What is it about?
Here we review the actual knowledge regarding the possible role of c-Src signaling in cystic fibrosis.
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Why is it important?
c-Src in involved in regulation of many cellular activities and its chronic stimulation in cystic fibrosis could lead to a variety of altered functions through c-Src signaling.
Perspectives
The exact role of c-Src in the CFTR signaling events is not clear. It is related to ROS accumulation and IL-1b secretion, by yet unknown mechanisms that involve the initial Cl- accumulation and Cl- as a second messenger for CFTR, although not in the classical view of a ligand-receptor interaction.
Dr Tomás A. Santa Coloma
Institute for Biomedical Research (BIOMED), CONICET, UCA
Read the Original
This page is a summary of: c- Src and its role in cystic fibrosis, European Journal of Cell Biology, October 2016, Elsevier,
DOI: 10.1016/j.ejcb.2016.08.001.
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