What is it about?
It is described here the use of synthetic peptides to map binding sites of protein ligands, their characteristic as agonists/antagonists and a semi-empirical method to calculate their free energy in solution, taking into account their entropic contribution.
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Why is it important?
The method described here allows for the first time to calculate the free energy of any region of a protein/peptide ligand. Only 3-4 data from binding are needed to calculate the free energy of any ligand/receptor region.
Perspectives
This method allows to calculate empirically the entropic contribution to the free energy of peptide ligands in solution. Now we need to find how this contribution could be theoretically predicted and why in some cases the free energy fall far away from the linear function that predict the free energy.
Dr Tomás A. Santa Coloma
Institute for Biomedical Research (BIOMED), CONICET, UCA
Read the Original
This page is a summary of: Overlapping synthetic peptides as a tool to map protein-protein interactions ̶ FSH as a model system of nonadditive interactions, Biochimica et Biophysica Acta (BBA) - General Subjects, July 2022, Elsevier,
DOI: 10.1016/j.bbagen.2022.130153.
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