What is it about?
This is a review article that provide information on the pathophysiological functions of kinins and their receptor antagonists along with their current therapeutic potentials.
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Why is it important?
Kinins play a number of pathophysiological events, including pain, inflammation, shock, pancreatitis, etc. Some of these processes are life-threatening in nature and there are difficulties in their clinical management due to the lack of drugs specifically antagonising kinin receptor. Although there are some receptors antagonists developed, no compound has been introduced to clinical applications. Therefore, the subject is important in terms of development of specific drugs, which are effective in the therapy of serious pathophysiological events.
Read the Original
This page is a summary of: Kinin Receptors and Their Antagonists as Novel Therapeutic Agents, Current Pharmaceutical Design, January 2001, Bentham Science Publishers, DOI: 10.2174/1381612013398338.
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