methods, June 2001, Elsevier

    Dr Tomás A. Santa Coloma

  35. NF-κB Activation Is Involved in Regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Interleukin-1β

    Article • Journal of Biological Chemistry, February 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Tomás A. Santa Coloma

  36. Single strand differential display applied to identify phosphatases during cerebellar development

    Article • Journal of Neuroscience Methods, January 2001, Elsevier

    Dr Tomás A. Santa Coloma

  37. Article • Cellular and Molecular Neurobiology, January 2001, Springer Science + Business Media

    Dr Tomás A. Santa Coloma

  38. Interleukin-1β regulates CFTR expression in human intestinal T84 cells

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, February 2000, Elsevier

    Dr Tomás A. Santa Coloma

  39. Intracellular Ca2+ in capacitated sperm

    Article • IUBMB Life, April 1997, Wiley

    Dr Tomás A. Santa Coloma

  40. TGF-b1 modulates calcium uptake

    Article • Endocrinology, April 1993, Endocrine Society

    Dr Tomás A. Santa Coloma

  41. FSH induces Ca2+ uptake upon partial degradation

    Article • Endocrinology, December 1992, Endocrine Society

    Dr Tomás A. Santa Coloma

  42. The size of the mature membrane receptor for follicle-stimulating hormone is larger than that predicted from its cDNA

    Article • Journal of Molecular Endocrinology, October 1992, Bioscientifica

    Dr Tomás A. Santa Coloma

  43. Solution structure of a synthetic peptide corresponding to a receptor binding region of FSH (hFSH-? 33?53)

    Article • The Protein Journal, October 1992, Springer Science + Business Media

    Dr Tomás A. Santa Coloma

  44. Identification and characterization of the chicken transforming growth factor-beta 3 promoter.

    Article • Molecular Endocrinology, August 1992, Endocrine Society

    Dr Tomás A. Santa Coloma

  45. Identification and characterization of the chicken transforming growth factor-beta 3 promoter

    Article • Molecular Endocrinology, August 1992, Endocrine Society

    Dr Tomás A. Santa Coloma

  46. Serine analogues of hFSH-beta-(33–53) and hFSH-beta-(81–95) inhibit hFSH binding to receptor

    Article • Biochemical and Biophysical Research Communications, May 1992, Elsevier

    Dr Tomás A. Santa Coloma

  47. Synthetic human follicle-stimulating hormone-beta-(1-15) peptide-amide binds Ca2+ and possesses sequence similarity to calcium binding sites of calmodulin

    Article • Endocrinology, March 1992, Endocrine Society

    Dr Tomás A. Santa Coloma

  48. Synthetic human follicle-stimulating hormone-beta-(1-15) peptide-amide binds Ca2+ and possesses sequence similarity to calcium binding sites of calmodulin.

    Article • Endocrinology, March 1992, Endocrine Society

    Dr Tomás A. Santa Coloma

  49. A synthetic peptide corresponding to hFSH-β-(81–95) has thioredoxin-like activity

    Article • Molecular and Cellular Endocrinology, July 1991, Elsevier

    Dr Tomás A. Santa Coloma

  50. A synthetic peptide encompassing two discontinuous regions of hFSH-β subunit mimics the receptor binding surface of the hormone

    Article • Molecular and Cellular Endocrinology, July 1991, Elsevier

    Dr Tomás A. Santa Coloma

  51. Synthetic Peptides Corresponding to Human Follicle- Stimulating Hormone (hFSH)-β-(l–15) and hFSH-β- (51–65) Induce Uptake of45Ca++by Liposomes: Evidence for Calcium-Conducting Transmembrane Channel Formation*

    Article • Endocrinology, June 1991, Endocrine Society

    Dr Tomás A. Santa Coloma

  52. Sulfhydryl groups are involved in the interaction of FSH with its receptor

    Article • Biochemical and Biophysical Research Communications, May 1991, Elsevier

    Dr Tomás A. Santa Coloma

  53. Solid-phase assay for determination of binding parameters of ligand-protein complexes with high dissociation rates

    Article • Analytical Biochemistry, February 1991, Elsevier

    Dr Tomás A. Santa Coloma

  54. Structure-function relationships of the glycoprotein hormones and their receptors

    Article • Trends in Pharmacological Sciences, January 1991, Elsevier

    Dr Tomás A. Santa Coloma

  55. Identification of a follicle-stimulating hormone receptor-binding region in hFSH-beta-(81-95) using synthetic peptides.

    Article • Journal of Biological Chemistry, March 1990, Elsevier

    Dr Tomás A. Santa Coloma

  56. A synthetic peptide corresponding to human FSH beta-subunit 33-53 binds to FSH receptor, stimulates basal estradiol biosynthesis, and is a partial antagonist of FSH

    Article • Biochemistry, February 1990, American Chemical Society (ACS)

    Dr Tomás A. Santa Coloma

  57. The use of computers in the teaching of hormone receptor interactions in the presence of two types of binding sites or negative cooperativity

    Article • Biochemical Education, April 1988, Elsevier

    Dr Tomás A. Santa Coloma

  58. Improvement on the competitive binding assay for the measurement of cyclic AMP by using ammonium sulphate precipitation

    Article • Biochemical Journal, August 1987, Portland Press Ltd.

    Dr Tomás A. Santa Coloma

  59. Cyclic biospecific affinity chromatographic method for the purification of the sex steroid binding protein (SBP): Application to the purification of SBP from toad

    Article • Journal of Chromatography B Biomedical Sciences and Applications, January 1987, Elsevier

    Dr Tomás A. Santa Coloma

  60. Sex steroid binding protein from Bufo arenarum: Further characterization

    Article • Comparative Biochemistry and Physiology Part A Physiology, January 1986, Elsevier

    Dr Tomás A. Santa Coloma

  61. Characterization of a sexual steroid binding protein in Bufo arenarum

    Article • General and Comparative Endocrinology, November 1985, Elsevier

    Dr Tomás A. Santa Coloma

  62. Biosynthesis of bufadienolides in toads. V. the origin of the cholesterol used by toad parotoid glands for biosynthesis of bufadienolides

    Article • Steroids, July 1984, Elsevier

    Dr Tomás A. Santa Coloma