All Stories

  1. Tregs protect against invariant NKT cell‐mediated autoimmune colitis and hepatitis

    Article • Immunology, November 2023, Wiley

    Professor Tim D Sparwasser

  2. The evolutionary tug-of-war of macrophage metabolism during bacterial infection

    Article • Trends in Endocrinology and Metabolism, November 2023, Elsevier

    Professor Tim D Sparwasser

  3. A clinically-relevant STING agonist restrains human TH17 cell inflammatory profile

    Article • International Immunopharmacology, November 2023, Elsevier

    Professor Tim D Sparwasser

  4. Inhibition of Mitochondrial Translation Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation by Targeting Vγ4+ γδ T Cells

    Article • Journal of Investigative Dermatology, October 2023, Elsevier

    Professor Tim D Sparwasser

  5. Targeting ACC1 in T cells ameliorates psoriatic skin inflammation

    Article • Journal of Molecular Medicine, August 2023, Springer Science + Business Media

    Professor Tim D Sparwasser

  6. Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis

    Article • Annals of the Rheumatic Diseases, May 2023, BMJ

    Professor Tim D Sparwasser

  7. Antibodies to variable surface antigens induce antigenic variation in the intestinal parasite Giardia lamblia

    Article • Nature Communications, May 2023, Springer Science + Business Media

    Professor Tim D Sparwasser

  8. Regulation of DC metabolism by nitric oxide in murine GM‐CSF cultures

    Article • European Journal of Immunology, December 2022, Wiley

    Professor Tim D Sparwasser

  9. Guidelines for mouse and human DC functional assays

    Article • European Journal of Immunology, December 2022, Wiley

    Professor Tim D Sparwasser

  10. Guidelines for mouse and human DC generation

    Article • European Journal of Immunology, October 2022, Wiley

    Professor Tim D Sparwasser

  11. STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program

    Article • Cell Reports, May 2022, Elsevier

    Professor Tim D Sparwasser

  12. γδ T cells license immature B cells to produce a broad range of polyreactive antibodies

    Article • Cell Reports, May 2022, Elsevier

    Professor Tim D Sparwasser

  13. Correction: TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice

    Article • PLoS Pathogens, November 2021, PLOS

    Professor Tim D Sparwasser

  14. Transient Depletion of Foxp3+ Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice

    Article • Frontiers in Immunology, August 2021, Frontiers

    Professor Tim D Sparwasser

  15. CD4+ T-cell differentiation and function: Unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria

    Article • Journal of Allergy and Clinical Immunology, July 2021, Elsevier

    Professor Tim D Sparwasser

  16. Structure‐Activity Relationship and Mode‐of‐Action Studies Highlight 1‐(4‐Biphenylylmethyl)‐1 H ‐imidazole‐Derived Small Molecules as Potent CYP121 Inhibitors

    Article • ChemMedChem, June 2021, Wiley

    Professor Tim D Sparwasser

  17. Dendritic cell metabolism: moving beyond in vitro-culture-generated paradigms

    Article • Current Opinion in Biotechnology, April 2021, Elsevier

    Professor Tim D Sparwasser

  18. Clarithromycin impairs tissue-resident memory and Th17 responses to macrolide-resistant Streptococcus pneumoniae infections

    Article • Journal of Molecular Medicine, February 2021, Springer Science + Business Media

    Professor Tim D Sparwasser

  19. Inflammation in the Human Periodontium Induces Downregulation of the α1- and β1-Subunits of the sGC in Cementoclasts

    Article • International Journal of Molecular Sciences, January 2021, MDPI AG

    Professor Tim D Sparwasser

  20. Regulating T-cell differentiation through the polyamine spermidine

    Article • Journal of Allergy and Clinical Immunology, January 2021, Elsevier

    Professor Tim D Sparwasser

  21. Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

    Article • Immunity, January 2021, Elsevier

    Professor Tim D Sparwasser

  22. Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection

    Article • Mucosal Immunology, January 2021, Elsevier

    Professor Tim D Sparwasser

  23. Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo

    Article • European Journal of Immunology, December 2020, Wiley

    Professor Tim D Sparwasser

  24. Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy

    Article • Communications Biology, December 2020, Springer Science + Business Media

    Professor Tim D Sparwasser

  25. The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment

    Article • Frontiers in Immunology, July 2020, Frontiers

    Professor Tim D Sparwasser

  26. Notch and TLR signaling coordinate monocyte cell fate and inflammation

    Article • eLife, July 2020, eLife

    Professor Tim D Sparwasser

  27. Notch and TLR signaling coordinate monocyte cell fate and inflammation

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Professor Tim D Sparwasser

  28. Regulatory T Cells Limit Pneumococcus-Induced Exacerbation of Lung Fibrosis in Mice

    Article • The Journal of Immunology, May 2020, The American Association of Immunologists

    Professor Tim D Sparwasser

  29. TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection

    Article • PLoS Pathogens, March 2020, PLOS

    Professor Tim D Sparwasser

  30. The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

    Article • Cell Reports, March 2020, Elsevier

    Professor Tim D Sparwasser

  31. The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells

    Article • Cell Reports, December 2019, Elsevier

    Dr Christoph Bock, Professor Tim D Sparwasser

  32. Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis

    Article • November 2019, Cold Spring Harbor Laboratory Press

    Professor Tim D Sparwasser

  33. CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells

    Article • Nature Immunology, October 2019, Springer Science + Business Media

    Professor Tim D Sparwasser

  34. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult

    Article • Immunity, May 2019, Elsevier

    Professor Tim D Sparwasser

  35. Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction

    Article • Immunity, May 2019, Elsevier

    Professor Tim D Sparwasser

  36. TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice

    Article • PLoS Pathogens, April 2019, PLOS

    Professor Tim D Sparwasser

  37. C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function

    Article • Circulation, April 2019, Wolters Kluwer Health

    Professor Tim D Sparwasser

  38. Regulatory T Cells in an Endogenous Mouse Lymphoma Recognize Specific Antigen Peptides and Contribute to Immune Escape

    Article • Cancer Immunology Research, March 2019, American Association for Cancer Research (AACR)

    Professor Tim D Sparwasser

  39. TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion

    Article • Frontiers in Immunology, March 2019, Frontiers

    Professor Tim D Sparwasser

  40. Epithelium‐specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile

    Article • European Journal of Immunology, March 2019, Wiley

    Professor Tim D Sparwasser

  41. Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

    Article • Nature Communications, January 2019, Springer Science + Business Media

    Professor Tim D Sparwasser

  42. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation

    Article • Cell Metabolism, September 2018, Elsevier

    Professor Tim D Sparwasser

  43. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

    Article • Cell Metabolism, September 2018, Elsevier

    Professor Tim D Sparwasser

  44. Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction

    Article • JCI Insight, August 2018, American Society for Clinical Investigation

    Professor Tim D Sparwasser

  45. Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APCmin/+ mice

    Article • Cancer Immunology Immunotherapy, April 2018, Springer Science + Business Media

    Professor Tim D Sparwasser

  46. Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts

    Article • Immunological Reviews, April 2018, Wiley

    Professor Tim D Sparwasser

  47. A new RelB-dependent CD117+ CD172a+ murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo

    Article • European Journal of Immunology, April 2018, Wiley

    Professor Tim D Sparwasser

  48. De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages

    Article • Frontiers in Immunology, April 2018, Frontiers

    Professor Tim D Sparwasser

  49. Cytokines, Antibodies, and Histopathological Profiles during Giardia Infection and Variant-Specific Surface Protein-Based Vaccination

    Article • Infection and Immunity, March 2018, ASM Journals

    Professor Tim D Sparwasser

  50. Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses

    Article • Frontiers in Immunology, March 2018, Frontiers

    Professor Tim D Sparwasser

  51. Adenoviral vector-mediated GM-CSF gene transfer improves anti-mycobacterial immunity in mice – role of regulatory T cells

    Article • Immunobiology, March 2018, Elsevier

    Professor Tim D Sparwasser

  52. Dendritic cells conditioned by activin A–induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma

    Article • Journal of Allergy and Clinical Immunology, February 2018, Elsevier

    Professor Tim D Sparwasser

  53. Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease

    Article • The Journal of Immunology, January 2018, The American Association of Immunologists

    Professor Tim D Sparwasser

  54. Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases

    Article • Frontiers in Immunology, November 2017, Frontiers

    Professor Tim D Sparwasser

  55. Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function

    Article • International Journal for Parasitology, August 2017, Elsevier

    Professor Tim D Sparwasser

  56. The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion

    Article • PLoS Pathogens, June 2017, PLOS

    Professor Tim D Sparwasser

  57. Tregs restrain dendritic cell autophagy to ameliorate autoimmunity

    Article • Journal of Clinical Investigation, June 2017, American Society for Clinical Investigation

    Professor Tim D Sparwasser

  58. MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium

    Article • PLoS Pathogens, May 2017, PLOS

    Professor Tim D Sparwasser

  59. IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection

    Article • PLoS Pathogens, April 2017, PLOS

    Professor Tim D Sparwasser

  60. Metabolites: deciphering the molecular language between DCs and their environment

    Article • Seminars in Immunopathology, December 2016, Springer Science + Business Media

    Professor Tim D Sparwasser

  61. Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

    Article • Science Translational Medicine, October 2016, American Association for the Advancement of Science

    Professor Tim D Sparwasser

  62. Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease

    Article • Science Translational Medicine, October 2016, American Association for the Advancement of Science

    Professor Tim D Sparwasser

  63. Immunometabolism and autoimmunity

    Article • Immunology and Cell Biology, October 2016, Wiley

    Professor Tim D Sparwasser

  64. Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling

    Article • Cell Reports, October 2016, Elsevier

    Professor Tim D Sparwasser

  65. Metabolic pathways in T cell activation and lineage differentiation

    Article • Seminars in Immunology, October 2016, Elsevier

    Professor Tim D Sparwasser

  66. Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease

    Article • European Journal of Immunology, July 2016, Wiley

    Professor Tim D Sparwasser

  67. pDCs Take a Deep Breath to Fight Viruses

    Article • Immunity, June 2016, Elsevier

    Professor Tim D Sparwasser

  68. Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection

    Article • Retrovirology, April 2016, Springer Science + Business Media

    Professor Tim D Sparwasser

  69. Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

    Article • Proceedings of the National Academy of Sciences, March 2016, Proceedings of the National Academy of Sciences

    Professor Tim D Sparwasser

  70. In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice

    Article • European Journal of Immunology, January 2016, Wiley

    Professor Tim D Sparwasser

  71. Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection

    Article • Mucosal Immunology, December 2015, Springer Science + Business Media

    Professor Tim D Sparwasser

  72. Microbe-associated immunomodulatory metabolites: Influence on T cell fate and function

    Article • Molecular Immunology, December 2015, Elsevier

    Professor Tim D Sparwasser

  73. CD4 + T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion

    Article • Immunity, November 2015, Elsevier

    Professor Tim D Sparwasser

  74. Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1

    Article • Nature Communications, October 2015, Springer Science + Business Media

    Professor Tim D Sparwasser

  75. Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming

    Article • Journal of Investigative Dermatology, October 2015, Elsevier

    Professor Tim D Sparwasser

  76. Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

    Article • Mucosal Immunology, August 2015, Springer Science + Business Media

    Professor Tim D Sparwasser

  77. Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease

    Article • Journal of Clinical Investigation, August 2015, American Society for Clinical Investigation

    Professor Tim D Sparwasser

  78. Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths

    Article • Mucosal Immunology, August 2015, Nature

    Professor Tim D Sparwasser

  79. Active suppression of intestinal CD4+TCRαβ+ T-lymphocyte maturation during the postnatal period

    Article • Nature Communications, July 2015, Springer Science + Business Media

    Professor Tim D Sparwasser

  80. Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production

    Article • The Journal of Immunology, July 2015, The American Association of Immunologists

    Professor Tim D Sparwasser

  81. Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production

    Article • PLoS ONE, May 2015, PLOS

    Professor Tim D Sparwasser

  82. De Novo–Induced Self-Antigen–Specific Foxp3+ Regulatory T Cells Impair the Accumulation of Inflammatory Dendritic Cells in Draining Lymph Nodes

    Article • The Journal of Immunology, May 2015, The American Association of Immunologists

    Professor Tim D Sparwasser

  83. Ligation of TLR7 on CD19+CD1dhiB cells suppresses allergic lung inflammation via regulatory T cells

    Article • European Journal of Immunology, April 2015, Wiley

    Professor Tim D Sparwasser

  84. Treg-cell depletion promotes chemokine production and accumulation of CXCR3+conventional T cells in intestinal tumors

    Article • European Journal of Immunology, April 2015, Wiley

    Professor Tim D Sparwasser

  85. Erratum: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

    Article • Nature Reports Stem Cells, April 2015, Springer Science + Business Media

    Professor Tim D Sparwasser

  86. Foxp3 + Regulatory T Cells Play a Protective Role in Angiotensin II–Induced Aortic Aneurysm Formation in Mice

    Article • Hypertension, April 2015, Wolters Kluwer Health

    Professor Tim D Sparwasser

  87. Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells

    Article • The EMBO Journal, March 2015, EMBO

    Professor Tim D Sparwasser

  88. Fatty acid metabolism in the regulation of T cell function

    Article • Trends in Immunology, February 2015, Elsevier

    Professor Tim D Sparwasser

  89. PD-L1hi B cells are critical regulators of humoral immunity

    Article • Nature Communications, January 2015, Springer Science + Business Media

    Professor Tim D Sparwasser

  90. Development of a unique epigenetic signature during in vivo Th17 differentiation

    Article • Nucleic Acids Research, January 2015, Oxford University Press (OUP)

    Professor Tim D Sparwasser

  91. The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells

    Article • January 2015, Elsevier

    Professor Tim D Sparwasser

  92. A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection

    Article • The Journal of Immunology, December 2014, The American Association of Immunologists

    Professor Tim D Sparwasser

  93. Dendritic cell specific targeting of MyD88 signalling pathways in vivo

    Article • European Journal of Immunology, December 2014, Wiley

    Professor Tim D Sparwasser

  94. Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow

    Article • Blood, November 2014, American Society of Hematology

    Professor Tim D Sparwasser

  95. 96

    Article • Cytokine, November 2014, Elsevier

    Professor Tim D Sparwasser

  96. Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression

    Article • OncoImmunology, October 2014, Taylor & Francis

    Professor Tim D Sparwasser

  97. CD4+FoxP3+regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection

    Article • European Journal of Immunology, October 2014, Wiley

    Professor Tim D Sparwasser

  98. Advantages of Foxp3+regulatory T cell depletion using DEREG mice

    Article • Immunity Inflammation and Disease, October 2014, Wiley

    Professor Tim D Sparwasser

  99. CD28 Superagonist-Mediated Boost of Regulatory T Cells Increases Thrombo-Inflammation and Ischemic Neurodegeneration during the Acute Phase of Experimental Stroke

    Article • Journal of Cerebral Blood Flow & Metabolism, October 2014, SAGE Publications

    Professor Tim D Sparwasser

  100. Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

    Article • Science Translational Medicine, October 2014, American Association for the Advancement of Science

    Professor Tim D Sparwasser

  101. FoxP3+ Regulatory T Cells Determine Disease Severity in Rodent Models of Inflammatory Neuropathies

    Article • PLoS ONE, October 2014, PLOS

    Professor Tim D Sparwasser

  102. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

    Article • Nature Reports Stem Cells, October 2014, Springer Science + Business Media

    Professor Tim D Sparwasser

  103. Characterization of tetraspanin-2 expressing cells in the mouse

    Article • Journal of Neuroimmunology, October 2014, Elsevier

    Professor Tim D Sparwasser

  104. Fluorochrome-based definition of naturally occurring Foxp3+regulatory T cells of intra- and extrathymic origin

    Article • European Journal of Immunology, September 2014, Wiley

    Professor Tim D Sparwasser

  105. Depletion of Regulatory T Cells Augments a Vaccine-Induced T Effector Cell Response against the Liver-Stage of Malaria but Fails to Increase Memory

    Article • PLoS ONE, August 2014, PLOS

    Professor Tim D Sparwasser

  106. Few Foxp3+regulatory T cells are sufficient to protect adult mice from lethal autoimmunity

    Article • European Journal of Immunology, August 2014, Wiley

    Professor Tim D Sparwasser

  107. The Immunotherapeutic Role of Regulatory T Cells in Leishmania (Viannia) panamensis Infection

    Article • The Journal of Immunology, August 2014, The American Association of Immunologists

    Professor Tim D Sparwasser

  108. Regulatory T cells and T‐cell‐derived IL‐10 interfere with effective anti‐cytomegalovirus immune response

    Article • Immunology and Cell Biology, July 2014, Wiley

    Professor Tim D Sparwasser, Professor Werner Muller

  109. Rapid Rebound of the Treg Compartment in DEREG Mice Limits the Impact of Treg Depletion on Mycobacterial Burden, but Prevents Autoimmunity

    Article • PLoS ONE, July 2014, PLOS

    Professor Tim D Sparwasser

  110. Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer

    Article • Cancer Research, June 2014, American Association for Cancer Research (AACR)

    Professor Werner Muller, Professor Tim D Sparwasser

  111. Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals

    Article • Journal of Autoimmunity, May 2014, Elsevier

    Professor Tim D Sparwasser

  112. MP35-17 COMBINATION OF MTOR INHIBITION AND CD4 DEPLETION GENERATES ANTITUMOR IMMUNITY

    Article • The Journal of Urology, April 2014, Elsevier

    Professor Tim D Sparwasser

  113. Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium

    Article • Mucosal Immunology, March 2014, Springer Science + Business Media

    Professor Tim D Sparwasser

  114. Foxp3+ T Cells Inhibit Antitumor Immune Memory Modulated by mTOR Inhibition

    Article • Cancer Research, February 2014, American Association for Cancer Research (AACR)

    Professor Tim D Sparwasser

  115. MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection

    Article • European Journal of Immunology, February 2014, Wiley

    Professor Tim D Sparwasser

  116. Foxp3+ Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice

    Article • PLoS Pathogens, February 2014, PLOS

    Professor Tim D Sparwasser

  117. Dendritic Cells Coordinate Innate Immunity via MyD88 Signaling to Control Listeria monocytogenes Infection

    Article • Cell Reports, February 2014, Elsevier

    Professor Tim D Sparwasser

  118. HIV Nef Expression Favors the Relative Preservation of CD4+ T Regulatory Cells That Retain Some Important Suppressive Functions

    Article • The Journal of Immunology, January 2014, The American Association of Immunologists

    Professor Tim D Sparwasser

  119. Assessing the Suppressive Activity of Foxp3+ Regulatory T Cells

    Article • January 2014, Springer Science + Business Media

    Professor Tim D Sparwasser

  120. Mouse Cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells

    Article • Virology Journal, January 2014, Springer Science + Business Media

    Professor Tim D Sparwasser

  121. Salmonella enterica Serovar Typhimurium Infection-Induced CD11b+Gr1+Cells Ameliorate Allergic Airway Inflammation

    Article • Infection and Immunity, December 2013, ASM Journals

    Professor Tim D Sparwasser

  122. Gene Trap Mice Reveal an Essential Function of Dual Specificity Phosphatase Dusp16/MKP-7 in Perinatal Survival and Regulation of Toll-like Receptor (TLR)-induced Cytokine Production

    Article • Journal of Biological Chemistry, December 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Tim D Sparwasser

  123. Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection

    Article • Virology, December 2013, Elsevier

    Professor Cheryl Anne Jones, Professor Tim D Sparwasser

  124. CD4 blockade directly inhibits mouse and human CD4+ T cell functions independent of Foxp3+ Tregs

    Article • Journal of Autoimmunity, December 2013, Elsevier

    Professor Tim D Sparwasser

  125. Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity

    Article • PLoS Pathogens, October 2013, PLOS

    Professor Tim D Sparwasser

  126. Absence of Siglec-H in MCMV Infection Elevates Interferon Alpha Production but Does Not Enhance Viral Clearance

    Article • PLoS Pathogens, September 2013, PLOS

    Professor Tim D Sparwasser

  127. Infiltrating Foxp3+Regulatory T Cells From Spontaneously Tolerant Kidney Allografts Demonstrate Donor-Specific Tolerance

    Article • American Journal of Transplantation, September 2013, Wiley

    Professor Tim D Sparwasser

  128. Schistosoma mansoni-Mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3+ Treg Cells

    Article • PLoS Neglected Tropical Diseases, August 2013, PLOS

    Professor Tim D Sparwasser

  129. Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells

    Article • Nature Communications, July 2013, Springer Science + Business Media

    Professor Tim D Sparwasser

  130. Regulatory CD4+Foxp3+ T Cells Control the Severity of Anaphylaxis

    Article • PLoS ONE, July 2013, PLOS

    Professor Tim D Sparwasser

  131. In vivo targeting of human DC-SIGN drastically enhances CD8+T-cell-mediated protective immunity

    Article • European Journal of Immunology, July 2013, Wiley

    Professor Tim D Sparwasser

  132. Administration of anti-CD25 mAb leads to impaired α-galactosylceramide-mediated induction of IFN-γ production in a murine model

    Article • Immunobiology, June 2013, Elsevier

    Professor Tim D Sparwasser

  133. Foxp3+ Regulatory T Cells Are Required for Recovery from Severe Sepsis

    Article • PLoS ONE, May 2013, PLOS

    Professor Tim D Sparwasser

  134. IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection

    Article • PLoS Pathogens, May 2013, PLOS

    Professor Tim D Sparwasser

  135. Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity

    Article • Immunity, May 2013, Elsevier

    Professor Tim D Sparwasser

  136. Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells

    Article • Blood, April 2013, American Society of Hematology

    Professor Tim D Sparwasser

  137. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

    Article • Journal of Clinical Investigation, February 2013, American Society for Clinical Investigation

    Professor Tim D Sparwasser, Dr Daniel FJ Ketelhuth

  138. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature

    Article • Blood, January 2013, American Society of Hematology

    Professor Tim D Sparwasser

  139. Foxp3+Regulatory T Cells in Mouse Models of Type 1 Diabetes

    Article • Journal of Diabetes Research, January 2013, Hindawi Publishing Corporation

    Professor Tim D Sparwasser

  140. 1,25-Dihydroxyvitamin D Exerts Similar Immunosuppressive Effects as UVR but Is Dispensable for Local UVR-Induced Immunosuppression

    Article • Journal of Investigative Dermatology, December 2012, Elsevier

    Professor Tim D Sparwasser

  141. The Temporal and Spatial Dynamics of Foxp3+ Treg Cell–Mediated Suppression during Contact Hypersensitivity Responses in a Murine Model

    Article • Journal of Investigative Dermatology, December 2012, Elsevier

    Professor Tim D Sparwasser

  142. Toll-Like Receptor–2 Agonist–Allergen Coupling Efficiently Redirects Th2 Cell Responses and Inhibits Allergic Airway Eosinophilia

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2012, American Thoracic Society

    Professor Tim D Sparwasser

  143. IκBNS Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor

    Article • Immunity, December 2012, Elsevier

    Professor Tim D Sparwasser

  144. On the Role of Regulatory T Cells during Viral-Induced Inflammatory Lesions

    Article • The Journal of Immunology, November 2012, The American Association of Immunologists

    Professor Tim D Sparwasser

  145. T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

    Article • Immunity, November 2012, Elsevier

    Professor Tim D Sparwasser

  146. Regulatory T Cells Increase the Avidity of Primary CD8+ T Cell Responses and Promote Memory

    Article • Science, October 2012, American Association for the Advancement of Science

    Professor Tim D Sparwasser

  147. Absence of Foxp3+ Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation

    Article • PLoS ONE, October 2012, PLOS

    Professor Tim D Sparwasser

  148. Neuropilin 1 deficiency on CD4+Foxp3+regulatory T cells impairs mouse melanoma growth

    Article • The Journal of Experimental Medicine, October 2012, Rockefeller University Press

    Professor Tim D Sparwasser

  149. Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy

    Article • Clinical & Experimental Allergy, September 2012, Wiley

    Professor Tim D Sparwasser

  150. Optimal Isolation of Functional Foxp3+ Induced Regulatory T Cells Using DEREG Mice

    Article • PLoS ONE, September 2012, PLOS

    Professor Tim D Sparwasser

  151. Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells

    Article • Cancer Immunology Immunotherapy, August 2012, Springer Science + Business Media

    Professor Tim D Sparwasser

  152. Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice

    Article • Hepatology, August 2012, Wolters Kluwer Health

    Professor Ulrike Protzer, Professor Tim D Sparwasser

  153. Vagaries of Fluorochrome Reporter Gene Expression in Foxp3+ Regulatory T Cells

    Article • PLoS ONE, August 2012, PLOS

    Professor Tim D Sparwasser

  154. α-MSH-Stimulated Tolerogenic Dendritic Cells Induce Functional Regulatory T Cells and Ameliorate Ongoing Skin Inflammation

    Article • Journal of Investigative Dermatology, July 2012, Elsevier

    Professor Tim D Sparwasser

  155. Identification and expansion of highly suppressive CD8+FoxP3+ regulatory T cells after experimental allogeneic bone marrow transplantation

    Article • Blood, June 2012, American Society of Hematology

    Professor Tim D Sparwasser

  156. Foxp3+ Cells Control Th2 Responses in a Murine Model of Atopic Dermatitis

    Article • Journal of Investigative Dermatology, June 2012, Elsevier

    Professor Tim D Sparwasser

  157. Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells

    Article • Journal of Clinical Investigation, May 2012, American Society for Clinical Investigation

    Professor Tim D Sparwasser

  158. PDGF-Producing CD4+ Foxp3+ Regulatory T Lymphocytes Promote Lung Fibrosis

    Article • May 2012, American Thoracic Society

    Professor Tim D Sparwasser

  159. Strong Impact of CD4+Foxp3+ Regulatory T Cells and Limited Effect of T Cell-Derived IL-10 on Pathogen Clearance during Plasmodium yoelii Infection

    Article • The Journal of Immunology, April 2012, The American Association of Immunologists

    Professor Werner Muller, Professor Tim D Sparwasser

  160. Foxp3+ Regulatory T Cells Control Persistence of Viral CNS Infection

    Article • PLoS ONE, March 2012, PLOS

    Professor Tim D Sparwasser

  161. Regulatory T Cells Selectively Preserve Immune Privilege of Self-Antigens during Viral Central Nervous System Infection

    Article • The Journal of Immunology, March 2012, The American Association of Immunologists

    Professor Tim D Sparwasser

  162. Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer

    Article • OncoImmunology, March 2012, Taylor & Francis

    Professor Tim D Sparwasser

  163. Schistosomes Induce Regulatory Features in Human and Mouse CD1dhi B Cells: Inhibition of Allergic Inflammation by IL-10 and Regulatory T Cells

    Article • PLoS ONE, February 2012, PLOS

    Professor Tim D Sparwasser

  164. Lack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing mice

    Article • Blood, February 2012, American Society of Hematology

    Professor Tim D Sparwasser

  165. A limited role for regulatory T cells in post-ischemic neovascularization

    Article • Journal of Cellular and Molecular Medicine, January 2012, Wiley

    Professor Tim D Sparwasser, Professor Paul HA Quax

  166. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection

    Article • Mucosal Immunology, January 2012, Springer Science + Business Media

    Professor Tim D Sparwasser, Prof Cecilia Johansson

  167. Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity

    Article • Frontiers in Immunology, January 2012, Frontiers

    Professor Tim D Sparwasser

  168. Induction of Regulatory T Cells by a Murine  -Defensin

    Article • The Journal of Immunology, December 2011, The American Association of Immunologists

    Professor Tim D Sparwasser, Professor Werner Muller

  169. Multiple Layers of CD80/86-Dependent Costimulatory Activity Regulate Primary, Memory, and Secondary Lymphocytic Choriomeningitis Virus-Specific T Cell Immunity

    Article • Journal of Virology, December 2011, ASM Journals

    Professor Tim D Sparwasser

  170. Rapid In Vivo Conversion of Effector T Cells into Th2 Cells during Helminth Infection

    Article • The Journal of Immunology, December 2011, The American Association of Immunologists

    Professor Tim D Sparwasser

  171. Gut-Tropic T Cells That Express Integrin α4β7 and CCR9 Are Required for Induction of Oral Immune Tolerance in Mice

    Article • Gastroenterology, December 2011, Elsevier

    Professor Tim D Sparwasser

  172. Platelet-Derived Growth Factor–Producing CD4+Foxp3+Regulatory T Lymphocytes Promote Lung Fibrosis

    Article • American Journal of Respiratory and Critical Care Medicine, December 2011, American Thoracic Society

    Professor Tim D Sparwasser

  173. Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation

    Article • Blood, October 2011, American Society of Hematology

    Professor Tim D Sparwasser

  174. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation

    Article • Nature Immunology, October 2011, Springer Science + Business Media

    Professor Tim D Sparwasser

  175. In vivo reprogramming of UV radiation–induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity

    Article • Journal of Allergy and Clinical Immunology, October 2011, Elsevier

    Professor Tim D Sparwasser

  176. Tregs in infection and vaccinology: heroes or traitors?

    Article • Microbial Biotechnology, September 2011, Wiley

    Professor Tim D Sparwasser

  177. Regulatory T Cells Selectively Control CD8+ T Cell Effector Pool Size via IL-2 Restriction

    Article • The Journal of Immunology, August 2011, The American Association of Immunologists

    Professor Tim D Sparwasser, Naeha Subramanian

  178. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

    Article • Nature Immunology, August 2011, Springer Science + Business Media

    Professor Tim D Sparwasser

  179. Foxp3-Mediated Suppression of CD95L Expression Confers Resistance to Activation-Induced Cell Death in Regulatory T Cells

    Article • The Journal of Immunology, July 2011, The American Association of Immunologists

    Professor Tim D Sparwasser

  180. Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis

    Article • Kidney International, July 2011, Elsevier

    Professor Tim D Sparwasser

  181. Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice

    Article • Journal of Clinical Investigation, July 2011, American Society for Clinical Investigation

    Professor Tim D Sparwasser

  182. The adjuvant effect of TLR agonists on CD4+ effector T cells is under the indirect control of regulatory T cells

    Article • European Journal of Immunology, June 2011, Wiley

    Professor Tim D Sparwasser

  183. Inhibiting CXCR3-Dependent CD8+ T Cell Trafficking Enhances Tolerance Induction in a Mouse Model of Lung Rejection

    Article • The Journal of Immunology, May 2011, The American Association of Immunologists

    Professor Tim D Sparwasser

  184. Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs

    Article • European Journal of Immunology, April 2011, Wiley

    Professor Tim D Sparwasser

  185. CD4 + CD25 + regulatory T cells control CD8 + T-cell effector differentiation by modulating IL-2 homeostasis

    Article • Proceedings of the National Academy of Sciences, April 2011, Proceedings of the National Academy of Sciences

    Professor Tim D Sparwasser

  186. Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy

    Article • Proceedings of the National Academy of Sciences, April 2011, Proceedings of the National Academy of Sciences

    Professor Tim D Sparwasser

  187. Strongyloides ratti Infection Induces Expansion of Foxp3+ Regulatory T Cells That Interfere with Immune Response and Parasite Clearance in BALB/c Mice

    Article • The Journal of Immunology, February 2011, The American Association of Immunologists

    Professor Tim D Sparwasser

  188. CD8+Foxp3+ T cells share developmental and phenotypic features with classical CD4+Foxp3+ regulatory T cells but lack potent suppressive activity

    Article • European Journal of Immunology, February 2011, Wiley

    Professor Tim D Sparwasser

  189. CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

    Article • Cancer Research, February 2011, American Association for Cancer Research (AACR)

    Professor Tim D Sparwasser

  190. Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

    Article • Immunity, February 2011, Elsevier

    Professor Tim D Sparwasser, Professor Werner Muller

  191. IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

    Article • Cell, February 2011, Elsevier

    Professor Tim D Sparwasser

  192. Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1)

    Article • Proceedings of the National Academy of Sciences, January 2011, Proceedings of the National Academy of Sciences

    Professor Tim D Sparwasser

  193. Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8 + T cells and reduces chronic retroviral set points

    Article • Proceedings of the National Academy of Sciences, January 2011, Proceedings of the National Academy of Sciences

    Professor Tim D Sparwasser

  194. In Vivo Depletion of FoxP3+ Tregs Using the DEREG Mouse Model

    Article • January 2011, Springer Science + Business Media

    Professor Tim D Sparwasser

  195. Tolerance Rather Than Immunity Protects From Helicobacter pylori–Induced Gastric Preneoplasia

    Article • Gastroenterology, January 2011, Elsevier

    Professor Tim D Sparwasser

  196. A novel bacterial artificial chromosome-transgenic Podoplanin–Cre mouse targets lymphoid organ stromal cells in vivo

    Article • Frontiers in Immunology, January 2011, Frontiers

    Professor Tim D Sparwasser

  197. CD4+ Natural Regulatory T Cells Prevent Experimental Cerebral Malaria via CTLA-4 When Expanded In Vivo

    Article • PLoS Pathogens, December 2010, PLOS

    Professor Tim D Sparwasser

  198. T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract

    Article • Nature Reports Stem Cells, November 2010, Springer Science + Business Media

    Professor Tim D Sparwasser

  199. Extracellular NAD+shapes the Foxp3+regulatory T cell compartment through the ART2–P2X7 pathway

    Article • The Journal of Experimental Medicine, October 2010, Rockefeller University Press

    Professor Tim D Sparwasser

  200. Selective Depletion of Foxp3+ Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma

    Article • Cancer Research, October 2010, American Association for Cancer Research (AACR)

    Professor Tim D Sparwasser

  201. Conditional Regulatory T-Cell Depletion Releases Adaptive Immunity Preventing Carcinogenesis and Suppressing Established Tumor Growth

    Article • Cancer Research, October 2010, American Association for Cancer Research (AACR)

    Professor Tim D Sparwasser

  202. The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways

    Article • Mucosal Immunology, September 2010, Springer Science + Business Media

    Professor Tim D Sparwasser

  203. Correction: Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation

    Article • European Journal of Immunology, August 2010, Wiley

    Professor Tim D Sparwasser

  204. Bedeutung Foxp3+ regulatorischer T-Zellen in der infektiösen experimentellen Kolitis der Maus

    Article • Seminars in Musculoskeletal Radiology, August 2010, Thieme Publishing Group

    Professor Tim D Sparwasser

  205. Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist

    Article • Immunobiology, July 2010, Elsevier

    Professor Tim D Sparwasser, Professor Eicke Latz

  206. Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation

    Article • European Journal of Immunology, June 2010, Wiley

    Professor Tim D Sparwasser, Professor Heinz Günther Fehrenbach

  207. Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk

    Article • Journal of Allergy and Clinical Immunology, June 2010, Elsevier

    Professor Tim D Sparwasser

  208. The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

    Article • The Journal of Experimental Medicine, May 2010, Rockefeller University Press

    Professor Tim D Sparwasser

  209. Foxp3+ T Cells Induce Perforin-Dependent Dendritic Cell Death in Tumor-Draining Lymph Nodes

    Article • Immunity, February 2010, Elsevier

    Professor Tim D Sparwasser

  210. FoxP3 + regulatory T cells essentially contribute to peripheral CD8 + T-cell tolerance induced by steady-state dendritic cells

    Article • Proceedings of the National Academy of Sciences, January 2010, Proceedings of the National Academy of Sciences

    Professor Tim D Sparwasser

  211. Immunostimulatory RNA Blocks Suppression by Regulatory T Cells

    Article • The Journal of Immunology, December 2009, The American Association of Immunologists

    Professor Tim D Sparwasser

  212. Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation

    Article • Molecular Immunology, December 2009, Elsevier

    Professor Tim D Sparwasser

  213. Cutting Edge: Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice

    Article • The Journal of Immunology, November 2009, The American Association of Immunologists

    Professor Tim D Sparwasser

  214. Limited Role of CD4+Foxp3+ Regulatory T Cells in the Control of Experimental Cerebral Malaria

    Article • The Journal of Immunology, November 2009, The American Association of Immunologists

    Professor Tim D Sparwasser

  215. Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+cells

    Article • European Journal of Immunology, November 2009, Wiley

    Professor Tim D Sparwasser

  216. The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response

    Article • Blood, October 2009, American Society of Hematology

    Professor Tim D Sparwasser

  217. Nonfunctional Regulatory T Cells and Defective Control of Th2 Cytokine Production in Natural Scurfy Mutant Mice

    Article • The Journal of Immunology, October 2009, The American Association of Immunologists

    Professor Tim D Sparwasser

  218. Regulatory T Cells Suppress Antiviral Immune Responses and Increase Viral Loads during Acute Infection with a Lymphotropic Retrovirus

    Article • PLoS Pathogens, August 2009, PLOS

    Professor Tim D Sparwasser

  219. Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+regulatory T cells

    Article • Proceedings of the National Academy of Sciences, July 2009, Proceedings of the National Academy of Sciences

    Professor Tim D Sparwasser

  220. Conventional Bone Marrow-Derived Dendritic Cells Contribute to Toll-Like Receptor-Independent Production of Alpha/Beta Interferon in Response to Inactivated Parapoxvirus Ovis

    Article • Journal of Virology, July 2009, ASM Journals

    Professor Tim D Sparwasser

  221. Erratum: Corrigendum: Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

    Article • Nature Reports Stem Cells, July 2009, Springer Science + Business Media

    Professor Tim D Sparwasser

  222. Abstract: 150 SELECTIVE DEPLETION OF FOXP3+ REGULATORY T CELLS EXACERBATES EXPERIMENTAL ATHEROSCLEROSIS IN MICE

    Article • Atherosclerosis Supplements, June 2009, Elsevier

    Professor Tim D Sparwasser

  223. Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

    Article • Nature Reports Stem Cells, April 2009, Springer Science + Business Media

    Professor Tim D Sparwasser

  224. DC activated via dectin-1 convert Treg into IL-17 producers

    Article • European Journal of Immunology, November 2008, Wiley

    Professor Tim D Sparwasser

  225. Circumvention of regulatory CD4+ T cell activity during cross-priming strongly enhances T cell-mediated immunity

    Article • European Journal of Immunology, May 2008, Wiley

    Professor Tim D Sparwasser

  226. Decreased Pathology and Prolonged Survival of Human DC-SIGN Transgenic Mice during Mycobacterial Infection

    Article • The Journal of Immunology, May 2008, The American Association of Immunologists

    Professor Tim D Sparwasser

  227. BAC to immunology ? bacterial artificial chromosome-mediated transgenesis for targeting of immune cells

    Article • Immunology, July 2007, Wiley

    Professor Tim D Sparwasser

  228. Selective depletion of Foxp3 + regulatory T cells induces a scurfy-like disease

    Article • The Journal of Experimental Medicine, January 2007, Rockefeller University Press

    Professor Tim D Sparwasser

  229. Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guérin by Flt3-ligand generated dendritic cells

    Article • Immunobiology, September 2006, Elsevier

    Professor Tim D Sparwasser

  230. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

    Article • Nature, July 2006, Springer Science + Business Media

    Professor Tim D Sparwasser

  231. The Bcl10–Malt1 complex segregates FcεRI-mediated nuclear factor κB activation and cytokine production from mast cell degranulation

    Article • The Journal of Experimental Medicine, January 2006, Rockefeller University Press

    Professor Tim D Sparwasser

  232. General method for the modification of different BAC types and the rapid generation of BAC transgenic mice

    Article • genesis, January 2004, Wiley

    Professor Tim D Sparwasser

  233. In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

    Article • Immunity, August 2002, Elsevier

    Professor Tim D Sparwasser

  234. Functional and Antigenic Characterization of Human, Rhesus Macaque, Pigtailed Macaque, and Murine DC-SIGN

    Article • Journal of Virology, November 2001, ASM Journals

    Professor Stefan Pöhlmann, Professor Tim D Sparwasser

  235. IgG subclass switch capacity is low in switched and in IgM-only, but high in IgD+IgM+, post-germinal center (CD27+) human B cells

    Article • European Journal of Immunology, January 2001, Wiley

    Professor Tim D Sparwasser

  236. Bacterial CpG-DNA activates dendritic cellsin vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins

    Article • European Journal of Immunology, December 2000, Wiley

    Professor Tim D Sparwasser

  237. CpG-DNA-Mediated Transient Lymphadenopathy Is Associated with a State of Th1 Predisposition to Antigen-Driven Responses

    Article • The Journal of Immunology, August 2000, The American Association of Immunologists

    Professor Tim D Sparwasser

  238. Consequences of Bacterial CpG DNA-Driven Activation of Antigen-Presenting Cells

    Article • January 2000, Springer Science + Business Media

    Professor Tim D Sparwasser

  239. Hematopoietic Remodeling Triggered by CpG DNA

    Article • January 2000, Springer Science + Business Media

    Professor Tim D Sparwasser

  240. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

    Article • The EMBO Journal, November 1998, Wiley

    Professor Tim D Sparwasser

  241. Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells

    Article • European Journal of Clinical Microbiology & Infectious Diseases, July 1998, Springer Science + Business Media

    Professor Tim D Sparwasser

  242. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

    Article • European Journal of Immunology, June 1998, Wiley

    Professor Tim D Sparwasser

  243. Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines

    Article • European Journal of Immunology, December 1997, Wiley

    Professor Tim D Sparwasser

  244. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock

    Article • European Journal of Immunology, July 1997, Wiley

    Professor Tim D Sparwasser

  245. Bacterial DNA causes septic shock

    Article • Nature, March 1997, Springer Science + Business Media

    Professor Tim D Sparwasser

  246. IMMUNE CELLS SENSE PATHOGENS VIA DNA-MOTIFS: INDUCTION OF LETHAL TOXIC SHOCK

    Article • Shock, March 1997, Wolters Kluwer Health

    Professor Tim D Sparwasser