What is it about?
Single-walled carbon nanohorns (SWNHs) may be useful as carriers for anticancer drugs due to their particular structure. However, the interactions between the material itself and cancerous or normal cells have seldom been studied.
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Why is it important?
We found that the unmodified SWNHs inhibited mitotic entry, growth, and proliferation of human liver cell lines and promoted their apoptosis, especially in hepatoma cell lines. Individual spherical SWNH particles were found inside the nuclei of human hepatoma HepG2 cells and the lysosomes of normal human liver L02 cells, implying that SWNH particles could penetrate into human liver cells and the different interacted mechanisms on human normal cell lines compared to hepatoma cell lines.
Perspectives
we have for the first time demonstrated that small amounts of unmodified SWNHs could suppress cell proliferation in human liver cell lines, affect their cell cycle, and promote their apoptosis in a dose-dependent manner, especially in a hepatoma cell line. Apoptosis of liver cells induced by SWNHs was involved in caspase-3, caspase-7, p53, and SIRT1. During culture, individual SWNH particles could pass through the cellular membrane and enter the nuclei of HepG2 cells and the lysosomes of L02 cells. These discoveries imply different interaction mechanisms between L02 cells, HepG2 cells, and SWNHs. In order to clarify the problems of SWNH transmembrane pathways and subcellular structure oriented interactive mechanisms between SWNHs and liver cells, it is evident that further research is needed on the basis of discoveries in this work.
jinqian zhang
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This page is a summary of: Single-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines, International Journal of Nanomedicine, February 2014, Taylor & Francis,
DOI: 10.2147/ijn.s56353.
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