All Stories

  1. Mitochondrial Fragmentation Induced by the CFTR Modulators Lumacaftor and Ivacaftor in Immortalized Cystic Fibrosis Cell Lines

    Article • Cells, October 2025, MDPI AG

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  2. Yellow fever virus infection alters mitochondrial network dynamics and trigger IFN-I response via TLR2 pathway

    Article • International Immunopharmacology, June 2025, Elsevier

    PhD Angel Gabriel Valdivieso

  3. Vitamin D and retinoic acid stimulates GPRC5A expression.

    Article • Biomolecules, May 2025, MDPI AG

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  4. GPRC5A is a phorbol ester and retinoic acid induced gene associated to different diseases.

    Article • Biochemistry and Cell Biology, December 2023, Canadian Science Publishing

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  5. Apolipoprotein E4 heterologous expression, purification under non-denaturing conditions, and effects on neuronal clonal cell lines

    Article • Protein Expression and Purification, October 2023, Elsevier

    PhD Angel Gabriel Valdivieso

  6. Epidermal growth factor receptor activity upregulates lactate dehydrogenase A expression, lactate dehydrogenase activity, and lactate secretion in cultured IB3-1 cystic fibrosis lung epithelial cells

    Article • Biochemistry and Cell Biology, August 2021, Canadian Science Publishing

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  7. CFTR chloride channel activity modulates the mitochondrial morphology in cultured epithelial cells

    Article • The International Journal of Biochemistry & Cell Biology, June 2021, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  8. NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl – concentration

    Article • Immunology, May 2021, Wiley

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  9. PEIG1/GPRC5A as a phorbol ester induced gene

    Article • Archives of Biochemistry and Biophysics, July 2020, Elsevier

    PhD Angel Gabriel Valdivieso, Dr Tomás A. Santa Coloma

  10. Cl- as a signaling effector

    Article • Biological Reviews, June 2019, Wiley

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  11. Increased intracellular chloride upregulates LDH expression/activity and lactic acid secretion

    Article • Cellular and Molecular Life Sciences, January 2019, Springer Science + Business Media

    Dr Tomás A. Santa Coloma, Dr. Cristian Jorge Alejandro Asensio , PhD Angel Gabriel Valdivieso

  12. Mitochondrial Alterations and Oxidative Stress in Cystic Fibrosis

    Article • January 2019, Springer Science + Business Media

    PhD Angel Gabriel Valdivieso

  13. PRO-INFLAMMATORY ACTIVITY AND OXIDATIVE STRESS ON A LINE OF CYSTIC FIBROSIS (CF) HUMAN RESPIRATORY EPITHELIUM

    Article • September 2018, European Respiratory Society (ERS)

    PhD Angel Gabriel Valdivieso

  14. Cigarette smoke extract causes increased cellular and mitochondrial ROS and inflammation

    Article • August 2018, Science Trends

    PhD Angel Gabriel Valdivieso, Dr Tomás A. Santa Coloma

  15. NAC blocks oxidative burst in lung epithelial cells exposed to cigarette smoke

    Article • Redox Biology, June 2018, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  16. Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons

    Article • Molecular Neurobiology, April 2018, Springer Science + Business Media

    PhD Angel Gabriel Valdivieso

  17. CFTR failure produces a Cl- accumulation that induces epiregulin upregulation through an IL1B loop

    Article • Journal of Cellular Biochemistry, November 2017, Wiley

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  18. Cl- as a second messenger for CFTR

    Article • Archives of Biochemistry and Biophysics, November 2017, Elsevier

    PhD Angel Gabriel Valdivieso, Dr Tomás A. Santa Coloma

  19. Cl- acts as a second messenger and pro-inflammatory signal

    Article • Journal of Cellular Biochemistry, April 2017, Wiley

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  20. CFTR failure stimulates IL-1b secretion and autocrine signaling through c-Src

    Article • Archives of Biochemistry and Biophysics, February 2017, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  21. Cl- modulates the expression of specific genes

    Article • Cellular Physiology and Biochemistry, January 2016, Karger Publishers

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  22. Blocking Interleukin-1β signaling rescues mitochondrial Complex I Activity and improves ROS Levels

    Article • PLOS One, June 2014, PLOS

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  23. CFTR modulates ROS levels and mitochondrial function - Review

    Article • Redox Biology, January 2013, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  24. Mitochondrial Complex I-III Activity Is Reduced in Cells with Impaired CFTR Function

    Article • PLOS One, November 2012, PLOS

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  25. Measurement of CFTR activity using fluorescence spectrophotometry with SPQ

    Article • Analytical Biochemistry, November 2011, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  26. CISD1 codifies a mitochondrial protein upregulated by the CFTR channel

    Article • Biochemical and Biophysical Research Communications, January 2008, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso

  27. The expression of the mitochondrial gene MT-ND4 is downregulated in cystic fibrosis

    Article • Biochemical and Biophysical Research Communications, May 2007, Elsevier

    Dr Tomás A. Santa Coloma, PhD Angel Gabriel Valdivieso