What is it about?
Obese individuals have higher rates of cancer incidence and cancer-related mortality. The worse outcomes observed are caused by altered physiology in obesity and its impact on pharmacokinetics, increased risk of underdosing and treatment-related toxicity.
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Photo by National Cancer Institute on Unsplash
Why is it important?
Our findings show that actual total body weight dosing appears to be a better approach to dosing anticancer drugs in both adults and children when aiming for curative results, showing no difference in toxicity and no limitation in treatment outcomes when compared to adjusted doses.
Perspectives
Writing this article highlighted the gap in knowledge regarding chemotherapy adjustment in obese children. I hope this work contributes to raising awareness of the need for robust studies in the field and to improve cancer treatment outcomes in this population as a consequence.
João Pedro Thimotheo Batista
Universidade Federal de Minas Gerais
Read the Original
This page is a summary of: Chemotherapy and Anticancer Drugs Adjustment in Obesity: A Narrative
Review, Current Medicinal Chemistry, March 2023, Bentham Science Publishers,
DOI: 10.2174/0929867329666220806140204.
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